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    ALK KINASE INHIBITOR AND ITS USE
    71.
    发明申请
    ALK KINASE INHIBITOR AND ITS USE 审中-公开

    公开(公告)号：US20180050037A1

    公开(公告)日：2018-02-22

    申请号：US15239288

    申请日：2016-08-17

    Applicant: Macau University of Science and Technology

    Inventor： Xiao-Jun Yao ,  Elaine Lai-Han Leung ,  Lian-Xiang Luo ,  Liang Liu

    IPC: A61K31/519

    CPC classification number: A61K31/519

    Abstract: A compound for treating a disease, in particular cancer like non-small cell lung cancer, exceptionally inhibits activity of oncogenic ALK kinase. Compositions, particularly pharmaceutical compositions, are provided comprising this compound. Methods for targeting cancer cells harboring an abnormality in the ALK gene are also The compound for treating a disease has certain structural elements, namely a tricyclic, more specifically heterocyclic, backbone as the core part of the compound at least one highly electronegative atom in form of a tertiary amine attached to the backbone via an at most 6-membered linking group with a terminal highly electronegative atom in form of a nitrogen as secondary amine, and a further hydrophobic moiety fused to the backbone. The structural components allow for an advantageous interaction with the ALK kinase domain. The compound therefor represents a highly promising treatment option for patients in particular those bearing ALK-dependent non-small cell lung cancer.

    Cobalt-polypyridyl complex for treatment of cancer, a pharmaceutical composition and a kit comprising it
    72.
    发明授权
    Cobalt-polypyridyl complex for treatment of cancer, a pharmaceutical composition and a kit comprising it 有权

    公开(公告)号：US09895338B1

    公开(公告)日：2018-02-20

    申请号：US15242883

    申请日：2016-08-22

    Applicant: Macau University of Science and Technology

    Inventor： Kam Wai Wong ,  Man Chung Wong

    IPC: A61K31/28 ,  A61K31/555 ,  A61K45/06

    CPC classification number: A61K31/555 ,  A61K31/28 ,  A61K45/06 ,  A61K2300/00

    Abstract: A method for treating a subject suffering from a cancer, in particular a multidrug-resistant cancer includes administrating a cobalt-polypyridyl complex to the subject. A method for suppressing the growth of cancer cells, in particular inducing autophagy of the cancer cells, inducing cell cycle arrest of the cancer cells and/or inhibiting cell invasion of the cancer cells and for specifically targeting cancer cells with multidrug-resistance includes contacting said cancer cells with the cobalt-polypyridyl complex. A pharmaceutical composition and a kit are provided and include the cobalt-polypyridyl complex. Unexpectedly, the cobalt-polypyridyl complex is especially suitable to treat cancer, in particular multidrug-resistant cancer with an exceptionally increased cytotoxic activity towards multidrug-resistant cancer cells.

    MAC design for wireless hot-spot networks
    77.
    发明授权
    MAC design for wireless hot-spot networks 有权

    公开(公告)号：US09743309B2

    公开(公告)日：2017-08-22

    申请号：US14945306

    申请日：2015-11-18

    Applicant: Macau University of Science and Technology

    Inventor： Li Feng

    IPC: H04W28/02 ,  H04W74/08 ,  H04L12/54 ,  H04L1/18 ,  H04L12/911

    CPC classification number: H04W28/021 ,  H04L1/1854 ,  H04L47/70 ,  H04W74/08 ,  H04W74/0816

    Abstract: In widely deployed wireless “hot-spot” networks, nodes frequently join or leave, inelastic/elastic and saturated/non-satuarted flows coexist. In such dynamic and diverse environments, it is challenging to maximize the channel utilization while providing satisfactory user experiences. In this invention, one proposes a novel contention-on-demand (CoD) MAC scheme to address this problem. The CoD scheme consists of a fixed-CW algorithm, a dynamic-CW algorithm, and an admission control unit. The fixed-CW algorithm allows elastic flows to access limited system bandwidth; the dynamic-CW algorithm enables inelastic flows to contend for channel on demand and quickly adapt to network change; and the admission control unit rejects overloaded traffic for providing good user experiences. One then performs an asymptotic analysis to develop a simple but efficient admission control rule. Finally, extensive simulations verify that the scheme is very effective and the theoretical result is very accurate.

    PacketUsher: Accelerating Computer-Intensive Packet Processing
    78.
    发明申请
    PacketUsher: Accelerating Computer-Intensive Packet Processing 有权

    公开(公告)号：US20170163538A1

    公开(公告)日：2017-06-08

    申请号：US14972062

    申请日：2015-12-16

    Applicant: Macau University of Science and Technology

    Inventor： Li Feng ,  Liang Zhou ,  Zhijun Xu ,  Yujun Zhang

    IPC: H04L12/803 ,  H04L12/851 ,  H04L12/707 ,  H04L29/06

    CPC classification number: H04L47/125 ,  H04L45/24 ,  H04L47/2483 ,  H04L69/22

    Abstract: Compute-intensive packet processing (CIPP) in a computer system comprising a programmable computing platform is accelerated by using a packet I/O engine, implemented on the platform, to perform packet I/O functions, where the packet I/O engine is configured to achieve direct access to a network interface card (NIC) from a user application. For a Linux-based computer system, standard I/O mechanisms of Linux are bypassed and only the packet I/O engine is used in performing the I/O functions. Furthermore, the computer system is configured to: process a batch of packets, instead of packet by packet, in every function call; and when moving a packet between a buffer of an individual user application and a queue of the packet I/O engine, copy a packet descriptor of the packet instead the entire packet. In addition, workflows across different working threads are balanced and parallelism is exploited to fully utilize resources of the platform.

    CAFFEOYLQUINIC ACID-RICH EXTRACT AND PREPARATION AS WELL AS USE THEREOF
    79.
    发明申请
    CAFFEOYLQUINIC ACID-RICH EXTRACT AND PREPARATION AS WELL AS USE THEREOF 审中-公开

    公开(公告)号：US20170095443A1

    公开(公告)日：2017-04-06

    申请号：US14872198

    申请日：2015-10-01

    Applicant: Macau University of Science and Technology

    Inventor： Pei Luo

    IPC: A61K31/357 ,  A61K36/28 ,  A61K31/216

    CPC classification number: A61K31/357 ,  A61K31/216 ,  A61K36/28 ,  A61K2300/00

    Abstract: A caffeoylquinic acid-rich extract obtained from Erigeron multiradiatus and a method for producing the same. A caffeoylquinic acid-rich extract includes at least 15% by weight of a mixture of certain caffeoylquinic acids. The extract with the mixture of caffeoylquinic acids is highly efficacious in treating and preventing myocardial ischemia or myocardial ischemia reperfusion injuries. A method for treating or preventing a disease caused by myocardial ischemia or myocardial ischemia reperfusion includes administering a therapeutically effective amount of the caffeoylquinic acid-rich extract to a subject. Pharmaceutical compositions including the caffeoylquinic acid-rich extract are also disclosed.

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