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    Thrombin peptide derivatives
    75.
    发明专利
    Thrombin peptide derivatives 未知

    公开(公告)号：AU2003256343B2

    公开(公告)日：2006-12-21

    申请号：AU2003256343

    申请日：2003-07-01

    Applicant: ORTHOLOGIC CORP

    Inventor： CARNEY DARRELL H

    IPC: A61K38/00 ,  A61K38/48 ,  C07K20060101 ,  C12N9/74

    Abstract: Disclosed are thrombin peptide derivatives comprising a polypeptide having the amino acid sequence SEQ ID NO. 2: Arg-Gly-Asp-Ala-Xaa-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val, or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Xaa is alanine, glycine, serine, or an S-protected cysteine. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO. 2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.

    Thrombin peptide derivative dimers
    76.
    发明专利
    Thrombin peptide derivative dimers 未知

    公开(公告)号：AU2003247848B2

    公开(公告)日：2006-12-21

    申请号：AU2003247848

    申请日：2003-07-01

    Applicant: ORTHOLOGIC CORP

    Inventor： CARNEY DARREL H

    IPC: C07K14/705 ,  A61K38/17 ,  C07K16/28 ,  C12N9/74 ,  C12N15/85 ,  C12Q1/68 ,  G01N33/50

    Abstract: Disclosed are thrombin peptide derivative dimers comprising two polypeptides having the amino acid sequence Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val (SEQ ID NO:2), or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO:2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.

    77.
    发明专利
    未知

    公开(公告)号：AT328606T

    公开(公告)日：2006-06-15

    申请号：AT02703130

    申请日：2002-01-16

    Applicant: ORTHOLOGIC CORP

    Inventor： CARNEY DARRELL H

    IPC: A61K38/00 ,  A61K38/48 ,  A61P3/10 ,  A61P17/02

    Abstract: Disclosed is a method of promoting healing of a chronic dermal skin ulcer, such as a diabetic ulcer, on a subject. The method comprises the step of contacting the chronic dermal skin ulcer with an effective amount of an agonist of the non-proteolytically activated thrombin receptor.

    78.
    发明专利
    未知

    公开(公告)号：DE69532305D1

    公开(公告)日：2004-01-22

    申请号：DE69532305

    申请日：1995-10-04

    Applicant: ORTHOLOGIC CORP

    Inventor： KAUFMAN J ,  CHIABRERA E

    IPC: A61B17/00 ,  A61F2/28 ,  A61H23/02 ,  A61N1/00 ,  A61N7/00

    Abstract: A method of ultrasonic bone-therapy subjects a bone to an ultrasonic excitation pulse signal of finite duration, supplied to a transducer next to the bone, and involving a sinusoidal signal in the ultrasonic region to approximately 2 MHz peculiarly modulated by a sinusoidal signal with frequency between about 0 Hz and about 25 kHz; the excitation signal is repeated in the range of 1 to 5000 Hz. The exposure time for therapy is chosen to be in the range of 5 minutes to 1 hour, for 1 to 3 times a day, for a period of days as necessary for healing or for promoting bone growth and ingrowth. An apparatus for implementing the above method for ultrasonic bone therapy is disclosed comprising a transducer having a transmitting and a receiving element, a special waveform signal generator, and a computer for performing the necessary operations defining a preferred treatment regime.

    79.
    发明专利
    未知

    公开(公告)号：AT232696T

    公开(公告)日：2003-03-15

    申请号：AT94900592

    申请日：1993-11-08

    Applicant: ORTHOLOGIC CORP

    Inventor： KAUFMAN JONATHAN J ,  CHIABRERA ALESSANDRO

    IPC: A61M11/08 ,  A61B8/00 ,  A61B8/08 ,  A61B17/56 ,  A61H23/02 ,  A61J7/04 ,  A61M15/00 ,  A61M16/00 ,  A61N7/00 ,  G01N29/30 ,  G01N29/34

    Abstract: Non-invasive therapeutic treatment and/or quantitative evaluation of bone tissue are performed in vivo, by subjecting bone to an ultrasonic acoustic signal pulse of finite duration, and involving a composite sine-wave signal consisting of plural discrete frequencies that are spaced in the ultrasonic region to approximately 2 MHz; the excitation signal is repeated substantially in the range 1 to 1000 Hz. In a quantitative evaluation, the composite sine-wave signal is supplied to one of two transducers on opposite sides of the bone, and the signal received by the other transducer is processed (a) to sequentially average the most recently received given number of successive signals to obtain an averaged per-pulse signal and (b) to produce a Fourier transform of the averaged per-pulse bone-transmitted signal. In a separate operation not involving the bone, the same transducers are subjected to the same excitation, reception and processing, wherein the transducers are exposed to a medium of known acoustic properties and path length, all to the end of producing a reference Fourier transform which is processed with the Fourier transform of the bone-transmitted signal, to yield an evaluation or measurement. In a therapeutic treatment, the transducer supplied by the composite sine-wave signal is thus supplied for a period or periods of time, and with a magnitude, as may be prescribed by the physician for a given patient.

    80.
    发明专利
    未知

    公开(公告)号：AT196243T

    公开(公告)日：2000-09-15

    申请号：AT96937150

    申请日：1996-11-14

    Applicant: ORTHOLOGIC CORP

    Inventor： SARINGER JOHN H ,  CULHANE JEFFREY J

    IPC: A61H1/02

    Abstract: The present invention provides continuous passive motion (CPM) devices for joints. An ankle CPM device includes a lower leg support attached at its lower end to a semi-circular track. An actuator slides along the track and can be locked in any desired position on the track. A shaft is pivotally connected at one end thereof to the actuator and a shoe is attached at the other end thereof. When the actuator is positioned at the bottom of the track the ankle joint of the patient undergoes inversion/eversion motion. When the motor housing is rotated 90 DEG and positioned near the top of the track plantar/dorsi flexion movement is obtained. A combination of both types of joint movement are obtained for the actuator in intermediate positions. A wrist CPM device includes a brace for the forearm attached to a semi-circular track on which an actuator is mounted. A hand grip is mounted on a semi-circular bracket and a shaft extends between the actuator and a coupling slidably mounted on the semi-circular bracket. With the actuator positioned below the forearm, when the actuator pivots the shaft the wrist joint undergoes ulnar/radial deviation movement and when the motor is rotated 90 DEG and positioned at the side of the arm extension/flexion movement of the wrist joint is obtained. Positioning the actuator in intermediate positions produces wrist movement which is a combination of extension/flexion and ulnar/radial deviation of the wrist joint.

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