公开(公告)号：DK1559431T3

公开(公告)日：2007-07-30

申请号：DK04258191

申请日：2004-12-30

Applicant: ORTHOLOGIC CORP

Inventor： HOBSON DAVID M ,  CROWTHER ROGER S ,  CARNEY DARRELL H ,  TANG ANDREW PO KWAN

IPC: A61K38/48 ,  A61K9/06 ,  A61K31/198 ,  A61K31/473 ,  A61K31/4745 ,  A61K38/36 ,  A61K47/10 ,  A61K47/12 ,  A61K47/16 ,  A61K47/18 ,  A61K47/20 ,  A61P17/02

Abstract: Disclosed are pharmaceutical compositions comprising a thrombin peptide derivatives and a chelating agent and/or a pharmaceutically acceptable thiol-containing compound. The pharmaceutical compositions optionally further comprise an antioxidant. Also, disclosed are methods for activating the non-proteolytically activated thrombin receptor in a subject in need of such treatment. The methods comprise the step of administering an effective amount of a thrombin peptide derivative in the pharmaceutical composition described above.

公开(公告)号：HK1080390A1

公开(公告)日：2006-04-28

申请号：HK06101502

申请日：2006-02-03

Applicant: ORTHOLOGIC CORP

Inventor： HOBSON DAVID M ,  CARNEY DARRELL H ,  TANG ANDREW PO KWAN

IPC: A61K20060101 ,  A61K9/06 ,  A61K31/198 ,  A61K31/473 ,  A61K31/4745 ,  A61K38/36 ,  A61K38/48 ,  A61K47/10 ,  A61K47/12 ,  A61K47/16 ,  A61K47/18 ,  A61K47/20 ,  A61P20060101

Abstract: Disclosed are pharmaceutical compositions comprising a thrombin peptide derivatives and a chelating agent and/or a pharmaceutically acceptable thiol-containing compound. The pharmaceutical compositions optionally further comprise an antioxidant. Also, disclosed are methods for activating the non-proteolytically activated thrombin receptor in a subject in need of such treatment. The methods comprise the step of administering an effective amount of a thrombin peptide derivative in the pharmaceutical composition described above.

公开(公告)号：ES2287660T3

公开(公告)日：2007-12-16

申请号：ES04258191

申请日：2004-12-30

Applicant: ORTHOLOGIC CORP

Inventor： HOBSON DAVID M ,  CROWTHER ROGER S ,  CARNEY DARRELL H ,  TANG ANDREW PO KWAN

IPC: A61K38/48 ,  A61K9/06 ,  A61K31/198 ,  A61K31/473 ,  A61K31/4745 ,  A61K38/36 ,  A61K47/10 ,  A61K47/12 ,  A61K47/16 ,  A61K47/18 ,  A61K47/20 ,  A61P17/02

Abstract: Una composición farmacéutica que comprende: a) un derivado peptídico de trombina con una longitud de 14 a 23 aminoácidos y que comprende la secuencia de aminoácidos Asp- Ala-R, en la que R es el dominio conservado de la esterasa de la serina; y b) un agente quelante y/o un compuesto que contiene tiol aceptable desde el punto de vista farmacéutico.

公开(公告)号：PL1559431T3

公开(公告)日：2007-10-31

申请号：PL04258191

申请日：2004-12-30

Applicant: ORTHOLOGIC CORP

Inventor： HOBSON DAVID M ,  CROWTHER ROGER S ,  CARNEY DARRELL H ,  TANG ANDREW PO KWAN

IPC: A61K38/48 ,  A61K9/06 ,  A61K31/198 ,  A61K31/473 ,  A61K31/4745 ,  A61K38/36 ,  A61K47/10 ,  A61K47/12 ,  A61K47/16 ,  A61K47/18 ,  A61K47/20 ,  A61P17/02

公开(公告)号：AT357928T

公开(公告)日：2007-04-15

申请号：AT04258191

申请日：2004-12-30

Applicant: ORTHOLOGIC CORP

Inventor： HOBSON DAVID M ,  CROWTHER ROGER S ,  CARNEY DARRELL H ,  TANG ANDREW PO KWAN

IPC: A61K9/06 ,  A61K31/198 ,  A61K31/473 ,  A61K31/4745 ,  A61K38/36 ,  A61K38/48 ,  A61K47/10 ,  A61K47/12 ,  A61K47/16 ,  A61K47/18 ,  A61K47/20 ,  A61P17/02

Abstract: Disclosed are pharmaceutical compositions comprising a thrombin peptide derivatives and a chelating agent and/or a pharmaceutically acceptable thiol-containing compound. The pharmaceutical compositions optionally further comprise an antioxidant. Also, disclosed are methods for activating the non-proteolytically activated thrombin receptor in a subject in need of such treatment. The methods comprise the step of administering an effective amount of a thrombin peptide derivative in the pharmaceutical composition described above.

公开(公告)号：DE602004005564T2

公开(公告)日：2007-12-13

申请号：DE602004005564

申请日：2004-12-30

Applicant: ORTHOLOGIC CORP

Inventor： HOBSON DAVID M ,  CROWTHER ROGER S ,  CARNEY DARRELL H ,  TANG ANDREW PO KWAN

IPC: A61K38/48 ,  A61K9/06 ,  A61K31/198 ,  A61K31/473 ,  A61K31/4745 ,  A61K38/36 ,  A61K47/10 ,  A61K47/12 ,  A61K47/16 ,  A61K47/18 ,  A61K47/20 ,  A61P17/02

Abstract: Disclosed are pharmaceutical compositions comprising a thrombin peptide derivatives and a chelating agent and/or a pharmaceutically acceptable thiol-containing compound. The pharmaceutical compositions optionally further comprise an antioxidant. Also, disclosed are methods for activating the non-proteolytically activated thrombin receptor in a subject in need of such treatment. The methods comprise the step of administering an effective amount of a thrombin peptide derivative in the pharmaceutical composition described above.

公开(公告)号：PT1559431E

公开(公告)日：2007-07-02

申请号：PT04258191

申请日：2004-12-30

Applicant: ORTHOLOGIC CORP

Inventor： CARNEY DARRELL H ,  CROWTHER ROGER S ,  HOBSON DAVID M ,  TANG ANDREW PO KWAN

IPC: A61K38/48 ,  A61K9/06 ,  A61K31/198 ,  A61K31/473 ,  A61K31/4745 ,  A61K38/36 ,  A61K47/10 ,  A61K47/12 ,  A61K47/16 ,  A61K47/18 ,  A61K47/20 ,  A61P17/02

公开(公告)号：DE602004005564D1

公开(公告)日：2007-05-10

申请号：DE602004005564

申请日：2004-12-30

Applicant: ORTHOLOGIC CORP

Inventor： HOBSON DAVID M ,  CROWTHER ROGER S ,  CARNEY DARRELL H ,  TANG ANDREW PO KWAN

IPC: A61K38/48 ,  A61K9/06 ,  A61K31/198 ,  A61K31/473 ,  A61K31/4745 ,  A61K38/36 ,  A61K47/10 ,  A61K47/12 ,  A61K47/16 ,  A61K47/18 ,  A61K47/20 ,  A61P17/02

Abstract: Disclosed are pharmaceutical compositions comprising a thrombin peptide derivatives and a chelating agent and/or a pharmaceutically acceptable thiol-containing compound. The pharmaceutical compositions optionally further comprise an antioxidant. Also, disclosed are methods for activating the non-proteolytically activated thrombin receptor in a subject in need of such treatment. The methods comprise the step of administering an effective amount of a thrombin peptide derivative in the pharmaceutical composition described above.