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    ANTIBIOTIC SENSITIVITY TESTING METHOD
    71.
    发明申请
    ANTIBIOTIC SENSITIVITY TESTING METHOD 审中-公开
    抗生素敏感性测试方法

    公开(公告)号：WO2008107881A2

    公开(公告)日：2008-09-12

    申请号：PCT/IL2008/000283

    申请日：2008-03-05

    Applicant: POCARED DIAGNOSTICS LTD. ,  INGBER, Gal ,  GURFINKEL, Jonathan

    Inventor： INGBER, Gal ,  GURFINKEL, Jonathan

    IPC: C12Q1/18

    CPC classification number: G01N33/9446

    Abstract: The method includes several steps including obtaining a bacterial sample; identifying the type of bacteria in the bacterial sample; selecting a set of antibiotics based on the identity of the bacteria in the bacterial sample; obtaining a control sample from the bacterial sample; placing the bacterial sample in solutions containing the set of antibiotics; determining concentration of bacteria in the respective antibiotic solutions; determining growth curves for the respective antibiotic solutions based on the determined bacterial concentration; and comparing the growth curves for the respective antibiotic solutions with a growth curve determined from the control sample. An identification and quantification system may be used to select the set of antibiotics, and further may be used in the steps of determining concentration of bacteria in the respective antibiotic solutions and determining growth curves for the respective antibiotic solutions based on the determined bacterial concentration.

    Abstract translation: 该方法包括获得细菌样品的几个步骤; 鉴定细菌样品中细菌的类型; 根据细菌样本中细菌的特征选择一组抗生素; 从细菌样品获得对照样品; 将细菌样品置于含有该组抗生素的溶液中; 确定各抗生素溶液中​​细菌的浓度; 基于确定的细菌浓度确定各抗生素溶液的生长曲线; 并将各抗生素溶液的生长曲线与从对照样品测定的生长曲线进行比较。 可以使用鉴定和定量系统来选择该组抗生素，并且还可以用于确定各抗生素溶液中​​的细菌浓度并基于确定的细菌浓度确定各抗生素溶液的生长曲线的步骤。

    PROCESSOR FILTER ARRANGEMENT THAT INCLUDES METHOD AND APPARATUS TO REMOVE WASTE FLUID THROUGH A FILTER
    72.
    发明申请
    PROCESSOR FILTER ARRANGEMENT THAT INCLUDES METHOD AND APPARATUS TO REMOVE WASTE FLUID THROUGH A FILTER 审中-公开

    公开(公告)号：WO2019026026A1

    公开(公告)日：2019-02-07

    申请号：PCT/IB2018/055827

    申请日：2018-08-02

    Applicant: POCARED DIAGNOSTICS LTD.

    Inventor： INGBER, Gal

    IPC: G01N1/00 ,  G01N21/03 ,  G01N33/48 ,  B01D65/02 ,  G01F1/00

    Abstract: An apparatus for processing a biological sample for optical analysis having a cartridge with a sample supply container and a couvette, a cartridge/magazine holding the cartridge, and a cassette fan positioned over the cartridge. A filter cassette is mounted within the cassette fan, wherein the filter cassette has an inlet for receiving a sample from the sample supply container, an outlet for discharging the filter sample into the couvette, and valves therein to manipulate the sample for filtering. A cassette clamp is positioned over the filter cassette to secure the cassette and operate the filter cassette. A method for implementing this apparatus is also described herein. Additionally an apparatus is used for and a method measures waste fluid that passes over a filter element to control the amount of rinse fluid passing over the filter element.

    REAGENT-FREE IDENTIFICATION OF BACTERIA CONTAINING RESISTANCE GENES USING A RAPID INTRINSIC FLUORESCENCE METHOD
    73.
    发明申请
    REAGENT-FREE IDENTIFICATION OF BACTERIA CONTAINING RESISTANCE GENES USING A RAPID INTRINSIC FLUORESCENCE METHOD 审中-公开
    使用快速内在荧光法测定含有耐药基因的细菌

    公开(公告)号：WO2016142825A1

    公开(公告)日：2016-09-15

    申请号：PCT/IB2016/051247

    申请日：2016-03-04

    Applicant: POCARED DIAGNOSTICS LTD.

    Inventor： GURFINKEL, Jonathan ,  INGBER, Gal

    IPC: G06F19/00

    CPC classification number: G01N21/6486 ,  C12Q1/04 ,  G01N33/4833 ,  G01N2021/6417 ,  G01N2201/062 ,  G01N2201/129

    Abstract: This invention relates to a method that allows for the differentiation of isolates of commonly encountered bacteria that contain specific antibiotic-resistance genes from similar isolates that do not harbor the gene. More particularly, the invention relates to a method that utilizes an automated rapid platform system that employs intrinsic fluorescence, optical data analysis, and artificial intelligence methods to analyze multi-dimensional optical characteristics of bacterial strains.

    Abstract translation: 本发明涉及允许从不含基因的相似分离物中分离含有特异抗生素抗性基因的常见细菌的分离物的方法。 更具体地，本发明涉及利用采用固有荧光，光学数据分析和人工智能方法来分析细菌菌株的多维光学特性的自动化快速平台系统的方法。

    SYSTEM FOR CONDUCTING THE IDENTIFICATION OF BACTERIA IN BIOLOGICAL SAMPLES
    74.
    发明申请
    SYSTEM FOR CONDUCTING THE IDENTIFICATION OF BACTERIA IN BIOLOGICAL SAMPLES 审中-公开
    用于在生物样品中鉴定细菌的系统

    公开(公告)号：WO2011035304A3

    公开(公告)日：2011-08-04

    申请号：PCT/US2010049658

    申请日：2010-09-21

    Applicant: POCARED DIAGNOSTICS LTD ,  INGBER GAL ,  ATTERBURY WILLIAM G ,  HOLLEY DAVE ,  KLAUSING THOMAS A ,  LAUDO JOHN S ,  SCHAEFER JASON A ,  TALBERT SHERWOOD ,  TALLARICO JOHN

    Inventor： INGBER GAL ,  ATTERBURY WILLIAM G ,  HOLLEY DAVE ,  KLAUSING THOMAS A ,  LAUDO JOHN S ,  SCHAEFER JASON A ,  TALBERT SHERWOOD ,  TALLARICO JOHN

    IPC: G01N35/02 ,  C12M1/38 ,  C12Q1/04 ,  C12Q1/06

    CPC classification number: G01N35/025 ,  B04B9/14 ,  G01N2035/00504 ,  G01N2035/0434 ,  G01N2035/0458

    Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a cooling, heating and fan arrangement for maintaining a predetermined optimum temperature of the samples during testing; a visual, circumferential and axial alignment system for aligning the samples within the carousel; a transfer system for transferring the samples from the carousel to the centrifuge; a balancing system of minimizing the rotational vibrations of the centrifuge; a safety system and anti-tipping design for the sample containing system; liquid dispensing arms for dispensing the buffered saline solution; and discharge ports for discharging and disposing of the liquid removed from the samples to a location external of the system.

    Abstract translation: 本发明涉及一种用于对微生物（例如生物样品中的细菌）进行鉴定和定量的系统。 更具体地说，本发明涉及一种包括冷却，加热和风扇装置的系统，用于在测试期间保持样品的预定最佳温度; 视觉的，圆周的和轴向的对准系统，用于对准转盘内的样品; 用于将样品从旋转式传送器传送到离心机的传送系统; 使离心机的旋转振动最小化的平衡系统; 样品容纳系统的安全系统和防倾翻设计; 用于分配缓冲盐水溶液的液体分配臂; 以及排出口，用于将从样品中除去的液体排出并处理至系统外部的位置。

    Filter arrangement using elution fluid and method for using the same
    78.
    发明授权
    Filter arrangement using elution fluid and method for using the same 有权

    公开(公告)号：US11073450B2

    公开(公告)日：2021-07-27

    申请号：US15955163

    申请日：2018-04-17

    Applicant: POCARED Diagnostics LTD.

    Inventor： Gal Ingber

    IPC: G01N1/34 ,  B01L3/00 ,  G01N1/40

    Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. In an intermediate step, the particles captured by the filter may be rinsed with a rinsing fluid such as water to pass additional undersized particles through the filter, thereby providing a purer sample. To improve efficiency, check valves may be used for passageways with one-way flow. Additionally, a configuration of three-way stopcocks may also be utilized. Finally, a sandwich arrangement is possible, wherein a single bottom element is sandwiched between two opposing top elements.

    Method and Apparatus for Processing and Analyzing Particles Extracted From Tangential Filtering
    79.
    发明申请
    Method and Apparatus for Processing and Analyzing Particles Extracted From Tangential Filtering 有权

    公开(公告)号：US20210187417A1

    公开(公告)日：2021-06-24

    申请号：US17141322

    申请日：2021-01-05

    Applicant: POCARED Diagnostics LTD.

    Inventor： Jonathan Gurfinkel ,  Gal Ingber

    IPC: B01D29/00 ,  G01G17/06 ,  B01L3/00 ,  G01N33/493 ,  G01N1/30 ,  B01D37/00 ,  C12Q1/24 ,  G01N1/40

    Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. A configuration using a slider valve may also be utilized. Additionally, an arrangement of supply and receiving containers may be used to minimize the number of containers required. A mass flow meter may be incorporated to measure the flow of elution fluid. Finally, a wash stage of the filtering process may be used to introduce stain onto the particles for further analysis, such as that associated with Gram staining and these stained particles may be further analyzed.

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