公开(公告)号：WO02071562A9

公开(公告)日：2004-04-22

申请号：PCT/US0206221

申请日：2002-03-01

Applicant: STC UNM

Inventor： HUANG XIAODONG ,  STINTZ ANDREAS ,  MALLOY KEVIN J ,  LIU GUANGTIAN ,  LESTER LUKE ,  CHENG JULIAN

IPC: H01L29/06 ,  H01S5/042 ,  H01S5/12 ,  H01S5/14 ,  H01S5/183 ,  H01S5/34 ,  H01S5/40

CPC classification number: B82Y30/00 ,  B82Y10/00 ,  B82Y20/00 ,  H01S5/0421 ,  H01S5/0425 ,  H01S5/18311 ,  H01S5/1833 ,  H01S5/18341 ,  H01S5/1835 ,  H01S5/18358 ,  H01S5/18372 ,  H01S5/18383 ,  H01S5/18397 ,  H01S5/305 ,  H01S5/3054 ,  H01S5/3412 ,  Y10S977/951

Abstract: A quantum dot vertical cavity surface-emitting laser has a low threshold gain. Top and bottom mirrors have a low mirror loss, with at least one of the mirrors being laterally oxidized to form semiconductor/oxide mirror pairs. In one embodiment, mode control layers reduce the optical field intensity in contact layers, reducing optical absorption. In one embodiment, delamination features are included to inhibit the tendency of laterally oxidized mirrors form delaminating.

Abstract translation: 量子点垂直腔面发射激光器具有低阈值增益。 顶部和底部反射镜具有低的反射镜损耗，其中至少一个反射镜被横向氧化以形成半导体/氧化物反射镜对。 在一个实施例中，模式控制层减少接触层中的光场强度，减少光吸收。 在一个实施例中，包括分层特征以抑制横向氧化镜形成分层的倾向。

公开(公告)号：WO2017066795A3

公开(公告)日：2017-05-18

申请号：PCT/US2016057407

申请日：2016-10-17

Applicant: STC UNM

Inventor： HAN SANG EON ,  HAN SANG M

IPC: F28F3/00 ,  C09D5/32 ,  C09D7/12 ,  C09K5/14

CPC classification number: F28F13/185 ,  F24J2/485 ,  F28F2245/06

Abstract: The present prevention provides a surface coating for cooling a surface by light scattering comprising a plurality of successive layers, each of the layers may be comprised of a plurality of spheres arranged to form a structure comprised of packed spheres. Each layer may have a different arrangement of packed spheres to create to a different light scattering property in each of the layers. The coating of the structures may also be formed by randomly packed spheres and the spheres may have a uniform diameter.

Abstract translation: 本预防提供了用于通过包含多个连续层的光散射来冷却表面的表面涂层，每个层可以包括多个球体，所述球体被布置以形成由填充球体组成的结构。 每层可以具有不同的填充球的排列，以在每个层中产生不同的光散射特性。 结构的涂层也可以由无规填充的球体形成，并且球体可以具有均匀的直径。

公开(公告)号：WO2017023407A3

公开(公告)日：2017-04-06

申请号：PCT/US2016035289

申请日：2016-06-01

Applicant: STC UNM ,  JOHNSON PATRICK ,  BRINKER C JEFFREY ,  CARNES ERIC ,  TIMMINS GRAHAM ,  MUTTIL PAVAN

Inventor： JOHNSON PATRICK ,  BRINKER C JEFFREY ,  CARNES ERIC ,  TIMMINS GRAHAM ,  MUTTIL PAVAN

IPC: A61K9/12 ,  A61K9/127 ,  A61K9/26 ,  B82Y5/00 ,  C12N11/04

CPC classification number: A61K9/1617 ,  A61K9/0073

Abstract: This disclosure describes compositions, vaccine, and methods that involve a biocomposite material Generally, the biocomposite material includes a cell and a lipid-silica matrix at least partially encapsulating the cell. In some cases, the cell can be viable but not culturable (VBNC). In some cases, the lipid-silica matrix includes a dried sol and/or possesses ordered nanostructure.

Abstract translation: 本公开描述涉及生物复合材料的组合物，疫苗和方法通常，生物复合材料包括至少部分地包封细胞的细胞和脂质 - 二氧化硅基质。 在某些情况下，细胞可以存活但不可培养（VBNC）。 在一些情况下，脂质二氧化硅基质包括干燥的溶胶和/或具有有序的纳米结构。

公开(公告)号：WO2015081294A3

公开(公告)日：2015-07-16

申请号：PCT/US2014067764

申请日：2014-11-26

Applicant: STC UNM ,  BRUECK STEVEN R J ,  EDWARDS JEREMY SCOTT ,  NEUMANN ALEXANDER ,  KUZNETSOVA YULIYA ,  MENDOZA EDGAR A

Inventor： BRUECK STEVEN R J ,  EDWARDS JEREMY SCOTT ,  NEUMANN ALEXANDER ,  KUZNETSOVA YULIYA ,  MENDOZA EDGAR A

IPC: B01L7/00 ,  C12M1/34 ,  C12Q1/68

CPC classification number: G01N33/48721 ,  B01L3/502707 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2300/0896 ,  B01L2300/16 ,  B01L2300/168 ,  B01L2400/0421 ,  C12Q1/6869 ,  C23C16/345 ,  C23C16/45525 ,  C23C16/50 ,  G01N21/65 ,  G01N2021/653 ,  G01N2201/061 ,  C12Q2563/155 ,  C12Q2565/631

Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (> wavelength), ~ 1-nm aperture "tortuous" nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.

Abstract translation: 长时间读取，无标记，光学纳米孔长链分子测序的方法和设备。 通常，本公开描述了基于纳米通道的整合以提供具有广泛间隔（>波长），〜1nm孔径“曲折”纳米孔的单个长链分子的新型测序技术，其缓慢移位足以提供大量平行的， 使用光学技术的单基准分辨率。 使用简单的胶体纳米颗粒的新颖的定向自组装纳米加工方案用于在展开长链分子的纳米通道上形成纳米孔阵列。 在纳米颗粒阵列的表面，工程等离子体/极化结构中的强定域电磁场允许使用光学技术的单碱基分辨率。

公开(公告)号：WO2013056132A3

公开(公告)日：2013-06-13

申请号：PCT/US2012060072

申请日：2012-10-12

Applicant: STC UNM ,  SANDIA CORP

Inventor： ASHLEY CARLEE ERIN ,  BRINKER C JEFFREY ,  CARNES ERIC C ,  FEKRAZAD MOHAMMAD HOUMAN ,  FELTON LINDA A ,  NEGRETE OSCAR ,  PADILLA DAVID PATRICK ,  WILKINSON BRIAN S ,  WILKINSON DAN C ,  WILLMAN CHERYL L

IPC: A61K9/16 ,  A61K31/7088 ,  A61K31/7105 ,  A61K38/17 ,  A61K47/48 ,  A61K48/00 ,  A61K49/08

CPC classification number: A61K47/48823 ,  A61K9/0014 ,  A61K9/107 ,  A61K9/1271 ,  A61K9/5078 ,  A61K31/192 ,  A61K31/465 ,  A61K31/506 ,  A61K31/513 ,  A61K31/704 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K33/24 ,  A61K38/00 ,  A61K38/17 ,  A61K38/45 ,  A61K38/47 ,  A61K45/06 ,  A61K47/483 ,  A61K47/48561 ,  A61K47/48815 ,  A61K47/48861 ,  A61K47/6923 ,  A61K48/0008 ,  A61K49/0082 ,  A61K49/0423 ,  B82Y5/00 ,  C07K7/06 ,  C07K2319/00 ,  C12N15/113 ,  C12N15/1131 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2810/40 ,  C12Y204/02036 ,  C12Y302/02022 ,  A61K2300/00

Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.

Abstract translation: 本发明涉及用于特异性靶向肝细胞和其它癌细胞的原细胞，其包含具有支持的脂质双层的纳米多孔二氧化硅核心; 至少一种促进癌细胞死亡的药物（例如传统的小分子，大分子货物（例如siRNA或蛋白质毒素如蓖麻毒素A链或白喉毒素A链）和/或组蛋白包装的质粒DNA 设置在纳米多孔硅芯内（优选超螺旋以更有效地将DNA包装到原细胞中），其任选地用核定位序列修饰以帮助定位癌细胞核内的原细胞，以及表达参与治疗的肽的能力 （凋亡/细胞死亡）或作为报告物，靶向肽靶向待治疗的组织中的癌细胞，使得原细胞与靶细胞的结合是特异性和增强的，并且促进内源性逃逸的融合肽 原细胞和包封的DNA。根据本发明的原细胞可用于治疗癌症，特别是包括肝细胞（肝）癌症 选择性结合肝细胞组织或在癌症诊断中起作用的新型结合肽（c-MET肽），包括癌症治疗和药物发现。

公开(公告)号：WO2013020096A3

公开(公告)日：2013-05-02

申请号：PCT/US2012049613

申请日：2012-08-03

Applicant: STC UNM ,  UNIV FLORIDA ,  WHITTEN DAVID G ,  SCHANZE KIRK S ,  JI EUNKYUNG ,  DASCIER DIMITRI ,  PARTHASARATHY ANAND ,  CORBITT THOMAS S ,  CICOTTE KIRSTEN ,  DIRK ELIZABETH LEBLEU ,  ZHU XUZHI

Inventor： WHITTEN DAVID G ,  SCHANZE KIRK S ,  JI EUNKYUNG ,  DASCIER DIMITRI ,  PARTHASARATHY ANAND ,  CORBITT THOMAS S ,  CICOTTE KIRSTEN ,  DIRK ELIZABETH LEBLEU ,  ZHU XUZHI

IPC: A01N25/34 ,  A01N27/00 ,  A01N33/12 ,  A61L15/00 ,  A61L15/10 ,  A61L15/42

CPC classification number: A01N43/90 ,  A01N25/34 ,  A01N33/12 ,  A01N37/10 ,  A01N43/10 ,  A61L15/20 ,  A61L15/46 ,  A61L2300/208 ,  A61L2300/404 ,  D01H7/00 ,  A01N59/00 ,  A01N2300/00

Abstract: The invention provides methods and materials for decontamination of surfaces and fabrics, such as non-woven fabrics, that are contaminated with infestations of microorganisms such as bacteria. Biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group can be used to decontaminate infested surfaces in the presence of oxygen and, optionally, illumination. Fibers incorporating biocidal oligomers having conjugated oligo-(aryl/heteroaryl ethynyl) structures and comprising at least one cationic group, wherein the oligomer is physically associated with or covalently bonded to, or both, the fiber-forming polymer can be used to form non-woven mats. Biocidal non-woven mats prepared by methods of the invention, incorporating the biocidal oligomers, can be used to suppress bacterial growth in wound and surgical dressings and personal hygiene products.

Abstract translation: 本发明提供了用于对诸如细菌等微生物侵染的表面和织物（例如无纺织物）进行净化的方法和材料。 具有共轭低聚 - （芳基/杂芳基乙炔基）结构并且包含至少一个阳离子基团的杀生物低聚物可用于在氧气和任选地照射的情况下净化受侵染的表面。 包含具有共轭低聚 - （芳基/杂芳基乙炔基）结构并且包含至少一个阳离子基团的杀生物低聚物的纤维，其中所述低聚物与纤维形成聚合物物理缔合或共价键合或共同形成， 编织垫 通过本发明的方法制备的结合有杀生物剂的低分子化合物的杀生物无纺布垫可用于抑制伤口和手术敷料以及个人卫生产品中的细菌生长。

公开(公告)号：WO2012174344A3

公开(公告)日：2013-05-02

申请号：PCT/US2012042609

申请日：2012-06-15

Applicant: STC UNM ,  SEROV ALEXEY ,  HALEVI BARR ,  ARTYUSHKOVA KATERYNA ,  ATANASSOV PLAMEN B

Inventor： SEROV ALEXEY ,  HALEVI BARR ,  ARTYUSHKOVA KATERYNA ,  ATANASSOV PLAMEN B

IPC: B01J31/12 ,  B01J38/02 ,  H01M4/90

CPC classification number: H01M4/8652 ,  B01J23/70 ,  B01J23/8892 ,  B01J35/0033 ,  B01J37/084 ,  H01M4/8621 ,  H01M4/8885 ,  H01M4/9041 ,  H01M4/9083 ,  H01M4/9091 ,  H01M2004/8689

Abstract: A method of preparing M-N-C catalysts utilizing a sacrificial support approach and inexpensive and readily available polymer precursors as the source of nitrogen and carbon is disclosed. Exemplary polymer precursors include non-porphyrin precursors with no initial catalytic activity. Examples of suitable non-catalytic non-porphyrin precursors include, but are not necessarily limited to low molecular weight precursors that form complexes with iron such as 4-aminoantipirine, phenylenediamine, hydroxysuccinimide, ethanolamine, and the like.

Abstract translation: 公开了一种使用牺牲支撑方法制备M-N-C催化剂的方法，并且公开了廉价且容易获得的聚合物前体作为氮和碳的来源。 示例性聚合物前体包括没有初始催化活性的非卟啉前体。 合适的非催化非卟啉前体的实例包括但不一定限于与铁形成络合物的低分子量前体，例如4-氨基安替比林，苯二胺，羟基琥珀酰亚胺，乙醇胺等。

公开(公告)号：WO2012174335A3

公开(公告)日：2013-04-04

申请号：PCT/US2012042593

申请日：2012-06-15

Applicant: STC UNM ,  SEROV ALEXEY ,  HALEVI BARR ,  ROBSON MICHAEL ,  PATTERSON WENDY ,  ARTYUSHKOVA KATERYNA ,  ATANASSOV PLAMEN B

Inventor： SEROV ALEXEY ,  HALEVI BARR ,  ROBSON MICHAEL ,  PATTERSON WENDY ,  ARTYUSHKOVA KATERYNA ,  ATANASSOV PLAMEN B

IPC: B01J37/08 ,  B01J23/10 ,  B01J23/75 ,  B01J31/12 ,  H01M4/88 ,  H01M4/90

CPC classification number: H01M4/9091 ,  H01M4/90 ,  H01M2004/8689 ,  Y02E60/50

Abstract: A method of preparing M-N-C catalysts utilizing a sacrificial support approach and inexpensive and readily available polymer precursors as the source of nitrogen and carbon is disclosed. Exemplary polymer precursors include those that do not form complexes with iron, but which do complex with silica, for example, polyetheleneimine (PEI), Poly(2-ethyl-2-oxazoline), Poly(acrylamide-co-diallyldimethylammonium chloride), Poly(melamine-co-formaldehyde), Poly[[6-[(l,l,3,3-tetramethylbutyl)amino]-s-triazine-2,4-diyl]-[(2,2,6,6-tetramethyl-4-piperidyl)imino] -hexamethylene- [(2,2,6,6-tetramethyl-4-piperidyl)imino] and the like.

Abstract translation: 公开了一种使用牺牲支撑方法制备M-N-C催化剂的方法，并且公开了廉价且容易获得的聚合物前体作为氮和碳的来源。 示例性聚合物前体包括不与铁形成络合物但与二氧化硅络合的那些，例如聚乙烯亚胺（PEI），聚（2-乙基-2-恶唑啉），聚（丙烯酰胺 - 共二烯丙基二甲基氯化铵），聚 （三聚氰胺 - 共 - 甲醛），聚[[6 - [（1,1,3,3-四甲基丁基）氨基] -s-三嗪-2,4-二基] - [（2,2,6,6-四甲基 -4-哌啶基）亚氨基] - 六亚甲基 - [（2,2,6,6-四甲基-4-哌啶基）亚氨基]等。

公开(公告)号：WO2013040567A2

公开(公告)日：2013-03-21

申请号：PCT/US2012055774

申请日：2012-09-17

Applicant: STC UNM ,  PATTERSON WENDY ,  ROBSON MICHAEL ,  WALKER CANDACE ,  SEROV ALEXEY ,  HALEVI BARR ,  ARTYUSHKOVA KATERYNA ,  ATANASSOV PLAMEN B

Inventor： PATTERSON WENDY ,  ROBSON MICHAEL ,  WALKER CANDACE ,  SEROV ALEXEY ,  HALEVI BARR ,  ARTYUSHKOVA KATERYNA ,  ATANASSOV PLAMEN B

IPC: B01J31/12 ,  B01J21/08

CPC classification number: H01M4/9041 ,  H01M4/9016 ,  H01M4/9091

Abstract: Methods for forming novel fuel cell catalysts are described. The catalyst has a physical structure that is the inverse image of a plurality of hierarchically structured sacrificial support particles. The particles may be formed independently and then infused with one or more transitional metallic salts and nitrogen carbon precursors, or the sacrificial support precursors, transitional metallic salts, and nitrogen carbon precursors may all be combined in such a way that a hierarchically structured sacrificial support with the infused transitional metallic salts and nitrogen carbon precursors is formed in a single step. The infused sacrificial support is then pyrolized, at least once, and the sacrificial support is removed, resulting in the catalyst.

Abstract translation: 描述了形成新型燃料电池催化剂的方法。 该催化剂具有物理结构，该物理结构是多个分层结构的牺牲载体颗粒的反转图像。 颗粒可以独立形成，然后灌注一种或多种过渡金属盐和氮碳前体，或者牺牲载体前体，过渡金属盐和氮碳前体都可以这样的方式组合，使得分层结构的牺牲载体与 注入的过渡金属盐和氮碳前体在一个步骤中形成。 然后将注入的牺牲性支持物热解，至少一次，并且牺牲性支持物被去除，导致催化剂。

公开(公告)号：WO2012154944A9

公开(公告)日：2013-02-21

申请号：PCT/US2012037300

申请日：2012-05-10

Applicant: STC UNM ,  DERETIC VOJO ,  CASTILLO ELISEO ,  BRADFUTE STEVEN

Inventor： DERETIC VOJO ,  CASTILLO ELISEO ,  BRADFUTE STEVEN

IPC: A61K39/395 ,  A61P29/00

CPC classification number: A61K31/436 ,  A61K31/12 ,  A61K31/136 ,  A61K31/4184 ,  A61K31/4365 ,  A61K31/4535 ,  A61K31/472 ,  A61K31/473 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/54 ,  A61K31/546 ,  A61K31/5685 ,  A61K31/585 ,  A61K31/65 ,  C07K16/18 ,  G01N33/56972 ,  G01N33/6893 ,  G01N2333/9015

Abstract: The invention provides methods of treating autophagy mediated diseases and disorders and related pharmaceutical compositions, diagnostics, screening techniques and kits. In one embodiment, the invention provides a method of determining whether a subject suffers from, or is at risk of developing, and autophagy mediated disease state and/or condition by evaluating LC3 levels.

Abstract translation: 本发明提供治疗自噬介导的疾病和病症的方法和相关的药物组合物，诊断，筛选技术和试剂盒。 在一个实施方案中，本发明提供了通过评估LC3水平来确定受试者是否患有或有风险发展和自噬介导的疾病状态和/或病症的方法。