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    PRESERVATION OF CELL-FREE NUCLEIC ACIDS
    72.
    发明申请
    PRESERVATION OF CELL-FREE NUCLEIC ACIDS 审中-公开

    公开(公告)号：US20180163256A1

    公开(公告)日：2018-06-14

    申请号：US15894077

    申请日：2018-02-12

    Applicant: Streck, Inc.

    Inventor： M. Rohan Fernando

    IPC: C12Q1/6806

    CPC classification number: C12Q1/6806 ,  C09K15/20 ,  C12Q2527/125 ,  C12Q2527/127

    Abstract: A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.

    Devices and compositions for preservation of cell-free nucleic acids
    73.
    发明授权
    Devices and compositions for preservation of cell-free nucleic acids 有权

    公开(公告)号：US09926590B2

    公开(公告)日：2018-03-27

    申请号：US15601682

    申请日：2017-05-22

    Applicant: Streck, Inc.

    Inventor： M. Rohan Fernando

    IPC: C12Q1/68

    CPC classification number: C12Q1/6806 ,  C09K15/20 ,  C12Q2527/125 ,  C12Q2527/127

    Abstract: Devices including a composition for preserving and processing cell-free nucleic acids located within a blood sample and methods of using the same are disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The device may include a direct blood draw tube comprising a composition formulated for stabilizing cell-free nucleic acids within a blood sample including one or more formaldehyde releaser preservative agents, ethylenediaminetetraacetic acid (EDTA), one or more solvents, and formaldehyde. The composition is free of separately added formaldehyde but contains the formaldehyde as a result of the one or more formaldehyde releaser preservative agents. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.

    DETECTION OF ANTIBIOTIC RESISTANCE GENES
    77.
    发明申请
    DETECTION OF ANTIBIOTIC RESISTANCE GENES 审中-公开

    公开(公告)号：WO2020243644A1

    公开(公告)日：2020-12-03

    申请号：PCT/US2020/035422

    申请日：2020-05-29

    Applicant: STRECK, INC.

    Inventor： COSSETTE, Stephanie ,  CONNELLY, Christopher ,  TORRES-GONZALEZ, Maria ,  ALAO, Esther

    IPC: C12Q1/689 ,  C12Q2600/16

    Abstract: Assays and methods for detecting resistance to beta- lactam antibiotics including detection of multiple β-lactamase family specific gene targets by polymerase chain reaction or microarray. One or more kits including primers and/or probes for identification of β-lactamase genes selected from the group consisting of one or more of the following: MOX-like, FOX-like, ACC-like, ACT/MIR-like, CMY-2-like, DHA-like, CTX-M-14-like, CTX-M-15-like, VIM-like, NDM-like, IMP-like, KPC-like, and OXA-48-like, OXA-51-like, OXA-143-like, OXA-58-like, OXA-23- like, OXA-24/40-like, TEM-like, SHV-like, and GES-like. A kit may also include one or more primers and/or probes for the identification a non-beta lactamase gene family which confers antibiotic resistance, such as the MCR-1 gene.

    BLOOD COLLECTION DEVICE FOR STABILIZING CELL -FREE PLASMA DNA
    78.
    发明申请
    BLOOD COLLECTION DEVICE FOR STABILIZING CELL -FREE PLASMA DNA 审中-公开
    用于稳定细胞 - 血浆等离子体DNA的血液收集装置

    公开(公告)号：WO2013123030A3

    公开(公告)日：2013-10-31

    申请号：PCT/US2013025912

    申请日：2013-02-13

    Applicant: STRECK INC

    Inventor： RYAN WAYNE L ,  FERNANDO M ROHAN ,  DAS KAUSIK

    IPC: C12Q1/68

    CPC classification number: C12N15/1003 ,  C12Q1/6806 ,  C12Q2527/125

    Abstract: Methods and devices for stabilizing and preserving circulating cell- free plasma DNA for analysis are disclosed. The methods and devices use diazolidinyl urea or imidazolidinyl urea as a preservative, EDTA as an anticoagulant and glycine as a quenching agent to quench any free formaldehyde from the protective composition.

    Abstract translation: 公开了用于稳定和保存循环的无细胞血浆DNA进行分析的方法和装置。 方法和装置使用重氮烷基脲或咪唑烷基脲作为防腐剂，EDTA作为抗凝剂，甘氨酸作为猝灭剂，从保护组合物中淬灭任何游离甲醛。

    IMMATURE RETICULOCYTE FRACTION REFERENCE CONTROL AND RELATED METHODS
    79.
    发明申请
    IMMATURE RETICULOCYTE FRACTION REFERENCE CONTROL AND RELATED METHODS 审中-公开
    即时网络分数参考控制和相关方法

    公开(公告)号：WO2013019290A9

    公开(公告)日：2013-05-02

    申请号：PCT/US2012034434

    申请日：2012-04-20

    Applicant: STRECK INC ,  RYAN WAYNE L ,  SCHOLL JOHN W

    Inventor： RYAN WAYNE L ,  SCHOLL JOHN W

    IPC: G01N33/96

    CPC classification number: G01N33/96

    Abstract: A composition (and associated methods) including a plurality of treated red blood cells for simulating reticulocytes, and particularly an immature reticulocyte fraction, of whole blood when processed as a sample in an automated analyzer capable of detecting reticulocytes. A method for making the composition or other simulated reticuolcyte may include steps of contacting a suspension of a plurality of red blood cells each having a membrane in an initial state that surrounds an interior volume of a cell with an effective amount of a hypertonic permeabilizing solution including dimethyl sulfoxide and a hypotonic loading agent delivery solution including a loading agent, for a sufficient time to form a plurality of pores in the membrane, for permitting the loading agent to enter into the interior volume of the cells, and, after entry of a desired amount of the loading agent into the interior volume of the cell, for sealing the pores for substantially restoring the membrane to the initial state while substantially encapsulating the loading agent within the resulting cell, and preferably also retaining within the resulting cell a substantial amount of hemoglobin from the original starting red blood cell.

    Abstract translation: 当在能够检测网织红细胞的自动分析仪中作为样品处理时，包括多个经处理的红细胞用于模拟网织红细胞尤其是未成熟网织红细胞部分的组合物（和相关方法）。 用于制备组合物或其他模拟网状细胞的方法可以包括以下步骤：使多种红细胞的悬浮液与包含细胞内部体积的初始状态下的膜接触，所述初始状态包含有效量的高渗透性溶液，所述高渗透性溶液包括 二甲基亚砜和包括负载剂的低渗负载剂递送溶液混合足够的时间以在膜中形成多个孔，用于允许负载剂进入细胞的内部体积中，并且在输入期望的 将填充剂的量加入细胞的内部容积中，用于密封孔隙以使膜基本上恢复至初始状态，同时将所述加载剂基本上包封在所得细胞内，并且优选还在所得细胞内保留大量血红蛋白 从最初的红血球开始。

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