IMPLANTABLE NEUROMODULATION SYSTEM INCLUDING WIRELESSLY CONNECTED PULSE GENERATOR AND ELECTRODE ARRAY ASSEMBLY
    72.
    发明申请
    IMPLANTABLE NEUROMODULATION SYSTEM INCLUDING WIRELESSLY CONNECTED PULSE GENERATOR AND ELECTRODE ARRAY ASSEMBLY 审中-公开
    可插拔的神经网络系统,包括无线连接的脉冲发生器和电极阵列总成

    公开(公告)号:WO2008080073A3

    公开(公告)日:2008-08-28

    申请号:PCT/US2007088580

    申请日:2007-12-21

    Abstract: An implantable neuromodulation system (30) including an electrode array assembly (32) and an implantable pulse generator (34). Signals are wirelessly translated from the implantable pulse generator to the electrode array assembly. A power extractor and supply circuit integral with the electrode array assembly extracts the power from the signals. Instructions contained in the signals are executed by a switch circuit (156) also part of the electrode array assembly for selectively flowing current between selected ones of the electrodes (124) that are part of the assembly.

    Abstract translation: 一种包括电极阵列组件(32)和可植入脉冲发生器(34)的可植入神经调节系统(30)。 信号从可植入脉冲发生器无线地转换到电极阵列组件。 与电极阵列组件集成的电源提取器和电源电路从信号中提取电源。 包含在信号中的指令也由开关电路(156)执行,也是电极阵列组件的一部分,用于选择性地在组件的一部分的电极(124)中选择的电流之间流动电流。

    BONE MORPHOGENETIC PROTEINS
    73.
    发明申请
    BONE MORPHOGENETIC PROTEINS 审中-公开
    骨形态蛋白

    公开(公告)号:WO2008051526A9

    公开(公告)日:2008-06-19

    申请号:PCT/US2007022454

    申请日:2007-10-23

    CPC classification number: C07K14/51

    Abstract: The present invention provides modified highly potent bone morphogenetic proteins. In particular, the present invention features a chimeric bone morphogenetic protein including a dimer with each monomer containing a type I receptor binding site derived from a member of the BMP subfamily and a type II receptor binding site derived from a member of the TGF-ß subfamily. As a result, the chimeric bone morphogenetic protein has improved binding affinity to type II receptor relative to the naturally-occurring BMP subfamily member from which the type I receptor binding site is derived. Also provided are modified bone morphogenetic proteins having reduced affinity for Noggin. Other embodiments of modified BMPs, compositions and method of use are also included.

    Abstract translation: 本发明提供了改进的高效骨形态发生蛋白。 特别地,本发明的特征在于包含二聚体的嵌合骨形态发生蛋白,每个单体含有源自BMP亚家族成员的I型受体结合位点和衍生自TGF-β亚家族成员的II型受体结合位点 。 结果,相对于衍生I型受体结合位点的天然存在的BMP亚家族成员,嵌合骨形态发生蛋白具有改善的对II型受体的结合亲和力。 还提供了对Noggin具有降低的亲和力的修饰的骨形态发生蛋白。 还包括修饰的BMP,组合物和使用方法的其它实施方案。

    SYSTEM AND METHOD FOR 3-D TRACKING OF SURGICAL INSTRUMENT IN RELATION TO PATIENT BODY
    74.
    发明申请
    SYSTEM AND METHOD FOR 3-D TRACKING OF SURGICAL INSTRUMENT IN RELATION TO PATIENT BODY 审中-公开
    手术器械与患者身体三维跟踪的系统与方法

    公开(公告)号:WO2007111955A3

    公开(公告)日:2008-04-24

    申请号:PCT/US2007007147

    申请日:2007-03-22

    Abstract: A system (100) and method for tracking the three-dimensional position and orientation of a surgical instrument as the instrument (112) is being utilized within the interior of a patient body (102). A stereoscopic camera system (106) generates a stereoscopic image of the patient body which is subsequently rendered on a display device (102). A wireless signal transmitted by an electromagnetic field generator (104) is received by a sensor (114) on the surgical instrument (112). Utilizing this sensor data, a processor (120) calculates the position and orientation of the surgical instrument (112) and then superimposes upon the rendered stereoscopic image of the patient body (102) a graphical representation indicative of the position and orientation of the surgical instrument (112).

    Abstract translation: 用于跟踪作为仪器(112)的外科器械的三维位置和方向的系统(100)和方法正在患者体内(102)的内部使用。 立体照相机系统(106)产生随后在显示装置(102)上呈现的患者身体的立体图像。 由电磁场发生器(104)发射的无线信号由外科器械(112)上的传感器(114)接收。 利用该传感器数据,处理器(120)计算外科器械(112)的位置和取向,然后叠加在患者身体(102)的呈现的立体图像上,指示手术器械的位置和取向的图形表示 (112)。

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