公开(公告)号：AU2017233716A1

公开(公告)日：2018-10-04

申请号：AU2017233716

申请日：2017-03-08

Applicant: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： NEWMAN AMY HAUCK ,  KUMAR VIVEK ,  SHAIK ANVER BASHA

IPC: C07D209/42 ,  A61K31/404 ,  A61P25/18 ,  A61P25/24 ,  C07D307/85 ,  C07D471/04 ,  C07D513/04

Abstract: Disclosed herein novel dopamine D3 receptor selective antagonists/partial agonists compounds with high affinity and metabolic stability useful for the treatment of psychiatric and neurological disorders and as research and diagnostic tools. Also disclosed are methods of making the compounds.

公开(公告)号：AU2016343722A1

公开(公告)日：2018-05-24

申请号：AU2016343722

申请日：2016-10-28

Applicant: ALETA BIOTHERAPEUTICS INC ,  THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： LOBB ROY ,  RENNERT PAUL DAVID ,  SCHILLER JOHN TODD

IPC: C12N5/07 ,  C12N5/0783 ,  C12N5/10

Abstract: Some embodiments of the present disclosure are directed to methods that include delivering to a subject a nucleic acid encoding an antigen, wherein the nucleic acid is delivered via a tumor-selective vehicle or via intratumoral injection, and delivering to the subject an immune cell expressing a receptor that binds to the antigen.

公开(公告)号：AU2013379773B2

公开(公告)日：2018-04-19

申请号：AU2013379773

申请日：2013-04-30

Applicant: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： GROS ALENA ,  ROSENBERG STEVEN A

IPC: A61K35/14 ,  C12N5/0783 ,  G01N33/50 ,  G01N33/569

Abstract: Methods of obtaining a cell population enriched for tumor-reactive T cells, the method comprising: (a) obtaining a bulk population of peripheral blood mononuclear cells (PBMCs) from a sample of peripheral blood; (b) specifically selecting CD8

公开(公告)号：AU2008269585B2

公开(公告)日：2015-03-19

申请号：AU2008269585

申请日：2008-06-26

Applicant: THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD ,  THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： PLATT FRANCES MARY ,  PORTER FORBES DENNISON ,  LLOYD-EVANS EMYR

IPC: A61K31/195 ,  A61K31/40 ,  A61K31/42 ,  A61K31/431 ,  A61K31/445 ,  A61K31/513 ,  A61K31/52 ,  A61K31/5375 ,  A61K31/58 ,  A61K31/6615 ,  A61K31/675 ,  A61K31/685 ,  A61K31/7008 ,  A61K31/7012 ,  A61P43/00

Abstract: The present invention provides a compound which is an inhibitor of sphingolipid biosynthesis for use in the treatment of a disease which has a secondary Niemann-Pick type C disease like cellular phenotype.

公开(公告)号：AU2009209652B2

公开(公告)日：2013-03-21

申请号：AU2009209652

申请日：2009-01-28

Applicant: HRA PHARMA LAB ,  THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： ULMANN ANDRE ,  GAINER ERIN ,  BLITHE DIANA ,  NIEMAN LYNNETTE

IPC: A61K31/57 ,  A61P5/36 ,  A61P15/00

Abstract: The invention relates to a method for treating uterine fibroids, which method comprises administering to a patient in need thereof, an effective amount of 17α-acetoxy-l l&bgr;-[4-JV, N-dimethylamino-phenyl)-19-norpregna- 4, 9-diene-3, 20-dione (ulipristal) or any metabolite thereof. More particularly, the method is useful for reducing or stopping bleeding in a patient afflicted with uterine fibroids, and/or for reducing the size of uterine fibroids.

公开(公告)号：AU2009202359A1

公开(公告)日：2009-07-02

申请号：AU2009202359

申请日：2009-06-12

Applicant: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： NEWMAN JASON T ,  COLLINS PETER L ,  SKIADOPOULOS MARIO H ,  MURPHY BRIAN R

IPC: C12P21/04 ,  A61K20060101 ,  A61K35/76 ,  A61K39/00 ,  A61K39/155 ,  A61P31/14 ,  C07K14/115 ,  C12N7/00 ,  C12N7/01 ,  C12N7/04 ,  C12N15/45 ,  C12N15/86

公开(公告)号：RS66199B1

公开(公告)日：2024-12-31

申请号：RSP20241262

申请日：2015-02-04

Applicant: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  KITE PHARMA INC

Inventor： BETTER MARC ,  FELDMAN STEVEN A ,  ROSENBERG STEVEN A

IPC: C12N5/0783 ,  A61K38/17 ,  A61K39/00 ,  A61P35/00 ,  C07K14/725

公开(公告)号：AU2017347854B2

公开(公告)日：2022-12-08

申请号：AU2017347854

申请日：2017-10-26

Applicant: INTIMA BIOSCIENCE INC ,  UNIV MINNESOTA ,  THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： HENLEY THOMAS ,  RHODES ERIC ,  CHOUDHRY MODASSIR ,  MORIARITY BRANDEN ,  WEBBER BEAU ,  ROSENBERG STEVEN A ,  PALMER DOUGLAS C ,  RESTIFO NICHOLAS P

IPC: C12N5/0783 ,  A61K35/17 ,  C07K14/47 ,  C07K14/725

Abstract: Methods of producing a population of genetically modified cells using viral or non-viral vectors. Disclosed are also modified viruses for producing a population of genetically modified cells and/or for the treatment of cancer.

公开(公告)号：RS62156B1

公开(公告)日：2021-08-31

申请号：RSP20210938

申请日：2017-03-08

Applicant: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： NEWMAN AMY HAUCK ,  KUMAR VIVEK ,  SHAIK ANVER BASHA

IPC: C07D209/42 ,  A61K31/404 ,  A61P25/18 ,  A61P25/24 ,  C07D307/85 ,  C07D471/04 ,  C07D513/04

公开(公告)号：AU2017253935A1

公开(公告)日：2018-11-01

申请号：AU2017253935

申请日：2017-04-18

Applicant: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： MYLES IAN ANTHENI ,  DATTA SANDIP K

IPC: A61K9/00 ,  A61K9/06 ,  A61K35/74

Abstract: Pharmaceutical compositions are disclosed that includes a therapeutically effective amount of a purified viable gram negative bacteria and a pharmaceutically acceptable carrier. The pharmaceutical compositions are formulated for topical administration. Methods of treating atopic dermatitis using these pharmaceutical compositions are also disclosed.