公开(公告)号：US20190049368A1

公开(公告)日：2019-02-14

申请号：US16068087

申请日：2016-12-20

Applicant: TOKUSHIMA UNIVERSITY

Inventor： Yoshihiro Deguchi

IPC: G01N21/27 ,  G01N21/39

CPC classification number: G01N21/27 ,  G01N21/031 ,  G01N21/3504 ,  G01N21/39

Abstract: A gas analysis device includes a laser light source configured to output a laser beam, an irradiation unit configured to irradiate a measurement region including measurement target gas with the laser beams in plural directions, plural photoreceivers each configured to receive a laser beam having passed through the measurement region and output an electric signal according to intensity of the received laser beam, and an analyzer configured to analyze the physical state of the measurement target gas based on the electric signal output from each photoreceiver. The analyzer sets a function (e.g. two-dimensional polynomial f(X,Y)) representing the physical state (e.g. concentration, temperature) of the target gas at least in the measurement region, and measures the physical state of the target gas by determining a coefficient of each of terms included in the function based on a measured value obtained from the electric signal output from the photoreceiver.

公开(公告)号：US20190023739A1

公开(公告)日：2019-01-24

申请号：US16070896

申请日：2017-01-16

Applicant: TOKUSHIMA UNIVERSITY ,  ONCOTHERAPY SCIENCE, INC.

Inventor： TOYOMASA KATAGIRI ,  TAKASHI MIYAMOTO ,  RIE HAYASHI

IPC: C07K7/04 ,  A61P35/00

Abstract: The present invention provides peptides containing a structure in which a portion of the dominant negative peptide of BIG3 which inhibits the interaction between BIG3 and PHB2 is substituted with stapling structure(s). Peptides of the present invention have excellent cell growth inhibitory actions. Furthermore, their cell growth inhibitory actions continue for a longer time than the actions of peptides without stapling structures. Therefore, these peptides have features suitable for clinical applications in cancer therapy.

公开(公告)号：US20180311313A1

公开(公告)日：2018-11-01

申请号：US15938839

申请日：2018-03-28

Applicant: TOKUSHIMA UNIVERSITY

Inventor： Akihito YAMAMOTO ,  Minoru UEDA ,  Kohki MATSUBARA ,  Akio SUZUMURA ,  Koichi FURUKAWA ,  Yoshihiro MATSUSHITA ,  Hirotaka WAKAYAMA ,  Nobunori TAKAHASHI ,  Shin TSUNEKAWA ,  Takako IZUMOTO

IPC: A61K38/19 ,  C12N5/0786 ,  A61K45/06 ,  A61K38/17 ,  A61K31/737

CPC classification number: A61K38/195 ,  A61K31/737 ,  A61K38/178 ,  A61K45/06 ,  C12N5/0645 ,  C12N2501/21 ,  C12N2501/59 ,  C12N2501/90 ,  A61K2300/00

Abstract: A composition having tissue repair activity, which is capable of promoting reactions associated with tissue repair, contains at least one selected from the group consisting of a first component that is a protein having a monocyte chemotactic protein-1 (MCP-1) activity, a second component that is a protein having the extracellular domain activity of sialic acid-binding immunoglobulin-type lectin-9 (Siglec-9), and a third component that is at least one of chondroitin sulfate and chondroitin sulfate proteoglycan.

公开(公告)号：US09651467B2

公开(公告)日：2017-05-16

申请号：US14888841

申请日：2014-04-30

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro Deguchi ,  Masaaki Nagase ,  Ryousuke Dohi ,  Nobukazu Ikeda ,  Kouji Nishino ,  Michio Yamaji ,  Tadayuki Yakushijin

IPC: G01N9/00 ,  G01N21/05 ,  G01N21/59 ,  G01N9/24 ,  G01N21/33 ,  G01N21/85

CPC classification number: G01N9/00 ,  G01N9/24 ,  G01N21/05 ,  G01N21/33 ,  G01N21/59 ,  G01N21/85 ,  G01N2201/08

Abstract: This invention is related to an optical-analysis-type raw material fluid density detector including a detector main body and a light oscillation unit and a light detection unit that are provided on the upper surface or the under surface of the detector main body, in which the detector main body has at least one recess formed in the upper surface and the under surface, a fluid flow path connecting a fluid inlet of the detector main body to the recess, a fluid flow path connecting the recesses to each other, and a fluid flow path connecting the recess to a fluid outlet of the detector main body; the light oscillation unit is disposed in the recess that is closest to the inlet; and light detection units are disposed in the remaining recesses.

公开(公告)号：US09393554B2

公开(公告)日：2016-07-19

申请号：US14654996

申请日：2014-02-04

Applicant: TOKUSHIMA UNIVERSITY ,  MITSUBISHI RAYON CO., LTD.

Inventor： Shigeru Sugiyama ,  Yuuki Katou ,  Toshiya Yasukawa ,  Shuji Akihara ,  Wataru Ninomiya

IPC: C07C45/51 ,  B01J29/03 ,  B01J35/10 ,  B01J29/035 ,  C07C45/52 ,  C07C47/02

CPC classification number: B01J29/0308 ,  B01J29/035 ,  B01J35/1061 ,  C07C45/52 ,  C07C47/02

Abstract: Provided is a method that produces a saturated aldehyde from a 1,2-alkanediol in high yield. Disclosed is a method for producing a saturated aldehyde from a 1,2-alkanediol in the presence of a regular mesoporous material.

Abstract translation: 提供了以高产率从1,2-链烷二醇生产饱和醛的方法。 公开了一种在常规介孔材料存在下由1,2-链烷二醇生产饱和醛的方法。

公开(公告)号：US20160169800A1

公开(公告)日：2016-06-16

申请号：US14909424

申请日：2014-07-18

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro Deguchi ,  Masaaki Nagase ,  Nobukazu Ikeda ,  Michio Yamaji

IPC: G01N21/59 ,  G01N21/33

CPC classification number: G01N21/5907 ,  G01N21/33 ,  G01N2021/3148 ,  G01N2021/5969 ,  G01N2021/8411 ,  G01N2021/8578 ,  G01N2201/0627 ,  G01N2201/0691

Abstract: An inline concentration meter includes a light source unit emitting mixed light containing at least two wavelengths with a phase difference, a detecting unit including a light incident part for entering the mixed light emitted from the light source unit into a fluid passage of a detector body and at least two light detection parts receiving the mixed light passed through the fluid passage, a computing processor unit conducting frequency analyses of detection signals of the mixed light output from the respective light detection parts and computing variations of intensities of the detection signals corresponding to absorbances in at least two frequency ranges to compute a concentration of fluid in the fluid passage based on the variations of the intensities of the detection signals, and a recording/displaying unit recording and displaying a value of the fluid concentration computed at the computing processor unit.

Abstract translation: 在线浓度计包括发射包含至少两个具有相位差的波长的混合光的光源单元，包括用于将从光源单元发射的混合光进入检测器主体的流体通道的光入射部分的检测单元，以及 接收通过流体通道的混合光的至少两个光检测部件，计算处理器单元，对从各个光检测部分输出的混合光的检测信号进行频率分析，并计算与吸光度对应的检测信号的强度变化 至少两个频率范围，用于基于检测信号的强度的变化计算流体通道中的流体浓度;以及记录/显示单元，记录和显示在计算处理器单元处计算的流体浓度的值。

公开(公告)号：US20250145719A1

公开(公告)日：2025-05-08

申请号：US19017160

申请日：2025-01-10

Applicant: Ono Pharmaceutical Co., Ltd. ,  Tokushima University

Inventor： Taku OKAZAKI ,  Daisuke Sugiura ,  Takeo Maeda ,  Shiro Shibayama

IPC: C07K16/28 ,  A61K39/00 ,  A61P37/06

Abstract: The present application provides an immunosuppressive agent containing a substance that is selected from anti-CD80 antibodies and anti-PD-L1 antibodies and that promotes binding between PD-L1 and PD-1.

公开(公告)号：US20250098642A2

公开(公告)日：2025-03-27

申请号：US18291989

申请日：2021-08-20

Applicant: JTEKT CORPORATION ,  TOKUSHIMA UNIVERSITY

Inventor： Masayuki TAKESHIMA ,  Yoshiyuki SHIBATA ,  Toshimasa SOKU ,  Kazuya NUMAZAKI ,  Fumiki MORIMATSU ,  Kentaroh TAKAGAKI ,  Maki HIRATA

IPC: A01K1/03 ,  A01K1/02 ,  A01K29/00

Abstract: A management system for an experimental animal is provided. This management system includes an information identifying unit configured to identify experimental information on the experimental animal to be transported to an experiment site, and a stress value calculating unit configured to calculate a stress value indicating stress to be suffered by the experimental animal during transportation based on the experimental information. The experimental information includes at least a part of a transportation distance for the transportation of the experimental animal, a transportation period for the transportation of the experimental animal, the number of the experimental animals to be transported at a time, an age of the experimental animal, and information on pretreatment given to the experimental animal prior to the transportation.

公开(公告)号：US12078590B2

公开(公告)日：2024-09-03

申请号：US17905486

申请日：2021-03-04

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro Deguchi ,  Masaaki Nagase ,  Kouji Nishino ,  Nobukazu Ikeda

IPC: G01N21/3504 ,  G01N21/27 ,  G01N21/31

CPC classification number: G01N21/274 ,  G01N21/314 ,  G01N21/3504

Abstract: A concentration measurement method performed in a concentration measurement device including an electric unit having a light source and a photodetector, a fluid unit having a measurement cell through which a gas flows, and a processing circuit for calculating a concentration of the gas based on an intensity of a light passing through the measurement cell. The concentration measurement method includes a step of determining an absorption coefficient of the measurement gas using a reference absorption coefficient determined in association with the reference gas and a correction factor associated with the measurement gas, and a step of obtaining a concentration of the measurement gas flowing in the measurement cell using the absorption coefficient of the measurement gas. When the absorption peak wavelength of the measurement gas is longer than the peak wavelength of the light source, a reference gas having a longer absorption peak wavelength than the peak wavelength of the light source is used, and when the absorption peak wavelength of the measurement gas is shorter than the peak wavelength of the light source, a reference gas having a shorter absorption peak wavelength than the peak wavelength of the light source is used.

公开(公告)号：US20240287465A1

公开(公告)日：2024-08-29

申请号：US18662797

申请日：2024-05-13

Applicant: FUJIFILM Corporation ,  Tokushima University

Inventor： Kentaro NAKAMURA ,  Mitsuo SHIMADA ,  Tetsuya IKEMOTO

IPC: C12N5/071

CPC classification number: C12N5/0676 ,  C12N2500/38 ,  C12N2501/12 ,  C12N2501/16 ,  C12N2501/335 ,  C12N2506/1384

Abstract: An object of the present invention is to provide a method for producing insulin-producing cells having sufficient glucose responsiveness from mesenchymal stem cells, an insulin-producing cell having sufficient glucose responsiveness, a cell structure containing the insulin-producing cell, and a pharmaceutical composition. According to the present invention, there is provided a method for producing an insulin-producing cell from a mesenchymal stem cell, including (a) a step of producing a cell structure by incubating a plurality of biocompatible macromolecular blocks and a plurality of mesenchymal stem cells, and (b) a step of culturing one or more of the mesenchymal stem cells before the incubation in the step (a), the mesenchymal stem cell in the incubation in the step (a), or the cell structure produced in the step (a) in a medium containing the GLP-1 receptor agonist, and (c) a step of culturing the cell structure obtained in the step (a) or the step (b) in a medium containing the water-soluble vitamin and the hepatocyte growth factor.