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公开(公告)号：KR1020150072797A
公开(公告)日：2015-06-30
申请号：KR1020130160350
申请日：2013-12-20
Applicant: (주)아모레퍼시픽
IPC: A61K8/49 , A61K31/52 , A61K31/519 , A61Q19/00 , A61P17/00
CPC classification number: A61K8/4926 , A23L29/035 , A23L29/045 , A61K8/347 , A61K8/4953 , A61K31/522 , A61K47/10 , A61K47/22 , Y10S514/909
Abstract: 본발명에따른조성물은용해도가낮은카페인을니아신아미드및 바닐린과함께조성물에함유함으로써, 니아신아미드및 바닐린이카페인의용해도를증가시키고석출을방지하여높은안정도를가지는조성물을제공할수 있다. 더욱이, 본발명에따른조성물은니아신아미드및 바닐린을함께포함함으로써카페인에니아신아미드또는바닐린을각각처리하는경우보다더 소량을사용하면서도카페인의용해도를현저히증가시키는상승효과를제공할수 있다. 이로써본 발명에따른조성물은우수한지방분해촉진또는셀룰라이트제거효과를제공할수 있으므로, 식품분야뿐만아니라화장료및 의약분야에서도유용하게사용될수 있다.
Abstract translation: 在本发明中，提供了一种组合物，其中具有低溶解度的咖啡因与烟酰胺和香草醛混合，从而使得烟酰胺和香草醛能够增加咖啡因的溶解度并防止吸入，同时具有高稳定性，其中包含烟酰胺和香草醛的组合物可显着地 与咖啡因中分别处理烟酰胺和香草醛相比，即使使用少量的组合物，也增加咖啡因的溶解度，从而具有除去脂肪团并用于食品，化妆品和医疗领域的良好效果。
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72.发明授权바닐로이드 수용체의 강력한 길항제로서 사용하는 신규한화합물 또는 약제학적으로 허용가능한 그의 염； 및 이를함유하는 약제학적 조성물 有权作为有效的香草酸受体拮抗剂的新型化合物或其药学上可接受的盐;以及含有它们的药物组合物
公开(公告)号：KR101374749B1
公开(公告)日：2014-03-18
申请号：KR1020060019873
申请日：2006-03-02
Applicant: (주)아모레퍼시픽
IPC: C07D213/36 , C07D213/61 , C07C233/64
Abstract: 본 발명은 바닐로이드 수용체 (Vanilloid Receptor 1 ; VR1 ; TRPV1)의 길항제로서 신규한 화합물 또는 약제학적으로 허용가능한 그의 염; 및 이를 함유하는 약제학적 조성물에 관한 것이다.
본 발명의 화합물 또는 조성물은 통증, 편두통, 관절통, 신경통, 신경병증, 신경손상, 피부질환, 과민성방광, 과민성대장증후군, 변실금, 호흡기질환, 피부, 눈 또는 점막의 자극, 위십이지장궤양, 염증성질환, 이(耳)질환, 및 심장질환 등의 예방 및 치료에 유용하다.
바닐로이드 수용체 길항제, N-페닐벤즈아마이드 유도체-
公开(公告)号：KR101360708B1
公开(公告)日：2014-02-07
申请号：KR1020117031696
申请日：2010-06-18
Applicant: (주)아모레퍼시픽
CPC classification number: A61Q19/005 , A61K8/97 , A61K36/49
Abstract: 본 발명은 밤껍질 추출물을 유효 성분으로 포함하는 가려움증 완화 또는 억제용 화장료 조성물에 관한 것이다. 본 발명에 따른 화장료 조성물에 포함되는 밤껍질 추출물은 본 발명에 따른 하나의 실시예에서, 가려움의 자극원인 단백분해효소 활성 수용체-2(Proteinase-Activated Receptor-2: PAR-2)의 활성을 억제함으로써, 우수한 가려움증 완화 또는 억제 효과를 발휘할 수 있음이 확인되었는 바, 가려움증 완화 또는 억제용 화장료 조성물의 유효 성분으로 적합하게 사용될 수 있다.
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公开(公告)号：KR101338681B1
公开(公告)日：2013-12-09
申请号：KR1020117031657
申请日：2010-06-18
Applicant: (주)아모레퍼시픽
CPC classification number: A23L33/105 , A23V2002/00 , A23V2200/318
Abstract: 본 발명은 밤껍질 추출물을 유효 성분으로 포함하는 가려움증 완화 또는 억제용 건강 식품 또는 약학 조성물에 관한 것이다. 본 발명에 따른 건강 식품 또는 약학 조성물에 포함되는 밤껍질 추출물은 본 발명에 따른 하나의 실시예에서, 가려움의 자극원인 단백분해효소 활성 수용체-2(Proteinase-Activated Receptor-2: PAR-2)의 활성을 억제함으로써, 우수한 가려움증 완화 또는 억제 효과를 발휘할 수 있음이 확인되었는 바, 가려움증 완화 또는 억제용 건강 식품 또는 약학 조성물의 유효 성분으로 적합하게 사용될 수 있다.
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公开(公告)号：KR1020130081963A
公开(公告)日：2013-07-18
申请号：KR1020120003098
申请日：2012-01-10
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: An agent for promoting hair growth is provided to have an excellent hair growth promotion effect and to be able to prevent hair loss by containing saponin of Torreya plant seeds. CONSTITUTION: A hair growth promotion agent includes saponin of Torreya plant seeds as an active ingredient. The Torreya plant includes at least one selected from the group consisting of Torreya california, Torreya fargesii, Torreya grandis, Torreya jackii, Torreya nucifera and Torreya taxifolia. The saponin of Torreya plant seeds is included at 0.001 to 20 weight% based on the total weight of the promoting agent. A pharmaceutical composition for promoting hair growth contains the hair growth promoting agent. A cosmetic composition includes the hair growth promoting agent. [Reference numerals] (AA) Score; (BB) Week; (CC) Voice comparison group; (DD) Minoxidil 2%; (EE) Example 1; (FF,GG) Comparative example
Abstract translation: 目的：提供促进毛发生长的药剂以具有优异的毛发生长促进作用，能够通过含有Torreya植物种子的皂苷来防止脱发。 构成：毛发生长促进剂包括Torreya植物种子的皂苷作为活性成分。 Torreya植物包括加拿大的Torreya，Torreya fargesii，Torreya grandis，Torreya jackii，Torreya nucifera和Torreya taxifolia中的至少一种植物。 基于促进剂的总重量，Torreya植物种子的皂苷的含量为0.001至20重量％。 用于促进毛发生长的药物组合物含有毛发生长促进剂。 化妆品组合物包括毛发生长促进剂。 （附图标记）（AA）得分; （BB）周; （CC）语音比较组; （DD）米诺地尔2％; （EE）实施例1; （FF，GG）比较例
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Patent Agency Ranking
公开(公告)号：KR1020130055114A
公开(公告)日：2013-05-28
申请号：KR1020110120662
申请日：2011-11-18
Applicant: (주)아모레퍼시픽
IPC: A61K31/05 , A61K31/192 , A61K31/185 , A61P17/00
Abstract: PURPOSE: Carnosic acid, a derivative thereof, or a pharmaceutically acceptable salt thereof is provided to suppress c-kit activation and signal transduction in melanocytes, and to improve skin whitening. CONSTITUTION: A c-kit activity inhibitor contains carnosic acid of chemical formula 1, a derivative thereof, or a pharmaceutically acceptable salt thereof as an active ingredient. The derivative is carnosic acid methyl ester or carnosic acid ethyl alcohol. The carnosic acid, a derivative thereof, or a pharmaceutically acceptable salt thereof is derived from rosemary and/or sage. The inhibitor contains 0.0001-10 wt% of the active ingredient. A composition for skin whitening contains the derivative of chemical formula 1 or a pharmaceutically acceptable salt thereof. The composition further contains one or more selected from a group consisting of a Gycyrrhiza extract, arbutin, ascorbic acid, and kojic acid.
Abstract translation: 目的：提供鼠尾草酸，其衍生物或其药学上可接受的盐以抑制黑素细胞中的c-kit活化和信号转导，并改善皮肤美白。 构成：c-kit活性抑制剂含有化学式1的鼠尾草酸，其衍生物或其药学上可接受的盐作为活性成分。 衍生物为卡诺卡因酸甲酯或鼠尾草醇乙醇。 鼠尾草酸，其衍生物或其药学上可接受的盐衍生自迷迭香和/或鼠尾草。 抑制剂含有0.0001-10重量％的活性成分。 用于皮肤美白的组合物含有化学式1的衍生物或其药学上可接受的盐。 组合物还含有选自由甘草提取物，熊果苷，抗坏血酸和曲酸组成的组中的一种或多种。
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公开(公告)号：KR1020130037405A
公开(公告)日：2013-04-16
申请号：KR1020110101797
申请日：2011-10-06
Applicant: (주)아모레퍼시픽
IPC: C07C233/43 , A61K8/42 , A61K31/165 , A61Q7/00
CPC classification number: C07C233/65 , C07C233/59 , C07C255/57
Abstract: PURPOSE: A novel adamantane derivative compound is provided to decrease androgen, thereby obtaining hair growth and sebum secretion inhibiting effects. CONSTITUTION: A novel adamantane derivative compound is represented by chemical formula 1. In chemical formula 1, X is -NHCO- or -CONH-; R1 is C0-C5 alkyl or C1-C5 alkoxy; R2 is selected from NO2, CN, and NH2; and R3 is C1-C5 haloalkyl. The anti-androgen composition comprises the compound, isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, anhydride thereof, or a solvent thereof.
Abstract translation: 目的：提供一种新的金刚烷衍生物，以减少雄激素，从而获得毛发生长和皮脂分泌抑制作用。 组成：一种新颖的金刚烷衍生化合物由化学式1表示。在化学式1中，X是-NHCO-或-CONH-; R1是C0-C5烷基或C1-C5烷氧基; R2选自NO2，CN和NH2; 并且R 3是C 1 -C 5卤代烷基。 抗雄激素组合物包含化合物，其异构体，其药学上可接受的盐，其前药，其酸酐或其溶剂。
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公开(公告)号：KR1020130025768A
公开(公告)日：2013-03-12
申请号：KR1020110089285
申请日：2011-09-02
Applicant: (주)아모레퍼시픽
IPC: C07D407/14 , C07D407/12 , A61K8/49 , A61Q19/02
Abstract: PURPOSE: A novel kojic acid derivative with a skin whitening effect is provided to suppress pigmentation. CONSTITUTION: A novel kojic acid derivative with a skin whitening effect contains a kojic acid derivative of chemical formula 1 or an isomer, a pharmaceutically acceptable salt, a prodrug, a hydrate, or a solvate thereof. In chemical formula 1, R1 is -CH2- or -CH2CH2-; R2 is -CH2OC(O)- or -CH2OC(O)CH=CH-; and n is 1, 2, or 3.
Abstract translation: 目的：提供一种具有皮肤美白效果的新型曲酸衍生物，以抑制色素沉着。 构成：具有皮肤美白效果的新型曲酸衍生物含有化学式1的曲酸衍生物或其异构体，药学上可接受的盐，前药，水合物或溶剂化物。 在化学式1中，R 1是-CH 2 - 或-CH 2 CH 2 - ; R 2是-CH 2 OC（O） - 或-CH 2 OC（O）CH = CH-; 且n为1,2或3。
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公开(公告)号：KR1020130004616A
公开(公告)日：2013-01-14
申请号：KR1020110065010
申请日：2011-06-30
Applicant: (주)아모레퍼시픽
IPC: C07D309/40 , A61K8/49 , A61K8/35 , A61Q19/02
Abstract: PURPOSE: A kojic acid derivative and a cosmetic composition containing the same for skin whitening are provided to suppress melanogenesis and pigmentation with skin safety and to be applied to an external use skin formulation. CONSTITUTION: A kojic acid derivative is denoted by chemical formula 1. A method for preparing the derivative of chemical formula 1 and a pharmaceutically acceptable salt thereof comprises a step of reacting halo kojic acid of chemical formula 2 and inorganic salts of benzoic acid containing an adamantane group of chemical formula 3 to prepare a kojic ester compound. A method for preparing a derivative and pharmaceutically acceptable salt comprises: a step of reacting the kojic acid with halo-thionyl and preparing halo kojic acid; a step of reacting adamantane with benzoic acid containing a substituent of hydrogen, hydroxyl, or alkoxy of 1-3 carbon atoms and preparing benzoic acid containing the adamantane group; a step of reacting an inorganic compound with the benzoic acid and preparing inorganic salts; and a step of reacting prepared kojic acid chloride and inorganic salt of benzoic acid and preparing a kojic acid ester compound. A composition for whitening contains 0.01-20 wt% of the derivative and pharmaceutically acceptable salts thereof as active ingredients.
Abstract translation: 目的：提供曲酸衍生物和含有其的用于皮肤美白的化妆品组合物以抑制黑色素生成和皮肤安全性的色素沉积并施用于外用皮肤制剂。 组合物：曲酸衍生物由化学式1表示。制备化学式1的衍生物的方法及其药学上可接受的盐包括使化学式2的卤代曲酸与含有金刚烷的苯甲酸的无机盐反应的步骤 化学式3组，以制备曲酸酯化合物。 制备衍生物和药学上可接受的盐的方法包括：使曲酸与卤代亚硫酰基反应并制备卤代曲酸的步骤; 使金刚烷与含有1-3个碳原子的氢，羟基或烷氧基的取代基的苯甲酸反应并制备含有金刚烷基的苯甲酸的步骤; 使无机化合物与苯甲酸反应并制备无机盐的步骤; 和使制备的曲酸酰氯和苯甲酸的无机盐反应并制备曲酸酯化合物的步骤。 用于增白的组合物含有0.01-20重量％的衍生物和其药学上可接受的盐作为活性成分。
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公开(公告)号：KR1020110138001A
公开(公告)日：2011-12-26
申请号：KR1020100058068
申请日：2010-06-18
Applicant: (주)아모레퍼시픽
CPC classification number: A61K36/48
Abstract: PURPOSE: An antithrombotic composition containing a fraction of colored extract is provided to treat circulatory system diseases such as hypertension and diabetes. CONSTITUTION: An antithrombotic composition contains a resin fraction of colored bean extract isolated using water, C1-C5 alcohol, or mixture thereof. The concentration of C1-C5 is 1-40%(v/v) and includes methanol, ethanol, isopropyl alcohol, n-propyl alcohol, n-butanol, or isobutanol. A pharmaceutical composition for relieving or treating vascular diseases contains the composition as an active ingredient, containing the resin fraction. A health food composition for preventing or relieving vascular diseases contains the composition as an active ingredient, containing the resin fraction. The vascular diseases are obesity, diabetes, stroke, cerebral hemorrhage, arteriosclerosis, angina, myocardial infarction, hypertension, anemia, or hyperlipidemia.
Abstract translation: 目的：提供含有一部分有色提取物的抗血栓形成组合物，用于治疗高血压和糖尿病等循环系统疾病。 构成：抗血栓组合物含有使用水，C1-C5醇或其混合物分离的有色豆提取物的树脂级分。 C1-C5的浓度为1-40％（v / v），包括甲醇，乙醇，异丙醇，正丙醇，正丁醇或异丁醇。 用于缓解或治疗血管疾病的药物组合物含有含有树脂级分的作为活性成分的组合物。 用于预防或缓解血管疾病的保健食品组合物含有含有树脂级分的作为活性成分的组合物。 血管疾病是肥胖症，糖尿病，中风，脑出血，动脉硬化，心绞痛，心肌梗死，高血压，贫血或高脂血症。
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