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公开(公告)号：KR1020080049610A
公开(公告)日：2008-06-04
申请号：KR1020070103465
申请日：2007-10-15
Applicant: (주)아모레퍼시픽
IPC: A61K31/353 , A61K31/375 , A61K31/355 , A61P39/06
Abstract: An anti-oxidative composition is provided to show synergetic effect as an antioxidizing agent by mixing a water-soluble anti-oxidative material with an oil-soluble anti-oxidative material, reduce possible side effects caused by taking a single anti-oxidative material and increase the maintenance time of in vivo anti-oxidation efficacy. An anti-oxidative composition comprises a water-soluble anti-oxidative material such as vitamin C, epigallocatechin-3-gallate(EGCG), proanthocyanidin and gallic acid and an oil-soluble anti-oxidative material such as vitamin E, curcumin, carotene, lipoic acid and coenzyme Q10. Further, the water-soluble anti-oxidative material and the oil-soluble anti-oxidative material are mixed at a weight rate of 1:2 to 4:1.
Abstract translation: 提供抗氧化组合物以通过将水溶性抗氧化剂材料与油溶性抗氧化材料混合来显示作为抗氧化剂的协同作用，减少由于使用单一抗氧化材料而引起的可能的副作用并增加 维持时间的体内抗氧化功效。 抗氧化组合物包含水溶性抗氧化物质如维生素C，表没食子儿茶-3-没食子酸酯（EGCG），原花青素和没食子酸，以及油溶性抗氧化物质如维生素E，姜黄素，胡萝卜素， 硫辛酸和辅酶Q10。 此外，将水溶性抗氧化剂材料和油溶性抗氧化剂材料以1:2至4:1的重量比混合。
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公开(公告)号：KR1020080006895A
公开(公告)日：2008-01-17
申请号：KR1020060066207
申请日：2006-07-14
Applicant: (주)아모레퍼시픽
Abstract: A method of manufacturing green tea with a high content of Gallocatechin-3-gallate(GCG) by subjecting green tea leaf to steam treatment at high temperature and pressure to epimerize epigallocatechin-3-gallate(EGCG) after steaming or roasting treatment of the green tea leaf is provided to increase the content of GCG by a thermal conversion method. To make green tea with a high content of Gallocatechin-3-gallate, green tea leaf is treated with steam or roasted. In the process, the steam treatment is performed more than 2 times or roasting time is increased by more than 20%. The steam treatment or roasting is performed within 30min. After the steam treatment or roasting, steam sterilization treatment is additionally performed for 1 to 240min.
Abstract translation: 一种通过在高温高压下对绿茶叶进行蒸汽处理来制造具有高含量的Gallocatechin-3-没食子酸酯（GCG）的绿茶的方法，以在对绿色的蒸汽或焙烧处理后对表没食子儿茶素-3-没食子酸酯（EGCG）进行差向异构化 提供茶叶以通过热转化方法增加GCG的含量。 为了制备高含量的Gallocatechin-3-没食子酸酯的绿茶，用蒸汽或焙烤处理绿茶叶。 在此过程中，蒸汽处理时间超过2次，焙烧时间提高20％以上。 蒸汽处理或焙烧在30分钟内进行。 蒸汽处理或焙烧后，进行1〜240分钟的蒸汽灭菌处理。
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公开(公告)号：KR1020080004906A
公开(公告)日：2008-01-10
申请号：KR1020060063824
申请日：2006-07-07
Applicant: (주)아모레퍼시픽
IPC: C07D311/04 , A61K31/353
CPC classification number: C07D311/58
Abstract: A method for preparing gallocatechin gallate is provided to increase the solubility of epigallocatechin gallate into a reaction solvent by using an organic solvent and increase the conversion rate into the gallocatechin gallate through epimerization by adjusting the pH, thereby capable of increasing the production amount of the gallocatechin gallate. A method for preparing gallocatechin gallate comprises a step of converting epigallocatechin gallate into the gallocatechin gallate by dissolving the epigallocatechin gallate in an alcohol-based solvent such as ethanol and methanol or a polyol based solvent such as butylene glycol, propylene glycol and polyethylene glycol and then heating the solution at a temperature of about 120 deg.C for 30-60 minutes.
Abstract translation: 提供了没食子儿茶素没食子酸酯的制备方法，以通过使用有机溶剂提高表没食子儿茶素没食子酸酯在反应溶剂中的溶解度，并通过调节pH提高通过差向异构化得到的儿茶素没食子酸酯的转化率，从而能够增加喜树碱的产生量 没食子酸酯。 没食子酸儿茶素没食子酸酯的制备方法包括将表没食子儿茶素没食子酸酯溶解在醇类溶剂如乙醇和甲醇或多元醇类溶剂如丁二醇，丙二醇和聚乙二醇中，将表没食子儿茶素没食子酸酯转化为喜树碱没食子酸酯，然后 在约120℃的温度下加热溶液30-60分钟。
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公开(公告)号：KR1020070106822A
公开(公告)日：2007-11-06
申请号：KR1020060039138
申请日：2006-05-01
Applicant: (주)아모레퍼시픽
IPC: A61K31/353 , A61P3/10
CPC classification number: A61K31/353
Abstract: A composition containing (-)catechin is provided to increase expression of adiponectin by inhibiting expression of a transition factor KLF7(Kruppel-like factor 7) and promotes sugar absorption in adipocytes of mammals, so that the composition is useful for preventing and treating diabetes mellitus, arteriosclerosis and obesity. A composition for preventing and treating diabetes mellitus, arteriosclerosis and obesity contains 0.01-30 wt.%, preferably 1-15 wt.% of (-)catechin represented by the formula(1), wherein the (-)catechin is isolated from green tea. The daily dosage of (-)catechin is 0.1-50 mg/kg, preferably 1-20 mg/kg and the expression of adiponectin in a mammal adipocyte is increased by treating an adipocyte with (-)catechin for 24 hours.
Abstract translation: 提供含有（ - ）儿茶素的组合物，通过抑制转录因子KLF7（Kruppel样因子7）的表达来增加脂联素的表达，并促进哺乳动物脂肪细胞中的糖吸收，使得该组合物可用于预防和治疗糖尿病 ，动脉硬化和肥胖。 用于预防和治疗糖尿病，动脉硬化和肥胖症的组合物含有0.01-30重量％，优选1-15重量％的由式（1）表示的（ - ）儿茶素，其中（ - ）儿茶素与绿色分离 茶。 （ - ）儿茶素的日剂量为0.1-50mg / kg，优选为1-20mg / kg，通过用（ - ）儿茶素处理脂肪细胞24小时，哺乳动物脂肪细胞中脂联素的表达增加。
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公开(公告)号：KR1020070094340A
公开(公告)日：2007-09-20
申请号：KR1020060024905
申请日：2006-03-17
Applicant: (주)아모레퍼시픽
Abstract: 본발명은녹차성분및 백자인추출물을함유하여피지분비억제효과를나타내는화장료조성물에관한것으로, 더욱상세하게는녹차추출물또는녹차구성성분인카테킨(catechins)류, 플라보놀 (flavonols)류및 그유도체로이루어진군에서선택된 1종이상과백자인추출물을일정한성분비로함유함으로써과잉피지억제효과및 여드름완화효과를갖는화장료조성물에관한것이다.
Abstract translation: 提供化妆品组合物，以一定比例包含绿茶或绿茶提取物中含有的成分和东方蓟马提取物，以一定比例控制皮脂的代谢，从而有效减轻或改善痤疮并抑制过多的皮脂。 化妆品组合物包含0.001-30.0重量％的绿茶成分，例如绿茶，儿茶素，黄酮醇或其衍生物作为有效成分的提取物，以及Thujae orientalis Semen的提取物，其中儿茶素是表没食子儿茶素（EGCG） ，并且没食子儿茶素没食子酸gallocatechin（GCG）和黄酮醇是槲皮素，山奈酚和杨梅素。
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Patent Agency Ranking
公开(公告)号：KR1020070074090A
公开(公告)日：2007-07-12
申请号：KR1020060001810
申请日：2006-01-06
Applicant: (주)아모레퍼시픽
CPC classification number: A61Q19/02 , A61K8/4926 , A61K8/4946
Abstract: A composition comprising a benzimidazole amine derivative or an aminoquinoline derivative is provided to inhibit signaling of a cell in melanocyte with which a c-kit protein is involved so as to control the function of the melanocyte, thereby providing skin-whitening effect. The composition for inhibiting c-kit protein or skin-whitening comprises 0.0001-10 wt.% of a benzimidazole amine derivative such as 1-(4-methoxyphenyl)-N-(1-naphthalenylmethal)-1H-benzimidazole-5-amine represented by the formula(1) or an aminoquinoline derivative such as 2-amino-3-(3,4-dimethoxyphenyl)-quinoline represented by the formula(2).
Abstract translation: 提供包含苯并咪唑胺衍生物或氨基喹啉衍生物的组合物以抑制黑素细胞的细胞的信号传导，其中涉及c-kit蛋白质以控制黑素细胞的功能，从而提供皮肤美白效果。 用于抑制c-kit蛋白或皮肤美白的组合物包含0.0001-10重量％的苯并咪唑胺衍生物，例如1-（4-甲氧基苯基）-N-（1-萘基甲基）-1H-苯并咪唑-5-胺，其代表 通式（1）表示的氨基喹啉衍生物或由式（2）表示的2-氨基-3-（3,4-二甲氧基苯基） - 喹啉。
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公开(公告)号：KR1020070014672A
公开(公告)日：2007-02-01
申请号：KR1020050069506
申请日：2005-07-29
Applicant: (주)아모레퍼시픽
Abstract: A skin external composition for inhibiting phagocytosis of keratinocytes comprising genistein or daidzein is provided to reduce mobility of melanosomes transferred from melanocytes in keratinocytes by inhibiting phagocytosis of keratinocytes activated by exposure to ultra violet ray without cytotoxicity, so that chloasma, freckles and speckles are treated and prevented. The skin external composition for inhibiting phagocytosis of keratinocytes comprises at least one selected from genistein and daidzein, wherein the amount of genistein or daidzein is 0.0001-10 wt.%; the genistein or daidzein is an isoflavone produced from Leguminosae plants and shows estrogen effects; and the composition is formulated as cream, lotion, ointment, aqueous solution, suspension, dispersion or emulsion.
Abstract translation: 提供了一种用于抑制包含染料木黄酮或黄豆苷原的角质形成细胞吞噬作用的皮肤外用组合物，以通过抑制通过暴露于紫外线而没有细胞毒性活化的角质形成细胞的吞噬作用来降低角质形成细胞中从黑素细胞转移的黑素体的移动性，从而处理黄褐斑，雀斑和斑点 预防。 用于抑制角化细胞吞噬的皮肤外用组合物包含选自染料木黄酮和黄豆苷原中的至少一种，其中染料木黄酮或黄豆苷原的量为0.0001-10重量％; 染料木素或黄豆苷原是由豆科植物产生的异黄酮，显示雌激素作用; 并将组合物配制成霜剂，洗剂，软膏，水溶液，悬浮液，分散体或乳液。
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公开(公告)号：KR1020040061733A
公开(公告)日：2004-07-07
申请号：KR1020020088025
申请日：2002-12-31
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: Provided is a skin whitening cosmetic composition which contains rhaponticin and rhapontigenin as an active ingredient. Therefore, the composition has high skin absorption and inhibits the synthesis of melanin. CONSTITUTION: A skin whitening cosmetic composition is characterized by containing, based on the total weight of the composition, 0.0001-10 wt.% of one of rhaponticin and rhapontigenin which are extracted from Rheum coreanum Nakai.
Abstract translation: 目的：提供含有作为活性成分的罗非曲
汀和rhapontigenin的皮肤美白化妆品。 因此，该组合物具有高的皮肤吸收并抑制黑色素的合成。 构成：皮肤美白化妆品组合物的特征在于，基于组合物的总重量含有0.0001-10重量％的从大黄中提取的rhaponticin和rhapontigenin之一。-
公开(公告)号：KR1020030077271A
公开(公告)日：2003-10-01
申请号：KR1020020016298
申请日：2002-03-26
Applicant: (주)아모레퍼시픽
IPC: C07K5/10
CPC classification number: C07K5/1016 , A61K8/64 , A61K38/07 , A61Q19/00 , A61Q19/02
Abstract: PURPOSE: Provided is a melanogenesis-suppressing peptide which effectively suppresses the activation of tyrosinase in the melanogenesis cells. A topical skin-whitening composition containing the melanogenesis-suppressing peptide involves excellent skin whitening effect, and effective improvement and prevention of chloasma, freckles, and other melanin pigmentation. CONSTITUTION: The melanogenesis-suppressing peptide is selected from the group consisting of peptides with the amino acid sequences of SEQ ID NO 1-4. A method of manufacturing the melanogenesis-suppressing peptide comprises the steps of preparing chemical peptide random-sequenced mixtures with 76 cases of 4(locations)x19(amino acids); selecting two or three amino acids per the respective peptide locations with enzyme activity inhibitory effect from the peptide mixtures using tyrosinase extracted from mushrooms; synthesizing secondary peptides based on the selected peptide sequences; and testing the whitening effect and the cell stability of the secondary peptides, and finally selecting the peptide with the amino acid sequences of SEQ ID NO 1-4.
Abstract translation: 目的：提供有效抑制黑素生成细胞中酪氨酸酶活化的黑素生成抑制肽。 含有黑素生成抑制肽的局部皮肤美白组合物具有优异的皮肤美白效果，有效改善和防止黄褐斑，雀斑和其他黑色素色素沉着。 构成：黑素生成抑制肽选自具有SEQ ID NO 1-4的氨基酸序列的肽。 制备黑素生成抑制肽的方法包括以下步骤：制备具有76个4（位置）x19（氨基酸）的76个化学肽随机排序的混合物; 使用从蘑菇提取的酪氨酸酶从肽混合物中选择两个或三个氨基酸，每个肽位置具有酶活性抑制作用; 基于所选择的肽序列合成二级肽; 并测试第二肽的美白效果和细胞稳定性，最后选择具有SEQ ID NO 1-4的氨基酸序列的肽。
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