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公开(公告)号：KR1020130131628A
公开(公告)日：2013-12-04
申请号：KR1020120055319
申请日：2012-05-24
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/4926 , A61K9/0014 , A61K31/445 , A61Q19/02
Abstract: The present invention relates to a composition for skin whitening, wherein the composition contains Plumarol as an active ingredient. The composition for skin whitening according to the present invention suppresses the protein expression of tyrosinase, which is a melanogenic enzyme, and inhibits melanogenesis, by containing Plumarol as an active ingredient, thereby exhibiting a whitening effect. [Reference numerals] (AA) Comparative example 1;(BB) Example 1;(CC) Example 2
Abstract translation: 本发明涉及一种用于皮肤美白的组合物，其中该组合物含有Plumarol作为活性成分。 根据本发明的皮肤美白组合物通过含有Plumarol作为活性成分抑制作为黑素生成酶的酪氨酸酶的蛋白质表达并抑制黑素生成，从而表现出美白效果。 （AA）比较例1（BB）实施例1（CC）实施例2
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公开(公告)号：KR1020130128907A
公开(公告)日：2013-11-27
申请号：KR1020120053095
申请日：2012-05-18
Applicant: (주)아모레퍼시픽
CPC classification number: A61K31/133 , A23L29/035 , A23L29/045 , A23V2200/318 , A61K8/41 , A61Q19/02
Abstract: The present invention relates to a whitening composition which suppresses or prevents melanogenesis and, particularly, to a composition containing valiolamine derivative of chemical formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient.
Abstract translation: 本发明涉及抑制或预防黑素生成的增白组合物，特别涉及包含化学式1的缬草烯胺衍生物或其药学上可接受的盐作为活性成分的组合物。
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公开(公告)号：KR1020130001123A
公开(公告)日：2013-01-03
申请号：KR1020120061988
申请日：2012-06-11
Applicant: (주)아모레퍼시픽
IPC: C12N15/113 , A61K8/00 , A61Q19/02 , A61Q7/00
CPC classification number: C12N15/1137 , A61K8/606 , A61K31/7105 , A61K2800/78 , A61K2800/782 , A61Q5/10 , C12N15/113 , C12N2310/113 , C12N2310/141 , G01N33/5023
Abstract: PURPOSE: A composition containing miRNA or an antisense molecule of the miRNA is provided to regulate tyrosinase mRNA expression and pigmentation and to enhance skin whitening effect. CONSTITUTION: A composition for regulating pigmentation and expression of a pigmentation-related gene contains miRNA of sequence number 1 as an active ingredient. The miRNA is selected among sequences of sequence number 1 and is also selected among oligonucleotide molecules containing 22 continuous bases with CCCUGAG. The pigmentation-related gene is tyrosinase mRNA. The composition is a cosmetic or pharmaceutical composition for skin whitening. A composition for regulating pigmentation and expression of a pigmentation-related gene contains a base sequence which is complementary to miRNA of sequence number and an antisense nucleic acid molecule of sequence number 2, which is hybridizable with the miRNA. [Reference numerals] (AA) Relative mRNA expression of TYR/GAPDH; (BB) Comparative embodiment 1; (CC) Comparative embodiment 2; (DD) MiR-125b derivatives
Abstract translation: 目的：提供含有miRNA或miRNA的反义分子的组合物，以调节酪氨酸酶mRNA表达和色素沉着，并增强皮肤美白效果。 构成：用于调节色素沉着相关基因的色素沉着和表达的组合物含有序列号1的miRNA作为活性成分。 miRNA选自序列号1的序列，也选自含有CCCUGAG的22个连续碱基的寡核苷酸分子。 色素沉着相关基因是酪氨酸酶mRNA。 该组合物是用于皮肤美白的化妆品或药物组合物。 用于调节色素沉着相关基因的色素沉着和表达的组合物含有与序列号的miRNA互补的碱基序列和与miRNA杂交的序列号2的反义核酸分子。 （AA）相对mRNA表达TYR / GAPDH; （BB）比较实施例1; （CC）比较实施例2; （DD）MiR-125b衍生物
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公开(公告)号：KR1020120139430A
公开(公告)日：2012-12-27
申请号：KR1020110059227
申请日：2011-06-17
Applicant: (주)아모레퍼시픽
IPC: C12N15/113 , A61K31/7088 , A61Q19/00 , A61Q7/00
Abstract: PURPOSE: A composition containing miRNA for controlling pigmentation gene expression is provided to suppress tyrosinase, tyrosinase-related proteins, and melan-A expression. CONSTITUTION: A composition for controlling pigmentation gene expression contains miRNA containing a base of sequence number 1 as an active ingredient. The miRNA has continuous 27 bases containing ccuucuu of sequence number 1 and a base which suppresses pigmentation gene expression. The pigmentation gene is tyrosinase, tyrosinase-related protein 1, or melan-A gene. The miRNA targets 909-915th nucleic acids of melan A mRNA 3'-UTR. The composition is a cosmetic or pharmaceutical composition for skin whitening. A composition for controlling pigmentation gene expression contains a complementary base with miRNA of sequence number 1. [Reference numerals] (AA) Relative TYR/GAPDH mRNA expression level; (BB) Comparative embodiment 1; (CC) Comparative embodiment 2; (DD) Embodiment 1
Abstract translation: 目的：提供含有miRNA用于控制色素沉着基因表达的组合物，以抑制酪氨酸酶，酪氨酸酶相关蛋白和黑色素A表达。 构成：用于控制色素沉着基因表达的组合物含有含有序列号1的碱基作为活性成分的miRNA。 miRNA具有连续的27个碱基，其含有序列号1的碱基和抑制色素沉着基因表达的碱基。 色素沉着基因是酪氨酸酶，酪氨酸酶相关蛋白1或黑色素A基因。 miRNA靶向黑色A mRNA 3'-UTR的第909-915个核酸。 该组合物是用于皮肤美白的化妆品或药物组合物。 用于控制色素沉着基因表达的组合物含有与序列号1的miRNA的互补碱基。[参考数字]（AA）相对TYR / GAPDH mRNA表达水平; （BB）比较实施例1; （CC）比较实施例2; （DD）实施例1
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公开(公告)号：KR100921947B1
公开(公告)日：2009-10-15
申请号：KR1020030082144
申请日：2003-11-19
Applicant: (주)아모레퍼시픽
CPC classification number: A61Q19/02 , A61K8/4986 , A61K8/97 , A61K2800/70
Abstract: 본 발명은 멜라닌 합성경로를 조절하여 멜라닌 과다 생성 억제; 멜라닌 색소의 조절; 및 멜라닌 배출 촉진;의 3단계로 미백작용을 하는 피부 미백 화장료 조성물에 관한 것이다. 더욱 상세하게는, 본 발명의 피부 미백 화장료 조성물은 멜라닌 과다 생성 억제 미백기능과 동시에 멜라닌 색소 조절 미백기능을 하는 EPS 복합체 및 멜라닌 배출촉진제로서 각질제거제를 함유하여 우수한 미백효과를 나타낸다.
멜라닌 * 각질제거 * 미백 * EPS 복합체-
Patent Agency Ranking76.发明公开카텝신 Ｇ 저해제를 함유하는 피부노화 방지용 피부외용제조성물 및 항노화용 물질을 스크리닝하는 방법 有权用于外用于含皮肤抑制剂G抑制剂以防止皮肤老化的筛选组合物和用于开发抗病材料的筛选方法
公开(公告)号：KR1020080040612A
公开(公告)日：2008-05-08
申请号：KR1020070111803
申请日：2007-11-02
Applicant: (주)아모레퍼시픽
IPC: A61K31/166 , A61K8/44 , A61K8/34 , A61Q19/08
CPC classification number: A61K8/42 , A61K2800/522 , A61Q19/08
Abstract: A skin external composition comprising a cathepsin G inhibitor is provided to prevent an adhesion protein from being degraded by intrinsic aging and photo-aging, reduce the production of metalloproteinase and inhibit the activity of metalloproteinase, thereby being more potent anti-aging substance than existing anti-aging substances. A method for screening anti-aging materials is provided to develop the anti-aging materials which effectively inhibit the quantitative and qualitative increase of metalloproteinase, resulting from the degradation of an adhesion protein by cathepsin G in skin cells without direct UV irradiation. A skin external composition for preventing skin aging comprises 0.01-10 wt% a cathepsin G inhibitor as an effective ingredient, wherein the cathepsin G inhibitor is at least one selected from the group consisting of compounds represented by formulae(1) to (4). The composition is formulated into skin lotion, astringent lotion, milk lotion, nourishing cream, essence, massage cream, eye cream, pack, body lotion, body cream, body oil or body essence. A method for screening an anti-aging material comprises the steps of: (a) adding an anti-aging candidate material to a substrate in the presence of cathepsin G enzyme; and (b) measuring the inhibition of activity of the cathepsin G enzyme. Further, the measure of the inhibition of activity of the cathepsin G enzyme is performed by measuring a concentration of a produced metalloprotease.
Abstract translation: 提供包含组织蛋白酶G抑制剂的皮肤外用组合物，以防止粘附蛋白由于内在老化和光老化而降解，减少金属蛋白酶的产生并抑制金属蛋白酶的活性，从而比现有的抗老化物质更有效的抗衰老物质 化学物质。 提供了一种筛选抗衰老材料的方法，以开发有效抑制金属蛋白酶定量和定性增加的抗衰老材料，这是由皮肤细胞中组织蛋白酶G在组织蛋白酶G中的降解引起的，而不需要直接的紫外线照射。 用于防止皮肤老化的皮肤外用组合物包含0.01-10重量％的组织蛋白酶G抑制剂作为有效成分，其中组织蛋白酶G抑制剂是选自由式（1）至（4）表示的化合物中的至少一种。 该组合物配制成皮肤洗剂，收敛剂，乳液，滋养霜，精华液，按摩霜，眼霜，包装，身体乳液，身体霜，身体油或身体精华。 用于筛选抗衰老材料的方法包括以下步骤：（a）在组织蛋白酶G酶存在下将抗老化候选材料加入到底物中; 和（b）测量组织蛋白酶G酶的活性的抑制。 此外，组织蛋白酶G酶的活性的抑制的测量是通过测量产生的金属蛋白酶的浓度进行的。
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公开(公告)号：KR100774437B1
公开(公告)日：2007-11-08
申请号：KR1020060113662
申请日：2006-11-17
Applicant: (주)아모레퍼시픽
IPC: A61K31/343 , A61K8/49 , A61Q19/02
CPC classification number: A61K8/4973 , A61K31/343 , A61Q19/02
Abstract: A skin external composition for skin-whitening containing manassantin B is provided to inhibit mobility of melanin by inhibiting binding of melanophilin as a carrier of melanosome in a melanocyte with myosin 5a, thereby forming melanosome aggregation and whitening the skin. A skin external composition for skin-whitening contains 0.001-10% of manassantin B which is extracted from Saururus chinensis Baill by extracting Saururus chinensis Baill with water or organic solvent selected from ethanol, methanol, butanol, ether, ethylacetate, chloroform and methylene chloride, filtering the extract, concentrating the filtered solution under reduced pressure, extracting the concentrate with methylene chloride and concentrating the extract under reduced pressure, and is formulated as solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation or spray.
Abstract translation: 提供含有马桑丁汀B的皮肤外用组合物，用于通过抑制作为黑素细胞的黑素体的载体的黑色素细胞与肌球蛋白5a的结合来抑制黑色素的迁移，从而形成黑素体聚集并使皮肤变白。 用于皮肤美白的皮肤外用组合物含有0.001-10％的苦参碱B，其通过用水或选自乙醇，甲醇，丁醇，乙醚，乙酸乙酯，氯仿和二氯甲烷的有机溶剂萃取中华白菜， 过滤浓缩滤液，减压浓缩萃取液，减压浓缩，配制成溶液，悬浮液，乳液，糊剂，凝胶，乳液，乳液，粉末，皂，表面活性剂， 含有清洁，油，粉底，乳液粉底，蜡基或喷雾剂。
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公开(公告)号：KR100636737B1
公开(公告)日：2006-10-20
申请号：KR1020050032607
申请日：2005-04-20
Applicant: (주)아모레퍼시픽
IPC: C07C225/20
Abstract: Provided are a gallic acid adamantamine amide compound which inhibits the generation of melanin, a method for preparing the compound, and a cosmetic composition containing the compound. The gallic acid adamantamine amide compound is represented by the formula 1. The method comprises the steps of dissolving gallic acid in a solvent, adding a catalyst and a base to the solution drop by drop, and reacting it with acetic anhydride to prepare the acetylated compound represented by the formula II (See the reaction scheme 1); dissolving the acetylated compound in a solvent and adding a base, ethyl chloroformate and adamantamine to prepare the amide compound represented by the formula III; and reacting the obtained amide compound with a base to hydrolyze it, thereby preparing the gallic acid adamantamine amide compound represented by the formula 1. Preferably the catalyst is dimethyl aminopyridine; and the base is triethylamine.
Abstract translation: 本发明提供抑制黑色素生成的没食子酸金刚胺酰胺化合物，其制备方法以及含有该化合物的化妆品组合物。 没食子酸金刚烷胺酰胺化合物由式1表示。该方法包括以下步骤：将没食子酸溶解在溶剂中，逐滴向溶液中加入催化剂和碱，并使其与乙酸酐反应以制备乙酰化的化合物 由式II表示（参见反应方案1）; 将乙酰化的化合物溶解在溶剂中，加入碱，氯甲酸乙酯和金刚烷胺制备式III所示的酰胺化合物; 并使所得酰胺化合物与碱反应以将其水解，从而制备式1代表的没食子酸金刚烷胺酰胺化合物。优选该催化剂是二甲基氨基吡啶; 碱是三乙胺。
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公开(公告)号：KR102045879B1
公开(公告)日：2019-11-18
申请号：KR1020180042940
申请日：2018-04-12
Applicant: (주)아모레퍼시픽 , 경희대학교 산학협력단
IPC: G01N33/50 , G01N33/68 , A23L33/13 , A61K31/7105 , A61K31/713 , A61K48/00 , A61P27/02
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