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71.发明公开풀루란 유도체―폴리에틸렌이민 접합체를 포함하는 생리활성 물질 전달체 및 이의 제조방법 有权包含改性的PULLULAN-POLYETHYLENEIMINE CONJUGATE的生物活性剂递送系统及其生产方法
公开(公告)号：KR1020120001214A
公开(公告)日：2012-01-04
申请号：KR1020100061907
申请日：2010-06-29
Applicant: 가톨릭대학교 산학협력단
IPC: A61K9/32 , A61K31/719 , A61K47/36 , A61K47/30
CPC classification number: A61K47/61 , A61K47/59 , A61K48/00 , A61K2121/00
Abstract: PURPOSE: A bioactive substance delivery system containing cationic polymer conjugates is provided to stably maintain bond between the conjugate and genes. CONSTITUTION: A bioactive substance delivery system contains cationic polymer conjugates in which pullulan derivatives and polyethylene imine are conjugated. The pullulan derivative has a methyl group, bile acid, cholesterol, or non-ionic poly amino acid introduced to pullulan. A method for preparing the delivery system comprises: a step of acetylating the pullulan to synthesize a hydrophobic pullulan derivative; a step of polymerizing the hydrophobic pullulan derivative and a crosslinking agent; and a step of polymerizing the polymer and polyethylene imine. A gene therapeutic agent contains the delivery system as an active ingredient.
Abstract translation: 目的：提供含有阳离子聚合物缀合物的生物活性物质递送系统，以稳定保持缀合物和基因之间的结合。 构成：生物活性物质输送系统含有阳离子聚合物共轭物，其中支链淀粉衍生物和聚乙烯亚胺共轭。 支链淀粉衍生物具有引入支链淀粉的甲基，胆汁酸，胆固醇或非离子聚氨基酸。 制备递送系统的方法包括：乙酰化支链淀粉以合成疏水支链淀粉衍生物的步骤; 聚合疏水性支链淀粉衍生物和交联剂的步骤; 和使聚合物和聚乙烯亚胺聚合的步骤。 基因治疗剂含有作为活性成分的递送系统。
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72.发明公开
公开(公告)号：KR1020100124160A
公开(公告)日：2010-11-26
申请号：KR1020090043267
申请日：2009-05-18
Applicant: (주) 태웅메디칼 , 신경민 , 가톨릭대학교 산학협력단
IPC: A61K49/00 , A61P43/00 , A61K31/765 , A61K33/38
CPC classification number: A61K47/02 , A61K9/167 , A61K9/1682 , A61K31/765 , A61K49/00 , A61L2430/36
Abstract: PURPOSE: A radiopacity poly(pivalic acid vinyl/acetic acid vinyl)/poly(vinyl alcohol) microsphere embolic material is provided to improve simplicity. CONSTITUTION: A poly(vinyl pivalate/acetic acid vinyl)/poly(vinyl alcohol) microsphere embolic material comprises: a 54-63% of syndiotactic dyad by copolymerizing mixture of pivalate monomer and acetic acid vinyl monomer; a core having poly(vinyl pivalate/acetic acid vinyl); and polyvinyl alcohol outer cover prepared by saponification of a part of core. A method for manufacturing the poly(vinyl pivalate/acetic acid vinyl)/poly(vinyl alcohol) microsphere embolic material comprises: a step of copolymerizing a mixture of vinyl pivalate monomer and acetic acid vinyl monomer to form the core; a step of adding 0.1-100 weight part of inorganic salt and milling; and a step of performing saponification.
Abstract translation: 目的：提供放射性聚（新戊酸乙烯基/乙酸乙烯基）/聚（乙烯醇）微球栓塞材料，以提高简单性。 构成：聚（乙烯基乙酸乙烯酯）/聚（乙烯醇）微球体栓塞材料包括：通过共聚新戊酸单体和乙酸乙烯基单体的混合物，54-63％的间同立构二元体; 具有聚（新戊酸乙烯酯/乙酸乙烯酯）的核心; 和通过一部分芯的皂化制备的聚乙烯醇外覆盖层。 聚（乙烯醇乙烯基）/聚（乙烯醇）微球栓塞材料的制造方法包括：使新戊酸乙烯酯单体和乙酸乙烯基单体的混合物共聚形成核心的步骤; 加入0.1-100重量份无机盐和研磨的步骤; 和进行皂化的步骤。
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公开(公告)号：KR1020100100497A
公开(公告)日：2010-09-15
申请号：KR1020090019417
申请日：2009-03-06
Applicant: 가톨릭대학교 산학협력단
IPC: A61K9/14 , A61K31/728 , A61K47/36 , A61K9/08
CPC classification number: A61K9/146 , A61K9/0019 , A61K31/704 , A61K47/36 , A61K2121/00 , B82Y5/00
Abstract: PURPOSE: A nanoparticle formed by autoagglutination is provided to use as a carrier of various drugs and to ensure sustained release of drug. CONSTITUTION: A nanoparticle is formed by autoagglutination of amphipathic hyaluronic acid and drug. The hyaluronic acid is acetylated. A method for preparing the nanoparticle comprises: a step of dissolving hyaluronic acid and C2-C4 alkanoic acid anhydride in a solvent to obtain C2-C4 alkanoylated hyaluronic acid product; a step of mixing the product with water to precipitate C2-C4 alkanoylated hyaluronic acid; a step of dialyzing hyaluronic acid and drug into a dialyzer; a step of performing autoagglutination of the C2-C4 alkanoylated hyaluronic acid and drug to form nanoparticles; and a step of freeze-drying the nanoparticles.
Abstract translation: 目的：提供通过自动凝集形成的纳米颗粒，用作各种药物的载体并确保药物的持续释放。 构成：通过两亲性透明质酸和药物的自凝集形成纳米颗粒。 透明质酸被乙酰化。 制备纳米颗粒的方法包括：将透明质酸和C 2 -C 4链烷酸酐溶解在溶剂中以获得C 2 -C 4烷酰化透明质酸产物的步骤; 将产物与水混合以沉淀C 2 -C 4烷酰化透明质酸的步骤; 将透明质酸和药物透析成透析器的步骤; 进行C2-C4烷酰化透明质酸和药物的自凝集形成纳米粒子的步骤; 以及冷冻干燥纳米颗粒的步骤。
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74.发明公开폴리-락티드-코-글리콜라이드 미립구, 그 제조방법, 및그것을 포함하는 단백질 또는 펩티드 약물 제제 无效POLY（LACTIDE-CO-GLYCOLIDE）MICROSPHERE，其制备方法和包含其的蛋白质或肽类药物制剂
公开(公告)号：KR1020090116494A
公开(公告)日：2009-11-11
申请号：KR1020080042475
申请日：2008-05-07
Applicant: 가톨릭대학교 산학협력단
CPC classification number: A61K47/593 , A61K9/0019 , A61K9/1652 , A61K47/36 , A61K47/6925
Abstract: PURPOSE: A peptide or protein drug, and micro sphere particle containing PLGA(Poly-lactide-co-glycolide) are provided to form ionic binding complex with polysaccharide. CONSTITUTION: A PLGA micro sphere particle contains a peptide or protein drug, PLGA and polysaccharide with sulfate residue in the PLGA micro sphere particle. A method for preparing the PLGA micro sphere particle comprises: a step of preparing peptide or protein drug solution to have pH concentration under isoelectric point of the peptide or protein drug; a step of preparing liquid solution containing polysaccharide with sulfate residue to have pH concentration under isoelectric point; a step of mixing prepared solutions to form polysaccharide-peptide or polysaccharide-protein complex; a step of stirring mixed solution with PLGA solution to produce w/o emulsion; a step of dispersing the w/o emulsion in dispersing medium to form PLGA micro sphere particle; and a step of collecting formed PLGA micro sphere particle.
Abstract translation: 目的：提供一种肽或蛋白质药物和含有PLGA（聚丙交酯 - 共 - 乙交酯）的微球粒子，以形成与多糖的离子结合复合物。 构成：PLGA微球粒子在PLGA微球粒子中含有肽或蛋白质药物PLGA和具有硫酸盐残基的多糖。 制备PLGA微球粒子的方法包括：制备肽或蛋白质药物溶液以在肽或蛋白质药物的等电点下具有pH浓度的步骤; 用硫酸盐残渣制备含多糖的液体溶液，使pH浓度等于等电点的步骤; 混合制备的溶液以形成多糖 - 肽或多糖 - 蛋白质复合物的步骤; 用PLGA溶液搅拌混合溶液以产生w / o乳液的步骤; 将w / o乳液分散在分散介质中以形成PLGA微球颗粒的步骤; 以及收集形成的PLGA微球粒子的步骤。
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公开(公告)号：KR1020070092438A
公开(公告)日：2007-09-13
申请号：KR1020060022573
申请日：2006-03-10
Applicant: 가톨릭대학교 산학협력단
Inventor： 나건
CPC classification number: A61K47/36 , A61K9/0087 , A61K47/12 , B82Y5/00
Abstract: A nano-aggregate having pullulan is provided to be used for delivering an anti-cancer agent by being able to apply as a bio-material due to biodegradability thereof and showing excellent characteristics as a drug carrier. A nano-aggregate is prepared by self-assembling an ester-bond conjugate of a hydrophobicized monomer cyclic compound having a carboxyl group and pullulan, wherein the conjugate is a conjugate of pullulan-folic acid, a conjugate of pullulan-biotin, or a conjugate of pullulan-bile acid. To transfer a drug such as protein, nucleic acid, chemical materials and natural materials, the nano-aggregate is used.
Abstract translation: 提供了具有支链淀粉的纳米骨料，用于通过由于其生物降解性而能够作为生物材料施用并显示作为药物载体的优异特性来递送抗癌剂。 通过自组装具有羧基和支链淀粉的疏水化单体环状化合物的酯键缀合物制备纳米骨料，其中所述缀合物是支链淀粉 - 叶酸的结合物，支链淀粉 - 生物素的缀合物或缀合物 的支链淀粉酸。 为了转移蛋白质，核酸，化学材料和天然材料等药物，使用纳米骨料。
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Patent Agency Ranking
公开(公告)号：KR102150980B1
公开(公告)日：2020-09-02
申请号：KR1020180169373
申请日：2018-12-26
Applicant: 가톨릭대학교 산학협력단
IPC: G01N33/569 , G01N33/548 , A61K41/00 , A61K47/61
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公开(公告)号：KR1020180133353A
公开(公告)日：2018-12-14
申请号：KR1020180155303
申请日：2018-12-05
Applicant: 가톨릭대학교 산학협력단
Abstract: 본 발명은 지질-광감작제 나노결합체 및 이의 제조 방법에 관한 것으로, 더욱 상세하게는 지질 리포좀 내부에 광감작제가 봉입되거나, 지질 리포좀 외부에 광감작제가 결합되어 구성되며, 지질과 광감작제를 연결하는 연결자는 미생물이 분비하는 효소에 의하여 특이적으로 분해되는 것을 특징으로 하는 지질-광감작제 나노결합체 및 이의 제조 방법에 관한 것이다. 본 발명에 따른 지질-광감작제 나노결합체는 피부 투과성이 우수하여 진피층에 존재하는 균의 사멸률을 높일 수 있고, 균이 분비하는 분해효소인 리파아제에 의해 지질-광감작제 나노결합체가 분해되어 무좀균, 여드름균을 포함하는 효소를 분비하는 미생물이 존재하는 부위에서 특이적으로 균을 사멸시킬 수 있다. 또한, 광역학 치료법으로 치료함으로써 기존의 항진균제를 장기간 복용할 시 일어날 수 있는 간독성 등의 부작용의 위험을 낮추며, 항생제 내성균 발생 위험 역시 낮출 수 있어, 무좀, 여드름 치료를 비롯한 효소를 분비하는 미생물에 의해 발생하는 질환의 예방 또는 치료에 유용하게 사용될 수 있다.
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公开(公告)号：KR101838336B1
公开(公告)日：2018-04-26
申请号：KR1020140117471
申请日：2014-09-04
Applicant: 가톨릭대학교 산학협력단
Abstract: 본발명은지질-광감작제나노결합체및 이의제조방법에관한것으로, 더욱상세하게는지질리포좀내부에광감작제가봉입되거나, 지질리포좀외부에광감작제가결합되어구성되며, 지질과광감작제를연결하는연결자는미생물이분비하는효소에의하여특이적으로분해되는것을특징으로하는지질-광감작제나노결합체및 이의제조방법에관한것이다. 본발명에따른지질-광감작제나노결합체는피부투과성이우수하여진피층에존재하는균의사멸률을높일수 있고, 균이분비하는분해효소인리파아제에의해지질-광감작제나노결합체가분해되어무좀균, 여드름균을포함하는효소를분비하는미생물이존재하는부위에서특이적으로균을사멸시킬수 있다. 또한, 광역학치료법으로치료함으로써기존의항진균제를장기간복용할시 일어날수 있는간독성등의부작용의위험을낮추며, 항생제내성균발생위험역시낮출수 있어, 무좀, 여드름치료를비롯한효소를분비하는미생물에의해발생하는질환의예방또는치료에유용하게사용될수 있다.
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公开(公告)号：KR101765335B1
公开(公告)日：2017-08-22
申请号：KR1020140129020
申请日：2014-09-26
Applicant: 서울대학교산학협력단 , 기초과학연구원 , 가톨릭대학교 산학협력단
CPC classification number: C08G69/40 , A61K49/1857 , C08G69/08 , C08G81/00
Abstract: 본발명은초극미세나노입자를함유하는암 세포조영용 MRI 조영제조성물에관한것이다. 보다상세하게는, 본발명은특정범위의수소이온농도(pH) 조건에서분리되는리간드 A, 및특정범위의수소이온농도조건에서표면전하가변하는리간드 B를포함하는, 자기조립리간드조성물, 그리고상기리간드조성물과 MRI 조영용나노입자를포함하는암 세포조영용 MRI 조영제조성물, 그리고이들의제조방법에대한것이다.
Abstract translation: 本发明涉及含有超细纳米粒子的癌细胞成像用MRI造影剂组合物。 更具体地说，本发明涉及一种自组装配体组合物，其包含在一定范围的氢离子浓度（pH）条件下分离的配体A和表面电荷在特定范围的氢离子浓度范围内变化的配体B， 本发明涉及包含配体组合物和MRI造影增强纳米粒子的癌细胞成像MRI造影剂组合物及其制备方法。
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