公开(公告)号：AU2016238925A1

公开(公告)日：2016-11-03

申请号：AU2016238925

申请日：2016-10-07

Applicant: ABBVIE BAHAMAS LTD

Inventor： DEGOEY DAVID A ,  KATI WARREN M ,  HUTCHINS CHARLES W ,  DONNER PAMELA L ,  KRUEGER ALLAN C ,  RANDOLPH JOHN T ,  MOTTER CHRISTOPHER E ,  NELSON LISSA T ,  PATEL SACHIN V ,  MATULENKO MARK A ,  KEDDY RYAN G ,  JINKERSON TAMMIE K ,  GAO YI ,  LIU DACHUN ,  PRATT JOHN K ,  ROCKWAY TODD W ,  MARING CLARENCE J ,  HUTCHINSON DOUGLAS K ,  FLENTGE CHARLES A ,  WAGNER ROLF ,  TUFANO MICHAEL D ,  BETEBENNER DAVID A ,  SARRIS KATHY ,  WOLLER KEVIN R ,  WAGAW SEBLE H ,  CALIFANO JEAN C ,  LI WENKE ,  CASPI DANIEL D ,  BELLIZZI MARY E ,  CARROLL WILLIAM A

IPC: C07D403/14

Abstract: ANTI-VIRAL COMPOUNDS Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：CA2849420C

公开(公告)日：2016-07-12

申请号：CA2849420

申请日：2008-09-17

Applicant: ABBVIE BAHAMAS LTD

Inventor： FLENTGE CHARLES A ,  HUTCHINSON DOUGLAS K ,  BETEBENNER DAVID A ,  DEGOEY DAVID A ,  DONNER PAMELA L ,  KATI WARREN M ,  KRUEGER ALLAN C ,  LIU DACHUN ,  LIU YAYA ,  LONGENECKER KENTON L ,  MARING CLARENCE J ,  MOTTER CHRISTOPHER E ,  PRATT JOHN K ,  RANDOLPH JOHN T ,  ROCKWAY TODD W ,  STEWART KENT D ,  WAGNER ROLF ,  BARNES DAVID M ,  CHEN SHUANG ,  FRANCZYK THADDEUS S II ,  GAO YI ,  HAIGHT ANTHONY R ,  HENGEVELD JOHN E ,  KOTECKI BRIAN J ,  LOU XIAOCHUN ,  ZHANG GEOFF G Z

IPC: A61K31/505 ,  A61K31/7056 ,  A61P31/14

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

公开(公告)号：PL2692346T3

公开(公告)日：2016-05-31

申请号：PL13191041

申请日：2011-10-12

Applicant: ABBVIE BAHAMAS LTD

Inventor： DEGOEY DAVID A ,  KATI WARREN M ,  HUTCHINS CHARLES W ,  DONNER PAMELA L ,  KRUEGER ALLAN C ,  RANDOLPH JOHN T ,  MOTTER CHRISTOPHER E ,  NELSON LISSA T ,  PATEL SACHEL V ,  MATULENKO MARK A ,  KEDDY RYAN G ,  JINKERSON TAMMIE K ,  GAO YI ,  LIU DACHUN ,  PRATT JOHN K ,  ROCKWAY TODD W ,  MARING CLARENCE J ,  HUTCHINSON DOUGLAS K ,  FLENTGE CHARLES A ,  WAGNER ROLF ,  TUFANO MICHAEL D ,  BETEBENNER DAVID A ,  SARRIS KATHY ,  WOLLER KEVIN R ,  WAGAW SEBEL H ,  CALIFANO JEAN C ,  LI WENKE ,  CASPI DANIEL D ,  BELLIZZI MARY E ,  CARROLL WILLIAM A

IPC: A61K31/454 ,  A61P31/14

公开(公告)号：RS53856B1

公开(公告)日：2015-08-31

申请号：RSP20150123

申请日：2010-06-10

Applicant: ABBVIE BAHAMAS LTD

Inventor： RANDOLPH JOHN T ,  MATULENKO MARK A ,  KEDDY RYAN G ,  JINKERSON TAMMIE K ,  HUTCHINSON DOUGLAS K ,  FLENTGE CHARLES A ,  WAGNER ROLF ,  MARING CLARENCE J ,  TUFANO MICHAEL D ,  BETEBENNER DAVID A ,  ROCKWAY TODD W ,  DEGOEY DAVID A ,  LIU DACHUN ,  PRATT JOHN K ,  SARRIS KATHY ,  WOLLER KEVIN R ,  WAGAW SEBLE H ,  CALIFANO JEAN C ,  LI WENKE ,  CASPI DANIEL D ,  BELLIZZI MARY E ,  GAO YI ,  KATI WARREN M ,  HUTCHINS CHARLES W ,  DONNER PAMELA L ,  KRUEGER ALLAN C ,  MOTTER CHRISTOPHER E ,  NELSON LISSA T ,  PATEL SACHIN V

IPC: C07D403/14 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/4439 ,  A61P31/14 ,  C07D401/14 ,  C07D417/14

Abstract: Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

公开(公告)号：NZ618277A

公开(公告)日：2015-07-31

申请号：NZ61827708

申请日：2008-09-17

Applicant: ABBVIE BAHAMAS LTD

Inventor： HUTCHINSON DOUGLAS K ,  BARNES DAVID M ,  WAGNER ROLF ,  TUFANO MICHAEL D ,  PRATT JOHN K ,  MOTTER CHRISTOPHER E ,  LONGENECKER KENTON L ,  HUANG PEGGY P ,  BETEBENNER DAVID A ,  GAO YI ,  FRANCZYK II THADDEUS S ,  ROCKWAY TODD W ,  HENRY RODGER F ,  KOTECKI BRIAN J ,  LOU XIAOCHUN ,  RANDOLPH JOHN T ,  FLENTGE CHARLES A ,  STEWART KENT D ,  MARING CLARENCE J ,  LIU YAYA ,  LIU DACHUN ,  KRUEGER ALLAN C ,  KATI WARREN M ,  DEGOEY DAVID A ,  DONNER PAMELA L ,  HAIGHT ANTHONY R ,  SARRIS KATHY ,  ZHANG GEOFF G Z ,  HENGEVELD JOHN E ,  CHEN SHUANG

IPC: C07D417/10 ,  A61K31/513 ,  A61P31/12 ,  C07D239/22 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D409/10 ,  C07D413/10

Abstract: Disclosed are Uracil or Thymine derivatives of formula (I) useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N-(4(3-t- butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1-(2H)-yl)2-methoxy-styryl-phenyl)methanesulfonamide. Also disclosed are crystalline forms of the compounds and processes for preparing the compounds and the crystal forms.

公开(公告)号：PL2368882T3

公开(公告)日：2015-04-30

申请号：PL11171399

申请日：2008-09-17

Applicant: ABBVIE BAHAMAS LTD

Inventor： FLENTGE CHARLES A ,  HUTCHINSON DOUGLAS K ,  BETEBENNER DAVID A ,  DEGOEY DAVID A ,  DONNER PAMELA L ,  KATI WARREN M ,  KRUEGER ALLAN C ,  LIU DACHUN ,  LIU YAYA ,  LONGENECKER KENTON L ,  MARING CLARENCE J ,  MOTTER CHRISTOPHER E ,  PRATT JOHN K ,  RANDOLPH JOHN T ,  ROCKWAY TODD W ,  STEWART KENT D ,  WAGNER ROLF ,  BARNES DAVID M ,  CHEN SHUANG ,  FRANCZYK II THADDEUS S ,  GAO YI ,  HAIGHT ANTHONY R ,  HENGEVELD JOHN E ,  KOTECKI BRIAN J ,  LOU XIAOCHUN ,  ZHANG GEOFF G Z

IPC: C07D239/22 ,  A61K31/513 ,  A61P31/12 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10

公开(公告)号：HRP20150017T1

公开(公告)日：2015-04-24

申请号：HRP20150017

申请日：2015-01-08

Applicant: ABBVIE BAHAMAS LTD

Inventor： RANDOLPH JOHN T ,  MATULENKO MARK A ,  KEDDY RYAN G ,  JINKERSON TAMMIE K ,  HUTCHINSON DOUGLAS K ,  FLENTGE CHARLES A ,  WAGNER ROLF ,  MARING CLARENCE J ,  TUFANO MICHAEL D ,  BETEBENNER DAVID A ,  ROCKWAY TODD W ,  DEGOEY DAVID A ,  LIU DACHUN ,  PRATT JOHN K ,  SARRIS KATHY ,  WOLLER KEVIN R ,  WAGAW SEBLE H ,  CALIFANO JEAN C ,  LI WENKE ,  CASPI DANIEL D ,  BELLIZZI MARY E ,  GAO YI ,  KATI WARREN M ,  HUTCHINS CHARLES W ,  DONNER PAMELA L ,  KRUEGER ALLAN C ,  MOTTER CHRISTOPHER E ,  NELSON LISSA T ,  PATEL SACHIN V

IPC: C07D403/14 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/4439 ,  A61P31/14 ,  C07D401/14 ,  C07D417/14

公开(公告)号：HRP20141102T1

公开(公告)日：2015-03-13

申请号：HRP20141102

申请日：2014-11-12

Applicant: ABBVIE BAHAMAS LTD

Inventor： FLENTGE CHARLES A ,  HUTCHINSON DOUGLAS K ,  BETEBENNER DAVID A ,  DEGOEY DAVID A ,  DONNER PAMELA L ,  KATI WARREN M ,  KRUEGER ALLAN C ,  LIU DACHUN ,  LIU YAYA ,  LONGENECKER KENTON L ,  MARING CLARENCE J ,  MOTTER CHRISTOPHER E ,  PRATT JOHN K ,  RANDOLPH JOHN T ,  ROCKWAY TODD W ,  STEWART KENT D ,  WAGNER ROLF ,  BARNES DAVID M ,  CHEN SHUANG ,  FRANCZYK II THADDEUS S ,  GAO YI ,  HAIGHT ANTHONY R ,  HENGEVELD JOHN E ,  KOTECKI BRIAN J ,  LOU XIAOCHUN ,  ZHANG GEOFF GZ

IPC: C07D239/22 ,  A61K31/513 ,  A61P31/12 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10

公开(公告)号：PT2368882E

公开(公告)日：2014-11-27

申请号：PT11171399

申请日：2008-09-17

Applicant: ABBVIE BAHAMAS LTD

Inventor： LIU DACHUN ,  LIU YAYA ,  WAGNER ROLF ,  CHEN SHUANG ,  LOU XIAOCHUN ,  FLENTGE CHARLES A ,  HUTCHINSON DOUGLAS K ,  BETEBENNER DAVID A ,  DEGOEY DAVID A ,  DONNER PAMELA L ,  KATI WARREN M ,  KRUEGER ALLAN C ,  LONGENECKER KENTON L ,  MARING CLARENCE J ,  MOTTER CHRISTOPHER E ,  PRATT JOHN K ,  RANDOLPH JOHN T ,  ROCKWAY TODD W ,  STEWART KENT D ,  BARNES DAVID M ,  FRANCZYK THADDEUS S II ,  GAO YI ,  HAIGHT ANTHONY R ,  HENGEVELD JOHN E ,  KOTECKI BRIAN J ,  ZHANG GEOFF G Z

IPC: C07D239/22 ,  A61K31/513 ,  A61P31/12 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10

公开(公告)号：AU2008302448B2

公开(公告)日：2014-11-06

申请号：AU2008302448

申请日：2008-09-17

Applicant: ABBVIE BAHAMAS LTD

Inventor： HENRY RODGER F ,  DONNER PAMELA L ,  LOU XIAOCHUN ,  KOTECKI BRIAN J ,  BARNES DAVID M ,  MARING CLARENCE J ,  BETEBENNER DAVID A ,  LONGENECKER KENTON L ,  FLENTGE CHARLES A ,  LIU DACHUN ,  PRATT JOHN K ,  ZHANG GEOFF G Z ,  WAGNER ROLF ,  HENGEVELD JOHN E ,  FRANCZYK II THADDEUS S ,  TUFANO MICHAEL D ,  HUTCHINSON DOUGLAS K ,  ROCKWAY TODD W ,  KATI WARREN M ,  GAO YI ,  RANDOLPH JOHN T ,  KRUEGER ALLAN C ,  HUANG PEGGY P ,  CHEN SHUANG ,  HAIGHT ANTHONY R ,  LIU YAYA ,  STEWART KENT D ,  DEGOEY DAVID A ,  SARRIS KATHY ,  MOTTER CHRISTOPHER E

IPC: C07D239/22 ,  A61K31/513 ,  A61P31/12 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10

Abstract: Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4-dioxo-3,4-dihydropyrimidin-1 (2H)- y!)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N-(4(3-t- butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1 (2H)-yl)2-methoxy-styryl- phenyl)methanesulfonamide.