公开(公告)号：WO1994001206A1

公开(公告)日：1994-01-20

申请号：PCT/US1993006343

申请日：1993-07-02

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  KRAUSS, Alan, R. ,  GRUEN, Dieter, M. ,  LAMICH, George, J.

IPC: B01D59/44

CPC classification number: H01J49/40

Abstract: A time-of-flight direct recoil ion scattering spectrometer (10) is comprised of a device (12) for producing a beam of ions and a device (14, 16) for pulsing said beam of ions. The device (12) and the pulsed device (14, 16) is operative to dynamically adjust the interval between successive beam pulses in accordance with the combination of ion beam mass and energy to maximize repetition rate consistent with resolved data separation. An ion beam emitted from a sample (24) is detected after the sample is bombarded by a pulsed beam of ions from the spectrometer (10), and the incoming ion beam path and outgoing beam path of said spectrometer (10) undergo differential pumping.

Abstract translation: 飞行时间直接反冲离子散射光谱仪（10）由用于产生离子束的装置（12）和用于脉冲所述离子束的装置（14,16）组成。 装置（12）和脉冲装置（14,16）可操作以根据离子束质量和能量的组合来动态地调整连续射束脉冲之间的间隔，以使与分辨数据分离一致的重复频率最大化。 在样品被来自光谱仪（10）的脉冲离子束轰击之后，检测从样品（24）发射的离子束，并且所述光谱仪（10）的入射离子束路径和出射光束路径经历差分泵浦。

公开(公告)号：WO1993021343A1

公开(公告)日：1993-10-28

申请号：PCT/US1993003560

申请日：1993-04-14

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  BELL, Graeme, I. ,  STOFFEL, Markus ,  TAKEDA, Jun ,  VIONNET, Nathalie ,  YASUDA, Kazuki ,  PILLEIS, Simon, J. ,  ZOUALI, Habib ,  VELHO, Gilberto ,  COHEN, Daniel ,  FROGUEL, Philippe

IPC: C12Q01/68

CPC classification number: C12N9/12 ,  C12Q1/6883 ,  C12Q2600/156

Abstract: The invention relates to the observed tight linkage between DNA polymorphisms in the glucokinase gene (GCK) on the short arm of chromosome 7, and NIDDM in a cohort of sixteen French families having MODY. It further relates to identification of mutations in GCK and their linkage with diabetes in particular families are disclosed. This invention provides the first evidence implicating specific mutations in a gene involved in glucose metabolism in the pathogenesis of NIDDM. The invention further discloses the isolation and characterization of human pancreatic beta -cell GCK and a method for searching for mutations that cause early-onset NIDDM. To assess the effect of these mutations on glucokinase activity, a method is disclosed for generating an alpha -carbon backbone model for human glucokinase based on the crystal structure of the structurally-related yeast hexokinase B. Thus, in its most general sense, the invention relates to a method for detecting a propensity to develop early-onset, non-insulin-dependent diabetes mellitus.

Abstract translation: 本发明涉及在染色体7的短臂上的葡萄糖激酶基因（GCK）中的DNA多态性与具有MODY的16个法国家族的NIDDM中观察到的紧密连锁。 其进一步涉及GCK突变的鉴定及其与特定家族中糖尿病的联系。 本发明提供了涉及NIDDM发病机理中参与葡萄糖代谢的基因中的特定突变的第一个证据。 本发明进一步公开了人胰腺β细胞GCK的分离和表征，以及用于搜索引起早发型NIDDM的突变的方法。 为了评估这些突变对葡糖激酶活性的影响，公开了一种基于结构相关的酵母己糖激酶B的晶体结构产生人类葡萄糖激酶的α-碳骨架模型的方法。因此，在其最普遍的意义上，本发明 涉及用于检测发展早发型非胰岛素依赖性糖尿病倾向的方法。

公开(公告)号：WO1993017689A1

公开(公告)日：1993-09-16

申请号：PCT/US1993002356

申请日：1993-03-09

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  GRDINA, David, J.

IPC: A61K31/66

CPC classification number: C07C323/25 ,  A61K31/13 ,  A61K31/185 ,  A61K31/425 ,  A61K31/66 ,  C07F9/1651 ,  C07H5/10 ,  C07H9/06

Abstract: A method and pharmaceutical for protecting against genotoxic damage in irradiated cells. Reduction of mutations at the hypoxanthine-guanine phosphoribosyl transferase locus is accomplished by administering an effective dose of a compound having protected sulfhydryl groups which metabolize in vivo to produce both free sulfhydryl groups and disulfides.

Abstract translation: 用于在辐射细胞中防止遗传毒性损伤的方法和药物。 次黄嘌呤 - 鸟嘌呤磷酸核糖基转移酶基因座上的突变的减少是通过施用有效剂量的具有被保护的巯基的化合物来实现的，所述化合物在体内代谢以产生游离的巯基和二硫键。

公开(公告)号：WO1993008633A1

公开(公告)日：1993-04-29

申请号：PCT/US1992008861

申请日：1992-10-16

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  SMITHER, Robert, K.

IPC: H02K44/02

CPC classification number: H02K44/04

Abstract: An electromagnetic induction pump in which an electrically conductive liquid is made to flow by means of a force created by interaction of a permanent magnetic field and a DC current. The pump achieves high efficiency through combination of: powerful permanent magnet materials (32, 33) which provide a high strength field that is uniform and constant; steel tubing (11) formed into a coil which is constructed to carry conducting liquids with minimal electrical resistance and heat; and application of a voltage applied across buss bars (16, 17) to induce a DC current which continuously produces a force in the direction of the desired flow.

公开(公告)号：WO1992011033A1

公开(公告)日：1992-07-09

申请号：PCT/US1991009651

申请日：1991-12-19

Applicant: ARCH DEVELOPMENT CORPORATION ,  DANA-FARBER CANCER INSTITUTE

Inventor： ARCH DEVELOPMENT CORPORATION ,  DANA-FARBER CANCER INSTITUTE ,  WEICHSELBAUM, Ralph, R. ,  HALLAHAN, Dennis, E. ,  SUKHATME, Vikas, P. ,  KUFE, Donald, W.

IPC: A61K43/00

CPC classification number: A61K41/0023 ,  C07K14/52 ,  C07K14/525 ,  C12N15/63 ,  C12N15/67 ,  C12N15/85

Abstract: This invention relates to genetic constructs which comprise an enhancer-promoter region which is responsive to radiation, and at least one structural gene whose expression is controlled by the enhancer-promoter. This invention also relates to methods of destroying, altering, or inactivating cells in target tissue by delivering the genetic constructs to the cells of the tissues and inducing expression of the structural gene or genes in the construct by exposing the tissues to ionizing radiation. This invention is useful for treating patients with cancer, clotting disorders, myocardial infarction, and other diseases for which target tissues can be identified and for which gene expression of the construct within the target tissues can alleviate the disease or disorder.

Abstract translation: 本发明涉及包含对辐射有响应的增强子 - 启动子区的遗传构建体和至少一个其表达受增强子启动子控制的结构基因。 本发明还涉及通过将遗传构建体递送至组织的细胞并通过将组织暴露于电离辐射来诱导构建体中的结构基因或基因表达来破坏，改变或灭活靶组织中的细胞的方法。 本发明可用于治疗癌症患者，凝血障碍，心肌梗塞以及可识别靶组织的其它疾病，靶组织中构建体的基因表达可以缓解疾病或病症。

公开(公告)号：WO1992010861A1

公开(公告)日：1992-06-25

申请号：PCT/US1991009365

申请日：1991-12-13

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  KAUN, Thomas, D.

IPC: H01M06/46

CPC classification number: H01M6/48 ,  H01M2/08 ,  H01M4/661 ,  H01M4/664 ,  H01M10/39

Abstract: A bipolar battery (10) having a plurality of cells (14) is disclosed. The bipolar battery (10) includes: a negative electrode (28); a positive electrode (25); and a separator element (40) disposed between the negative electrode (28) and the positive electrode (25) which insulates the electrodes from one another; an electrolyte disposed within at least one of the negative electrodes (28), the positive electrode (25) and the separator element (40) and an electrode containment structure including a cup-like electrode holder (38).

公开(公告)号：WO1992005124A1

公开(公告)日：1992-04-02

申请号：PCT/US1991006653

申请日：1991-09-13

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  KAUN, Thomas, D.

IPC: C04B33/34

CPC classification number: H01M2/1646 ,  C04B35/547 ,  C04B35/653 ,  C04B37/005 ,  C04B37/025 ,  C04B2235/6567 ,  C04B2237/08 ,  C04B2237/09 ,  C04B2237/343 ,  C04B2237/36 ,  C04B2237/403 ,  C04B2237/406 ,  H01M2/08 ,  H01M2/1613 ,  H01M4/664 ,  H01M6/185 ,  H01M10/39 ,  H01M10/3918 ,  H01M10/399

Abstract: Method of manufacture of ceramic materials which require stability in severely-corrosive environments having high alkali-metal activity, high sulfur/sulfide activity and/or molten halides at temperatures of 200-550 °C or organic salt (including SO2 and SO2Cl2) at temperatures of 25-200 °C. These sulfide ceramics form stoichiometric (single-phase) compounds with sulfides of Ca, Li, Na, K, Al, Mg, Si, Y, La, Ce, Ga, Ba, Zr and Sr and show melting-points that are sufficiently low and have excellent wettability with many metals (Fe, Ni, Mo) to easily form metal/ceramic seals. Ceramic compositions are also formulated to adequately match thermal expansion coefficient of adjacent metal components.

公开(公告)号：WO1991007423A1

公开(公告)日：1991-05-30

申请号：PCT/US1990006015

申请日：1990-10-19

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  LIAO, Shutsung ,  CHANG, Chawnshang

IPC: C07H21/00

CPC classification number: C07K16/18 ,  C07K14/47 ,  C07K14/721

Abstract: Disclosed are DNA sequences encoding DNA binding polypeptides including androgen receptor (AR) and TR2 polypeptides. Illustratively, human and rat AR-cDNA have 79 kD and 98 kD polypeptide expression products which are immunoprecipitable by human auto-immune anti-androgens receptor antibodies and are capable of binding androgens specifically and with high affinity. Also disclosed are antibodies and immunological methods and materials for detection of androgen receptor and TR2 polypeptides and hybridization methods and materials for detection of AR-and TR2-related nucleic acids.

Abstract translation: 公开了编码包括雄激素受体（AR）和TR2多肽的DNA结合多肽的DNA序列。 说明性地，人和大鼠AR-cDNA具有79kD和98kD多肽表达产物，其可被人自身免疫抗雄激素受体抗体免疫沉淀，并且能够以高亲和力特异性结合雄激素。 还公开了用于检测雄激素受体和TR2多肽的抗体和免疫学方法和材料以及用于检测AR和TR2相关核酸的杂交方法和材料。

公开(公告)号：WO1990013777A1

公开(公告)日：1990-11-15

申请号：PCT/US1990002427

申请日：1990-05-01

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  WINSTON, Roland ,  NING, Xiaohui

IPC: F24J02/18

CPC classification number: G02B19/0033 ,  F24S23/00 ,  F24S23/30 ,  F24S23/70 ,  F24S2023/837 ,  G02B19/0028 ,  G02B19/0042 ,  Y02E10/44

Abstract: A nonimaging radiant energy device may include a hyperbolically shaped reflective element with a radiant energy inlet and a radiant energy outlet. A convex lens is provided at the radiant energy inlet and a concave lens is provided at the radiant energy outlet. Due to the provision of the lenses and the shape of the walls of the reflective element, the radiant energy incident at the radiant energy inlet within a predetermined angle of acceptance is emitted from the radiant energy outlet exclusively within an acute exit angle. In another embodiment, the radiant energy device may include two interconnected hyperbolically shaped reflective elements with a respective convex lens being provided at each aperture of the device.

公开(公告)号：WO1990001545A1

公开(公告)日：1990-02-22

申请号：PCT/US1989003344

申请日：1989-08-02

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  COLLART, Frank, R. ,  HUBERMAN, Eliezer

IPC: C12N15/00

CPC classification number: C12N9/0006 ,  A61K48/00 ,  C07K16/40 ,  C12P19/32 ,  C12Y101/01205

Abstract: Disclosed are purified and isolated DNA sequences encoding eukaryotic proteins possessing biological properties of inosine 5'-monophosphate dehydrogenase (''IMPDH''). Illustratively, mammalian (e.g. human) IMPDH-encoding DNA sequences are useful in transformation or transfection of host cells for the large scale recombinant production of the enzymatically active expression products and/or products (e.g. GMP) resulting from IMPDH catalyzed synthesis in cells. Vectors including IMPDH-encoding DNA sequences are useful in gene amplification procedures. Recombinant proteins and synthetic peptides provided by the invention are useful as immunological reagents and in the preparation of antibodies (including polyclonal and monoclonal antibodies) for quantitive detection of IMPDH.

Abstract translation: 公开了编码具有肌苷5'-单磷酸脱氢酶（“IMPDH”）的生物学性质的真核蛋白质的纯化和分离的DNA序列。 说明性地，哺乳动物（例如人）IMPDH编码DNA序列可用于转化或转染宿主细胞，用于大规模重组产生由细胞中IMPDH催化合成产生的酶活性表达产物和/或产物（例如GMP）。 包含IMPDH编码DNA序列的载体可用于基因扩增过程。 本发明提供的重组蛋白质和合成肽可用作免疫学试剂和用于定量检测IMPDH的抗体（包括多克隆和单克隆抗体）的制备。