公开(公告)号：NO312154B1

公开(公告)日：2002-04-02

申请号：NO970164

申请日：1997-01-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  RENDENBACH-MUELLER BEATRICE ,  BACH ALFRED ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN

IPC: C07D277/22 ,  A61K31/425 ,  A61K31/426 ,  A61K31/433 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/454 ,  A61K31/496 ,  A61K31/54 ,  C07D277/20 ,  C07D277/32 ,  C07D277/36 ,  C07D277/42 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D417/12 ,  A61P25/00

Abstract: PCT No. PCT/EP95/02783 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02249 PCT Pub. Date Feb. 1, 1996The present invention relates to the use of thiazole and thiadiazole compounds of the following formula: where R1, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders of the central nervous system.

公开(公告)号：NO312030B1

公开(公告)日：2002-03-04

申请号：NO970162

申请日：1997-01-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  MUNSCHAUER RAINER ,  BIALOJAN SIEGFRIED ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN ,  DRESCHER KARLA

IPC: C07D239/26 ,  A61K31/505 ,  A61K31/506 ,  A61P25/16 ,  A61P25/24 ,  A61P25/26 ,  C07D239/38 ,  C07D239/46 ,  C07D239/56 ,  C07D239/60 ,  C07D401/00 ,  C07D401/12 ,  C07D239/28 ,  C07D403/12 ,  C07D403/14

Abstract: The present invention relates to the use of pyrimidine compounds of the following formula:wherein R1, R2, R3, A, B and Ar have the meanings indicated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.

公开(公告)号：NO311683B1

公开(公告)日：2002-01-07

申请号：NO970163

申请日：1997-01-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  RENDENBACH-MUELLER BEATRICE ,  BACH ALFRED ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN

IPC: A61K31/33 ,  A61K31/415 ,  C07D233/84 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/445 ,  A61K31/495 ,  A61K31/496 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D213/56 ,  C07D213/64 ,  C07D213/65 ,  C07D213/70 ,  C07D213/73 ,  C07D213/79 ,  C07D213/81 ,  C07D233/90 ,  C07D307/79 ,  C07D333/24 ,  C07D333/28 ,  C07D333/38 ,  C07D471/18

Abstract: PCT No. PCT/EP95/02782 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02246 PCT Pub. Date Feb. 1, 1996The present invention relate to the use of heterocyclic compounds of the following formula:Het-A-B-Arwhere Het, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.

公开(公告)号：BG63257B1

公开(公告)日：2001-07-31

申请号：BG10111097

申请日：1997-01-06

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  MUNSCHAUER RAINER ,  BIALOJAN SIEGFRIED ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN ,  DRESCHER KARLA

IPC: C07D239/26 ,  A61K31/505 ,  A61K31/506 ,  A61P25/16 ,  A61P25/24 ,  A61P25/26 ,  C07D239/38 ,  C07D239/46 ,  C07D239/56 ,  C07D239/60 ,  C07D401/00 ,  C07D401/12

Abstract: The invention relates to pyrimidine compounds with the formula wherein the meanings of the substituents are shown in the description. The compounds have affinity to the dopamine D3-receptors and can be applied for the treatment of diseases which react to dopamine D3-receptor antagonists, or agonists, respectively. 20 claims

公开(公告)号：DK0772604T3

公开(公告)日：1999-11-01

申请号：DK95926895

申请日：1995-07-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  MUNSCHAUER RAINER ,  BIALOJAN SIEGFRIED ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN ,  DRESCHER KARLA

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/435 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/505 ,  A61K31/53 ,  A61P1/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D249/12 ,  C07D249/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14

Abstract: PCT No. PCT/EP95/02781 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02520 PCT Pub. Date Feb. 1, 1996The present invention relates to triazole compounds of the following formula: where R1, R2, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.

公开(公告)号：DE59505853D1

公开(公告)日：1999-06-10

申请号：DE59505853

申请日：1995-07-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  MUNSCHAUER RAINER ,  BIALOJAN SIEGFRIED ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN ,  DRESCHER KARLA

IPC: C07D249/08 ,  A61K31/41 ,  A61K31/435 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/505 ,  A61K31/53 ,  A61P1/08 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D249/12 ,  C07D249/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14

Abstract: PCT No. PCT/EP95/02781 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02520 PCT Pub. Date Feb. 1, 1996The present invention relates to triazole compounds of the following formula: where R1, R2, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.

公开(公告)号：MX9700430A

公开(公告)日：1998-05-31

申请号：MX9700430

申请日：1995-07-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  RENDENBACH-MULLER BEATRICE ,  BACH ALFRED ,  UNGER LILIANE ,  TESCHENDORF HANS-JURGEN ,  WICKE CARSTEN

IPC: A61K31/33 ,  A61K31/415 ,  A61K31/44 ,  C07D233/84 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/445 ,  A61K31/495 ,  A61K31/496 ,  A61P25/18 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D213/56 ,  C07D213/64 ,  C07D213/65 ,  C07D213/70 ,  C07D213/73 ,  C07D213/79 ,  C07D213/81 ,  C07D233/90 ,  C07D307/79 ,  C07D333/24 ,  C07D333/28 ,  C07D333/38 ,  C07D471/18

Abstract: La presente invencion se refiere al uso de compuestos heterocíclicos de la formula general: Het-A-B-Ar donde Het, A, B y Ar tienen los significados establecidos en la descripcion. Los compuestos de conformidad con la presente invencion tiene una alta afinidad para el receptor D3 de la dopamina y pueden por consiguiente emplearse para tratar trastornos que responden a ligandos de D3 de dopamina.

公开(公告)号：BR9508295A

公开(公告)日：1998-01-13

申请号：BR9508295

申请日：1995-07-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  RENDENDACH-MULLER BEATRICE ,  BACH ALFRED ,  UNGER LILIANE ,  TESCHENDORF HANS-JURGEN ,  WICKE KARSTEN

IPC: C07D277/22 ,  A61K31/425 ,  A61K31/426 ,  A61K31/433 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/454 ,  A61K31/496 ,  A61K31/54 ,  C07D277/20 ,  C07D277/32 ,  C07D277/36 ,  C07D277/42 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D417/12

Abstract: PCT No. PCT/EP95/02783 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02249 PCT Pub. Date Feb. 1, 1996The present invention relates to the use of thiazole and thiadiazole compounds of the following formula: where R1, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders of the central nervous system.

公开(公告)号：SI9520081A

公开(公告)日：1997-08-31

申请号：SI9520081

申请日：1995-07-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  RENDENBACH-MUELLER BEATRICE ,  BACH ALFRED ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE CARSTEN

IPC: C07D277/22 ,  A61K31/425 ,  A61K31/426 ,  A61K31/433 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/454 ,  A61K31/496 ,  A61K31/54 ,  C07D277/20 ,  C07D277/32 ,  C07D277/36 ,  C07D277/42 ,  C07D285/12 ,  C07D285/125 ,  C07D285/135 ,  C07D417/12

Abstract: PCT No. PCT/EP95/02783 Sec. 371 Date Jan. 14, 1997 Sec. 102(e) Date Jan. 14, 1997 PCT Filed Jul. 14, 1995 PCT Pub. No. WO96/02249 PCT Pub. Date Feb. 1, 1996The present invention relates to the use of thiazole and thiadiazole compounds of the following formula: where R1, A, B and Ar have the meanings stated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders of the central nervous system.

公开(公告)号：CZ12397A3

公开(公告)日：1997-08-13

申请号：CZ12397

申请日：1995-07-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  MUNSCHAUER RAINER ,  BIALOJAN SIEGRIED ,  TESCHENDORF HANS-JURGEN ,  WICKE KARSTEN ,  DRESCHER KARLA

IPC: C07D239/26 ,  A61K31/505 ,  A61K31/506 ,  A61P25/16 ,  A61P25/24 ,  A61P25/26 ,  C07D239/38 ,  C07D239/46 ,  C07D239/56 ,  C07D239/60 ,  C07D401/00 ,  C07D401/12

Abstract: The present invention relates to the use of pyrimidine compounds of the following formula:wherein R1, R2, R3, A, B and Ar have the meanings indicated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.