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    Ultra-sensitive detection of molecules on single molecule arrays
    71.
    发明授权
    Ultra-sensitive detection of molecules on single molecule arrays 有权
    单分子阵列上分子的超灵敏检测

    公开(公告)号：US08846415B2

    公开(公告)日：2014-09-30

    申请号：US13527210

    申请日：2012-06-19

    Applicant: David C. Duffy ,  Evan Ferrell ,  Jeffrey D. Randall ,  David M. Rissin ,  David R. Walt

    Inventor： David C. Duffy ,  Evan Ferrell ,  Jeffrey D. Randall ,  David M. Rissin ,  David R. Walt

    IPC: G01N33/543

    CPC classification number: G01N33/54313 ,  C12Q1/6825 ,  G01N33/54326 ,  G01N33/54386

    Abstract: The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles to form a plurality of complexes, releasing at least a portion of some of the plurality of complexes, determining at least a portion of the plurality of complexes released, and determining a measure of the concentration of the analyte molecules or particles in a fluid sample.

    Abstract translation: 本发明涉及用于检测流体样品中的分析物分子或颗粒的系统和方法，并且在某些情况下，确定流体样品中分子或颗粒的浓度的量度。 本发明的方法可以包括固定多个分析物分子或颗粒以形成多个复合物，释放所述多个复合物中的至少一部分，确定所述多个复合物的至少一部分被释放，并且确定 测量流体样品中分析物分子或颗粒的浓度。

    ULTRA-SENSITIVE DETECTION OF MOLECULES ON SINGLE MOLECULE ARRAYS
    72.
    发明申请
    ULTRA-SENSITIVE DETECTION OF MOLECULES ON SINGLE MOLECULE ARRAYS 有权
    对单分子阵列分子的超敏感检测

    公开(公告)号：US20140243223A1

    公开(公告)日：2014-08-28

    申请号：US13527210

    申请日：2012-06-19

    Applicant: David C. Duffy ,  Evan Ferrell ,  Jeffrey D. Randall ,  David M. Rissin ,  David R. Walt

    Inventor： David C. Duffy ,  Evan Ferrell ,  Jeffrey D. Randall ,  David M. Rissin ,  David R. Walt

    IPC: G01N33/543 ,  C12Q1/68

    CPC classification number: G01N33/54313 ,  C12Q1/6825 ,  G01N33/54326 ,  G01N33/54386

    Abstract: The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles to form a plurality of complexes, releasing at least a portion of some of the plurality of complexes, determining at least a portion of the plurality of complexes released, and determining a measure of the concentration of the analyte molecules or particles in a fluid sample.

    Abstract translation: 本发明涉及用于检测流体样品中的分析物分子或颗粒的系统和方法，并且在某些情况下，确定流体样品中分子或颗粒的浓度的量度。 本发明的方法可以包括固定多个分析物分子或颗粒以形成多个复合物，释放所述多个复合物中的至少一部分，确定所述多个复合物的至少一部分被释放，并且确定 测量流体样品中分析物分子或颗粒的浓度。

    Controlled alteration of pores using fluid flow and fabrication of articles thereby
    73.
    发明授权
    Controlled alteration of pores using fluid flow and fabrication of articles thereby 有权
    使用流体流动控制孔隙的改变，从而制造制品

    公开(公告)号：US08663973B2

    公开(公告)日：2014-03-04

    申请号：US11658515

    申请日：2005-07-26

    Applicant: David J. Monk ,  David R. Walt

    Inventor： David J. Monk ,  David R. Walt

    IPC: B05D1/36 ,  B05D5/12 ,  B05D7/22

    CPC classification number: G01N33/5438 ,  B01J2219/00439 ,  B01J2219/0045 ,  B01J2219/00524 ,  B01J2219/00653 ,  Y10T428/13

    Abstract: The invention relates to microscopic structures and methods of making and using the structures. A method of forming a microscopic structure of a material includes obtaining a solution (310) containing the material, establishing a flowing stream of the solution (310) in a capillary (104), wherein the capillary (104) has an inner dimension that is smaller than about 300 micrometers, and maintaining the stream until a layer is built up along an inner wall of the capillary (104) from material deposited from the flowing stream, thereby forming a microscopic structure.

    Abstract translation: 本发明涉及微观结构及其制造和使用方法。 形成材料的微观结构的方法包括获得含有该材料的溶液（310），在毛细管（104）中形成溶液（310）的流动流，其中毛细管（104）的内部尺寸为 小于约300微米，并且保持流，直到沿着毛细管（104）的内壁从流动物料沉积的材料构建层，从而形成微观结构。

    ULTRA-SENSITIVE DETECTION OF MOLECULES OR PARTICLES USING BEADS OR OTHER CAPTURE OBJECTS
    76.
    发明申请
    ULTRA-SENSITIVE DETECTION OF MOLECULES OR PARTICLES USING BEADS OR OTHER CAPTURE OBJECTS 有权
    使用珠子或其他捕获物体对分子或颗粒进行超敏感检测

    公开(公告)号：US20120277114A1

    公开(公告)日：2012-11-01

    申请号：US13531061

    申请日：2012-06-22

    Applicant: David C. Duffy ,  David M. Rissin ,  David R. Walt ,  David Fournier ,  Cheuk Kan

    Inventor： David C. Duffy ,  David M. Rissin ,  David R. Walt ,  David Fournier ,  Cheuk Kan

    IPC: C40B30/04

    CPC classification number: G01N33/54393 ,  G01N33/54306 ,  G01N33/54313

    Abstract: The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components.

    Abstract translation: 本发明涉及用于检测流体样品中的分析物分子或颗粒的系统和方法，并且在某些情况下，确定流体样品中分子或颗粒的浓度的量度。 本发明的方法可以包括相对于多个捕获物体固定多个分析物分子或颗粒。 多个捕获对象的至少一部分可以在空间上分离成多个位置。 可以至少部分地确定包含相对于捕获对象固定的分析物分子的反应容器的数量，来测量流体样品中分析物分子的浓度。 在一些情况下，该测定可另外包括包括结合配体，前体标记试剂和/或酶组分的步骤。

    ULTRA-SENSITIVE DETECTION OF MOLECULES USING DUAL DETECTION METHODS
    79.
    发明申请
    ULTRA-SENSITIVE DETECTION OF MOLECULES USING DUAL DETECTION METHODS 有权
    使用双重检测方法进行超声检测分子

    公开(公告)号：US20110212462A1

    公开(公告)日：2011-09-01

    申请号：US12731135

    申请日：2010-03-24

    Applicant: David C. Duffy ,  David M. Rissin ,  David R. Walt ,  Linan Song ,  Lei Chang

    Inventor： David C. Duffy ,  David M. Rissin ,  David R. Walt ,  Linan Song ,  Lei Chang

    IPC: G01N33/53

    CPC classification number: G01N33/54393 ,  G01N33/5306

    Abstract: Described herein are systems and methods for the detection of and/or determination of a measure of the concentration of analyte molecules or particles in a fluid sample. In some cases, the systems and methods employ techniques to reduce or limit the negative effects associated with non-specific binding events. Certain methods of the present invention involve associating the analyte molecules at least a first type of binding ligand and at least a second type of binding ligand, and spatially segregating the analyte molecules into a plurality of locations on a surface. The presence of an analyte molecule at or in a location may be determined by determining the presence of both the first type of binding ligand and the second type of binding ligand.

    Abstract translation: 本文描述了用于检测和/或确定流体样品中分析物分子或颗粒的浓度的测量的系统和方法。 在某些情况下，系统和方法采用技术来减少或限制与非特异性结合事件相关的负面影响。 本发明的某些方法包括将分析物分子与至少第一类型的结合配体和至少第二类型的结合配体相关联，并将分析物分子空间分离成表面上的多个位置。 可以通过确定第一类型的结合配体和第二类型的结合配体的存在来确定在位置处或位置处的分析物分子的存在。

    RELATIVELY SMALL DEVICES APPLIED TO THE SKIN, MODULAR SYSTEMS, AND METHODS OF USE THEREOF
    80.
    发明申请
    RELATIVELY SMALL DEVICES APPLIED TO THE SKIN, MODULAR SYSTEMS, AND METHODS OF USE THEREOF 审中-公开
    适用于皮肤的相对小的装置，模块化系统及其使用方法

    公开(公告)号：US20110105952A1

    公开(公告)日：2011-05-05

    申请号：US12915820

    申请日：2010-10-29

    Applicant: Howard Bernstein ,  Donald E. Chickering, III ,  Douglas A. Levinson ,  David R. Walt ,  Shawn Davis ,  Ramin Haghgooie

    Inventor： Howard Bernstein ,  Donald E. Chickering, III ,  Douglas A. Levinson ,  David R. Walt ,  Shawn Davis ,  Ramin Haghgooie

    IPC: A61B5/00

    CPC classification number: A61B5/14514 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150297 ,  A61B5/150305 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15109 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15125 ,  A61B5/15144 ,  A61B5/15186 ,  A61B5/157 ,  A61B5/685 ,  A61B2560/0412 ,  A61B2560/0443 ,  A61M5/425 ,  A61M35/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0061 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583 ,  A61M2205/588

    Abstract: The present invention generally relates, in certain aspects, to relatively small devices applied to the skin, modular systems, and methods of use thereof. In some aspects, the device is constructed and arranged to have more than one module. For instance, the device may have a module for delivering to and/or withdrawing fluid from the skin and/or beneath the skin of a subject and a module for transmitting a signal indicative of the fluid delivered to and/or withdrawn from the skin and/or beneath the skin of the subject, a module for analyzing a fluid withdrawn from the skin and/or beneath the skin of the subject, or the like. In some embodiments, the modules are connectable and/or detachable from each other, and in some cases, the connections and/or detachments may be performed while the device is in contact with the subject, e.g., while affixed to the subject. In some embodiments, the device may be repeatedly applicable to the skin of the subject to deliver to and/or withdraw fluid from the skin and/or beneath the skin of a subject, e.g., at the same location, or at different locations on the skin of the subject. In some aspects, the devices may be self-contained and/or have a relatively small size, and in some cases, the device may be sized such that it is wearable and/or able to be carried by a subject. For example, the device may have a mass and/or dimensions that allow the device to be carried or worn by a subject for various periods of time, e.g., at least about an hour, at least about a day, at least about a week, etc., or no more than about an hour, no more than about 10 min, etc.

    Abstract translation: 本发明在某些方面通常涉及应用于皮肤的相对小的装置，模块化系统及其使用方法。 在一些方面，设备被构造和布置成具有多个模块。 例如，该装置可以具有用于递送到和/或从对象皮肤和/或皮肤下方的流体递送的模块和用于传送指示输送到皮肤和/或从皮肤递送的流体的信号的模块，以及 /或受试者皮肤下方的用于分析从皮肤抽出的流体和/或在受试者的皮肤下方的流体的模块等。 在一些实施例中，模块可彼此连接和/或可拆卸，并且在一些情况下，可以在设备与对象接触时执行连接和/或拆卸，例如在固定到对象的同时。 在一些实施例中，该装置可以重复地应用于受试者的皮肤，以递送至/或从对象的皮肤和/或皮肤下方例如在相同位置或不同位置递送流体 受试者的皮肤。 在一些方面，装置可以是独立的和/或具有相对较小的尺寸，并且在一些情况下，该装置的尺寸可被设定为使得其可穿戴和/或能够被受试者携带。 例如，该装置可以具有质量和/或尺寸，其允许受试者携带或穿戴不同时间段，例如至少约一小时，至少约一天，至少约一周 等等，或不超过约一小时，不超过约10分钟等

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