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公开(公告)号：US06620584B1
公开(公告)日：2003-09-16
申请号：US09574117
申请日：2000-05-19
Applicant: Mark Chee , David R. Walt
Inventor： Mark Chee , David R. Walt
IPC: C12Q168
CPC classification number: C12Q1/6874 , B01J2219/005 , B01J2219/00572 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , C07B2200/11 , C07H21/00 , C12Q1/6837 , C40B20/04 , C40B40/06 , C40B70/00 , C12Q2563/161 , C12Q2563/185 , C12Q2525/179 , C12Q2563/155 , C12Q2565/514
Abstract: The invention provides methods and compositions for combinatorially decoding arrays.
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公开(公告)号：US20120264622A1
公开(公告)日：2012-10-18
申请号：US13532606
申请日：2012-06-25
Applicant: Mark Chee , David R. Walt
Inventor： Mark Chee , David R. Walt
IPC: C40B20/04
CPC classification number: C12Q1/6874 , B01J2219/005 , B01J2219/00572 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , C07B2200/11 , C07H21/00 , C12Q1/6837 , C40B20/04 , C40B40/06 , C40B70/00 , C12Q2563/161 , C12Q2563/185 , C12Q2525/179 , C12Q2563/155 , C12Q2565/514
Abstract: Methods disclosed herein relate to identification of nucleotides in a nucleotide sequence.
Abstract translation: 本文公开的方法涉及鉴定核苷酸序列中的核苷酸。
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公开(公告)号：US20110251101A1
公开(公告)日：2011-10-13
申请号：US13159302
申请日：2011-06-13
Applicant: Mark Chee , David R. Walt
Inventor： Mark Chee , David R. Walt
IPC: C40B30/04
CPC classification number: C12Q1/6874 , B01J2219/005 , B01J2219/00572 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , C07B2200/11 , C07H21/00 , C12Q1/6837 , C40B20/04 , C40B40/06 , C40B70/00 , C12Q2563/161 , C12Q2563/185 , C12Q2525/179 , C12Q2563/155 , C12Q2565/514
Abstract: Methods disclosed herein relate to identification of nucleotides in a nucleotide sequence.
Abstract translation: 本文公开的方法涉及鉴定核苷酸序列中的核苷酸。
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公开(公告)号：US20090286688A1
公开(公告)日：2009-11-19
申请号：US12506116
申请日：2009-07-20
Applicant: Mark Chee , David R. Walt
Inventor： Mark Chee , David R. Walt
IPC: C40B20/04
CPC classification number: C12Q1/6874 , B01J2219/005 , B01J2219/00572 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , C07B2200/11 , C07H21/00 , C12Q1/6837 , C40B20/04 , C40B40/06 , C40B70/00 , C12Q2563/161 , C12Q2563/185 , C12Q2525/179 , C12Q2563/155 , C12Q2565/514
Abstract: Methods disclosed herein relate to identification of nucleotides in a nucleotide sequence.
Abstract translation: 本文公开的方法涉及鉴定核苷酸序列中的核苷酸。
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公开(公告)号：US20140135233A1
公开(公告)日：2014-05-15
申请号：US14157323
申请日：2014-01-16
Applicant: John R. Stuelpnagel , Mark Chee
Inventor： John R. Stuelpnagel , Mark Chee
IPC: C12Q1/68
CPC classification number: C12N15/1093 , C12Q1/6806 , C12Q1/6834 , C12Q1/6837 , C12Q1/686 , C12Q1/6876 , G11C7/1048 , H03K19/0966 , Y10S977/792 , C12Q2525/197 , C12Q2523/107
Abstract: The present invention is directed to methods and compositions for generating a pool of oligonucleotides. The invention finds use in preparing a population or subpopulations of oligonucleotides in solution. The pool of oligonucleotides finds use in a variety of nucleic acid detection and/or amplification assays.
Abstract translation: 本发明涉及用于产生寡核苷酸库的方法和组合物。 本发明用于制备溶液中寡核苷酸的群体或亚群。 寡核苷酸库可用于各种核酸检测和/或扩增测定。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20120329677A9
公开(公告)日：2012-12-27
申请号：US11506176
申请日：2006-08-18
Applicant: Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P.A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
Inventor： Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P.A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
CPC classification number: C12Q1/6874 , C12Q1/6886
Abstract: The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the CFTR gene.
Abstract translation: 本发明提供了固定化探针的阵列，以及采用阵列的方法，用于检测CFTR基因中的突变。
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公开(公告)号：US07612020B2
公开(公告)日：2009-11-03
申请号：US10767476
申请日：2004-01-28
Applicant: John Stuelpnagel , Mark Chee , Steven Auger
Inventor： John Stuelpnagel , Mark Chee , Steven Auger
IPC: C40B40/00 , C40B40/06 , C40B60/00 , G01N33/543
CPC classification number: B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00382 , B01J2219/005 , B01J2219/00511 , B01J2219/00524 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , C40B40/06 , G01N33/54393
Abstract: The invention relates to sensor compositions comprising a composite array of individual arrays, to allow for simultaneous processing of a number of samples. The invention further provides methods of making and using the composite arrays. The invention further provides a hybridization chamber for use with a composite array.
Abstract translation: 本发明涉及包括单独阵列的复合阵列的传感器组合物，以允许同时处理多个样品。 本发明还提供了制备和使用复合阵列的方法。 本发明还提供了一种与复合阵列一起使用的杂交室。
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公开(公告)号：US07399584B2
公开(公告)日：2008-07-15
申请号：US09510378
申请日：2000-02-22
Applicant: Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P. A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
Inventor： Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P. A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
CPC classification number: C07H21/00 , B01J19/0046 , B01J2219/00432 , B01J2219/00529 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C07B2200/11 , C12Q1/6827 , C12Q1/6837 , C12Q1/6869 , C12Q1/6874 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C40B40/06 , C40B60/14 , C12Q2565/513
Abstract: The invention provides methods of comparing a target nucleic acid with a reference nucleic acid using nucleic acid arrays.
Abstract translation: 本发明提供了使用核酸阵列比较靶核酸与参考核酸的方法。
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公开(公告)号：US20060229824A1
公开(公告)日：2006-10-12
申请号：US11367800
申请日：2006-03-03
Applicant: Maureen Cronin , Charles Miyada , Earl Hubbell , Mark Chee , Stephen Fodor , Xiaohua Huang , Robert Lipshutz , Peter Lobban , MacDonald Morris , Edward Sheldon
Inventor： Maureen Cronin , Charles Miyada , Earl Hubbell , Mark Chee , Stephen Fodor , Xiaohua Huang , Robert Lipshutz , Peter Lobban , MacDonald Morris , Edward Sheldon
IPC: G06F19/00
CPC classification number: C12Q1/6837 , B01J19/0046 , B01J2219/00432 , B01J2219/00529 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00644 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C07B2200/11 , C07H21/00 , C12Q1/6874 , C12Q1/6876 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , C40B40/06 , C40B60/14
Abstract: The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the biotransformation genes, such as cytochromes P450. For example, one such array comprises four probe sets. A first probe set comprises a plurality of probes, each probe comprising a segment of at least three nucleotides exactly complementary to a subsequence of a reference sequence from a biotransformation gene, the segment including at least one interrogation position complementary to a corresponding nucleotide in the reference sequence. Second, third and fourth probe sets each comprise a corresponding probe for each probe in the first probe set. The probes in the second, third and fourth probe sets are identical to a sequence comprising the corresponding probe from the first probe set or a subsequence of at least three nucleotides thereof that includes the at least one interrogation position, except that the at least one interrogation position is occupied by a different nucleotide in each of the four corresponding probes from the four probe sets.
Abstract translation: 本发明提供了固定化探针的阵列，以及采用该阵列的方法，用于检测生物转化基因如细胞色素P450中的突变。 例如，一个这样的阵列包括四个探针组。 第一探针组包含多个探针，每个探针包含与来自生物转化基因的参考序列的亚序列完全互补的至少三个核苷酸的片段，该片段包含与参考文献中的相应核苷酸互补的至少一个询问位置 序列。 第二，第三和第四探针组各自包括在第一探针组中的每个探针的相应探针。 第二，第三和第四探针组中的探针与包含来自第一探针组的相应探针或包含至少一个询问位置的至少三个核苷酸的亚序列的序列相同，除了至少一个询问 位置由来自四个探针组的四个相应探针中的每一个中的不同核苷酸占据。
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公开(公告)号：US20050191698A1
公开(公告)日：2005-09-01
申请号：US11107215
申请日：2005-04-14
Applicant: Mark Chee , John Stuelpnagel
Inventor： Mark Chee , John Stuelpnagel
CPC classification number: C12Q1/6813 , B01J2219/005 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , C12Q1/6874 , C40B40/06
Abstract: The invention relates to DNA sequencing by synthesis techniques, including those utilizing the detection of pyrophosphate (PPi) generated during the DNA synthesis reaction (pyrosequencing). The methods and compositions utilize biosensor arrays comprising microspheres distributed on a surface.
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