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    75.
    发明专利
    未知

    公开(公告)号：GR82242B

    公开(公告)日：1984-12-13

    申请号：GR840175221

    申请日：1984-07-05

    Applicant: HOECHST AG

    Inventor： URBACH HANSJORG DR ,  HENNING RAINER DR ,  BECKER REINHARD DR

    IPC: A61K31/40 ,  A61K31/403 ,  A61K31/405 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  A61P43/00 ,  C07D209/52 ,  C07D221/04 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K5/08 ,  C07K14/81

    Abstract: The invention relates to compounds of the formula I (I) in which n denotes 0 or 1, R denotes hydrogen, alkyl, alkenyl or aralkyl, R1 denotes hydrogen or alkyl, which can optionally be substituted by amino, acylamino or benzoylamino, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, each of which can be substituted by alkyl, alkoxy or halogen, aralkyl or aroylalkyl, both of which can be substituted in the aryl radical as defined previously, a monocyclic or bicyclic S- or O- and/or N-heterocyclic radical or a side chain of an aminoacid, R2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen, or Y and Z together denote oxygen, X denotes alkyl, alkenyl, cycloalkyl, aryl, which can be monosubstituted, disubstituted or trisubstituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, acylamino, alkylamino, dialkylamino and/or methylenedioxy, or 3-indolyl, and to a process for their preparation, agents containing them and and their use, and to 2-azabicyclo[3.1.0]hexane derivatives as intermediates, and a process for their preparation.

    76.
    发明专利
    未知

    公开(公告)号：GR78496B

    公开(公告)日：1984-09-27

    申请号：GR830170883

    申请日：1983-03-23

    Applicant: HOECHST AG

    Inventor： TEETZ VOLKER DR ,  HANSJORGURBACH DR ,  BECKER REINHARD DR

    IPC: A61K31/40 ,  A61K31/403 ,  A61K38/00 ,  A61P9/12 ,  C07D209/54 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06

    Abstract: The invention relates to compounds of the formula I (I) in which n denotes 1, 2, 3 or 4, R is alkyl, alkenyl cycloalkyl, aryl, optionally mono-, di- oder trisubstituted by alkyl, alkoxy, hydroxy, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy, or indol-3-yl, R1 denotes an optionally protected radical of a naturally occurring amino acid HOOC-CH(NH2)-R1, R2 denotes hydrogen, alkyl or optionally nitro-substituted aralkyl, R3 denotes hydrogen, alkyl or cycloalkyl or optionally nitro-substituted aralkyl and X denotes 2 hydrogen atoms or 1 oxygen atom, their physiologically tolerated salts with acids and, if R2 and/or R3 denote hydrogen, with bases, a process for their preparation, agents containing these derivatives and their use as medicaments.

    78.
    发明专利
    未知

    公开(公告)号：DE3246503A1

    公开(公告)日：1984-06-20

    申请号：DE3246503

    申请日：1982-12-16

    Applicant: HOECHST AG

    Inventor： URBACH HANSJOERG DR ,  HENNING RAINER DR ,  TEETZ VOLKER DR ,  BECKER REINHARD DR

    IPC: A61K31/40 ,  A61K31/403 ,  A61K38/00 ,  A61P9/12 ,  A61P43/00 ,  C07D209/52 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K14/81

    Abstract: The invention relates to derivatives of cis,endo-2-azabicyclo[5.3.0]decane-3-carboxylic acid of the formula I (I) in which R denotes hydrogen, alkyl, alkenyl or aralkyl, R1 denotes hydrogen, allyl, vinyl or a side chain of an optionally protected naturally occurring alpha -aminoacid, R2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen, or Y and Z together denote oxygen, X denotes alkyl, alkenyl, cycloalkyl, aryl which can be substituted once, twice or three times by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy, or denotes indol-3-yl, and their physiologically acceptable salts, a process for their preparation, agents containing them and their use.

    79.
    发明专利
    未知

    公开(公告)号：DE3227055A1

    公开(公告)日：1984-01-26

    申请号：DE3227055

    申请日：1982-07-20

    Applicant: HOECHST AG

    Inventor： HENNING RAINER DR ,  URBACH HANSJOERG DR ,  BECKER REINHARD DR

    IPC: A61K31/435 ,  A61K38/00 ,  A61P9/12 ,  C07D453/06 ,  C07K5/02 ,  A61K45/06

    Abstract: The novel derivatives have the formula I in which n denotes 0 or 2, R denotes hydrogen, alkyl or aralkyl, R denotes hydrogen or unsubstituted or amino-, acylamino- or benzoylamino-substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, each of which can be substituted by alkyl, alkoxy or halogen, aralkyl or aroylalkyl, both of which, as defined above, can be substituted in the aryl radical, an S- or O- and/or N-heterocyclic radical or a side chain of an amino acid, R denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen or Y and Z together denote oxygen and X denotes alkyl, alkenyl, cycloalkyl, aryl, which can be mono-, di- or trisubstituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino and/or methylenedioxy or denotes 3-indolyl.

    80.
    发明专利
    未知

    公开(公告)号：DE3210496A1

    公开(公告)日：1983-10-06

    申请号：DE3210496

    申请日：1982-03-23

    Applicant: HOECHST AG

    Inventor： URBACH HANSJOERG DR ,  HENNING RAINER DR ,  TEETZ VOLKER DR ,  WISSMANN HANS DR ,  BECKER REINHARD DR

    IPC: A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/405 ,  A61K38/00 ,  A61K38/55 ,  A61P9/12 ,  C07D209/42 ,  C07K1/02 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06 ,  C07K14/81 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/06 ,  C07D405/14 ,  C07D209/26

    Abstract: The invention relates to compounds of the formula I (I) in which n denotes 0 or 1, R denotes hydrogen, alkyl or aralky, R1 denotes hydrogen or alkyl, which can optionally be substituted by amino, acylamino or benzoylamino, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, which each can be substituted by alkyl, alkoxy or halogen, arylalkyl or aroylalkyl, both of which can be substituted in the aryl radical as defined in the aforegoing, a monocyclic or bicyclic sulfur or oxygen and/or nitrogen heterocyclic radical, or a side chain of a naturally occurring aminoacid, R2 denotes hydrogen, alkyl, alkenyl or arylalkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen or Y and Z together denote oxygen and X denotes alkyl, alkenyl, cycloalkyl, aryl, which is monosubstituted, disubstituted or trisubstituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy or 3-indolyl, and their physiologically acceptable salts, processes for their preparation, agents containing these and their use as medicaments and also bicyclic amino acids as their intermediates and processes for their preparation.

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