公开(公告)号：ES2187501T3

公开(公告)日：2003-06-16

申请号：ES93103301

申请日：1993-03-02

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  WAGNER ADALBERT DR ,  GERHARDS HERMANN DR ,  BECKER REINHARD DR ,  SCHOLKENS BERNWARD PROF DR

IPC: A61K31/4164 ,  A61K31/64 ,  A61P9/10 ,  A61P9/12 ,  A61K31/415 ,  C07D233/84 ,  C07D233/86 ,  C07D233/90

Abstract: Compounds of the formula (I) in which R is, for example, ethyl, R is, for example, methyl, n is, for example, zero, R is, for example, COOH and R is, for example, SO2NHCONHCH3 are highly active antagonists of angiotensin II receptors.

公开(公告)号：CZ286187B6

公开(公告)日：2000-02-16

申请号：CZ283097

申请日：1997-09-08

Applicant: HOECHST AG

Inventor： BECKER REINHARD DR ,  HENNING RAINER DR ,  TEETZ VOLKER DR ,  URBACH HANSJOERG DR

IPC: A61K38/55 ,  A61K31/275 ,  A61K31/277 ,  A61K31/40 ,  A61K31/401 ,  A61K31/41 ,  A61K31/425 ,  A61K31/455 ,  A61K31/47 ,  A61K31/55 ,  A61K45/06 ,  A61P3/00 ,  A61P3/14 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00

Abstract: In the present invention there is disclosed a pharmaceutical preparation intended for treating proteinuria and containing as an active substance a combination of trandolapril and verapamil.

公开(公告)号：DK0417698T3

公开(公告)日：1996-07-22

申请号：DK90117400

申请日：1990-09-10

Applicant: HOECHST AG

Inventor： LINZ WOLFGANG DR ,  HEITSCH HOLGER DR ,  HENNING RAINER DR ,  NICKEL WOLF-ULRICH DR ,  RUPPERT DIETER DR ,  URBACH HANSJOERG DR

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61P9/12 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07K5/02

Abstract: The invention relates to renin-inhibiting amino-acid derivatives of the formula in which R is a radical of a substituted nitrogen-containing heterocycle such as piperidine, X is CO, CS, SO2 or SO, Y is CH2, O or S, B is the residue of an amino acid of the formula H-B-OH, and R , R and R are as defined in the description, process for their preparation, agents containing them and their use.

公开(公告)号：DE59010189D1

公开(公告)日：1996-04-18

申请号：DE59010189

申请日：1990-09-10

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  LINZ WOLFGANG DR ,  NICKEL WOLF-ULRICH DR ,  RUPPERT DIETER DR ,  URBACH HANSJOERG DR

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61P9/12 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07K5/02

Abstract: The invention relates to renin-inhibiting amino-acid derivatives of the formula in which R is a radical of a substituted nitrogen-containing heterocycle such as piperidine, X is CO, CS, SO2 or SO, Y is CH2, O or S, B is the residue of an amino acid of the formula H-B-OH, and R , R and R are as defined in the description, process for their preparation, agents containing them and their use.

公开(公告)号：CZ280248B6

公开(公告)日：1995-12-13

申请号：CS90691

申请日：1991-04-02

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  HENNING RAINER DR ,  GERHARDS HERMANN DR ,  SCHOLKENS BERNHARD DR ,  CAILLE JEAN-CLAUDE ,  VEVERT JEAN-PAUL

IPC: A61K31/415 ,  A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4164 ,  A61K31/423 ,  A61K31/437 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/495 ,  A61K31/505 ,  A61K31/519 ,  A61P9/12 ,  A61P29/00 ,  A61P43/00 ,  C07D233/64 ,  C07D233/84 ,  C07D233/90 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D471/04 ,  C07D487/04

Abstract: The invention relates to compounds of the formula in which X, Y and Z are identical or different and are N or CR , R and R are as defined in the description, L is an alkylene radical, q = 0 or 1, and A is the radical of a fused heterobicycle. The invention furthermore relates to a method for the preparation of the abovementioned compounds, to compositions containing them, and to their use.

公开(公告)号：ES2076395T3

公开(公告)日：1995-11-01

申请号：ES91105178

申请日：1991-04-02

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  HENNING RAINER DR ,  GERHARDS HERMANN DR ,  SCHOLKENS BERNWARD DR ,  JEAN-CLAUDE CAILLE ,  JEAN-PAUL VEVERT

IPC: A61K31/415 ,  A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4164 ,  A61K31/423 ,  A61K31/437 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/495 ,  A61K31/505 ,  A61K31/519 ,  A61P9/12 ,  A61P29/00 ,  A61P43/00 ,  C07D233/64 ,  C07D233/84 ,  C07D233/90 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D471/04 ,  C07D487/04

Abstract: The invention relates to compounds of the formula in which X, Y and Z are identical or different and are N or CR , R and R are as defined in the description, L is an alkylene radical, q = 0 or 1, and A is the radical of a fused heterobicycle. The invention furthermore relates to a method for the preparation of the abovementioned compounds, to compositions containing them, and to their use.

公开(公告)号：AT124696T

公开(公告)日：1995-07-15

申请号：AT91105178

申请日：1991-04-02

Applicant: HOECHST AG

Inventor： WAGNER ADALBERT DR ,  HENNING RAINER DR ,  GERHARDS HERMANN DR ,  SCHOELKENS BERNWARD DR ,  JEAN-CLAUDE CAILLE ,  JEAN-PAUL VEVERT

IPC: A61K31/415 ,  A61K31/38 ,  A61K31/40 ,  A61K31/41 ,  A61K31/4155 ,  A61K31/4164 ,  A61K31/423 ,  A61K31/437 ,  A61K31/44 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/495 ,  A61K31/505 ,  A61K31/519 ,  A61P9/12 ,  A61P29/00 ,  A61P43/00 ,  C07D233/64 ,  C07D233/84 ,  C07D233/90 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D409/14 ,  C07D413/06 ,  C07D471/04 ,  C07D487/04

Abstract: The invention relates to compounds of the formula in which X, Y and Z are identical or different and are N or CR , R and R are as defined in the description, L is an alkylene radical, q = 0 or 1, and A is the radical of a fused heterobicycle. The invention furthermore relates to a method for the preparation of the abovementioned compounds, to compositions containing them, and to their use.

公开(公告)号：DE59102259D1

公开(公告)日：1994-08-25

申请号：DE59102259

申请日：1991-11-11

Applicant: HOECHST AG

Inventor： HEITSCH HOLGER DR ,  HENNING RAINER DR ,  LINZ WOLFGANG DR ,  SCHOELKENS BERNWARD PROF DR ,  URBACH HANSJOERG DR

IPC: A61K31/41 ,  A61K31/415 ,  A61K31/495 ,  A61K31/675 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D233/64 ,  C07D233/68 ,  C07D233/90 ,  C07D249/04 ,  C07D249/08 ,  C07D257/04 ,  C07D403/10

Abstract: The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and/or hyperplasia by administration of angiotensin II receptor blockers, preferably of the imidazole, pyrrole, pyrazole, triazole or tetrazole type.

公开(公告)号：AT105301T

公开(公告)日：1994-05-15

申请号：AT89105371

申请日：1981-08-22

Applicant: HOECHST AG

Inventor： GEIGER ROLF PROF DR ,  TEETZ VOLKER DR ,  URBACH HANSJOERG DR ,  SCHOELKENS BERNWARD DR ,  HENNING RAINER DR

IPC: C07K5/06 ,  A61K37/64

公开(公告)号：DE58906338D1

公开(公告)日：1994-01-20

申请号：DE58906338

申请日：1989-05-23

Applicant: HOECHST AG

Inventor： BECKER REINHARD DR ,  HENNING RAINER DR ,  URBACH HANSJOERG DR ,  TEETZ VOLKER DR ,  ENGLERT HEINRICH CHRISTIAN DR ,  MANIA DIETER DR

IPC: A61K31/40 ,  A61K38/55 ,  A61K45/06 ,  A61P25/02 ,  A61K37/64 ,  A61K37/02

Abstract: The invention relates to combinations of angiotensin converting enzyme inhibitors with potassium channel modulators, process for the preparation thereof and their use as medicines.