公开(公告)号：AU5253790A

公开(公告)日：1990-10-11

申请号：AU5253790

申请日：1990-04-03

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  EDENHOFER ALBRECHT ,  MARKI HANS PETER ,  NEIDHART WERNER ,  RAMUZ HENRI ,  WOSTL WOLFGANG

IPC: C07D263/08 ,  A61K38/00 ,  A61K38/55 ,  A61P9/00 ,  A61P9/12 ,  C07C237/04 ,  C07C237/08 ,  C07D233/54 ,  C07D233/64 ,  C07K1/06 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  C07K5/097 ,  C07K14/81 ,  A61K31/195 ,  A61K31/38 ,  A61K31/415 ,  A61K31/425 ,  A61K37/02 ,  C07C215/20 ,  C07C215/18 ,  C07C215/08 ,  C07C215/28 ,  C07C271/20 ,  C07C271/16 ,  C07C233/64

Abstract: The compounds of the formula in which A, R , R , R , R , R and n have the meaning stated in Claim 1, in the form of optically pure diastereomers, diastereomer mixtures, diastereomeric racemates or mixtures of diastereomeric racemates, and pharmaceutically utilisable salts thereof inhibit the action of the natural enzyme renin and can accordingly be used in the form of pharmaceutical products for controlling or preventing high blood pressure and heart failure. They can be prepared by various processes known per se.

公开(公告)号：AU5218890A

公开(公告)日：1990-10-04

申请号：AU5218890

申请日：1990-03-23

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  MARKI HANS PETER ,  NEIDHART WERNER ,  RAMUZ HENRI ,  WOSTL WOLFGANG

IPC: A61K31/16 ,  A61K31/27 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/425 ,  A61K31/426 ,  A61K31/4427 ,  A61K31/445 ,  A61K38/00 ,  A61K38/55 ,  A61P9/00 ,  A61P9/12 ,  C07C237/06 ,  C07C271/16 ,  C07C271/18 ,  C07C271/20 ,  C07D231/12 ,  C07D233/54 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D333/24 ,  C07D401/12 ,  C07D403/12 ,  C07K5/02 ,  C07K5/065 ,  A61K31/535 ,  C07C215/20 ,  C07C215/18 ,  C07C215/08 ,  C07D295/08 ,  C07D207/27 ,  C07D211/76 ,  C07D235/26 ,  C07C215/28

Abstract: The compounds of the formula … … in which A, R , R , R and R have the meaning stated in Claim 1,… in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diastereomeric racemates, and pharmaceutically utilisable salts thereof, inhibit the action of the natural enzyme renin and can accordingly be used in the form of pharmaceutical products for controlling or preventing high blood pressure and heart failure. They can be prepared by various processes known per se.

公开(公告)号：NO901033A

公开(公告)日：1990-09-07

申请号：NO901033

申请日：1990-03-05

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  EDENHOFER ALBRECHT ,  MARTIN JOSEPH ARMSTRONG ,  MERRETT JOHN HERBERT ,  NEIDHART WERNER

IPC: A61K31/195 ,  A61K31/27 ,  A61K31/335 ,  A61K31/357 ,  A61K31/42 ,  A61K31/421 ,  A61K31/47 ,  A61K31/472 ,  A61K38/00 ,  A61P31/12 ,  C07C211/08 ,  C07C211/36 ,  C07C229/30 ,  C07C233/88 ,  C07C237/22 ,  C07C251/36 ,  C07C271/22 ,  C07D213/40 ,  C07D217/06 ,  C07D233/26 ,  C07D263/04 ,  C07D295/12 ,  C07D295/13 ,  C07D295/20 ,  C07D295/205 ,  C07D317/30 ,  C07D405/12 ,  C07D413/12 ,  C07F7/18 ,  C07K1/113 ,  C07K5/02 ,  C07K5/06

CPC classification number: C07D213/40 ,  A61K38/00 ,  C07C237/22 ,  C07C251/36 ,  C07C271/22 ,  C07C2601/14 ,  C07C2602/08 ,  C07D217/06 ,  C07D233/26 ,  C07D263/04 ,  C07D295/13 ,  C07D295/205 ,  C07D317/30 ,  C07K5/0207

公开(公告)号：IS3560A7

公开(公告)日：1990-09-07

申请号：IS3560

申请日：1990-03-02

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  EDENHOFER ALBRECHT ,  MARTIN JOSEPH A ,  MERRETT JOHN H ,  NEIDHART WERNER

IPC: A61K20060101 ,  A61K31/16 ,  C07C20060101 ,  C07C237/22 ,  C07C271/22 ,  C07D213/40 ,  C07D217/06 ,  C07D233/24 ,  C07D263/04 ,  C07D295/20 ,  C07D317/20 ,  C07F7/18 ,  C07K5/02

公开(公告)号：HU901802D0

公开(公告)日：1990-07-28

申请号：HU180290

申请日：1990-03-23

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  MARKI HANS PETER ,  NEIDHART WERNER ,  RAMUZ HENRI ,  WOSTL WOLFGANG

IPC: A61K31/16 ,  A61K31/27 ,  A61K31/38 ,  A61K31/381 ,  A61K31/415 ,  A61K31/425 ,  A61K31/426 ,  A61K31/4427 ,  A61K31/445 ,  A61K38/00 ,  A61K38/55 ,  A61P9/00 ,  A61P9/12 ,  C07C237/06 ,  C07C271/16 ,  C07C271/18 ,  C07C271/20 ,  C07D231/12 ,  C07D233/54 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D333/24 ,  C07D401/12 ,  C07D403/12 ,  C07K5/02 ,  C07K5/065

Abstract: The compounds of the formula … … in which A, R , R , R and R have the meaning stated in Claim 1,… in the form of optically pure diastereomers, mixtures of diastereomers, diastereomeric racemates or mixtures of diastereomeric racemates, and pharmaceutically utilisable salts thereof, inhibit the action of the natural enzyme renin and can accordingly be used in the form of pharmaceutical products for controlling or preventing high blood pressure and heart failure. They can be prepared by various processes known per se.

公开(公告)号：NO901519D0

公开(公告)日：1990-04-03

申请号：NO901519

申请日：1990-04-03

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  EDENHOFER ALBRECHT ,  MAERKLI HANS PETER ,  NEIDHART WERNER ,  RAMUZ HENRI ,  WOSTL WOLFGANG

IPC: C07D263/08 ,  A61K38/00 ,  A61K38/55 ,  A61P9/00 ,  A61P9/12 ,  C07C237/04 ,  C07C237/08 ,  C07D233/54 ,  C07D233/64 ,  C07K1/06 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K5/08 ,  C07K5/097 ,  C07K14/81

Abstract: The compounds of the formula in which A, R , R , R , R , R and n have the meaning stated in Claim 1, in the form of optically pure diastereomers, diastereomer mixtures, diastereomeric racemates or mixtures of diastereomeric racemates, and pharmaceutically utilisable salts thereof inhibit the action of the natural enzyme renin and can accordingly be used in the form of pharmaceutical products for controlling or preventing high blood pressure and heart failure. They can be prepared by various processes known per se.

公开(公告)号：NZ222474A

公开(公告)日：1990-02-26

申请号：NZ22247487

申请日：1987-11-06

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  JAUNIN ROLAND ,  MARKI HANS-PETER ,  MARTI FRANZI ,  RAMUZ HENRI

IPC: A61K31/415 ,  A61K31/4184 ,  A61K31/425 ,  A61K31/428 ,  A61K31/44 ,  A61K31/55 ,  A61K31/551 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D233/54 ,  C07D233/64 ,  C07D235/14 ,  C07D235/26 ,  C07D243/14 ,  C07D277/62 ,  C07D277/64 ,  C07D401/06 ,  C07D471/04 ,  C07D487/04 ,  C07D521/00 ,  C07D235/04

Abstract: Compounds of the formula I wherein R is lower-alkyl, R1 is halogen, R2 is C1-C12-alkyl, R3 is hydroxy, lower-alkoxy, lower-alkyl-carbonyloxy, lower-alkoxy-lower-alkylcarbonoyloxy, lower-alkylaminocarbonyloxy, arylaminocarbonyloxy or aryl-lower alkylaminocarbonyloxy, X is C1-C18-alkylene which optionally can be interrupted by 1,4-phenylene or interrupted or lengthened by 1,4-cyclohexylene, A is di- or tri-substituted 2-imidazolyl attached via an ethylene group or a substituted or unsubstituted heterocycle selected from the group consisting of benzimidazolyl, benzimidazolonyl, imidazo[4,5-c]pyridinyl, imidazo[4,5-c]pyridinonyl, benzthiazolyl, benzodiazepine-2,5-dion-1-yl and pyrrolo[2,1-c]-[1,4]benzodiazepine-5,11-dion-10-yl and n is the number 0 or 1, in the form of racemates and optical antipodes, as well as N-oxides and pharmaceutically usable acid addition salts thereof. The compounds of formual I have a pronounced calcium-antagonistic and anti-arrhythmic activity and can accordingly be used as medicaments, especially for the control or prevention of angina pectoris, ischaemia, arrhythmias, high blood pressure and cardiac insufficiency.

公开(公告)号：ZA891464B

公开(公告)日：1989-12-27

申请号：ZA891464

申请日：1989-02-24

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  QUIRICO BRANCA ,  NEIDHART WERNER ,  WERNER NEIDHART ,  RAMUZ HENRI ,  HENRI RAMUZ ,  STADLER HEINZ ,  HEINZ STADLER ,  WOSTL WOLFGANG ,  WOLFGANG WOSTL

IPC: A61K20060101 ,  C07C20060101 ,  C07D20060101 ,  C07D233/64 ,  C07K20060101 ,  C07C ,  A61K ,  C07D ,  C07K

公开(公告)号：ZA8901464B

公开(公告)日：1989-12-27

申请号：ZA8901464

申请日：1989-02-24

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  QUIRICO BRANCA ,  NEIDHART WERNER ,  WERNER NEIDHART ,  RAMUZ HENRI ,  HENRI RAMUZ ,  STADLER HEINZ ,  HEINZ STADLER ,  WOSTL WOLFGANG ,  WOLFGANG WOSTL

IPC: A61K20060101 ,  C07C20060101 ,  C07D20060101 ,  C07D233/64 ,  C07K20060101 ,  C07C ,  A61K ,  C07D ,  C07K

公开(公告)号：NO890921A

公开(公告)日：1989-09-05

申请号：NO890921

申请日：1989-03-03

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  NEIDHART WERNER ,  RAMUZ HENRI ,  STADLER HEINZ ,  WOSTL WOLFGANG

IPC: A61K31/16 ,  A61K31/41 ,  A61K31/425 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K38/00 ,  A61P9/04 ,  A61P9/12 ,  C07C215/26 ,  C07C231/02 ,  C07C237/00 ,  C07C237/22 ,  C07C317/44 ,  C07C323/60 ,  C07D231/12 ,  C07D233/54 ,  C07D233/64 ,  C07D263/04 ,  C07D263/06 ,  C07D263/24 ,  C07D277/20 ,  C07D277/30 ,  C07D307/52 ,  C07D333/24 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  C07F9/6506 ,  C07K5/06 ,  C07K14/81 ,  C07C103/50

CPC classification number: C07D233/64 ,  C07C215/26 ,  C07C237/00 ,  C07C317/44 ,  C07D263/04 ,  C07D263/24 ,  C07D277/30 ,  C07D307/52 ,  C07D333/24 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D417/06 ,  C07D417/12 ,  Y02P20/55