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    STRAIN OF CHLAMYDIA
    71.
    发明申请
    STRAIN OF CHLAMYDIA 审中-公开
    CHLAMYDIA菌株

    公开(公告)号：WO1993004163A1

    公开(公告)日：1993-03-04

    申请号：PCT/US1992007103

    申请日：1992-08-24

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  FORSYTH DENTAL CENTER ,  OHIO STATE UNIVERSITY ,  STILLS, Harold, P., Jr. ,  FOX, James, G. ,  PASTER, Bruce, J. ,  DEWHIRST, Floyd, E.

    Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  FORSYTH DENTAL CENTER ,  OHIO STATE UNIVERSITY

    IPC: C12N01/20

    CPC classification number: C12R1/01 ,  A61K39/00 ,  C07K14/195 ,  C07K16/125 ,  C12Q1/689

    Abstract: The present invention relates to the discovery of a novel intracellular bacterium in hamsters with transmissible proliferative ileitis. This novel intracellular bacterium has been isolated in purified form and, on the basis of phylogenetic analysis, has been determined to possess 95 % similarity to Chlamydia psittaci and 98 % similarity to Chlamydia trachomatis. Thus, it has been discovered that the "Campylobacter-like organisms" long implicated in proliferative ileitis in hamsters, and likely in proliferative bowel diseases in other species as well, are not members of Campylobacter genus at all, but rather appear to be a novel species of Chlamydia.

    Abstract translation: 本发明涉及在具有可扩展性增殖性回肠炎的仓鼠中发现新的细胞内细菌。 已经确定了这种新型细胞内细菌的纯化形式，并且在系统发育分析的基础上已被确定为具有与衣原体鹦鹉热95％的相似性和98％与沙眼衣原体的相似性。 因此，已经发现，长期涉及仓鼠增生性回肠炎的肠弯曲杆菌样生物，并且在其他物种中也可能是增殖性肠病，并不是弯曲杆菌属的成员，而是似乎是一种小说 衣原体种。

    HETEROCYCLIC CHIRAL LIGANDS AND METHOD FOR CATALYTIC ASYMMETRIC DIHYDROXYLATION OF OLEFINS
    72.
    发明申请
    HETEROCYCLIC CHIRAL LIGANDS AND METHOD FOR CATALYTIC ASYMMETRIC DIHYDROXYLATION OF OLEFINS 审中-公开
    杂环化合物配体和烯烃的催化不对称二氢化的方法

    公开(公告)号：WO1992020677A1

    公开(公告)日：1992-11-26

    申请号：PCT/US1992003940

    申请日：1992-05-08

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  SHARPLESS, K., Barry ,  BELLER, Matthias ,  BLACKBURN, Brent ,  KAWANAMI, Yasahiro ,  KWONG, Hoi-Lun ,  OGINO, Yasukazu ,  SHIBATA, Toinoyuki ,  UKITA, Tatsuzo ,  WANG, Lisa

    IPC: C07D453/04

    CPC classification number: C07C29/48 ,  C07B2200/07 ,  C07C67/31 ,  C07C2601/14 ,  C07C2601/18 ,  C07D453/04 ,  C07C31/20 ,  C07C31/276 ,  C07C31/272 ,  C07C31/42 ,  C07C33/26 ,  C07C35/17 ,  C07C33/46

    Abstract: Osmium-catalyzed methods of addition to an olefin are discussed. In the method of asymmetric dihydroxylation of the present invention, an olefin, a chiral ligand, an organic solvent, water, an oxidant and an osmium-containing compound are combined. In the method of asymmetric oxyamination of the present invention, an olefin, a chiral ligand, an organic solvent, water, a metallochloramine derivative, an osmium-containing compound and, optionally, a tetraalkyl ammonium compound are combined. In the method of asymmetric diamination of the present invention, an olefin, a chiral ligand, an organic solvent, a metallo-chloramine derivative, an amine and an osmium-containing compound are combined. In one embodiment, an olefin, a chiral ligand which is a polymeric dihydroquinidine derivative or a dihydroquinine derivative, acetone, water, a base, an oxidant and osmium tetroxide are combined to effect asymmetric dihydroxylation of the olefin.

    Abstract translation: 讨论了添加到烯烃中的锇催化方法。 在本发明的不对称二羟基化方法中，合并烯烃，手性配体，有机溶剂，水，氧化剂和含锇化合物。 在本发明的不对称氧化法的方法中，合并烯烃，手性配体，有机溶剂，水，金属氯胺衍生物，含锇化合物和任选的四烷基铵化合物。 在本发明的不对称二氨基化方法中，合并烯烃，手性配体，有机溶剂，金属氯胺衍生物，胺和含锇化合物。 在一个实施方案中，将烯烃，作为聚合二氢奎尼丁衍生物或二氢喹啉衍生物的手性配体，丙酮，水，碱，氧化剂和四氧化锇组合以实现烯烃的不对称二羟基化。

    SOLID STATE OPTICAL CONVERTER
    73.
    发明申请
    SOLID STATE OPTICAL CONVERTER 审中-公开
    固态光转换器

    公开(公告)号：WO1992017801A2

    公开(公告)日：1992-10-15

    申请号：PCT/US1992002556

    申请日：1992-03-27

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  LE, Han, Q. ,  GOODHUE, William, D.

    IPC: G02B05/14

    CPC classification number: H01S5/041 ,  H01S3/094 ,  H01S5/0609

    Abstract: This invention provides an optical converter suitable for use as the gain medium in lasers, optical amplifiers and other optical devices. The converter consists of at least one and preferable two or more optical converter elements which are sandwiched and separated by inactive dielectric layers. An optical pump beam may be passed to the active converter elements through an anti-reflection layer at one surface of the converter and a high reflection mirror may be provided at the opposite side of the converter to reflect the pump beam incident thereon back into the converter for a second pass. Each converter element has one or more absorber layers, at least one radiation layer receiving energy from the absorber layers and preferably outputting energy at a slightly different wavelength than the wavelength at which the absorber layers optimally absorb, and preferably at least one index-of-refraction compensator (IRC) layer which compensates for changes in index-of-refraction induced by the absorber and radiator layers to provide a low divergence far field optical intensity profile for the converter with no substantial side bands.

    METHOD OF EXON AMPLIFICATION
    74.
    发明申请
    METHOD OF EXON AMPLIFICATION 审中-公开
    EXON放大方法

    公开(公告)号：WO1992013071A1

    公开(公告)日：1992-08-06

    申请号：PCT/US1992000692

    申请日：1992-01-27

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  BUCKLER, Alan, J. ,  CHANG, David, D. ,  SHARP, Phillip, A. ,  HOUSMAN, David, E.

    IPC: C12N15/00

    CPC classification number: C12N15/1051 ,  C12N15/67

    Abstract: A method of exon amplification, which is useful for fast and efficient isolation of a coding sequence from complex mammalian genomic DNA. Framents of genomic mammalian DNA are inserted into an intron contained within a splicing plasmid, resulting in a splicing plasmid construct. The construct is introduced into an appropriate host cell, resulting in replication of and transcription from the construct. The transcripts are processed into mature RNA. If an exon is present in the genomic DNA fragment contained in the plasmid intron, the splice sites of the DNA insert can be paired with 5' and 3' splice sites provided in the splicing construct. Mature RNA, which contains transcribed exons from the genomic DNA, is isolated, amplified via RNA-based PCR, and subsequently cloned.

    Abstract translation: 一种外源扩增方法，可用于从复杂的哺乳动物基因组DNA快速高效地分离编码序列。 将基因组哺乳动物DNA的构架插入到剪接质粒内包含的内含子中，产生剪接质粒构建体。 将构建体引入合适的宿主细胞中，导致构建体的复制和转录。 将转录物加工成成熟的RNA。 如果包含在质粒内含子中的基因组DNA片段中存在外显子，则DNA插入片段的剪接位点可以与剪接构建体中提供的5'和3'剪接位点配对。 分离含有来自基因组DNA的转录外显子的成熟RNA，通过基于RNA的PCR扩增，随后克隆。

    BEARING FOR HIGH RESOLUTION PRECISION CONTROL DEVICE
    77.
    发明申请
    BEARING FOR HIGH RESOLUTION PRECISION CONTROL DEVICE 审中-公开
    高分辨率精密控制装置的轴承

    公开(公告)号：WO1992011504A1

    公开(公告)日：1992-07-09

    申请号：PCT/US1991009730

    申请日：1991-12-20

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  TRUMPER, David, L.

    IPC: G01B07/00

    CPC classification number: G03F7/70816 ,  B82Y15/00 ,  F16C29/00 ,  F16C32/0444 ,  F16C32/0472 ,  F16C33/1035 ,  G01B5/0004 ,  G01B7/003 ,  G12B5/00

    Abstract: A magnetic bearing (10) is provided which may be utilized in a fine position control or movement system. Stability is enhanced by providing separate mechanisms for supporting the weight of a platen (12) or other object being controlled with electromagnets (22) utilized to control or compensate for motion of the platen (12) in N degrees of freedom. The support mechanism is preferably one or more permanent magnets (18, 40, 42) having an air gap (29) with the platen (12) which is greater than the air gap (26) for the electromagnets (22). The mechanism for supporting the weight of the platen (12) may be adjusted so as to support the weight of the platen (12) regardless of any changes in such weight by, for example, adjusting the air gap (29) for the permanent magnet (18, 40, 42) to compensate for weight changes. Resonant vibration is reduced by constructing the platen (12) of a hollowed, cellular structure, for example, a honeycomb structure.

    A FREQUENCY-DOUBLED, DIODE-PUMPED YTTERBIUM LASER
    79.
    发明申请
    A FREQUENCY-DOUBLED, DIODE-PUMPED YTTERBIUM LASER 审中-公开
    频率双重，双极泵浦YTTERBIUM激光

    公开(公告)号：WO1992009127A1

    公开(公告)日：1992-05-29

    申请号：PCT/US1991007893

    申请日：1991-10-24

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

    Inventor： MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  FAN, Tso, Yee ,  LACOVARA, Philip

    IPC: H01S03/091

    CPC classification number: H01S3/109 ,  H01S3/0632 ,  H01S3/08018 ,  H01S3/09415 ,  H01S3/106 ,  H01S3/1611 ,  H01S3/1618 ,  H01S3/164 ,  H01S3/1643

    Abstract: An ytterbium-doped solid state laser (2) including a resonant cavity (6) formed by an input mirror (8) and an output mirror (10); and a gain medium (4) within the resonant cavity, the gain medium (4) being made of an ytterbium-doped host material having an ytterbium ion doping level and a thickness sufficient to yield single longitudinal mode laser operation when the resonant cavity (6) is pumped by an external light source (12).

    Abstract translation: 包括由输入反射镜（8）和输出反射镜（10）形成的谐振腔（6）的镱掺杂固态激光器（2）; 以及所述谐振腔内的增益介质（4），所述增益介质（4）由具有镱离子掺杂水平的镱掺杂主体材料制成，并且当谐振腔（6）具有足以产生单纵模激光器操作的厚度时 ）被外部光源（12）泵送。

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