公开(公告)号：WO2004080339A3

公开(公告)日：2005-08-18

申请号：PCT/US2004006885

申请日：2004-03-08

Applicant: MEDTRONIC INC ,  STOKES KENNETH B ,  HOBOT CHRISTOPHER M ,  EBERT MICHAEL J

Inventor： STOKES KENNETH B ,  HOBOT CHRISTOPHER M ,  EBERT MICHAEL J

IPC: A61L27/54 ,  A61L31/16 ,  A61N1/05

CPC classification number: A61L31/16 ,  A61L27/54 ,  A61L2300/222 ,  A61L2300/41 ,  A61L2300/602 ,  A61L2300/606 ,  A61N1/056 ,  A61N1/0575

Abstract: A biostable polymeric substrate of an implantable medical device unit includes a demand-release bioactive composition including one or more bioactive agents covalently bound to surface-modifying end groups of the substrate. Certain cellular activities, in proximity to the polymeric substrate, release substances reacting with the end groups such that the end groups release the one or more bioactive agents, which modify the certain cellular activities.

Abstract translation: 植入式医疗装置单元的生物稳定的聚合物基质包括需求释放生物活性组合物，其包含与基底的表面改性端基共价结合的一种或多种生物活性剂。 在聚合物底物附近的某些细胞活性释放与端基反应的物质，使得端基释放一种或多种改变某些细胞活性的生物活性剂。

公开(公告)号：WO02064040A3

公开(公告)日：2003-05-15

申请号：PCT/US0204013

申请日：2002-02-11

Applicant: MEDTRONIC INC

Inventor： IAIZZO PAUL A ,  LASKE TIMOTHY G ,  LIPSON DAVID ,  SOMMER JOHN L ,  FRANKE LINDA ,  STOKES KENNETH B

IPC: A61B5/0215 ,  A61B5/029 ,  A61B5/042 ,  A61N1/05 ,  A61M25/01

CPC classification number: A61B5/0215 ,  A61B5/029 ,  A61B5/042 ,  A61N2001/0578

Abstract: A system and method for positioning an implantable medical device IMD 10 within a living body is disclosed. The IMD includes a flow-directed member 35 that is deployed within the body to carry the IMD via the flow of blood. The flow-directed member 35 may be an inflatable member such as a balloon, or a mechanical member such as a parachute structure that deploys within the body. The IMD further includes a pressure measuring device 32 and a pressure monitor 30 to obtain pressure measurement at one or more locations within the body adjacent the IMD. The pressure measurements are used to estimate the location of at least a portion of the IMD relative to the body to aid in positioning the IMD in the body without the use of a fluoro-visible media.

Abstract translation: 公开了一种用于将可植入医疗装置IMD 10定位在活体内的系统和方法。 IMD包括部署在身体内的流动指向的构件35，以经由血流携带IMD。 流动导向构件35可以是可膨胀构件，例如球囊，或者在体内部署的诸如降落伞结构的机械构件。 IMD还包括压力测量装置32和压力监测器30，以在与IMD相邻的身体内的一个或多个位置处获得压力测量。 压力测量用于估计IMD相对于身体的至少一部分的位置，以帮助将IMD定位在身体中而不使用荧光可见介质。

公开(公告)号：WO02064040A9

公开(公告)日：2002-11-28

申请号：PCT/US0204013

申请日：2002-02-11

Applicant: MEDTRONIC INC

Inventor： IAIZZO PAUL A ,  LASKE TIMOTHY G ,  LIPSON DAVID ,  SOMMER JOHN L ,  FRANKE LINDA ,  STOKES KENNETH B

IPC: A61B5/0215 ,  A61B5/029 ,  A61B5/042 ,  A61N1/05 ,  A61B17/00

CPC classification number: A61B5/0215 ,  A61B5/029 ,  A61B5/042 ,  A61N2001/0578

Abstract: A system and method for positioning an implantable medical device (IMD) within a living body is disclosed. The IMD includes a flow-directed member that is deployed within the body to carry the IMD via the flow of blood. The flow-directed member may be an inflatable member such as a balloon, or a mechanical member such as a parachute structure that deploys within the body. The IMD further includes a pressure measuring device and a pressure monitor to obtain pressure measurement at one or more locations within the body adjacent the IMD. The pressure measurements are used to estimate the location of at least a portion of the IMD relative to the body to aid in positioning the IMD in the body without the use of a fluoro-visible media.

Abstract translation: 公开了一种用于将可植入医疗装置（IMD）定位在生物体内的系统和方法。 IMD包括部署在身体内的流动导向的构件，以通过血流携带IMD。 流动导向构件可以是可膨胀构件，例如球囊，或者在体内部署的诸如降落伞结构的机械构件。 IMD还包括压力测量装置和压力监测器，用于在与IMD相邻的身体内的一个或多个位置处获得压力测量值。 压力测量用于估计IMD相对于身体的至少一部分的位置，以帮助将IMD定位在身体中而不使用荧光可见介质。

公开(公告)号：WO9520993A2

公开(公告)日：1995-08-10

申请号：PCT/US9414618

申请日：1994-12-19

Applicant: MEDTRONIC INC

Inventor： STOKES KENNETH B ,  PROCTOR KEITH J ,  MCVENES RICK D

IPC: A61N1/05 ,  G07D7/00

CPC classification number: A61N1/0568 ,  A61N1/0573 ,  A61N2001/0578

Abstract: An implantable lead (10) for establishing electrical contact between a medical device and body tissue, in which an active fixation mechanism (18) secures the lead (10) in place while allowing a distal electrode (14) on the lead to mechanically "float" with respect to the body tissue. In one embodiment, the active fixation mechanism (18) comprises a curved hook disposed on the lead (10) at a point spaced proximally back from the distal end (14) of the lead (10). The curved hook (18) defines a helix around at least a portion of the lead's circumference. A hollow introducer needle is slidably disposed on the lead (10). The hollow needle is provided with a longitudinal slit in a distal section of its length, such that the distal section of the needle can be advanced over the distal end (14) the lead (10), past the fixation hook, which is received in the longitudinal slit. With the needle slid over the distal end (14) of the lead (10), the needle is stabbed tangentially into an implant site, bringing the fixation hook (18) proximal to the surface of the body tissue. Then, the needle is twisted (bringing about a twisting of the lead (10)), causing the curved fixation hook (18) to pierce and engage the body tissue, securing the lead (10) in place. Then the needle is withdrawn from the body tissue and removed from the lead (10). In an alternative embodiment, the lead (10) can be placed by an endocardial approach using a flexible cannula with a longitudinally slotted tip.

Abstract translation: 一种用于在医疗装置和身体组织之间建立电接触的可植入引线（10），其中主动固定机构（18）将引线（10）固定在适当位置，同时允许导线上的远端电极（14）机械地“浮动 “相对于身体组织。 在一个实施例中，主动固定机构（18）包括设置在引线（10）上的远离引线（10）的远端（14）的近侧间隔的点的弯曲钩。 弯曲的钩（18）围绕引线的圆周的至少一部分限定螺旋。 中空导引针可滑动地设置在引线（10）上。 中空针在其长度的远端部分中设置有纵向狭缝，使得针的远端部分能够超过引导件（10）的远端（14）前进，通过固定钩 纵向狭缝。 当针滑过导线（10）的远端（14）时，针被切向地刺入植入位置，使得固定钩（18）靠近身体组织的表面。 然后，针被扭转（引起引线（10）的扭转），使得弯曲的固定钩（18）刺穿并接合身体组织，将引线（10）固定就位。 然后将针从身体组织中取出并从引线（10）中取出。 在替代实施例中，引线（10）可以通过使用具有纵向开口尖端的柔性套管的心内膜方式放置。

公开(公告)号：EP0538368A4

公开(公告)日：1995-04-19

申请号：EP91913321

申请日：1991-06-11

Applicant: MEDTRONIC INC

Inventor： STOKES KENNETH B ,  LINDEMANS FRED

IPC: A61N1/04 ,  A61N1/05 ,  A61N1/365

CPC classification number: A61N1/0568

Abstract: A small diameter, unipolar or bipolar, atrial or ventricular transvenous or epimyocardial pacing lead with a porous, platinized, steroid eluting cathode electrode exhibiting an effective surface area in the range of 0.1 to 4.0 mm , preferably 0.6 to 3.0 mm , provides low stimulation thresholds in the range of 0.5 volts, 0.5 milliseconds, very high pacing impedance (800 to 2,000 OMEGA ), relatively low polarization, good to excellent sensing, and adequately low source impedance. The high pacing impedance prolongs the longevity of pacing pulse generators and allows for the miniaturization of their components. The low thresholds allow large safety factors at low applied voltages, which also contribute to increased battery longevity.

Abstract translation: 小孔径，单极或双极，心房或心室经静脉或心外膜起搏导线，带有多孔的，镀铂的类固醇洗脱阴极，其有效表面积为0.1-4.0mm 2，优选0.6-3.0mm 2 >，提供0.5伏，0.5毫秒，非常高的起搏阻抗（800至2,000欧姆）范围内的低刺激阈值，相对低的极化，良好到极好的感测以及足够低的源阻抗。 高起搏阻抗延长了起搏脉冲发生器的使用寿命，并允许其组件小型化。 低阈值允许在较低的施加电压下具有较大的安全系数，这也有助于延长电池的使用寿命。

公开(公告)号：EP0957902A4

公开(公告)日：2000-09-13

申请号：EP97920371

申请日：1997-04-04

Applicant: MEDTRONIC INC

Inventor： STOKES KENNETH B ,  MORISSETTE JOSEE

IPC: A61K38/17 ,  A61K48/00 ,  A61M5/32 ,  A61M25/00 ,  C07K14/705 ,  A61K31/00 ,  A01N43/04 ,  C07H21/04

CPC classification number: A61K48/0075 ,  A61K38/1709 ,  A61K48/00 ,  A61M5/3291 ,  A61M2025/0089 ,  C07K14/705

Abstract: The present invention provides delivery systems for delivering conduction protein genetic material to cardiac cells in localized areas of the heart to improve the conductance therein. More specifically, there is provided a system for delivering connexin proteins or nucleic acid molecules encoding connexin proteins to a site in the heart which has been determined by mapping procedures to have a conduction disturbance. For cases where conduction is impaired, selected genetic material is delivered by Applicants' delivery system to cells around the disturbance area, in order to enhance overall conductivity patterns; in other cases, genetic material is selected to slow conduction in affected areas, so as to prevent, e.g., brady-tachy syndrome.