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    CONTROLLED VACUUM ARC MATERIAL DEPOSITION, METHOD AND APPARATUS
    71.
    发明申请
    CONTROLLED VACUUM ARC MATERIAL DEPOSITION, METHOD AND APPARATUS 审中-公开
    控制真空ARC材料沉积，方法和装置

    公开(公告)号：WO1985003954A1

    公开(公告)日：1985-09-12

    申请号：PCT/US1985000312

    申请日：1985-02-27

    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

    Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  RAMALINGAM, Subbiah ,  QI, Cai, Bao ,  KIM, Kyunghoon

    IPC: C23C13/12

    CPC classification number: H01J37/32055 ,  C23C14/325 ,  H01J37/32623 ,  H01J37/3266

    Abstract: A method and apparatus for vacuum arc deposition of material on a surface of an object (32), uses a vacuum chamber (12) accomodating the active surface of the cathode (24) and an anode (34). A power supply connected to the anode (34) and cathode (24) establishes an electric arc. The track of the arc is controlled with a magnetic field established with a permanent magnet (56) that is moved in a closed path relative to the cathode. A solenoid (68) modifies the main magnetic field produced on the active surface of the cathode (24).

    Abstract translation: 用于在物体（32）的表面上真空电弧沉积材料的方法和装置使用容纳阴极（24）的活性表面和阳极（34）的真空室（12）。 连接到阳极（34）和阴极（24）的电源建立电弧。 用与永久磁铁（56）建立的磁场来控制电弧的轨迹，该永磁体相对于阴极在闭合路径中移动。 螺线管（68）改变在阴极（24）的有源表面上产生的主磁场。

    CONSOLIDATED LIGANDS WITH INCREASED AFFINITIES AND METHODS OF USE THEREOF
    73.
    发明申请
    CONSOLIDATED LIGANDS WITH INCREASED AFFINITIES AND METHODS OF USE THEREOF 审中-公开
    具有增加的职能的合并配偶及其使用方法

    公开(公告)号：WO1998016638A1

    公开(公告)日：1998-04-23

    申请号：PCT/US1996016495

    申请日：1996-10-16

    Applicant: THE ROCKEFELLER UNIVERSITY ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

    Inventor： THE ROCKEFELLER UNIVERSITY ,  REGENTS OF THE UNIVERSITY OF MINNESOTA ,  COWBURN, David ,  ZHENG, Jie ,  BARANY, George ,  XU, Qinhong

    IPC: C12N15/12

    CPC classification number: C07K14/001 ,  A61K38/00 ,  C07K16/18 ,  Y02A50/401 ,  Y02A50/473

    Abstract: The invention relates to consolidated ligands, which include amino acid sequences which bind to at least two domains of a target protein. The consolidated ligands have increased affinity for the target protein over ligands directed to a single domain. Particularly preferred ligands include those directed to the Src Homology 2 and 3 (SH2, SH3) domains of eukaryotic protein tyrosine kinases, which are involved in complex regulation of the enzymic activity, obligatory for differentiation and growth control. Ligands of this kind of design may be widely useful as reagents in the investigation of SH interactions, and as leads for design of therapeutic agents.

    Abstract translation: 本发明涉及合并的配体，其包括与靶蛋白的至少两个结构域结合的氨基酸序列。 固结的配体对靶向单个结构域的配体的亲和力增加。 特别优选的配体包括涉及真核细胞蛋白酪氨酸激酶的Src同源2和3（SH2，SH3）结构域的那些，其涉及酶活性的复杂调节，必须进行分化和生长控制。 这种设计的配体可能广泛用作研究SH相互作用的试剂，以及治疗剂设计的引导。

    TRICYCLIC IBOGAINE ANALOGS, THEIR PREPARATION AND THEIR USE IN TREATING SUBSTANCE ABUSE
    77.
    发明申请
    TRICYCLIC IBOGAINE ANALOGS, THEIR PREPARATION AND THEIR USE IN TREATING SUBSTANCE ABUSE 审中-公开
    TRICYCLIC IBOGAINE ANALOGS，他们的准备及其在治疗物质滥用中的应用

    公开(公告)号：WO1997020847A1

    公开(公告)日：1997-06-12

    申请号：PCT/US1996017868

    申请日：1996-11-06

    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  UNIVERSITY OF MIAMI

    Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  UNIVERSITY OF MIAMI ,  EFANGE, S., Mbua, Ngale ,  MASH, Deborah, Carmen

    IPC: C07D495/04

    CPC classification number: C07D471/22 ,  Y10S514/812

    Abstract: The present invention provides a series of ibogaine analogs of formula (I) wherein: R1 is S or O; R2 is H, (C1-C4)alkyl, (C1-C4)alkoxy, OH, CN, CONH2, halo, oxazolyl, (C1-C4)alkylS, or (C1-C2)trifluoroalkyl; R3 is a phenyl group optionally substituted at the 2'- or 3'-position of the phenyl ring with halo, N(R)2, wherein each R is H or (C1-C4)alkyl; or NO2; and R4 is (C3-C6)cycloalkyl(C1-C4)alkyl, (C3-C6)cycloalkyl or (C1-C4)alkyl, optionally containing 1-2 double bonds, and the pharmaceutically acceptable salts thereof, useful to treat cocaine addiction and the use of other addictive substances.

    Abstract translation: 本发明提供了一系列式（I）的维生素类似物，其中：R1是S或O; R2是H，（C1-C4）烷基，（C1-C4）烷氧基，OH，CN，CONH2，卤素，恶唑基，（C1-C4）烷基或（C1-C2）三氟烷基; R3是在苯环的2'-或3'-位上任选被卤素取代的苯基，N（R）2，其中每个R是H或（C 1 -C 4）烷基; 或NO2; 并且R 4是（C 3 -C 6）烷基，（C 3 -C 6）烷基，（C 3 -C 6）环烷基或任选含有1-2个双键的（C 1 -C 4）烷基及其药学上可接受的盐，可用于治疗可卡因成瘾 并使用其他成瘾物质。

    METHOD OF GROWING RICKETTSIAE IN IXODES SCAPULARIS TICK CELL CULTURE AND PREPARING ANTIGENS AND VACCINES OF RICKETTSIAE
    80.
    发明申请
    METHOD OF GROWING RICKETTSIAE IN IXODES SCAPULARIS TICK CELL CULTURE AND PREPARING ANTIGENS AND VACCINES OF RICKETTSIAE 审中-公开
    在IXODES SCAPULARIS TICK细胞培养中制备病毒的方法和制备抗病毒剂和疫苗的方法

    公开(公告)号：WO1997008296A1

    公开(公告)日：1997-03-06

    申请号：PCT/US1996013594

    申请日：1996-08-23

    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  OKLAHOMA STATE UNIVERSITY

    Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  OKLAHOMA STATE UNIVERSITY ,  MUNDERLOH, Ulrike, G. ,  KURTTI, Timothy, J. ,  KOCAN, Katherine, M. ,  BLOUIN, Edmour, F. ,  EWING, Sidney, A.

    IPC: C12N05/06

    CPC classification number: C07K14/29 ,  A61K39/0233 ,  Y02A50/403

    Abstract: The invention is directed to methods of culturing rickettsiae in Ixodes scapularis cell lines. The methods of the invention provide for culture of microorganisms such as Anaplasma marginale, Ehrlichia canis, and Rickettsia rickettsii. A method of the invention involves incubating a rickettsia with an Ixodes scapularis tick cell culture in a culture medium under reduced oxygen and increased CO2 at a sufficient temperature until growth of the rickettsia is detected. The culture medium comprises a medium suitable for the growth of invertebrate cells supplemented with an organic buffer. The cell culture method can be used in large scale production of rickettsia containing products useful in diagnostic assays and vaccine preparations.

    Abstract translation: 本发明涉及在伊克斯氏肩胛骨细胞系中培养立克次氏体的方法。 本发明的方法提供了微生物的培养物，例如ma as margin，艾氏杆菌和立克次体体积立克次氏体。 本发明的方法包括在减压氧培养基中培养立克次体和肩胛骨蜱细胞培养物，并在足够的温度下升高CO 2，直到检测到立克次体的生长。 培养基包括适合于补充有机缓冲液的无脊椎动物细胞生长的培养基。 细胞培养方法可用于大规模生产含有诊断测定法和疫苗制剂的立克次体含有产品。

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