Abstract:
This invention is directed to a method for producing a coating layer of a coating composition comprising two or more components. The two or more components are mixed post atomization. This invention is also directed to a spray gun having a delivery device for producing such coating layer.
Abstract:
This invention is directed to a method for producing a coating layer of a coating composition by introducing a catalyst as a second component into an atomized stream of a first component of the coating composition. This invention is also directed to a spray gun for producing such coating layer.
Abstract:
Capsules and particles with at least one encapsulated and/or entrapped agent, such as therapeutic agent, imaging agents, and other constituents may be produced by electrohydrodynamic processes. More particularly, the agent encapsulated in a vehicle, capsule, particle, vector, or carrier may maximize treatment and/or imaging of malignant cancers while minimizing the adverse effects of treatment and/or imaging.
Abstract:
A nanoparticle coated hydrogel may be formed by a method of electrospraying nanoparticles on to a hydrogel surface includes providing a drug and polymer combination in solvent to an inner capillary of a coaxial capillary spray nozzle. A coating with a drug that releases over time may be provided. Open and closed matrixes may be selectively formed to help modify time release periods.
Abstract:
Electrospray methods and systems for coating of objects (e.g., medical devices such as a stent structure) with selected types of coatings (e.g., open matrix coating and closed film coating)
Abstract:
Spherical particles having a size on the order of 0.1 to 100 microns in size are created by systems and devices of several types. The device includes a source of a stream of gas which is forced through a liquid held under pressure in a pressure chamber with an exit opening therein. The stream of gas surrounded by the liquid in the pressure chamber flows out of an exit orifice of the chamber into a liquid thereby creating a monodispersion of bubbles with substantially uniform diameter. The bubbles are small in size and produced with a relatively small amount of energy relative to comparable systems. Small particles of liquid may also be produced. Applications of the technology range from oxygenating sewage with monodispersions of bubbles to inhalation therapy with monodisperse aerosol dispersions of pharmaceutically active drugs.
Abstract:
The invention is directed to a stable capillary microjet and a monodisperse aerosol formed when the microjet dissociates. A variety of devices and methods are disclosed which allow for the formation of a stream of a first fluid (e.g. a liquid) characterized by forming a stable capillary microjet over a portion of the stream wherein the microjet portion of the stream is formed by a second fluid (e.g. a gas). The second fluid is preferably in a different state from the first fluid-liquid-gas or gas-liquid combinations. However, the first and second fluids may be two different fluids in miscible in each other. The stable capillary microjet comprises a diameter dj at a given point A in the stream characterized by formula (I): wherein dj is the diameter of the stable microjet, ≅ indicates approximately equally to where an acceptable margin of error is +/- 10 %, rho 1 is the density of the liquid and DELTA Pg is change in second fluid pressure from the second fluid pressure at a low velocity region (feeding region) upstream of point A to the second fluid pressure at point A.
Abstract:
A novel device and method for the application of two or more components of a fibrin sealant using a gas is disclosed. The novel device and method involve the concentric arrangement of annular apertures (14, 16) for each of the components concentric with and radially outward of a center gas discharge aperture (12) in the exit end of a spray head (10). Reservoirs for each component, for example syringe cartridges or cylinders, are in discrete fluid communication with the spray head and preferably can be activated by a common means.
Abstract:
A device and method for dispensing a liquid with a gas includes an instrument having a cannula and a low-pressure tip. The low-pressure tip includes a tip housing that at least partially defines a high pressure chamber. A distal wall of the tip housing includes an aperture in fluid communication with the high pressure chamber. The low-pressure tip also includes a tube and a gas flow channel. The tube fluidly communicates liquid at a relatively low pressure from the cannula through the first aperture. The gas flow channel fluidly communicates gas from the cannula at a relatively high pressure and to the high pressure chamber for discharge from the aperture. The tube and aperture are adapted to dispense the liquid and the gas in order to create a low pressure zone distal of the tube to dispense droplets of the liquid.