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    FLOW CELL MODULES AND LIQUID SAMPLE ANALYZERS AND METHODS INCLUDING SAME
    72.
    发明申请
    FLOW CELL MODULES AND LIQUID SAMPLE ANALYZERS AND METHODS INCLUDING SAME 审中-公开
    流动细胞模块和液体样品分析仪及其包括的方法

    公开(公告)号：WO2016053613A3

    公开(公告)日：2016-05-26

    申请号：PCT/US2015050143

    申请日：2015-09-15

    Applicant: PERKINELMER HEALTH SCI INC

    Inventor： DICESARE JOSEPH L ,  JIN FENG ,  NEAL TIMOTHY P ,  AIKENS DAVID

    IPC: G01N21/03 ,  G01J3/44 ,  G01N21/05 ,  G01N21/64

    CPC classification number: G01J3/0202 ,  G01J3/0218 ,  G01J3/4406 ,  G01N21/05 ,  G01N21/645 ,  G01N2021/0389 ,  G01N2021/6417 ,  G01N2021/6482 ,  G01N2021/6484 ,  G01N2201/0642 ,  G01N2201/0826 ,  G01N2201/0833 ,  G02B6/262

    Abstract: A flow cell (250) for a fluorescence spectrometer includes a flow channel (254) to receive a flow of a liquid sample, an excitation light entrance window to receive excitation light from a light source, and an emission light exit window to transmit fluorescent emission light from the liquid sample in the flow channel from the flow cell. The excitation light entrance window and/or emission light exit window includes a waveguide including: a waveguide core (261, 262) formed of a core material; and a cladding medium (274) surrounding a portion of the waveguide core (261, 262), wherein the cladding medium (274) has a refractive index less than the refractive index of the core material. The waveguide defines a portion of the flow channel (254). At least one mirror (270, 272) integral with the flow cell body is positioned to reflect excitation light that has passed through the liquid sample in the flow channel (254) back into the liquid sample and/or to reflect emission light emitted from the liquid sample toward the emission light exit window. The excitation light entrance window is spaced a first distance from the flow channel and the emission light exit window is spaced a second distance from the flow channel, whereby the second distance is less than the first distance.

    Abstract translation: 用于荧光光谱仪的流动池（250）包括用于接收液体样品流的流动通道（254），用于接收来自光源的激发光的激发光入口窗口和用于透射荧光发射的发射光出射窗口 来自流动池的流动通道中的液体样品的光。 激发光入射窗口和/或发射光出射窗口包括波导，包括：由芯材形成的波导芯（261,262）; 以及围绕所述波导芯（261,262）的一部分的包层介质（274），其中所述包层介质（274）的折射率小于所述芯材料的折射率。 波导限定了流动通道（254）的一部分。 与流动池主体成一体的至少一个反射镜（270,272）被定位成将已经通过流动通道（254）中的液体样品的激发光反射回液体样品和/或反射从 液体样品朝向发射光出射窗口。 激发光入口窗口与流动通道间隔开第一距离，并且发射光出射窗口与流动通道间隔开第二距离，由此第二距离小于第一距离。

    A FLUORESCENT SUBSTANCE DETECTION SYSTEM
    74.
    发明申请
    A FLUORESCENT SUBSTANCE DETECTION SYSTEM 审中-公开
    荧光物质检测系统

    公开(公告)号：WO2016010494A1

    公开(公告)日：2016-01-21

    申请号：PCT/TR2014/000301

    申请日：2014-07-17

    Applicant: KUANTAG NANOTEKNOLOJILER GELIŞTIRME VE ÜRETIM A.Ş. ,  KOÇ ÜNIVERSITESI

    Inventor： UREY, Hakan ,  AKGUN, Osman Vedat ,  HEVES, Emre ,  CIVITCI, Fehmi ,  CAN, Basarbatu

    IPC: G01J3/44 ,  G01N21/64

    CPC classification number: G01N21/643 ,  G01N21/645 ,  G01N21/8507 ,  G01N2021/6421 ,  G01N2021/6484 ,  G01N2201/0624 ,  G01N2201/0826 ,  G01N2201/0833

    Abstract: In the present invention, a fluorescent substance detection system (S) for detecting fluorescent substances in any environment is provided. Said detection system (S) comprises at least one illumination unit (1) which emits light to said environment in order to excite said substances; detection units (2), at least at a number equal to the number of types of fluorescent substances, for detecting emissions coming from said excited fluorescent substances and bandpass filters (3), each connected to detection units (2) one by one, wherein bandpass filters (3) have a center wavelength matched to the center emission wavelength of corresponding fluorescent substance.

    Abstract translation: 在本发明中，提供了用于检测任何环境中的荧光物质的荧光物质检测系统（S）。 所述检测系统（S）包括至少一个照射单元（1），其向所述环境发射光以激发所述物质; 检测单元（2），至少等于荧光物质的数量的数量，用于检测来自所述激发的荧光物质的发射和带通滤光器（3），每个检测单元（2）逐个连接到检测单元（2），其中 带通滤波器（3）具有与相应荧光物质的中心发射波长匹配的中心波长。

    CLAM-SHELL LUMINOMETER
    76.
    发明申请
    CLAM-SHELL LUMINOMETER 审中-公开

    公开(公告)号：WO2014031327A2

    公开(公告)日：2014-02-27

    申请号：PCT/US2013053714

    申请日：2013-08-06

    Applicant: SIEMENS HEALTHCARE DIAGNOSTICS ,  COHEN BERI

    Inventor： COHEN BERI

    IPC: G01N21/27

    CPC classification number: G01N21/76 ,  G01N21/253 ,  G01N33/5302 ,  G01N2201/0221 ,  G01N2201/064 ,  G01N2201/08 ,  G01N2201/0833 ,  G01N2201/084

    Abstract: A clam-shell luminometer that, when closed, completely encloses an assay reaction mixture-containing reaction vessel and some portion of a reaction carousel or ring. The luminometer includes first and second portions that are coupled to each other, a photomultiplier tube, and plural fiber optic bundles that are optically coupled to the photomultiplier tube. First ends of the fiber optic bundles are disposed adjacent to the reaction vessel in the second portion so that the fiber optic bundles completely surround the perimeter or periphery of the reaction vessel.

    Abstract translation: 蛤壳式发光计在封闭时完全封闭含有测定反应混合物的反应容器和反应传送带或环的一部分。 发光计包括彼此耦合的第一和第二部分，光电倍增管以及光学耦合到光电倍增管的多个光纤束。 光纤束的第一端在第二部分中邻近反应容器设置，使得光纤束完全包围反应容器的周边或周边。

    BIOCHEMICAL REACTIONS SYSTEM
    78.
    发明申请
    BIOCHEMICAL REACTIONS SYSTEM 审中-公开
    生化反应体系

    公开(公告)号：WO2011124918A1

    公开(公告)日：2011-10-13

    申请号：PCT/GB2011/050686

    申请日：2011-04-06

    Applicant: IT-IS INTERNATIONAL LIMITED ,  WEBSTER, Benjamin, Masterman ,  HOWELL, James, Richard

    Inventor： WEBSTER, Benjamin, Masterman ,  HOWELL, James, Richard

    IPC: B01L7/00 ,  G01N21/64

    CPC classification number: B01L7/52 ,  B01L3/50851 ,  B01L3/50853 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1894 ,  G01N21/0332 ,  G01N2201/0826 ,  G01N2201/0833

    Abstract: A chemical and/or biochemical system (1) having at least one reaction vessel (3) in which chemical and/or biochemical reactions may take place, the temperature of the reaction vessels being cycled between at least a highest predetermined temperature and a lowest predetermined temperature, the system comprising a thermal mount (4) for receiving the reaction vessel (s), the thermal mount being thermally coupled to a first, thermally conductive side of a thermoelectric module (5), a second thermally conductive side of the thermoelectric module being thermally coupled to a heat sink (6) and being provided with a pair of electrical contacts (33) to which a pair of electrically conductive wires (34) is connected for coupling to a power source, characterized in that a flexible adhesive (31, 32) is provided between the first thermally conductive side of the thermoelectric module and the thermal mount and between the second thermally conductive side of the thermoelectric module and the heat sink, whereby the adhesive is relatively thermally insulating compared to the first and second thermally conductive sides of the thermoelectric module and forms the sole coupling, thermal or mechanical, between the thermoelectric module and the thermal mount and between the thermoelectric module and the heat sink.

    Abstract translation: 化学和/或生化系统（1）具有至少一个其中可能发生化学和/或生物化学反应的反应容器（3），反应容器的温度在至少最高预定温度和最低预定温度之间循环 所述系统包括用于接收所述反应容器的热安装座（4），所述热安装件热耦合到热电模块（5）的第一导热侧，所述热电模块的第二导热侧 被热耦合到散热器（6）并且设置有一对电触点（33），一对导电线（34）连接到所述一对电触头（34）以耦合到电源，其特征在于，柔性粘合剂（31） ，32）设置在热电模块的第一导热侧和热座之间以及热电模块的第二导热侧之间，并且热sin k，由此与热电模块的第一和第二导热侧相比，粘合剂相对热绝缘，并且在热电模块和热安装座之间以及热电模块和散热器之间形成热耦合或机械的单独耦合。

    OPTICAL SYSTEM FOR CHEMICAL AND/OR BIOCHEMICAL REACTIONS
    80.
    发明申请
    OPTICAL SYSTEM FOR CHEMICAL AND/OR BIOCHEMICAL REACTIONS 审中-公开
    化学和/或生物化学反应的光学系统

    公开(公告)号：WO2010079338A2

    公开(公告)日：2010-07-15

    申请号：PCT/GB2010/000028

    申请日：2010-01-08

    Applicant: IT-IS INTERNATIONAL LTD ,  HOWELL, James, Richard ,  WEBSTER, Benjamin, Masterman ,  CLARK, Mark, Quentin ,  HOWELL, Richard, Alfred

    Inventor： HOWELL, James, Richard ,  WEBSTER, Benjamin, Masterman ,  CLARK, Mark, Quentin ,  HOWELL, Richard, Alfred

    CPC classification number: B01J19/0046 ,  G01N21/253 ,  G01N21/6452 ,  G01N2201/0826 ,  G01N2201/0833

    Abstract: An apparatus for detecting spectra in light emanating from chemical or biochemical reactions occurring in at least one reaction vessel (3) of a plurality of reaction vessels is disclosed. Each reaction vessel (3) has a receptacle portion having an emitting area from which light can emanate. The apparatus may include a masking element (5) having an array of apertures (6) through which light from each reaction vessel (3) can escape. A plurality of light waveguides (7) are arranged to guide light from the apertures (6) in the masking element (5) to a light dispersing device (8) for dispersing the light from each waveguide (7) into a dispersed spectrum. A light detecting device (10) detects specific spectra in the dispersed spectra of light substantially simultaneously. In one embodiment, the apertures (6) are substantially smaller in size than the emitting area of the reaction vessel, but in another embodiment, the apertures (6) are substantially similar in size to the emitting area of the reaction vessel and the light waveguides (7) have a diameter that tapers from a first end substantially similar in diameter to the area of the top of the reaction vessel to a second end that is substantially smaller in diameter. In an alternative embodiment, the light waveguides are not used, when light from the small apertures is directed straight at the light dispersing device. In a further alternative embodiment, several light waveguides are provided for each reaction vessel, each waveguide directing light to a different detector for detecting a different specific spectrum.

    Abstract translation: 公开了一种用于检测在多个反应容器（3）中发生的化学或生物化学反应产生的光中的光谱的装置。 每个反应容器（3）具有容纳部分，该容器部分具有能够发出光的发射区域。 该装置可以包括具有孔（6）阵列的掩模元件（5），来自每个反应容器（3）的光可以通过该孔排出。 多个光波导（7）布置成将来自掩模元件（5）中的孔（6）的光引导到用于将来自每个波导（7）的光分散到分散光谱中的光分散装置（8）。 光检测装置（10）基本上同时检测光的分散光谱中的特定光谱。 在一个实施例中，孔（6）的尺寸基本上小于反应容器的发射面积，但是在另一个实施例中，孔（6）的大小与反应容器的发射面积基本相似，并且光波导 （7）的直径从直径基本上相似于反应容器顶部的面积的第一端逐渐变细到直径基本上较小的第二端。 在替代实施例中，当来自小孔的光直接指向光分散装置时，不使用光波导。 在另一替代实施例中，为每个反应容器提供几个光波导，每个波导将光引导到不同的检测器以检测不同的特定光谱。

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