公开(公告)号：WO1991007911A1

公开(公告)日：1991-06-13

申请号：PCT/US1990005967

申请日：1990-10-17

Applicant: CONCAT LTD.

Inventor： CONCAT LTD. ,  WINCHELL, Harry, S. ,  KLEIN, Joseph, Y. ,  SIMHON, Elliot, D. ,  CYJON, Rosa, L. ,  KLEIN, Ofer ,  ZAKLAD, Haim

IPC: A61B05/05

CPC classification number: G01R33/5601 ,  A61K49/06 ,  C07F9/6524

Abstract: Polyphosphonate ligands containing three or more phosphonate groups, combined with paramagnetic metal cations and administered in the form of pharmacologically acceptable salts, are useful as MRI contrast enhancement agents, which tend to localize in bone tissue without being conjugated to bone-specific biomolecules. Triazacyclononanes and tetraazacyclododecanes, with dihydroxyphosphorylmethyl or dihydroxyphosphorylethyl groups, optionally substituted at the methyl or ethyl bridges with alkyl, aryl, hydroxyl or amino groups, are particularly preferred.

Abstract translation: 含有三个或更多个膦酸酯基团的多膦酸酯配体与顺磁性金属阳离子组合并以药理学上可接受的盐的形式施用可用作MRI对比度增强剂，其倾向于定位在骨组织中而不与骨特异性生物分子缀合。 三氮杂环壬烷和四氮杂环十二烷与任选在甲基或乙基桥上被烷基，芳基，羟基或氨基取代的二羟基磷酰基甲基或二羟基磷酰基乙基是特别优选的。

公开(公告)号：WO1991007131A1

公开(公告)日：1991-05-30

申请号：PCT/US1990005821

申请日：1990-10-16

Applicant: MARQUARDT, Mark, R.

IPC: A61B05/05

CPC classification number: A61B6/4447 ,  A61B6/0457 ,  A61B6/0478

Abstract: An apparatus and method is disclosed for medically examining a patient's spine using a non-invasive technique such as computerized tomography (CT). In this apparatus and method the patient is seated in a generally vertically-oriented chair (10) which is tiltable in a forward and rearward direction, is pivotable relative to a vertical axis, is vertically movable and is stationary so as to adjustably induce gravitational effects on the patient's back. A pivotable chair back (12) can be included for controllably applying additional loads or flexion to the patient's back. An annularly-shaped examination device (52), such as a CT device, is horizontally positioned on a support frame (54) over the patient who is aligned with a central opening in the device (56). The device can be positioned about the patient and oriented horizontally or angularly displaced relative to the horizontal for optimizing or adjusting the generated image. The examination device may be tiltable about a horizontal axis transverse to the direction of tilting of the chair. Appropriate mechanisms are provided for the previously-described adjustment.

公开(公告)号：WO1990001900A1

公开(公告)日：1990-03-08

申请号：PCT/US1989003545

申请日：1989-08-17

Applicant: THE UNIVERSITY OF CONNECTICUT

Inventor： THE UNIVERSITY OF CONNECTICUT ,  WU, George, Y. ,  WU, Catherine, H.

IPC: A61B05/05

CPC classification number: G01R33/5601 ,  A61K49/085 ,  A61K49/14 ,  A61K51/0491 ,  A61K51/088

Abstract: Enhanced magnetic resonance imaging contrast is provided by targeting paramagnetic material specifically to selected mammalian cell types. A carrier system for the paramagnetic material utilizes receptor mediated endocytosis to endow cell specificity and is formed by complexing the paramagnetic material to a glycoprotein-chelator conjugate. The conjugate is formed by bonding receptor-specific ligands to chelating agents through covalent bonding. The carrier not only exhibits a high degree of cell spcificity but also provides significant accumulation of the paramagnetic material within the cell to contribute to the improved enhancement of the magnetic resonance contrast.

Abstract translation: 通过将特定的顺磁材料靶向选定的哺乳动物细胞类型来提供增强的磁共振成像对比度。 顺磁材料的载体系统利用受体介导的内吞来赋予细胞特异性，并通过使顺磁性材料与糖蛋白 - 螯合剂缀合物络合而形成。 通过共价键将受体特异性配体与螯合剂结合形成缀合物。 载体不仅表现出高度的细胞特异性，而且在细胞内提供顺磁材料的显着积累，有助于改善磁共振对比度的增强。

公开(公告)号：WO1989007416A1

公开(公告)日：1989-08-24

申请号：PCT/JP1989000154

申请日：1989-02-15

Applicant: YOKOGAWA MEDICAL SYSTEMS, LTD. ,  HOSHINO, Kazuya

Inventor： YOKOGAWA MEDICAL SYSTEMS, LTD.

IPC: A61B05/05

CPC classification number: G01R33/3621 ,  G01R33/3415

Abstract: A magnetic resonance imaging device of the invention effects the imaging by the multi-coil method while decreasing the hardware amount in the MR signal receiving system and decreasing the amount of operation for reconstituting the image. The magnetic resonance imaging device comprises a plurality of high-frequency coils for receiving MR signals that are arranged along the surface of an object of inspection and that have sensitive regions each overlapping with the neighboring ones, a plurality of signal synthesizers which are provided for the groups of MR signal receiving high-frequency coils whose sensitive regions are not overlapped by one another and which synthesize the signals received from the receiving high-frequency coils of the corresponding groups into one reception signal, a plurality of receivers which effect signal processing such as detection, A/D conversion and the like for the output signals from these plurality of signal synthesizers, and an image reconstitution device which reconstitutes the images based on output signals from the plurality of receivers and which synthesizes an image using a plurality of the reconstituted images.

公开(公告)号：WO1989000400A1

公开(公告)日：1989-01-26

申请号：PCT/HU1988000051

申请日：1988-07-20

Applicant: BAY, Zoltán ,  KISS, László ,  LAKATOSNÉ, Varsányi, Magda ,  VASS, Zoltán ,  VUKAN, György ,  SZIRAKI, Laura

IPC: A61B05/05

CPC classification number: A61B5/411 ,  A61B5/05 ,  A61B5/4547 ,  A61C8/00 ,  A61F2240/008

Abstract: The device comprises a reference electrode, a sensing electrode, and an electronic unit connected to each electrode. In the improvement according to the invention, the reference electrode (1) has a handle part (3) and a pointed part (4) in which are arranged an electrolyte (5) and a sensing contact connected to the pointed part (4) and impregnated with the electrolyte (5). The handle part (3) and the pointed part (4) are interconnected by a detachable connection.

Abstract translation: 该装置包括参考电极，感测电极和连接到每个电极的电子单元。 在根据本发明的改进中，参考电极（1）具有手柄部分（3）和尖部（4），其中布置有电解质（5）和连接到尖部（4）的感测触点， 用电解质（5）浸渍。 手柄部分（3）和尖部（4）通过可拆卸的连接相互连接。

公开(公告)号：WO1987004608A1

公开(公告)日：1987-08-13

申请号：PCT/JP1987000061

申请日：1987-01-28

Applicant: YOKOGAWA MEDICAL SYSTEMS, LTD. ,  SHIMAZAKI, Toru

Inventor： YOKOGAWA MEDICAL SYSTEMS, LTD.

IPC: A61B05/05

CPC classification number: G01R33/54 ,  G01R33/3607

Abstract: A scan controller for NMR imaging apparatus which stores control signals having high amplitude resolution for a variety of sequences using small amounts of memory, and which easily assembles any sequence. The waveforms of the control signals are stored in a waveform memory (101) while the amplitudes thereof are stored in an amplitude memory (102) in the order of events in the sequence, and the duration designating values thereof are stored in a time memory (103) in the order of events in the sequence. The waveform memory (101) is read by an address counter (104) which operates on clocks determined by values read from the time memory (103), and the output thereof is converted through a first D/A converter (105) into an analog signal and is produced. At this moment, the amplitude of the output signal of the first D/A converter (105) is determined by applying a stored amplitude read from the amplitude memory (102) for every event as a fullscale value to the first D/A converter (105) through a second D/A converter (106).

公开(公告)号：WO1987000024A1

公开(公告)日：1987-01-15

申请号：PCT/JP1986000122

申请日：1986-03-10

Applicant: MOTOYAMA, Hiroshi ,  NUKADA, Fumiaki

IPC: A61B05/05

CPC classification number: A61B5/053 ,  A61B5/4035 ,  A61B5/411 ,  A61B5/416

Abstract: An apparatus for diagnosing functions of internal organs and automatic nerves by applying a constant voltage across two or more electrodes attached to a living body, detecting and recording at high speeds an electric current that flows among the electrodes changes from time to time, and further operating predetermined parameters using the recorded data to obtain a variety of data related to the living body. The electrodes are scanned successively or arbitrarily by electrode scanning means (2), and a constant voltage is applied to the scanned electrodes by constant-voltage generating means (3). Instantaneous values of the current flowing between two electrodes are detected by detecting means (4) and are recorded in terms of digital values in recording means (5). Data recorded in recording means (5) are displayed by display means (7) via transmission means (8) and/or they are displayed by display means (7) after various parameters are operated by operation means (6) using the data recorded in recording means (5).

公开(公告)号：WO1981002833A1

公开(公告)日：1981-10-15

申请号：PCT/US1980001602

申请日：1980-12-01

Applicant: KALFAIAN M

IPC: A61B05/05

CPC classification number: A61N2/02 ,  A61N1/40

Abstract: Ailments occur by inoperative states of the molecular mechanisms in the tissue. There are functional electrons in the molecular mechanisms, which rotate back and forth angularly within an arc of 45 degrees in normal operation When these electrons rotate more than 45 degrees, they keep on rotating toward 90 degrees, and 180 degrees. Because of operational interrelationship between molecules, adjacent molecules also become inoperative step by step, and lose their normal magnetic rejection to foreign molecules, and growth starts by invasion, as cancer. These depolarized electrons cannot return back to their normal polar normalizations, and therefore, artificial polar control is required. These mechanisms, however, are arrayed in the tissue three dimensionally, and the invention provides radiation of electron-attracting field that rotates two dimensionally in the tissue in at least three mutually perpendicular planes, for normalizing the depolarized electrons, as cure of cancer.

Abstract translation: 疾病由组织中分子机制的不合作状态发生。 分子机制中存在功能电子，它们在正常操作中在45度的弧度内来回旋转。当这些电子旋转超过45度时，它们保持向90度和180度旋转。 由于分子之间的操作相互关系，相邻的分子也会逐步失效，并失去对外来分子的正常磁排斥，并且生长开始于入侵，作为癌症。 这些去极化的电子不能返回到正常的极化归一化，因此需要人工极化控制。 然而，这些机构三维排列在组织中，并且本发明提供了在至少三个相互垂直的平面中的组织中二维旋转的电子吸引场的辐射，用于使去极化的电子标准化，作为癌症的治愈。

公开(公告)号：WO1998027865A1

公开(公告)日：1998-07-02

申请号：PCT/US1997006774

申请日：1997-04-21

Applicant: BENARON, David, A.

Inventor： RUBINSKY, Boris

IPC: A61B05/05

CPC classification number: A61B5/1459 ,  A61B5/0059 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/14553 ,  A61B5/4076 ,  A61B5/415 ,  A61B5/418 ,  A61B5/6848 ,  A61B5/7264 ,  A61B6/506 ,  A61B17/068 ,  A61B18/00 ,  A61B18/14 ,  A61B2017/00022 ,  A61B2017/00123 ,  A61B2017/00508 ,  A61B2017/00557 ,  A61B2560/0276 ,  A61B2562/0242 ,  A61B2562/08 ,  G01N21/4795

Abstract: A diagnostic monitor for classifying biological tissue in which a light emitter (102) is optically coupled to the tissue to be diagnosed (145) and a light detector (174) is optically coupled to the tissue to detect a portion of the light which passes through the tissue. The tissue classifier (184) receives a signal from the detector and provides an optical classification output signal (195), wherein the tissue is classified by type or state, either for detection, localization, or imaging. A method of classifying tissue is also described.

Abstract translation: 用于分类生物组织的诊断监视器，其中光发射器（102）光学耦合到要诊断的组织（145）和光检测器（174），光学耦合到组织以检测通过的一部分光 组织。 组织分类器（184）从检测器接收信号并提供光学分类输出信号（195），其中根据类型或状态对组织进行分类，用于检测，定位或成像。 还描述了分类组织的方法。

公开(公告)号：WO1998018385A1

公开(公告)日：1998-05-07

申请号：PCT/CA1997000791

申请日：1997-10-28

Applicant: NOVID INC. ,  BLASZYNSKI, John, E. ,  TIBBS, Daniel, G.

Inventor： NOVID INC.

IPC: A61B05/05

CPC classification number: A63F9/183 ,  A61B5/0533 ,  A63F2250/265

Abstract: An electronic party game comprises display cards (11a, 11b) for displaying questions to be asked to a player and a response monitor (10) for monitoring the player's psycho-physiological responses to the questions. The response monitor (10) comprises a housing (14) dimensioned to be fitted into the palm of the player answering the questions, the housing having an outside top surface (16) shaped to receive two extended fingers of the player, and a pair of electrodes (26, 27) extending through the top surface, each of the electrodes being positioned to contact one of the extended fingers near the tip thereof, bias means (24) operatively coupled to an outside portion of the housing for selectively biasing the player's fingers against the electrodes, an electronic circuit (15) located within the housing (14) which generates an electric current from one electrode to the other through the player's fingers and a voltage signal correlatable with the change in resistance resulting from the player's response to the questions, and an indicator (28, 29) which generates a signal indicative of the changes in resistance.

Abstract translation: 电子派对游戏包括用于显示要向玩家提出的问题的显示卡（11a，11b）和用于监视玩家对问题的心理生理反应的响应监视器（10）。 响应监视器（10）包括尺寸适于安装在回答问题的玩家的手掌中的壳体（14），壳体具有外形顶部表面（16），其形状用于接收玩者的两个延长的手指，以及一对 延伸穿过顶表面的电极（26,27），每个电极定位成在其顶端接触延伸的指状物之一，偏置装置（24）可操作地联接到壳体的外部部分，用于选择性地偏置玩家的手指 位于壳体（14）内的电子电路（15），其通过玩家的手指从一个电极到另一个电极产生电流，以及与玩家对问题的响应导致的电阻变化相关的电压信号 ，以及产生指示电阻变化的信号的指示器（28,29）。