公开(公告)号：GEP20207186B

公开(公告)日：2020-11-25

申请号：GEAP2017014984

申请日：2017-06-26

Applicant: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE ,  THE UNIVERSITY OF CONNECTICUT

Inventor： THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE ,  THE UNIVERSITY OF CONNECTICUT

IPC: A61K39/12 ,  C07K14/005

Abstract: An invention relates to African swine fever recombinant virulent strain (ASFV-G) comprising two mutations ∆9GL/∆UK in polypeptides, vaccine compositions comprising said virus, and usage therefor pig protection from African swine fever virus Georgia 2007 isolate. s

公开(公告)号：WO1998022387A1

公开(公告)日：1998-05-28

申请号：PCT/US1997021141

申请日：1997-11-18

Applicant: THE UNIVERSITY OF CONNECTICUT ,  RUTGERS THE STATE UNIVERSITY OF NEW JERSEY

Inventor： THE UNIVERSITY OF CONNECTICUT ,  RUTGERS THE STATE UNIVERSITY OF NEW JERSEY ,  XIAO, Tongsan, D. ,  STRUTT, Peter, R. ,  KEAR, Bernard, H. ,  CHEN, Huimin ,  WANG, Donald, M.

IPC: C01B13/34

CPC classification number: B82Y30/00 ,  C01B13/34 ,  C01G1/02 ,  C01G3/02 ,  C01G9/02 ,  C01G23/04 ,  C01G25/02 ,  C01G31/02 ,  C01G39/02 ,  C01G41/02 ,  C01G45/00 ,  C01G45/02 ,  C01G49/02 ,  C01G51/04 ,  C01G53/00 ,  C01G53/04 ,  C01P2002/01 ,  C01P2002/52 ,  C01P2002/72 ,  C01P2002/77 ,  C01P2004/03 ,  C01P2004/04 ,  C01P2004/10 ,  C01P2004/12 ,  C01P2004/16 ,  C01P2004/32 ,  C01P2004/50 ,  C01P2004/61 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2006/11 ,  C01P2006/12 ,  C01P2006/14 ,  C01P2006/16 ,  C01P2006/17 ,  C01P2006/20 ,  C04B35/62231 ,  Y10T428/249924 ,  Y10T428/2913 ,  Y10T428/2927 ,  Y10T428/298 ,  Y10T428/2982

Abstract: A chemical synthetic route for nanostructured materials that is scalable to large volume production, comprising spray atomization of a reactant solution into a precursor solution to form a nanostructured oxide or hydroxide precipitate. The precipitate is then heat-treated followed by sonication, or sonicated followed by heat treatment. This route yields nanostructured doped and undoped nickel hydroxide, manganese dioxide, and ytrria-stabilized zirconia. Unusual morphological superstructures may be obtained, including well-defined cylinders or nanorods, as well as a novel structure in nickel hydroxide and manganese dioxide, comprising assemblies of nanostructured fibers, assemblies of nanostructured fibers and agglomerates of nanostructured particles, and assemblies of nanostructured fibers and nanostructured particles. These novel structures have high percolation rates and high densities of active sites, rendering them particularly suitable for catalytic applications.

Abstract translation: 用于可扩展到大批量生产的纳米结构材料的化学合成路线，包括将反应物溶液喷雾雾化成前体溶液以形成纳米结构氧化物或氢氧化物沉淀。 然后将沉淀物进行热处理，然后进行超声处理，或超声处理，随后进行热处理。 该路线产生纳米结构掺杂和未掺杂的氢氧化镍，二氧化锰和氧化钇稳定的氧化锆。 可以获得不寻常的形态上层结构，包括明确定义的圆柱体或纳米棒，以及在氢氧化镍和二氧化锰中的新结构，包括纳米结构纤维的组件，纳米结构纤维的组件和纳米结构化颗粒的附聚物，以及纳米结构纤维的组件 纳米结构粒子。 这些新型结构具有高渗滤速率和高密度的活性位点，使其特别适用于催化应用。

公开(公告)号：WO1996020410A1

公开(公告)日：1996-07-04

申请号：PCT/US1995016812

申请日：1995-12-22

Applicant: THE UNIVERSITY OF CONNECTICUT

Inventor： THE UNIVERSITY OF CONNECTICUT ,  MASHIKIAN, Matthew, S. ,  DU, Zhifang ,  MASHIKIAN, Paul, S.

IPC: G01R31/28

CPC classification number: G01R31/083

Abstract: A method and apparatus for detecting the location of an incipient fault in an insulated power system which includes the application of an excitation voltage to a power line to produce a partial discharge signal pulse at a fault (34) along the power line. The surface of the power line is scanned with two axially spaced sensors (30, 32) disposed adjacent the surface of the power line, the sensors detecting the partial discharge signal pulse to produce discrete detected pulses. These detected pulses are combined to produce a combined signal having an amplitude level which reaches an extreme value when the fault is located equidistantly between the sensors. The sensors are moved along the power line until the fault is located substantially equidistantly between the sensors as indicated by the extreme amplitude level of the combined signal.

Abstract translation: 一种用于检测绝缘电力系统中的初始故障位置的方法和装置，包括向电力线施加激励电压以在沿着电力线的故障（34）产生局部放电信号脉冲。 电力线的表面用邻近电力线表面设置的两个轴向间隔的传感器（30,32）进行扫描，传感器检测局部放电信号脉冲以产生离散的检测脉冲。 这些检测到的脉冲被组合以产生具有当故障等距离地位于传感器之间时达到极值的振幅电平的组合信号。 传感器沿着电力线移动，直到故障基本上等距离地位于传感器之间，如组合信号的极端幅度电平所示。

公开(公告)号：WO1994011389A1

公开(公告)日：1994-05-26

申请号：PCT/US1993010924

申请日：1993-11-10

Applicant: THE UNIVERSITY OF CONNECTICUT

Inventor： THE UNIVERSITY OF CONNECTICUT ,  ELGEBALY, Salwa, A.

IPC: C07K03/12

CPC classification number: C07K14/52 ,  A61K38/00 ,  C07K16/24

Abstract: A chemotactic factor released from tissue under ischemic conditions represents the initial signal that recruits neutrophils to the tissue. As released, the factor exists as a positively charged protein complex consisting of a low molecular weight active peptide factor that carries a neutral or negative charge and a weakly associated high molecular weight protein. The tissue derived complex exhibits a molecular weight of about 100,000-300,000 daltons and the factor is obtained therefrom by concentration and purification. The peptide factor is non-immune cell derived and non-serum derived and exhibits a molecular weight of approximately 3,000 daltons.

Abstract translation: 在局部缺血条件下从组织释放的趋化因子表示将嗜中性粒细胞募集到组织的初始信号。 释放后，该因子作为带正电荷的蛋白质复合体存在，其由携带中性或负电荷和弱相关高分子量蛋白质的低分子量活性肽因子组成。 组织衍生的复合物表现出约100,000-300,000道尔顿的分子量，并且通过浓缩和纯化从而获得该因子。 肽因子是非免疫细胞来源的，非血清来源的，分子量约为3,000道尔顿。

公开(公告)号：WO1998005436A1

公开(公告)日：1998-02-12

申请号：PCT/US1997013627

申请日：1997-08-04

Applicant: THE UNIVERSITY OF CONNECTICUT

Inventor： THE UNIVERSITY OF CONNECTICUT ,  BELL, James, P. ,  ZHANG, Xu ,  AGARWAL, Rajat

IPC: B05D01/18

CPC classification number: B05D7/142 ,  C09D4/00 ,  H05K3/0079 ,  H05K3/3452 ,  Y10T428/31692 ,  Y10T428/31699 ,  C08F220/00

Abstract: A composition and method are described for providing conformal protective or decorative polymer coatings on metals such as aluminum, copper, iron, steel, zinc, and this by dip autopolymerization. In accordance with the present invention, an acidic solution of organic monomer undergoes autopolymerization upon contact with a metal substrate, thereby forming a polymeric coating on the substrate. The method comprises providing the acidic monomer solution, dipping the metal substrate to be coated for a prescribed period of time depending on the thickness of the coating desired, and then removing the substrate from the solution. Importantly, the polymerization requires no application of external driving force, such as thermal or electrical energy. The coatings thus formed are up to 50 microns thick, and conform to the shape of the substrate. These coatings further have uniform thickness, and excellent thermal stability and protective properties. In one preferred embodiment of the present invention, the composition comprises an acidic solution of an organic electron acceptor monomer that undergoes autopolymerization in contact with a metal substrate, thereby forming a polymeric coating on the substrate. In another preferred embodiment of the present invention, the composition comprises an acidic solution of an organic electron acceptor monomer and an organic electron donor monomer that undergo autopolymerization in contact with a metal substrate, thereby forming a polymeric coating on the substrate. Metal-polymer composites are also described.

Abstract translation: 描述了一种组合物和方法，用于在诸如铝，铜，铁，钢，锌的金属上提供保形或装饰聚合物涂层，并且通过浸渍自聚合方法。 根据本发明，有机单体的酸性溶液在与金属基材接触时经历自聚合，从而在基材上形成聚合物涂层。 该方法包括提供酸性单体溶液，根据所需涂层的厚度将待涂覆的金属基材浸渍规定的时间，然后从溶液中除去基材。 重要的是，聚合不需要外部驱动力，例如热或电能。 如此形成的涂层最多达50微米厚，并且符合基材的形状。 这些涂层还具有均匀的厚度，以及优异的热稳定性和保护性能。 在本发明的一个优选实施方案中，组合物包含与金属基材接触的自聚合的有机电子受体单体的酸性溶液，从而在基材上形成聚合物涂层。 在本发明的另一个优选实施方案中，组合物包含有机电子受体单体和有机电子供体单体的酸性溶液，其经历与金属基材接触的自聚合，从而在基材上形成聚合物涂层。 还描述了金属 - 聚合物复合材料。

公开(公告)号：WO1991017761A1

公开(公告)日：1991-11-28

申请号：PCT/US1991003291

申请日：1991-05-10

Applicant: THE UNIVERSITY OF CONNECTICUT ,  WU, George, Y. ,  WU, Catherine, H.

Inventor： THE UNIVERSITY OF CONNECTICUT

IPC: A61K37/02

CPC classification number: B82Y5/00 ,  A61K47/67 ,  A61K47/6895

Abstract: A method of targeted rescue of cells from the effect of a chemotherapeutic cytotoxin is disclosed. A cytotoxin directed against diseased cells is administered with an antagonist-conjugate targetable to normal cells. The antagonist-conjugate is made up of an antagonist of the cytotoxin complexed with a cell-specific binding agent which specifically binds to a cellular surface component present on normal, but not diseased cells. The cellular surface component is typically a surface receptor of the cell which mediates endocytosis. The antagonist-conjugate is specifically taken up by normal cells to provide protection from the toxic effects of the cytotoxin. Diseased cells which lack the surface receptor do not take up effective amounts of the antagonist and consequently are unprotected.

Abstract translation: 公开了一种从化学治疗性细胞毒素的作用靶向拯救细胞的方法。 给予针对病变细胞的细胞毒素与可靶向正常细胞的拮抗剂缀合物一起施用。 拮抗剂缀合物由与细胞特异性结合剂复合的细胞毒素的拮抗剂组成，其特异性结合存在于正常但未患病细胞的细胞表面成分。 细胞表面组分通常是介导细胞内吞作用的细胞的表面受体。 拮抗剂 - 缀合物被正常细胞特异性摄取以提供免受细胞毒素毒性作用的保护。 缺乏表面受体的疾病细胞不占用有效量的拮抗剂，因此不受保护。

公开(公告)号：WO1991005360A1

公开(公告)日：1991-04-18

申请号：PCT/US1990005479

申请日：1990-09-26

Applicant: THE UNIVERSITY OF CONNECTICUT

Inventor： THE UNIVERSITY OF CONNECTICUT ,  NUDELMAN, Sol ,  BUCHROEDER, Richard, A.

IPC: G01J03/28

CPC classification number: G01J3/2823 ,  A61B3/145 ,  G01J2003/2826 ,  G01J2003/2833

Abstract: A video pixel spectrometer system employs an image aquisition device (12) and a spectrometer (14) to provide a video display of the spectral characteristics of an image sector for a series of discrete positions of the image sector. The output from the spectrometer (14) is converted to digital data and processed for displaying various video displays (D1, D2, D3, D4 and D5) of the spectral characteristics. Cameras (24, 26 and 28) are also employed to acquire images for processing of various physical features and to aid in positioning the input image.

Abstract translation: 视频像素光谱仪系统采用图像采集装置（12）和光谱仪（14）来为图像扇区的一系列离散位置提供图像扇区的光谱特性的视频显示。 光谱仪（14）的输出被转换为数字数据，并被处理以显示光谱特性的各种视频显示（D1，D2，D3，D4和D5）。 摄像机（24,26和28）也用于获取用于处理各种物理特征的图像并且有助于定位输入图像。

公开(公告)号：WO1990001900A1

公开(公告)日：1990-03-08

申请号：PCT/US1989003545

申请日：1989-08-17

Applicant: THE UNIVERSITY OF CONNECTICUT

Inventor： THE UNIVERSITY OF CONNECTICUT ,  WU, George, Y. ,  WU, Catherine, H.

IPC: A61B05/05

CPC classification number: G01R33/5601 ,  A61K49/085 ,  A61K49/14 ,  A61K51/0491 ,  A61K51/088

Abstract: Enhanced magnetic resonance imaging contrast is provided by targeting paramagnetic material specifically to selected mammalian cell types. A carrier system for the paramagnetic material utilizes receptor mediated endocytosis to endow cell specificity and is formed by complexing the paramagnetic material to a glycoprotein-chelator conjugate. The conjugate is formed by bonding receptor-specific ligands to chelating agents through covalent bonding. The carrier not only exhibits a high degree of cell spcificity but also provides significant accumulation of the paramagnetic material within the cell to contribute to the improved enhancement of the magnetic resonance contrast.

Abstract translation: 通过将特定的顺磁材料靶向选定的哺乳动物细胞类型来提供增强的磁共振成像对比度。 顺磁材料的载体系统利用受体介导的内吞来赋予细胞特异性，并通过使顺磁性材料与糖蛋白 - 螯合剂缀合物络合而形成。 通过共价键将受体特异性配体与螯合剂结合形成缀合物。 载体不仅表现出高度的细胞特异性，而且在细胞内提供顺磁材料的显着积累，有助于改善磁共振对比度的增强。

公开(公告)号：WO1989011252A1

公开(公告)日：1989-11-30

申请号：PCT/US1989002322

申请日：1989-05-26

Applicant: THE UNIVERSITY OF CONNECTICUT ,  NUDELMAN, Sol ,  OUIMETTE, Donald, R.

Inventor： THE UNIVERSITY OF CONNECTICUT

IPC: A61B17/36

CPC classification number: H01L31/02024 ,  A61B1/0008 ,  A61B1/00172 ,  A61B1/00193 ,  A61B1/042 ,  A61B18/24 ,  A61B2018/20351 ,  G02B6/4296 ,  G02B23/2469 ,  G02B23/26

Abstract: An image acquisition system employs spaced lateral effect diodes for acquiring signals which are processed to generate signals indicative of a three dimensional image of an object. An endoscope (50) is adapted for operation in association with an optical scanner (12) which generates a beam of radiation tracing out a raster (62). The endoscope (50) employs at least one optical channel comprising a bundle of coherent flexible optical fibers (52). Elemental photodetectors which may be mounted at either the distal end of the endoscope probe (50) or the proximal end of the endoscope probe (50) are employed for sensing reflected radiation and generating a video signal. The optical channel may also be employed for transmission of a therapy beam. The endoscope (50) is capable of obtaining multi-spectral and multi-dimensional images of the tissue under examination.

Abstract translation: 图像采集系统采用间隔的横向效应二极管来获取被处理以产生指示对象的三维图像的信号的信号。 内窥镜（50）适于与产生光栅跟踪光栅（62）的光学扫描器（12）相关联地操作。 内窥镜（50）采用至少一个包括一束相干柔性光纤（52）的光学通道。 可以安装在内窥镜探针（50）的远端或内窥镜探针（50）的近端的元件光电检测器用于感测反射的辐射并产生视频信号。 光通道也可以用于治疗束的传输。 内窥镜（50）能够获得正在检查的组织的多光谱和多维图像。

公开(公告)号：WO1996015666A1

公开(公告)日：1996-05-30

申请号：PCT/US1995014335

申请日：1995-11-06

Applicant: THE UNIVERSITY OF CONNECTICUT

Inventor： THE UNIVERSITY OF CONNECTICUT ,  VINOPAL, Robert, T. ,  NELSON, John, D., Jr. ,  GLYNN, Michael, W. ,  COUGHLIN, Robert, W. ,  VIETH, Robert, F. ,  GEIGER, Jon, R.

IPC: A01N25/00

CPC classification number: A01N43/40 ,  A01N37/44 ,  A01N37/40 ,  A01N37/36 ,  A01N37/06 ,  A01N37/02 ,  A01N2300/00

Abstract: Disclosed herein is an antimicrobial composition characterized by synergistic antibacterial and antifungal efficacy and comprising a pyrithione salt or pyrithione acid, and at least one compound selected from the group consisting of benzyl and lower alkyl esters of para-hydroxybenzoic acid, salts thereof, carboxylic acids, salts thereof, and combinations thereof. Also disclosed is a method of imparting antimicrobial activity to a composition comprising water or an organic solvent which comprises adding thereto an antimicrobially effective amount of the above-described antimicrobial composition.

Abstract translation: 本文公开了一种抗微生物组合物，其特征在于具有协同抗菌和抗真菌功效并且包含吡啶硫酮盐或吡啶硫酮酸，和至少一种选自对羟基苯甲酸的苄基和低级烷基酯，其盐，羧酸， 其盐，及其组合。 还公开了对包含水或有机溶剂的组合物赋予抗微生物活性的方法，其包括向其中加入抗微生物量的上述抗微生物组合物。