公开(公告)号：WO1995004498A1

公开(公告)日：1995-02-16

申请号：PCT/US1994008953

申请日：1994-08-09

Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY ,  PELC, Norbert, J.

IPC: A61B05/055

CPC classification number: G01R33/56308 ,  G01R33/56316

Abstract: Motion of a deformable region (85) within an object is tracked using phase contrast magnetic resonance imaging measurements by defining the region (85) with a plurality of vertices (A, B, C, D), obtaining magnetic resonance signals representative of at least one velocity component from each of the vertices (A, B, C, D) at a plurality of time frames, and tracking motion of the region (85) based on movement of the plurality of vertices (A, B, C, D). The region can be two-dimensional such as a polygon and ellipse or three-dimensional such as a polyhedron. The deformation can be homogeneous or non-homogeneous in which case the velocity component is defined as a polynomial of at least second order.

Abstract translation: 通过使用多个顶点（A，B，C，D）定义区域（85），使用相差磁共振成像测量来跟踪对象内的可变形区域（85）的运动，获得代表至少 根据多个顶点（A，B，C，D）的移动，跟踪多个顶点（A，B，C，D）中的每一个顶点（A，B，C，D） 。 该区域可以是二维的，例如多边形和椭圆形或三维的，例如多面体。 变形可以是均匀的或非均匀的，在这种情况下，速度分量被定义为至少二阶的多项式。

公开(公告)号：WO1995002361A1

公开(公告)日：1995-01-26

申请号：PCT/US1994007888

申请日：1994-07-14

Applicant: ZIMMER, Stevan, D. ,  HOVLAND, Claire, T.

IPC: A61B05/055

CPC classification number: G01R33/5673 ,  A61B5/0263 ,  A61B5/7285 ,  A61B8/06 ,  G01R33/28 ,  G01R33/5635

Abstract: This is an apparatus and method for monitoring blood flow for use in triggering an MR procedure. A magnetic resonance (MR) device (52) is arranged for conducting a predetermined MR procedure on a predetermined body portion of an examined body, and the MR device (52) produces a strong static magnetic field. A Doppler ultrasound probe (12) for providing blood flow velocity information in the strong static magnetic field is arranged to sense blood flow in a vessel (14, 16, 18) in the examined body. The blood flow velocity information is monitored and analyzed (50, 51) for determining when to trigger the desired MR procedure.

Abstract translation: 这是用于监测用于触发MR程序的血流的装置和方法。 磁共振（MR）装置（52）布置成用于在被检体的预定身体部分上进行预定的MR程序，并且MR装置（52）产生强静态磁场。 用于在强静态磁场中提供血流速度信息的多普勒超声探头（12）被布置成感测被检体内的血管（14,16,18）中的血流。 监测和分析血流速度信息（50,51）以确定何时触发所需MR程序。

公开(公告)号：WO1995001124A1

公开(公告)日：1995-01-12

申请号：PCT/US1994007344

申请日：1994-06-29

Applicant: MALLINCKRODT MEDICAL, INC.

Inventor： MALLINCKRODT MEDICAL, INC. ,  DUNN, T., Jeffrey ,  MOORE, Dennis, A. ,  PERIASAMY, Muthunadar, P. ,  ROGIC, Milorad, M. ,  WALLACE, Rebecca, A. ,  WHITE, David, H. ,  WOULFE, Steven, R.

IPC: A61B05/055

CPC classification number: C07C229/76 ,  A61K49/06 ,  C07C59/125 ,  C07C229/16 ,  C07C237/08 ,  C07F5/003 ,  Y10S514/836 ,  Y10T436/24

Abstract: The present invention provides new and structually diverse compositions for diagnostic imaging comprising compounds of general formula (I), wherein A is N or CR1; D, E, and F are independently O, -O(CH2)2O-, O(CH2)3O-, or NR5; X is CO2H, PO3H2, SO3H, or CONHOH; g, h, i, j, k, and m are an integer from 1 to 6 and R1 is as described in the specification.

Abstract translation: 本发明提供用于诊断成像的新的和结构不同的组合物，其包含通式（I）的化合物，其中A为N或CR 1; D，E和F独立地为O，-O（CH 2）2 O-，O（CH 2）3 O-或NR 5; X是CO 2 H，PO 3 H 2，SO 3 H或CONHOH; g，h，i，j，k和m为1〜6的整数，R1如说明书所述。

公开(公告)号：WO1994023649A1

公开(公告)日：1994-10-27

申请号：PCT/US1994004015

申请日：1994-04-12

Applicant: MALLINCKRODT MEDICAL, INC.

Inventor： MALLINCKRODT MEDICAL, INC. ,  DEUTSCH, Edward, A. ,  DEUTSCH, Karen, F. ,  NOSCO, Dennis, L. ,  RALSTON, William, H. ,  WHITE, David, H. ,  WILKING, Janet, B. ,  WOLFANGEL, Robert, G. ,  WOULFE, Steven, R.

IPC: A61B05/055

CPC classification number: A61K51/1241 ,  A61B90/39 ,  A61B2090/3925 ,  A61B2090/3954 ,  A61K47/6923 ,  A61K49/0414 ,  A61K49/1818 ,  A61K49/1842 ,  A61K49/1878 ,  A61K49/1881 ,  A61K49/225 ,  G01R33/281 ,  Y10S977/722 ,  Y10S977/881 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93 ,  Y10T436/24

Abstract: Treated calcium/oxyanion-containing particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, or tissue disease states is obtained. Depending on the diagnostic imaging technique, calcium/oxyanion-containing particles are treated to be paramagnetic, radiopaque, or echogenic. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described particles and then performing the medical diagnostic procedure.

Abstract translation: 公开了用于增强医学诊断成像例如磁共振成像（“MRI”），磁共振光谱（“MRS”），磁共振光谱成像（“MRSI”），X射线诊断成像， 和超声成像。 公开了新颖的涂层和制造技术来控制颗粒尺寸和颗粒聚集，从而获得用于肝脏，脾脏或组织疾病状态的器官特异性成像的组合物。 根据诊断成像技术，含钙/含氧阴离子的颗粒被处理为顺磁性，不透射线的或回声的。 还公开了执行医学诊断程序的诊断组合物和方法，其涉及向温血动物施用诊断有效量的上述颗粒，然后进行医学诊断程序。

公开(公告)号：WO1994022369A1

公开(公告)日：1994-10-13

申请号：PCT/US1994002556

申请日：1994-03-16

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  RUBINSKY, Boris ,  GILBERT, John ,  WONG, Sam ,  ROOS, Mark ,  PEASE, Grant

IPC: A61B05/055

CPC classification number: A61B18/02 ,  A61B90/10 ,  A61B2018/0262 ,  A61B2090/374 ,  G01R33/28 ,  G01R33/56308

Abstract: Methods and apparatus for magnetic resonance imaging (MRI) assisted cryosurgery. Optimal probe placements and cooling parameters are calculated prior to cryosurgery using MRI data. An MRI compatible probe (370) and a stereotactic probe positioning device (300) are provided. The resolution of the MR images is enhanced by mounting a radio frequency MR coil on the intracorporeal end of a cryoprobe. During cryosurgery, the temperature distribution in the frozen region is determined by solving the heat equation for the known boundary conditions. The temperature distribution in the unfrozen region is determined by T1 measurements. The process of freezing is controlled using information from the solution of the energy equation and temperature measurements in the unfrozen region. The extent of tissue damage may be ascertained using a special coil set on the cryoprobe.

Abstract translation: 磁共振成像（MRI）辅助冷冻手术的方法和装置。 在使用MRI数据进行冷冻手术之前计算最佳探针放置和冷却参数。 提供MRI兼容探针（370）和立体定向探针定位装置（300）。 通过将射频MR线圈安装在冷冻探针的体内末端来增强MR图像的分辨率。 在冷冻手术中，通过求解已知边界条件的热方程来确定冻结区域的温度分布。 未冷冻区域的温度分布由T1测量确定。 使用来自解冻区域的能量方程和温度测量的解的信息来控制冷冻过程。 可以使用冷冻探针上的专用线圈来确定组织损伤的程度。

公开(公告)号：WO1992022243A1

公开(公告)日：1992-12-23

申请号：PCT/US1992004858

申请日：1992-06-03

Applicant: HARDY, Tyrone, L.

Inventor： BRYNILDSON, Laura, D.

IPC: A61B05/055

CPC classification number: G06T17/00

Abstract: Method and apparatus for archiving and simultaneous display of brain scan images and a plurality of brain maps. The brain maps are proportioned to the individual brain of the scan images by a three-dimensional alignment process (504). Two-dimensional and three-dimensional displays are supported.

Abstract translation: 用于归档和同时显示脑扫描图像和多个脑图的方法和装置。 通过三维对准过程，脑图与扫描图像的个体脑成正比（504）。 支持二维和三维显示。

公开(公告)号：WO1992001419A1

公开(公告)日：1992-02-06

申请号：PCT/US1991005182

申请日：1991-07-23

Applicant: THE BETH ISRAEL HOSPITAL ASSOCIATION

Inventor： THE BETH ISRAEL HOSPITAL ASSOCIATION ,  FOSSEL, Eric, T.

IPC: A61B05/055

CPC classification number: A61K49/06 ,  G01R33/465

Abstract: A technique and an apparatus are disclosed for the detection of cancer using nuclear magnetic resonance (NMR). Specifically, NMR parameters for protons of lipid methyl and/or methylene groups are determined and compared against a corresponding value for healthy patients. Suppression of the water proton signal is employed where necessary in order to obtain a suitable spectrum for the non-water component protons. In the event that a positive reading is obtained, the level of plasma triglycerides is determined and if it is high, the patient's bodily fluid sample is further subjected to second proton nuclear magnetic spectroscopy. The area or the intensity of the portion correlating to 2.0 and 2.8 ppm of the resonance line generated in the second NMR is measured which discriminates between true and false positive results from the proton NMR reading and determines the presence or absence of cancer in the patient.

Abstract translation: 公开了使用核磁共振（NMR）检测癌症的技术和装置。 具体地，确定脂质甲基和/或亚甲基的质子的NMR参数，并将其与健康患者的相应值进行比较。 为了获得非水组分质子的合适谱，必要时采用水质子信号的抑制。 在获得正读数的情况下，确定血浆甘油三酯的水平，如果高，则患者的体液样品进一步进行第二质子核磁光谱。 测量与第二次NMR中产生的共振线的2.0和2.8ppm相关的部分的面积或强度，其区分来自质子NMR读数的真实和假阳性结果，并确定患者中是否存在癌症。