公开(公告)号：WO1994022369A1

公开(公告)日：1994-10-13

申请号：PCT/US1994002556

申请日：1994-03-16

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  RUBINSKY, Boris ,  GILBERT, John ,  WONG, Sam ,  ROOS, Mark ,  PEASE, Grant

IPC: A61B05/055

CPC classification number: A61B18/02 ,  A61B90/10 ,  A61B2018/0262 ,  A61B2090/374 ,  G01R33/28 ,  G01R33/56308

Abstract: Methods and apparatus for magnetic resonance imaging (MRI) assisted cryosurgery. Optimal probe placements and cooling parameters are calculated prior to cryosurgery using MRI data. An MRI compatible probe (370) and a stereotactic probe positioning device (300) are provided. The resolution of the MR images is enhanced by mounting a radio frequency MR coil on the intracorporeal end of a cryoprobe. During cryosurgery, the temperature distribution in the frozen region is determined by solving the heat equation for the known boundary conditions. The temperature distribution in the unfrozen region is determined by T1 measurements. The process of freezing is controlled using information from the solution of the energy equation and temperature measurements in the unfrozen region. The extent of tissue damage may be ascertained using a special coil set on the cryoprobe.

Abstract translation: 磁共振成像（MRI）辅助冷冻手术的方法和装置。 在使用MRI数据进行冷冻手术之前计算最佳探针放置和冷却参数。 提供MRI兼容探针（370）和立体定向探针定位装置（300）。 通过将射频MR线圈安装在冷冻探针的体内末端来增强MR图像的分辨率。 在冷冻手术中，通过求解已知边界条件的热方程来确定冻结区域的温度分布。 未冷冻区域的温度分布由T1测量确定。 使用来自解冻区域的能量方程和温度测量的解的信息来控制冷冻过程。 可以使用冷冻探针上的专用线圈来确定组织损伤的程度。