公开(公告)号：US12138479B2

公开(公告)日：2024-11-12

申请号：US17597509

申请日：2020-07-13

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Weiguo Lu ,  Xuejun Gu ,  Mingli Chen ,  Xun Jia ,  Steve Bin Jiang

IPC: A61N5/10

Abstract: The present disclosure is directed towards a treatment planning system for use in a stereotactic radiotherapy system. In particular, the disclosed systems and methods may be used for generating a treatment plan and/or verifying an existing treatment plan. Moreover, the disclosed systems and methods may be suitable for use in a clinical setting. A method for verifying a treatment plan of a stereotactic radiotherapy device may include the steps of receiving a treatment plan, generating a second treatment plan by applying a modified monte-carlo method to regions of interest in the treatment plan, and identifying discrepancies between the received treatment plan and the generated second treatment plan.

公开(公告)号：US12134609B2

公开(公告)日：2024-11-05

申请号：US18334325

申请日：2023-06-13

Applicant: IMMUNESENSOR THERAPEUTICS, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jian Qiu ,  Qi Wei ,  Matt Tschantz ,  Heping Shi ,  Youtong Wu ,  Huiling Tan ,  Lijun Sun ,  Chuo Chen ,  Zhijian Chen

IPC: C07D401/14 ,  C07D215/38 ,  C07D215/42 ,  C07D215/46 ,  C07D401/04 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/08 ,  C07D491/048 ,  C07F9/6503 ,  C07F9/6506

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US20240344084A1

公开(公告)日：2024-10-17

申请号：US18603950

申请日：2024-03-13

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Berge A. MINASSIAN ,  Emrah GUMUSGOZ

IPC: C12N15/86 ,  C12N7/00

CPC classification number: C12N15/86 ,  C12N7/00 ,  C12N2750/14143 ,  C12N2750/14151

Abstract: The present disclosure provides methods and compositions for the treatment of diseases and genetic disorders linked to CSTB loss and/or misfunction. The methods and compositions of the present disclosure include rAAV vectors and rAAV viral vectors comprising transgene nucleic acid molecules encoding CSTB polypeptides.

公开(公告)号：US12116597B2

公开(公告)日：2024-10-15

申请号：US17824621

申请日：2022-05-25

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Dong H. Kim ,  Yanning Rui ,  Zhen Xu ,  John Hagan

IPC: C12N5/071 ,  A61B17/12 ,  A61K31/351 ,  A61K31/37 ,  A61K31/404 ,  A61K31/4706 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/517 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/55 ,  A61K38/10 ,  A61P9/00 ,  A61P9/10 ,  C07K14/495

CPC classification number: C12N5/069 ,  A61B17/1215 ,  A61K31/351 ,  A61K31/37 ,  A61K31/404 ,  A61K31/4706 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/517 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/55 ,  A61K38/10 ,  A61P9/00 ,  A61P9/10 ,  C07K14/495 ,  C12N2510/02

Abstract: Disclosed here are uses of autophagy inhibitors for treating a subject at risk of suffering from an aneurysm. The present disclosure demonstrates that autophagy plays a role in THSD1-mediated focal adhesion stability and aneurysm formation and characterizes molecular targets for therapeutic intervention.

公开(公告)号：US20240318198A1

公开(公告)日：2024-09-26

申请号：US18274485

申请日：2022-02-02

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Ryan BUTLER ,  Steven J. GRAY ,  Hye Ri KANG ,  Berge A. MINASSIAN ,  Emrah GUMUSGOZ

IPC: C12N15/86 ,  C12N15/113

CPC classification number: C12N15/86 ,  C12N15/113 ,  C12N2310/531 ,  C12N2750/14143

Abstract: The present disclosure provides methods and compositions for the treatment of Angelman Syndrome The methods and compositions of the present disclosure comprise isolated nucleic acid molecules, rAAV vectors and rAAV viral vectors comprising polynucleotide sequences encoding for short hairpin RNA (shRNA) molecules directed against UBE3A-ATS.

公开(公告)号：US12091387B2

公开(公告)日：2024-09-17

申请号：US18353718

申请日：2023-07-17

Applicant: IMMUNESENSOR THERAPEUTICS, INC. ,  THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Qi Wei ,  Heping Shi ,  Matt Tschantz ,  Jian Qiu ,  Youtong Wu ,  Huiling Tan ,  Lijun Sun ,  Chuo Chen ,  Zhijian Chen

IPC: C07D215/12 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

CPC classification number: C07D215/12 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

公开(公告)号：US12084403B2

公开(公告)日：2024-09-10

申请号：US18173413

申请日：2023-02-23

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Kyoji Tsuchikama ,  Yasuaki Anami ,  Chisato Tsuchikama ,  Ningyang Zhang ,  Zhiqiang An

IPC: C07C247/04 ,  A61K31/40 ,  A61K45/06 ,  A61K47/68 ,  A61P35/00 ,  C07D209/20 ,  C07D403/12

CPC classification number: C07C247/04 ,  A61K31/40 ,  A61K47/6889 ,  A61P35/00 ,  C07D209/20 ,  C07D403/12 ,  A61K45/06

Abstract: In one aspect, the present disclosure provides compounds of the formula:




wherein the variables are as defined herein.

In another aspect, the present disclosure provides compounds of the formula:




wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure provides antibody drug conjugates comprising compounds of the present disclosure. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds and anti-body drug conjugates disclosed herein.

公开(公告)号：US12077772B2

公开(公告)日：2024-09-03

申请号：US17092240

申请日：2020-11-07

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Steven J. Gray ,  Frances C. Shaffo

IPC: C12N15/86 ,  A61K9/00 ,  A61K38/17 ,  A61K48/00 ,  C07K14/705 ,  C12N7/00

CPC classification number: C12N15/86 ,  A61K9/0085 ,  A61K38/1787 ,  A61K48/005 ,  A61K48/0083 ,  C07K14/70571 ,  C12N7/00 ,  C12N2750/14143 ,  C12N2800/22 ,  C12N2830/50

Abstract: The present disclosure provides methods and compositions for the treatment of diseases and genetic disorders linked to SLC6A1 loss and/or misfunction. The methods and compositions of the present disclosure comprise rAAV vectors and rAAV viral vectors comprising transgene nucleic acid molecules comprising nucleic acid sequences encoding for a GAT1 polypeptide.

公开(公告)号：US12073541B2

公开(公告)日：2024-08-27

申请号：US17633133

申请日：2020-08-10

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Zbyszek Otwinowski ,  Raquel Bromberg ,  Dominika Borek

IPC: G06T5/80 ,  H01J37/22

CPC classification number: G06T5/80 ,  H01J37/222 ,  G06T2207/10061 ,  H01J2237/223 ,  H01J2237/2826

Abstract: Methods for correcting one or more image aberrations in an electron microscopy image, including cryo-EM images, are provided. The method includes obtaining a plurality of electron microscope (EM) images of an internal reference grid sample having one or more known properties, the plurality of electron microscope images obtained for a plurality of optical conditions and for a plurality of coordinated beam-image shifts. The method may also include, among other features, determining an aberration correction function that predicts aberrations for every point in the imaged area using kernel canonical correlation analysis (KCCA).

公开(公告)号：US20240263385A1

公开(公告)日：2024-08-08

申请号：US18639315

申请日：2024-04-18

Applicant: The Board of Regents of The University of Texas System

Inventor： Mohammed Jasim Uddin ,  Jared Jaksik ,  H. Justin Moore

IPC: D06M11/83 ,  A41D13/11 ,  A41D31/30 ,  D06M16/00 ,  D06M101/06

CPC classification number: D06M11/83 ,  A41D13/1161 ,  A41D13/1192 ,  A41D31/30 ,  D06M16/00 ,  D06M2101/06 ,  D06M2200/00 ,  D06M2200/01 ,  D06M2400/02

Abstract: A method for forming a metallic nanoparticle and semiconductor coated surface, such as the surface of a fiber or other material is provided. The method can include the steps of coating at least one surface of a material, for example a textile material, with a semiconducting layer, and providing metallic nanoparticles on the semiconducting layer. The steps for coating a surface of a material with a semiconducting layer can include forming a titanium dioxide film on the surface of the textile or other material. The steps for depositing and/or providing metallic nanoparticles on the semiconducting layer can include immersing a surface having a semiconductor layer into a metallic nanoparticle precursor solution, drying the semiconductor layer, and exposing the semiconductor layer on the surface to UV radiation. The metallic nanoparticles can include gold and/or silver nanoparticles. Also disclosed are surface treated materials having a semiconductor layer thereon, wherein the semiconductor layer is treated to include metallic nanoparticles. The surface treated materials may comprise surfaces of a textile material, such as fibers. The surface treated materials are anti-microbial and resistant to peeling, as well as non-toxic to biological surfaces, such as skin. Treated fiber materials may be used in garments, masks, and other products that contact the skin, that are free of toxic/rash side effects.