公开(公告)号：WO2009085270A2

公开(公告)日：2009-07-09

申请号：PCT/US2008/014021

申请日：2008-12-22

Applicant: CODA THERAPEUTICS, INC. ,  BECKER, David, L. ,  GREEN, Colin, R. ,  DUFT, Bradford, J.

Inventor： BECKER, David, L. ,  GREEN, Colin, R. ,  DUFT, Bradford, J.

IPC: A61K48/00

CPC classification number: C12N15/113 ,  A61K31/7088 ,  A61K45/06 ,  A61L15/44 ,  A61L26/0066 ,  A61L2300/258 ,  A61L2300/432 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/315 ,  Y02A50/423

Abstract: Treatment of fibrosis and fibrotic diseases, disorders, and conditions, and associated methods, compositions, formulations and articles.

Abstract translation: 纤维化和纤维化疾病，病症和病症以及相关方法，组合物，制剂和制品的治疗。

公开(公告)号：WO2009085268A2

公开(公告)日：2009-07-09

申请号：PCT/US2008/014019

申请日：2008-12-22

Applicant: CODA THERAPEUTICS, INC. ,  DUFT, Bradford, J.

Inventor： DUFT, Bradford, J.

IPC: A61K48/00

CPC classification number: C12N15/1138 ,  A61K38/177 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/258 ,  C12N2310/11 ,  A61K2300/00

Abstract: Compositions, articles, devices and methods for the treatment and/or prevention of adhesions in humans and non-human animals.

Abstract translation: 用于治疗和/或预防人和非人动物粘连的组合物，制品，装置和方法。

公开(公告)号：WO2008060622A3

公开(公告)日：2008-05-22

申请号：PCT/US2007/024085

申请日：2007-11-15

Applicant: CODA THERAPEUTICS, INC. ,  GREEN, Colin, R. ,  DUFT, Bradford, J. ,  BECKER, David, L.

Inventor： GREEN, Colin, R. ,  DUFT, Bradford, J. ,  BECKER, David, L.

IPC: A61K38/18 ,  A61K31/711

Abstract: Methods and compositions comprising combinations of one or more anti-connexin agents and one or more other agents useful for the promotion and/or improvement of wound healing and/or tissue repair.

公开(公告)号：WO2015130840A3

公开(公告)日：2015-11-05

申请号：PCT/US2015017595

申请日：2015-02-25

Applicant: CODA THERAPEUTICS INC

Inventor： PHILLIPS ANTHONY ,  BANNAN SCOTT ,  MATSUOKA GROVE ,  DUFT BRADFORD ,  EISENBUD DAVID

IPC: A61K48/00 ,  A61K38/00 ,  A61P17/02

CPC classification number: C12N15/113 ,  C12N2310/11

Abstract: Connexin protein modulation methods and compositions are provided for the healing of resistant lesions, including lesions on subjects with multiple venous leg ulcers or multiple diabetic foot ulcers, and other responder subjects. Also provided are kits and articles of manufacture comprising a connexin protein modulating agent, for example, a connexin 43 modulating agent for use in the healing of resistant lesions.

Abstract translation: 提供连接蛋白调节方法和组合物用于治愈耐药性病变，包括具有多个静脉性腿溃疡或多发性糖尿病足溃疡的受试者和其他响应者受试者的损伤。 还提供了包含连接蛋白调节剂（例如连接蛋白43调节剂）的试剂盒和制品，用于治愈抵抗性病变。

公开(公告)号：WO2014145342A2

公开(公告)日：2014-09-18

申请号：PCT/US2014/030082

申请日：2014-03-15

Applicant: CODA THERAPEUTICS, INC.

Inventor： PHILLIPS, Anthony ,  EISENBUD, David ,  BANNAN, Scott ,  POOL, David ,  MATSUOKA, Grove ,  SUNDERLAND, Tracey ,  DUFT, Bradford

IPC: H04S5/00

CPC classification number: A61K31/7088 ,  A61B5/0064 ,  A61B5/0077 ,  A61B5/1072 ,  A61B5/1079 ,  A61B5/1109 ,  A61B5/445 ,  A61B5/4839 ,  A61B5/4848 ,  A61B5/7275 ,  A61B2503/40 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/70 ,  A61K31/7105 ,  A61K47/00 ,  A61K47/10 ,  A61K47/38 ,  A61K48/00 ,  C07K14/47 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/30 ,  C12N2320/35

Abstract: This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase.

Abstract translation: 本发明涉及通过施用抗连接蛋白试剂，特别是抗连接蛋白43反义多核苷酸来治疗慢性伤口的改进的方法，用途和试剂盒。 本发明的方法，用途和试剂盒基于令人惊讶且意外的发现，即在预处理阶段期间不增加或减小超过预定量的慢性伤口更适于成功治疗 伤口的大小在预处理阶段期间超出目标范围。

公开(公告)号：WO2009085272A3

公开(公告)日：2010-07-29

申请号：PCT/US2008014023

申请日：2008-12-22

Applicant: CODA THERAPEUTICS INC ,  DUFT BRADFORD J ,  GREEN COLIN R ,  BECKER DAVID L

Inventor： DUFT BRADFORD J ,  GREEN COLIN R ,  BECKER DAVID L

IPC: A61L27/22 ,  A61L27/54 ,  A61L31/04 ,  A61L31/16

CPC classification number: A61K38/08 ,  A61K9/0051 ,  A61K38/10 ,  A61K38/385 ,  A61L17/005 ,  A61L27/54 ,  A61L31/08 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/432 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608

Abstract: Medical devices comprising an anti-connexin agent suitable for introduction into a subject.

Abstract translation: 包含适用于引入受试者的抗连接蛋白药物的医疗装置。

公开(公告)号：WO2009085268A3

公开(公告)日：2009-10-01

申请号：PCT/US2008014019

申请日：2008-12-22

Applicant: CODA THERAPEUTICS INC ,  DUFT BRADFORD J

Inventor： DUFT BRADFORD J

IPC: A61K38/17 ,  A61K9/70 ,  A61L24/00 ,  A61P41/00 ,  C12N15/113

CPC classification number: C12N15/1138 ,  A61K38/177 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/258 ,  C12N2310/11 ,  A61K2300/00

Abstract: Compositions, articles, devices and methods for the treatment and/or prevention of adhesions in humans and non-human animals.

Abstract translation: 用于治疗和/或预防人和非人动物粘连的组合物，制品，装置和方法。

公开(公告)号：WO2009085270A3

公开(公告)日：2009-09-24

申请号：PCT/US2008014021

申请日：2008-12-22

Applicant: CODA THERAPEUTICS INC ,  BECKER DAVID L ,  GREEN COLIN R ,  DUFT BRADFORD J

Inventor： BECKER DAVID L ,  GREEN COLIN R ,  DUFT BRADFORD J

IPC: A61K31/7088 ,  A61L15/00 ,  A61P17/02 ,  A61P43/00 ,  C12N15/113

CPC classification number: C12N15/113 ,  A61K31/7088 ,  A61K45/06 ,  A61L15/44 ,  A61L26/0066 ,  A61L2300/258 ,  A61L2300/432 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/315

Abstract: Treatment of fibrosis and fibrotic diseases, disorders, and conditions, and associated methods, compositions, formulations and articles.

Abstract translation: 纤维化和纤维化疾病，病症和病症以及相关方法，组合物，制剂和制品的治疗。

公开(公告)号：WO2009085271A2

公开(公告)日：2009-07-09

申请号：PCT/US2008014022

申请日：2008-12-22

Applicant: CODA THERAPEUTICS INC ,  DUFT BRADFORD J

Inventor： DUFT BRADFORD J

IPC: A61K48/00 ,  C12N15/113

CPC classification number: A61K38/177 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/186 ,  A61K47/26 ,  A61K47/34 ,  A61K47/38 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2320/31 ,  A61K2300/00

Abstract: Methods, compounds, compositions, kits and articles of manufacture comprising anti-connexin agents for treatment of orthopedic disorders, diseases, or conditions, and improving recoveries and outcomes of orthopedic procedures or surgeries.

Abstract translation: 方法，化合物，组合物，试剂盒和制品，包括用于治疗骨科疾病，疾病或病症的抗连接蛋白剂，以及改善整形外科手术或手术的恢复和结果。

公开(公告)号：WO2009085269A2

公开(公告)日：2009-07-09

申请号：PCT/US2008014020

申请日：2008-12-22

Applicant: CODA THERAPEUTICS INC ,  BECKER DAVID L ,  GREEN COLIN R ,  DUFT BRADFORD J

Inventor： BECKER DAVID L ,  GREEN COLIN R ,  DUFT BRADFORD J

IPC: A61K48/00 ,  C12N15/113

CPC classification number: C12N15/1138 ,  A61K38/177 ,  C12N2310/11 ,  C12N2320/31 ,  A61K2300/00

Abstract: Methods, compounds, compositions, kits and articles of manufacture comprising anti- connexin agents for treatment of orthopedic disorder, disease, or condition, and promoting post-surgical wound-healing.

Abstract translation: 方法，化合物，组合物，试剂盒和制品，其包含用于治疗矫形障碍，疾病或病症的抗连接蛋白药物，以及促进手术后伤口愈合。