公开(公告)号：EP3332801A1

公开(公告)日：2018-06-13

申请号：EP17191973.1

申请日：2009-03-12

Applicant: LOMA LINDA UNIVERSITY

Inventor： LI, Fengchun ,  ESCHER, Alan P.

IPC: A61K39/00

CPC classification number: A61K39/001 ,  A61K2039/53 ,  A61K2039/55561

Abstract: Methods for preventing, delaying the onset of, or treating rejection of an allograft using a DNA vaccine, where the vaccine can comprise a polynucleotide encoding a pro-apoptotic protein, like BAX and/or a polynucleotide encoding an autoantigen or donor antigen, like secreted glutamic acid decarboxylase 55. Administering one of the DNA vaccines to a transplant recipeint, as described herein, can induce a donor specific tolerogenic response.

公开(公告)号：EP3322418A1

公开(公告)日：2018-05-23

申请号：EP16825052.0

申请日：2016-07-12

Applicant: Loma Linda University

Inventor： DUERKSEN-HUGHES, Penelope ,  YUAN, Chung-hsiang ,  FILIPPOVA, Maria ,  KRSTENANSKY, John

IPC: A61K31/437 ,  A61K31/4188 ,  C07D471/04

CPC classification number: A61K31/437 ,  A61K31/4184 ,  A61K31/522 ,  A61K31/555 ,  A61K31/704 ,  A61K33/24 ,  A61K38/19 ,  A61K45/06 ,  A61P35/00 ,  C07D471/04 ,  A61K2300/00

Abstract: Compositions and methods of treatment are provided for preventing cancers caused by high-risk human papilloma viruses (HPV). Cancers amenable to prevention include cervical cancer, head cancers, neck cancers, and oral cancers. The compositions block interaction between HPV 16 E6, one of two major viral oncogenes, and its partners, thereby resensitizing HPV positive cells to apoptosis.

公开(公告)号：EP3154433A2

公开(公告)日：2017-04-19

申请号：EP15809530.7

申请日：2015-06-15

Applicant: Loma Linda University

Inventor： SCHULTE, Reinhard, W. ,  BASHKIROV, Vladimir, A.

IPC: A61B6/03 ,  G01N23/04

CPC classification number: G01N23/046 ,  A61B6/032 ,  A61B6/14 ,  A61B6/4258 ,  A61B6/501 ,  A61B6/502 ,  A61B6/503 ,  A61B6/5205 ,  G01N2223/102 ,  G06T7/0012 ,  G06T11/003 ,  G06T11/006 ,  G06T2207/10028 ,  G06T2207/10081 ,  G06T2207/30016 ,  G06T2207/30036 ,  G06T2207/30048 ,  G06T2207/30061 ,  G06T2207/30068 ,  G06T2207/30084

Abstract: An imaging system can use high-energy electrons at a low dose level to generate 3D computed tomography images and/or 2D radiographic images of living tissue and other objects. In some embodiments, a nozzle directs a source of high-energy electrons to the imaging target, and a detector system detects physical quantities of electrons that interact with the imaging target. In some embodiments, a computer system can calculate estimated paths taken by individual electrons within the imaging target, determine interactions between voxels of a digitized image of the imaging target and individual electrons, and reconstruct a digitized image of the imaging target based at least in part on the determined interactions between individual electrons and voxels. The imaging target can include but is not limited to living tissue, humans, pediatric patients, small animals, and other objects, such as those used in industrial applications.

Abstract translation: 成像系统可以使用低剂量水平的高能电子来生成活体组织和其他物体的3D计算机断层摄影图像和/或2D放射照相图像。 在一些实施例中，喷嘴将高能电子源引导到成像靶，并且检测器系统检测与成像靶相互作用的电子的物理量。 在一些实施例中，计算机系统可以计算成像目标内的各个电子所采取的估计路径，确定成像目标的数字化图像的体素与各个电子之间的相互作用，以及至少部分地重构成像目标的数字化图像 关于个体电子和体素之间确定的相互作用。 成像目标可以包括但不限于生物体组织，人类，儿科患者，小动物和其他物体，例如在工业应用中使用的那些。

公开(公告)号：EP2983598A4

公开(公告)日：2016-11-30

申请号：EP14782807

申请日：2014-04-10

Applicant: FACULTY PHYSICIANS AND SURGEONS OF LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE

Inventor： BALDWIN DALTON DUANE

IPC: A61B17/29 ,  A61B17/34

CPC classification number: A61B17/00234 ,  A61B17/083 ,  A61B17/128 ,  A61B17/1285 ,  A61B17/29 ,  A61B17/2909 ,  A61B17/320016 ,  A61B17/3201 ,  A61B17/3421 ,  A61B18/1477 ,  A61B34/30 ,  A61B90/361 ,  A61B2017/00292 ,  A61B2017/00477 ,  A61B2017/2901 ,  A61B2017/2931 ,  A61B2017/306 ,  A61B2017/3443 ,  A61B2017/3454 ,  A61B2018/00982 ,  A61B2018/1422 ,  A61B2217/007 ,  A61M1/008 ,  A61M1/0086 ,  Y10T29/49826

公开(公告)号：EP2779934B1

公开(公告)日：2016-08-03

申请号：EP12849589.2

申请日：2012-11-17

Applicant: Loma Linda University

Inventor： JARAMILLO, David E.

IPC: A61C5/02 ,  A61C3/08

CPC classification number: A61C5/02 ,  A61C3/00 ,  A61C3/08 ,  A61C5/40 ,  A61C5/50 ,  F04C2270/041

公开(公告)号：EP2538839B1

公开(公告)日：2015-07-08

申请号：EP11748009.5

申请日：2011-02-23

Applicant: Loma Linda University ,  University Of California, Riverside

Inventor： GHOSH, Nirmalya ,  ASHWAL, Stephen ,  OBENAUS, Andre ,  BHANU, Bir

IPC: A61B5/05 ,  G06K9/32 ,  G06T7/00 ,  G06K9/38 ,  G06T7/40

CPC classification number: G06T7/0012 ,  G06K9/3233 ,  G06K9/38 ,  G06T7/11 ,  G06T7/136 ,  G06T7/143 ,  G06T7/155 ,  G06T7/162 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10104 ,  G06T2207/10116 ,  G06T2207/20036 ,  G06T2207/20072 ,  G06T2207/20076 ,  G06T2207/30016 ,  G06T2207/30024 ,  G06T2207/30048 ,  G06T2207/30052 ,  G06T2207/30056 ,  G06T2207/30061 ,  G06T2207/30084 ,  G06T2207/30088

公开(公告)号：EP2489729B1

公开(公告)日：2015-02-25

申请号：EP12159304.0

申请日：2007-09-28

Applicant: LOMA LINDA UNIVERSITY

Inventor： Li, Fengchun ,  Escher, Alan P.

IPC: A61K31/713 ,  C12N15/113 ,  A61P37/06 ,  A61K35/12

CPC classification number: C12N5/0602 ,  A61K31/7088 ,  A61K35/12 ,  A61K39/001 ,  A61K2035/122 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/531

Abstract: Mammalian host cells for use in a cell-mediated transfection process, which contain an RNAi molecule and an expression vector for a pro-apoptotic protein. The method includes inducing apoptotic cell (AC) death in mammalian cells that contain an RNAi molecule capable of down-regulating a chosen target gene. Living cells expressing the target gene are then exposed to the ACs. The ACs are processed by the living cells, and the RNAi molecule in the ACs down-regulates the expression of the target gene in living cells.

公开(公告)号：EP2779934A1

公开(公告)日：2014-09-24

申请号：EP12849589.2

申请日：2012-11-17

Applicant: Loma Linda University ,  Jaramillo, David E.

Inventor： JARAMILLO, David E.

IPC: A61C5/02

CPC classification number: A61C5/02 ,  A61C3/00 ,  A61C3/08 ,  A61C5/40 ,  A61C5/50 ,  F04C2270/041

Abstract: A device for placing, compacting or burnishing root repair materials for root-end surgery to fill root-end cavities during root-end surgery, and specifically for placing and compacting newer root repair materials to fill root-end cavities. A system for placing, compacting or burnishing root repair materials for root-end surgery to fill root-end cavities during root-end surgery, and specifically for placing, compacting or burnishing newer root repair materials. A method for placing, compacting or burnishing root repair materials for root-end surgery to fill root-end cavities during root-end surgery, and specifically for placing, compacting or burnishing root repair newer root repair materials to fill root-end cavities.

Abstract translation: 一种用于根部手术放置，压实或抛光根部修复材料以在根部手术期间填充根部腔的装置，并且具体地用于放置和压实较新的根部修复材料以填充根部腔。 一种用于根部手术放置，压实或抛光根部修复材料以填补根部末端腔的系统，并且专门用于放置，压实或抛光较新的根修复材料。 一种用于根部手术放置，压实或抛光根部修复材料以在根部手术期间填充根部腔的方法，并且专门用于放置，压实或抛光根修复较新的根修复材料以填充根端腔。

公开(公告)号：EP1789227B1

公开(公告)日：2013-07-17

申请号：EP05822313.2

申请日：2005-08-16

Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER

Inventor： DENNEY, Paul, E. ,  EASTMAN, Jay, R. ,  FALLARA, Paul, M. ,  JOSEPH, Andrew, P. ,  PHILLIPS, John, S. ,  PATENA, Michael, N. ,  BURNHAM, Tim ,  COLEMAN, Paul ,  HUANG, Ta-Chieh

IPC: B23K26/10 ,  B23K26/12

CPC classification number: B23K26/032 ,  B23K26/10 ,  B23K26/12 ,  B23K26/123 ,  B23K26/128

公开(公告)号：EP2538839A1

公开(公告)日：2013-01-02

申请号：EP11748009.5

申请日：2011-02-23

Applicant: Loma Linda University Medical Center ,  University Of California, Riverside

Inventor： GHOSH, Nirmalya ,  ASHWAL, Stephen ,  OBENAUS, Andre ,  BHANU, Bir

IPC: A61B5/05

CPC classification number: G06T7/0012 ,  G06K9/3233 ,  G06K9/38 ,  G06T7/11 ,  G06T7/136 ,  G06T7/143 ,  G06T7/155 ,  G06T7/162 ,  G06T2207/10081 ,  G06T2207/10088 ,  G06T2207/10104 ,  G06T2207/10116 ,  G06T2207/20036 ,  G06T2207/20072 ,  G06T2207/20076 ,  G06T2207/30016 ,  G06T2207/30024 ,  G06T2207/30048 ,  G06T2207/30052 ,  G06T2207/30056 ,  G06T2207/30061 ,  G06T2207/30084 ,  G06T2207/30088

Abstract: A method of analyzing a medical image, where the medical image comprises one or more than one region of interest, and where the method comprises a) providing the medical image comprising a set of actual image values; b) rescaling the actual image values to produce corresponding rescaled image values and to produce a rescaled image from the rescaled image values; c) deriving a histogram of the rescaled image values; d) using the histogram to derive an adaptive segmentation threshold; e) using the adaptive segmentation threshold to recursively split the rescaled image; f) terminating the recursive splitting of the sub(sub) images using one or more than one predetermined criteria; and g) identifying one sub(sub) image in the terminated Hierarchical Region Splitting Tree which comprises the region of interest.