公开(公告)号：EP3771553A1

公开(公告)日：2021-02-03

申请号：EP20188556.3

申请日：2020-07-30

Applicant: Nidek Co., Ltd. ,  Shizuoka Prefecture

Inventor： INUZUKA, Minoru ,  ABE, Koji ,  SHIBATA, Ryoji ,  SHIBAMOTO, Takahisa ,  UETA, Hiroyasu ,  NAGATSU, Yoshiyuki

IPC: B29D11/00 ,  B23K26/03 ,  B23K26/082 ,  D06P5/00

Abstract: A dyeing apparatus (30) fixes a dye on a resin body (8) by heating the resin body having the dye attached to a surface of the resin body (8). The dyeing apparatus includes laser light irradiation means (33) for emitting laser light toward a resin body (8) having a dye attached to a surface of the resin body (8), scanning means (36) for relatively scanning the resin body (8) with the laser light emitted from the laser light irradiation means (33), and control means (39) for controlling the scanning means (36) to change an irradiation position of the laser light on the resin body (8). The control means (39) controls the scanning means (36) to heat the resin body (8) having the dye attached to the surface thereof by repeatedly irradiating a two-dimensional region on the resin body (8) with the laser light a plurality of times, for fixing the dye on the resin body (8).

公开(公告)号：EP2392471B1

公开(公告)日：2019-03-13

申请号：EP10735795.6

申请日：2010-01-26

Applicant: Shizuoka Prefecture ,  Nidek Co., Ltd.

Inventor： UETA, Hiroyasu ,  INUZUKA, Minoru ,  TSUJIMOTO, Yutaka

IPC: B41M5/26 ,  B41M5/382 ,  B23K26/00

公开(公告)号：EP3276353A1

公开(公告)日：2018-01-31

申请号：EP17182572.2

申请日：2017-07-21

Applicant: Shizuoka Prefecture

Inventor： MOCHIZUKI, Tohru ,  OHSHIMA, Keiichi ,  HATAKEYAMA, Keiichi ,  YAMAGUCHI, Ken ,  NAKAO, Kanako

IPC: G01N33/574

Abstract: An object of the present invention is to provide a method for collecting highly accurate data for diagnosis, useful in diagnosing the presence or absence of extrahepatic bile duct carcinoma, intrahepatic bile duct carcinoma, or gallbladder carcinoma, and a kit for diagnosis.
When the concentration of CEACAM1 in a blood sample collected from a test subject is detected using a kit for diagnosis comprising an antibody specifically binding to CEACAM1 or a labeled product thereof, or the like and the CEACAM1 concentration is higher than the concentration of CEACAM1 in a blood sample derived from a non-carcinoma control subject or higher than a certain threshold value (cutoff value), data can be collected for diagnosing the test subject as having a high possibility of having extrahepatic bile duct carcinoma, intrahepatic bile duct carcinoma, or gallbladder carcinoma.

Abstract translation: 本发明的一个目的是提供一种用于收集高度准确的诊断数据的方法，用于诊断肝外胆管癌，肝内胆管癌或胆囊癌的存在或不存在，以及用于诊断的试剂盒。 当使用包含特异性结合CEACAM1的抗体或其标记产物等的诊断试剂盒检测从受试者采集的血液样品中的CEACAM1的浓度时，并且CEACAM1浓度高于CEACAM1的浓度 来自非癌对照对象的血液试样或高于某个阈值（截止值）的血液样品，可以收集数据用于诊断试验对象患有肝外胆管癌，肝内胆管癌或胆囊的可能性高 癌。

公开(公告)号：EP2520575B1

公开(公告)日：2016-11-30

申请号：EP10841060.6

申请日：2010-12-28

Applicant: General Incorporated Association Pharma Valley Project Supporting Organization ,  Shizuoka Prefecture ,  Kumamoto Health Science University ,  Kabushiki Kaisha Yakult Honsha

Inventor： ASAI, Akira ,  MATSUNO, Kenji ,  OGO, Naohisa ,  TAKAHASHI, Osamu ,  MASUDA, Yoshiaki ,  MUROYA, Ayumu ,  AKIYAMA, Yasuto ,  ASHIZAWA, Tadashi ,  OKAWARA, Tadashi

IPC: C07D413/04 ,  A61K31/4245 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/55 ,  A61P35/00 ,  A61P43/00 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

CPC classification number: C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

公开(公告)号：EP2875729A4

公开(公告)日：2016-03-09

申请号：EP13819577

申请日：2013-07-19

Applicant: NIPPON SODA CO ,  SHIZUOKA PREFECTURE

Inventor： KAGEYAMA CHIZUKO ,  IYOZUMI HIROYUKI ,  NUKUI HIDEKI ,  KATO KIMIHIKO ,  MANNEN JUNYA ,  TOMIDA KAZUYUKI ,  SANO SHINSUKE ,  KATO HIDEKI ,  MAKITA SATORU ,  MIZUNO TOSHIO

IPC: A01N43/08 ,  A01G7/06 ,  A01N37/52 ,  A01N43/40 ,  A01N43/54 ,  A01N43/56 ,  A01N43/707 ,  A01N47/24 ,  A01N47/34 ,  A01N51/00 ,  A01P21/00

CPC classification number: A01N43/08 ,  A01N37/50 ,  A01N37/52 ,  A01N43/40 ,  A01N43/50 ,  A01N43/54 ,  A01N43/56 ,  A01N43/707 ,  A01N47/24 ,  A01N47/34 ,  A01N51/00 ,  A01N2300/00

公开(公告)号：EP2520575A1

公开(公告)日：2012-11-07

申请号：EP10841060.6

申请日：2010-12-28

Applicant: General Incorporated Association Pharma Valley Project Supporting Organisation ,  Pharma Design Inc. ,  Shizuoka Prefecture ,  Kumamoto Health Science University ,  Kabushiki Kaisha Yakult Honsha

Inventor： ASAI, Akira ,  MATSUNO, Kenji ,  OGO, Naohisa ,  TAKAHASHI, Osamu ,  MASUDA, Yoshiaki ,  MUROYA, Ayumu ,  AKIYAMA, Yasuto ,  ASHIZAWA, Tadashi ,  OKAWARA, Tadashi

IPC: C07D413/04 ,  A61K31/4245 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/55 ,  A61P35/00 ,  A61P43/00 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

CPC classification number: C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

Abstract: Provided is a 1,3,4-oxadiazole-2-carboxamide compound which has STAT3 inhibitory activity and is useful as an anticancer agent. Provided is a 1,3,4-oxadiazole-2-carboxamide compound represented by formula (I) or a pharmacologically acceptable salt thereof (in the formula, Ar represents a furyl group or the like; R 1 represents a hydrogen atom or the like; and -X-Y represents a diaryl group such as a biphenyl group).

Abstract translation: 提供具有STAT3抑制活性并可用作抗癌剂的1,3,4-恶二唑-2-甲酰胺化合物。 提供由式（I）表示的1,3,4-恶二唑-2-甲酰胺化合物或其药学上可接受的盐（在该式中，Ar表示呋喃基等; R 1表示氢原子等 ; -XY表示二芳基如联苯基）。

公开(公告)号：EP2385049A1

公开(公告)日：2011-11-09

申请号：EP09836216.3

申请日：2009-12-25

Applicant: Shizuoka Prefecture Public University Corporation

Inventor： ISHIDA Hitoshi

IPC: C07D407/04 ,  A61K31/352 ,  A61K36/00 ,  A61P17/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/08 ,  A61P39/06 ,  C07D493/14

CPC classification number: C07D407/04 ,  A61K36/82 ,  C07D493/14

Abstract: Provided are a sulfated C-glycoside which is a novel compound serving as a precursor of chafuroside and chafuroside analogs; a method for efficiently producing the sulfated C-glycoside; and a method for efficiently producing chafuroside and chafuroside analogs using said sulfated C-glycoside. A sulfated C-glycoside represented by general formula (A1) or (B1) [wherein R 1 , R 2 and R 3 independently represent each a hydrogen atom or an OH group] is obtained by extracting tea leaves or tea tannins with water, a lower alcohol solvent having 1 to 3 carbon atoms or a liquid mixture comprising the same. Alternatively, the sulfated C-glycoside is produced by reacting a flavone C-glycoside such as isovitexin or vitexin with a sulfate group-introducing agent to thereby sulfate the flavone C-glycoside. By heating the sulfated C-glycoside thus obtained, chafuroside and chafuroside analogs are efficiently produced.

Abstract translation: 提供了一种硫酸化C-糖苷，它是一种新的化合物，用作沙夫沙罗和沙夫罗内酯类似物的前体; 一种有效生产硫酸化C-糖苷的方法; 以及使用所述硫酸化C-糖苷有效生产辣椒素和辣椒素类似物的方法。 通过用水提取茶叶或茶单宁获得由通式（A1）或（B1）表示的硫酸化C-糖苷[其中R 1，R 2和R 3各自独立地表示氢原子或OH基团] 具有1至3个碳原子的低级醇溶剂或包含其的液体混合物。 或者，硫酸化C-糖苷是通过使异黄酮苷或牡荆素等黄酮C糖苷与硫酸酯基导入剂反应而使黄酮C-糖苷硫酸化来制造的。 通过加热由此获得的硫酸化的C-糖苷，可以有效地制备沙夫罗辛和类胡萝卜素类似物。

公开(公告)号：EP2325181A1

公开(公告)日：2011-05-25

申请号：EP09794208.0

申请日：2009-07-10

Applicant: Pharma Ip General Incorporated Association ,  Pharma Design Inc. ,  Shizuoka Prefecture ,  Kumamoto Health Science University ,  Kabushiki Kaisha Yakult Honsha

Inventor： ASAI, Akira ,  MATSUNO, Kenji ,  OGO, Naohisa ,  YOKOTAGAWA, Takane ,  TAKAHASHI, Osamu ,  AKIYAMA, Yasuto ,  ASHIZAWA, Tadashi ,  OKAWARA, Tadashi

IPC: C07D401/12 ,  A61K31/4709 ,  A61P19/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

CPC classification number: C07D401/12 ,  A61K31/4709 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention provides a STAT3 inhibitor containing as an active ingredient, a quinolinecarboxamide derivative represented by the formula (I) (in the formula, W represents a bond or an alkylene chain; X represents O, S, or NR 34 ; and R 1 to R 8 and R 34 each represent H, halogen, alkyl, phenyl, furyl, thienyl, or the like.), or a pharmacologically acceptable salt thereof.

Abstract translation: 本发明提供含有式（I）所示的喹啉甲酰胺衍生物（式中，W表示键或亚烷基链，X表示O，S或NR 34，且R 1〜 和R34各自表示H，卤素，烷基，苯基，呋喃基，噻吩基等）或其药理学上可接受的盐。

公开(公告)号：EP3276353B1

公开(公告)日：2020-09-09

申请号：EP17182572.2

申请日：2017-07-21

Applicant: Shizuoka Prefecture

Inventor： MOCHIZUKI, Tohru ,  OHSHIMA, Keiichi ,  HATAKEYAMA, Keiichi ,  YAMAGUCHI, Ken ,  NAKAO, Kanako

IPC: G01N33/574

公开(公告)号：EP2875730A4

公开(公告)日：2016-03-09

申请号：EP13820583

申请日：2013-07-19

Applicant: NIPPON SODA CO ,  SHIZUOKA PREFECTURE

Inventor： KAGEYAMA CHIZUKO ,  IYOZUMI HIROYUKI ,  NUKUI HIDEKI ,  KATO KIMIHIKO ,  MANNEN JUNYA ,  TOMIDA KAZUYUKI ,  SANO SHINSUKE ,  KATO HIDEKI ,  MAKITA SATORU ,  MIZUNO TOSHIO

IPC: A01G7/06 ,  A01N43/08 ,  A01N43/16 ,  A01N57/16 ,  A01P21/00 ,  C07D307/62 ,  C07F9/655 ,  C07F9/6558

CPC classification number: A01N57/16 ,  A01N43/08 ,  A01N43/16 ,  C07D307/62 ,  C07F9/65515 ,  C07F9/65586 ,  C07H15/26 ,  A01N25/32 ,  A01N43/40 ,  A01N43/54 ,  A01N47/24 ,  A01N2300/00 ,  A01N25/22

Abstract: A method of providing a plant with stress resistance, comprising applying at least one substance (A) to the plant, said at least one substance (A) being selected from the group consisting of a compound represented by Formula (I) and the like and salts thereof. Phytotoxicity of a plant due to agricultural chemicals is reduced by providing the plant with stress resistance. [In Formula (I), R 1 to R 4 each independently represents a hydrogen atom, -SO 3 H, -PO 3 H 2 , a glycosyl group or -COR 11 . R 11 represents an unsubstituted or substituted C1 to C30 alkyl group or an unsubstituted or substituted C2 to C30 alkenyl group.].

Abstract translation: 一种提供植物抗胁迫性的方法，包括向所述植物施用至少一种物质（A），所述至少一种物质（A）选自由式（I）等表示的化合物和 的盐。 通过为植物提供抗压力，减少了农药对植物的植物毒性。 [式（I）中，R 1〜R 4各自独立地表示氢原子，-SO 3 H，-PO 3 H 2，糖基或-COR 11。 R 11表示未取代或取代的C 1至C 30烷基或未取代或取代的C 2至C 30烯基。