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    PLASMIDS AND METHODS FOR PEPTIDE DISPLAY AND AFFINITY-SELECTION ON VIRUS-LIKE PARTICLES OF RNA BACTERIOPHAGES
    81.
    发明申请
    PLASMIDS AND METHODS FOR PEPTIDE DISPLAY AND AFFINITY-SELECTION ON VIRUS-LIKE PARTICLES OF RNA BACTERIOPHAGES 审中-公开
    肽类显示的方法和方法及RNA病毒类病毒颗粒的选择

    公开(公告)号：WO2013003353A2

    公开(公告)日：2013-01-03

    申请号：PCT/US2012044206

    申请日：2012-06-26

    Applicant: STC UNM ,  PEABODY DAVID S ,  CHACKERIAN BRYCE

    Inventor： PEABODY DAVID S ,  CHACKERIAN BRYCE

    CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K2039/5256 ,  A61K2039/5258 ,  C07K2319/40 ,  C07K2319/735 ,  C12N2795/18122 ,  C12N2795/18123

    Abstract: The present invention relates to a system and method for controlling peptide display valency on virus-like particles (VLPs), especially including MS2 or PP7 VLPs. In this method, large amounts of wild-type and low quantities of single-chain dimer coat proteins may be produced from a single RNA. Valency is controlled in immunogen (vaccine) production by providing a system that allows the production of large amounts of wild-type and low quantities of single-chain dimer coating proteins from a single RNA, allowing facile adjustment of display valency levels on bacteriophage VLPs, especially MS2 or PP7 VLPs over a wide range, from few than one- on average- to as many as ninety per particle. This facilitates the production of immunogens and vaccines, including VLPs exhibiting low valency. Nucleic acid constructs useful in the expression of virus-like particles are disclosed, comprised of a coat polypeptide of bacteriophage such as MS2 or PP7 modified by insertion of a heterologous peptide, optionally comprising a carbohydrate mimotope, wherein the heterologous peptide is displayed on the virus-like particle and encapsidates bacteriphage mRNA.

    Abstract translation: 本发明涉及一种用于控制病毒样颗粒（VLPs），特别是包括MS2或PP7VLP的肽展示剂价态的系统和方法。 在该方法中，可以从单个RNA产生大量野生型和低量的单链二聚体外壳蛋白。 通过提供允许从单个RNA产生大量野生型和少量单链二聚体包被蛋白的系统，允许容易地调节噬菌体VLP上的显示价态水平，从而在免疫原（疫苗）生产中控制价值， 特别是广泛范围的MS2或PP7 VLP，从一个平均至少一个到每个颗粒的九十个。 这有助于免疫原和疫苗的生产，包括显示低效价的VLP。 公开了可用于病毒样颗粒表达的核酸构建体，其包括噬菌体的外壳多肽，例如通过插入异源肽修饰的MS2或PP7，任选地包含碳水化合物模拟表位，其中异源肽显示在病毒上 样颗粒并包裹细菌噬菌体mRNA。

    PLASMIDS AND METHODS FOR PEPTIDE DISPLAY AND AFFINITY-SELECTION ON VIRUS-LIKE PARTICLES OF RNA BACTERIOPHAGES
    84.
    发明申请
    PLASMIDS AND METHODS FOR PEPTIDE DISPLAY AND AFFINITY-SELECTION ON VIRUS-LIKE PARTICLES OF RNA BACTERIOPHAGES 审中-公开
    用于肽显示的方法和方法以及RNA嗜酸性粒细胞样病毒颗粒的选择

    公开(公告)号：WO2011082381A3

    公开(公告)日：2011-12-22

    申请号：PCT/US2010062638

    申请日：2010-12-31

    Applicant: STC UNM ,  PEABODY DAVID S ,  CHACKERIAN BRYCE

    Inventor： PEABODY DAVID S ,  CHACKERIAN BRYCE

    IPC: C12N7/01 ,  A61K39/12 ,  C07K14/005 ,  C12N15/33

    CPC classification number: A61K39/12 ,  A61K39/07 ,  A61K2039/5256 ,  A61K2039/5258 ,  C12N7/00 ,  C12N15/1037 ,  C12N2710/20022 ,  C12N2710/20034 ,  C12N2740/16034 ,  C12N2740/16134 ,  C12N2795/16021 ,  C12N2795/16022 ,  C12N2795/16023 ,  C12N2795/16042 ,  C12N2795/18023 ,  C40B40/08

    Abstract: The present invention relates to a system and method for controlling peptide display valency on virus-like particles (VLPs), especially including MS2 VLPs. In this method, large amounts of wild-type and low quantities of single-chain dimer coat proteins may be produced from a single RNA. Valency is controlled in immunogen (vaccine) production by providing a system that allows the production of large amounts of wild-type and low quantities of single-chain dimer coating proteins from a single RNA, allowing facile adjustment of display valency levels on VLPs, especially MS2 VLPS over a wide range, from few than one- on average- to as many as ninety per particle. This facilitates the production of immunogens and vaccines, including VLPs exhibiting low valency. Nucleic acid constructs useful in the expression of virus-like particles are disclosed, comprised of a coat polypeptide of MS2 modified by insertion of a heterologous peptide, wherein the heterologous peptide is displayed on the virus-like particle and encapsidates MS2 niRNA. Nucleic acid constructs are also disclosed which are useful in the expression of virus-like particles comprised of a coat polypeptide of PP7 modified by insertion of a heterologous peptide, wherein the heterologous peptide is displayed on the virus-like particle and encapsidates PP7 mRNA.

    Abstract translation: 本发明涉及一种用于控制病毒样颗粒（VLP）的肽显示价态的系统和方法，特别是包括MS2 VLP。 在该方法中，可以从单个RNA产生大量野生型和低量的单链二聚体外壳蛋白。 通过提供允许从单个RNA生产大量野生型和少量单链二聚体包被蛋白质的系统，允许容易调整VLP上的显示剂价位水平，特别是在免疫原（疫苗）生产中控制价值 MS2 VLPS在广泛的范围内，从一个平均至少一个到每个颗粒多达九十个。 这有助于免疫原和疫苗的生产，包括显示低价的VLP。 公开了可用于病毒样颗粒表达的核酸构建体，其由通过插入异源肽修饰的MS2的外壳多肽组成，其中异源肽显示在病毒样颗粒上并包裹MS2nRNA。 还公开了核酸构建体，其可用于表达由通过插入异源肽修饰的PP7的外壳多肽组成的病毒样颗粒的表达，其中异源肽显示在病毒样颗粒上并包裹PP7 mRNA。

    COMPOUNDS WITH REDUCED RING SIZE FOR USE IN DIAGNOSING AND TREATING MELANOMA, INCLUDING METASTATIC MELANOMA AND METHODS RELATED TO SAME
    85.
    发明申请
    COMPOUNDS WITH REDUCED RING SIZE FOR USE IN DIAGNOSING AND TREATING MELANOMA, INCLUDING METASTATIC MELANOMA AND METHODS RELATED TO SAME 审中-公开
    用于诊断和治疗黑色素瘤，包括转移性黑色素瘤及与其相关的方法的用于减小环大小的化合物

    公开(公告)号：WO2011066521A3

    公开(公告)日：2011-10-20

    申请号：PCT/US2010058282

    申请日：2010-11-30

    Applicant: STC UNM ,  MIAO YUBIN ,  GUO HAIXUN

    Inventor： MIAO YUBIN ,  GUO HAIXUN

    IPC: C07K7/64 ,  A61K38/12 ,  A61P35/00 ,  C07K7/00 ,  G01N33/574

    CPC classification number: C07K14/68 ,  A61K38/00 ,  A61K45/06 ,  A61K51/08 ,  A61K51/086 ,  A61K51/088 ,  C07K7/54

    Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue and decreased renal uptake in kidney, evidencing favorable pharmacokinetics of compounds of the present invention. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are also useful for initiating therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

    Abstract translation: 本发明涉及新的非侵入性诊断工具/化合物以对癌症，特别是黑素瘤，包括体内转移性黑素瘤进行成像。 本发明的化合物在癌细胞和组织中表现出增强的摄取并且降低肾中的肾摄取，证明了本发明化合物的有利药代动力学。 根据本发明的化合物代表使用非侵入性分子成像技术诊断和治疗黑素瘤包括转移性黑素瘤的进展。 本发明的新型探针也可用于启动黑素瘤治疗以及监测患者对化疗治疗和用于治疗黑素瘤/转移性黑素瘤的其他干预或疗法的反应。 根据本发明的化合物可以用作许多状况和疾病状态的诊断工具以及用于治疗这些状况和疾病状态的治疗剂。

    SYSTEM AND METHODS OF RESOURCE USAGE USING AN INTEROPERABLE MANAGEMENT FRAMEWORK
    87.
    发明申请
    SYSTEM AND METHODS OF RESOURCE USAGE USING AN INTEROPERABLE MANAGEMENT FRAMEWORK 审中-公开
    资源使用的系统和方法使用可互操作的管理框架

    公开(公告)号：WO2011062973A3

    公开(公告)日：2011-09-15

    申请号：PCT/US2010057009

    申请日：2010-11-17

    Applicant: STC UNM ,  HEILEMAN GREGORY L ,  JAMKHEDKAR PRAMOD A ,  LAMB CHRISTOPHER C

    Inventor： HEILEMAN GREGORY L ,  JAMKHEDKAR PRAMOD A ,  LAMB CHRISTOPHER C

    IPC: G06F13/14 ,  G06F13/38

    CPC classification number: G06F21/10 ,  G06F2221/0759

    Abstract: Generic rights expression language allowing interoperability across different computing environments including resource usage of different applications. A formal framework for usage management provides scaffolding upon which interoperable usage management systems can be built. Certain features of the framework are standardized, such as the operational semantics, including areas free of standards that necessitate choice and innovation to achieve a balance of flexibility and usability for interoperability in usage management systems.

    Abstract translation: 通用权限表达式语言允许跨不同计算环境的互操作性，包括不同应用程序的资源使用情况。 使用管理的正式框架提供了搭建可互操作的使用管理系统的脚手架。 框架的某些功能是标准化的，如操作语义，包括无需标准的区域，这些标准需要选择和创新，以实现使用管理系统中的互操作性的灵活性和可用性的平衡。

    INTUBATING STYLETS AND SYSTEMS AND METHODS FOR INTUBATION
    90.
    发明申请
    INTUBATING STYLETS AND SYSTEMS AND METHODS FOR INTUBATION 审中-公开
    插管式和用于插管的系统和方法

    公开(公告)号：WO2010065566A2

    公开(公告)日：2010-06-10

    申请号：PCT/US2009066293

    申请日：2009-12-01

    Applicant: STC UNM ,  JAIME FRANCISCO

    Inventor： JAIME FRANCISCO

    IPC: A61M25/00 ,  A61B1/04

    CPC classification number: A61M25/0147 ,  A61B1/267 ,  A61M16/0488

    Abstract: An intubating stylet has a proximal end and a distal end. The intubating stylet includes a housing at the proximal end of the stylet and a tip portion at the distal end of the stylet. The tip portion has a distal gear at its proximal end. An outer shaft extends from the housing to the tip portion and contains an inner shaft defining a hollow lumen. A distal end of the inner shaft includes a proximal gear coupled with the distal gear of the tip portion such that rotation of the inner shaft causes articulation of the tip portion. The stylet further includes a drive member in the housing and a control member coupled with the drive member. The drive member is coupled to the inner shaft and configured to rotate the inner shaft, and the control member is configured to receive a user input and to translate the input into operation of the drive member.

    Abstract translation: 插管管心针具有近端和远端。 插管管心针包括在通管丝的近端处的壳体和在通管丝的远端处的尖端部分。 尖端部分在其近端处具有远端齿轮。 外轴从壳体延伸到尖端部分并且包含限定中空内腔的内轴。 内轴的远端包括与尖端部分的远端齿轮联接的近端齿轮，使得内轴的旋转引起尖端部分的铰接。 探针还包括壳体中的驱动构件和与驱动构件联接的控制构件。 驱动构件联接到内轴并构造成旋转内轴，并且控制构件构造成接收用户输入并将输入转化成驱动构件的操作。

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