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公开(公告)号：NO840589A
公开(公告)日：1984-08-20
申请号：NO840589
申请日：1984-02-16
Applicant: STICHTING KATHOLIEKE UNIV , STICHTING FUND OND MATERIAL
Inventor： GROOT ROBERT AART DE , JANNER ALOISIO GIUSEPPE , MUELLER FRED MICHAEL
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公开(公告)号：DK72984A
公开(公告)日：1984-08-18
申请号：DK72984
申请日：1984-02-17
Applicant: STICHTING KATHOLIEKE UNIV , STICHTING FUND OND MATERIAL
Inventor： GROOT ROBERT AART DE , JANNER ALOISIO GIUSEPPE , MUELLER FRED MICHAEL
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公开(公告)号：IE832491L
公开(公告)日：1984-05-01
申请号：IE249183
申请日：1983-10-25
Applicant: STICHTING KATHOLIEKE UNIV
IPC: A61K31/505 , A61P35/00 , C07D239/54 , C07D239/04 , A61K31/495
Abstract: The invention concerns novel sparsomycin (Sc-Rs) derivatives having superior cytostatic activity compared to sparsomycin itself. Said derivatives contain a lipophilic group R2, selected from C2-C20-alkyl, aryl, aralkyl and alkaryl, which is preferably n-octyl or benzyl.
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公开(公告)号：DK496783D0
公开(公告)日：1983-10-31
申请号：DK496783
申请日：1983-10-31
Applicant: STICHTING KATHOLIEKE UNIV
IPC: A61K31/505 , A61P35/00 , C07D239/54 , C07D239
Abstract: The invention concerns novel sparsomycin (Sc-Rs) derivatives having superior cytostatic activity compared to sparsomycin itself. Said derivatives contain a lipophilic group R2, selected from C2-C20-alkyl, aryl, aralkyl and alkaryl, which is preferably n-octyl or benzyl.
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公开(公告)号：NL2026871B1
公开(公告)日：2022-06-30
申请号：NL2026871
申请日：2020-11-11
Applicant: STICHTING KATHOLIEKE UNIV
Inventor： RIK GERRIT HENDRIK LINDEBOOM , MICHIEL VERMEULEN
IPC: C12Q1/6804 , C12Q1/6806 , G01N33/68
Abstract: A method of determining the binding affinity of a molecule to native nucleic acid, the method includes adding the molecule to the native nucleic acid to a first batch of native nucleic acid at a first concentration and adding the molecule to a second batch of native nucleic acid at a second concentration. Molecule-native nucleic acid binding is then analysed in the first batch of native nucleic acid and the second batch of native nucleic acid. The binding affinity of the molecule to the native nucleic acid is then calculated based on the difference in molecule-native nucleic acid binding between the different concentrations in the first batch of native nucleic acid and the second batch of native nucleic acid.
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Patent Agency Ranking86.发明专利
公开(公告)号：CA2884154C
公开(公告)日：2021-07-20
申请号：CA2884154
申请日：2013-09-14
Applicant: STICHTING KATHOLIEKE UNIV
Inventor： FIGDOR CARL GUSTAV , DE VRIES INGRID JOLANDA MONIQUE , SRINIVAS MANGALA , CRUZ RICONDO LUIS JAVIER , DE KORTE CHRISTOFFEL LEENDERT
Abstract: The invention relates the use of a poly(lactic-co-glycolic) acid (PLGA) particle comprising a perfluoro crown ether and Gadolinium for in vitro imaging wherein the imaging is selected from the group consisting of acoustic imaging, photo acoustic imaging, ultrasound imaging and optical coherence imaging.
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公开(公告)号：DK3387011T3
公开(公告)日：2020-08-03
申请号：DK16822910
申请日：2016-12-07
Applicant: STICHTING KATHOLIEKE UNIV
Inventor： WILMER MARTIJN , MASEREEUW ROSALINDE
IPC: C07K14/705 , C12N5/071
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公开(公告)号：NL2022276B1
公开(公告)日：2020-07-15
申请号：NL2022276
申请日：2018-12-21
Applicant: STICHTING KATHOLIEKE UNIV
Inventor： NIGEL EDWARD HUSSEY
Abstract: The present invention is in the field of a National Indi— vidual Floating Transportation Infrastructure (NIFTI) wherein floating vehicles can travel by magnetic levitation and prop— agation. The vehicles can travel at heights substantially equal to existing road structures, and at relatively high speeds.
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公开(公告)号：AU2018370237A1
公开(公告)日：2020-06-04
申请号：AU2018370237
申请日：2018-11-20
Inventor： MULDER WILLEM , OCHANDO JORDI , FAYAD ZAHI , DUIVENVOORDEN RAPHAEL , TEUNISSEN BRAM , PEREZ-MEDINA CARLOS , NETEA MIHAI , JOOSTEN LEO
Abstract: The invention relates to therapeutic nanobiologic compositions and methods of treating patients who have had an organ transplant, or who suffer from atherosclerosis, arthritis, inflammatory bowel disease including Crohn's, autoimmune diseases and/or autoinflammatory conditions including diabetes, or after a cardiovascular events, including stroke and myocardial infarction, and to provide PET imaging of radiolabeled nanobiologics to show the location of accumulation in tissue, using nanobiologic compositions that inhibit trained immunity, which is the long-term increased responsiveness, the result of metabolic and epigenetic re-wiring of myeloid cells and their stem cells and progenitors in the bone marrow and spleen and blood induced by a primary insult, and characterized by increased cytokine excretion after re-stimulation with one or multiple secondary stimuli.
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公开(公告)号：ES2764252T3
公开(公告)日：2020-06-02
申请号：ES10737836
申请日：2010-07-16
Inventor： ROWAN ALAN EDWARD , NOLTE ROELAND JOHANNES MARIA , CORNELISSEN JEROEN JOHANNES LAMBERTUS MARIA , KITTO HEATHER JOY , SCHWARTZ ERIK , KOEPF MATTHIEU
Abstract: Procedimiento de preparación de isocianopéptido(s) de polioligo(alquilenglicol) que comprende las etapas de funcionalizar un isocianopéptido con cadenas laterales de oligo-(alquilenglicol), que tiene menos de 10 unidades de alquilenglicol, y posteriormente polimerizar los isocianopéptidos funcionalizados con oligo-alquilenglicol en un disolvente orgánico en presencia de un catalizador de níquel (II), por lo que los isocianopéptidos funcionalizados son isocianopéptidos sustituidos con alquilenglicol con un motivo peptídico sustituido en el terminal C con la cadena de oligo(alquilenglicol) obtenida mediante un proceso en el que un residuo de aminoácido se acopla a una cadena de (alquilen)glicol, seguido de un acoplamiento peptídico secuencial para introducir el número deseado de sustituyentes de aminoácidos, seguido luego por la formilación del terminal N del segmento peptídico y la posterior deshidratación para proporcionar dicho isocianopéptido funcionalizado con oligoalquilenglicol.
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