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    METHODS OF TREATING CANCERS AND ENHANCING EFFICACY OF T CELL REDIRECTING THERAPEUTICS
    81.
    发明专利
    METHODS OF TREATING CANCERS AND ENHANCING EFFICACY OF T CELL REDIRECTING THERAPEUTICS 未知

    公开(公告)号：PH12020551908A1

    公开(公告)日：2021-06-14

    申请号：PH12020551908

    申请日：2020-11-09

    Applicant: JANSSEN BIOTECH INC ,  STICHTING VUMC

    Inventor： ADAMS HOMER ,  GAUDET FRANCOIS ,  FRERICHS KRIS ,  VAN DE DONK NIELS ,  VERLEIJ CHRISTIE C P M

    IPC: A61K39/395 ,  A61P35/00 ,  C07K16/28 ,  C07K16/30 ,  C07K16/46 ,  C07K19/00

    Abstract: The disclosure provides methods of treating a cancer and/or killing tumor cells in a subject, comprising administering a therapeutically effective amount of an anti-CD38 antibody and a T cell redirecting therapeutic to the subject to treat the cancer. The disclosure provides a method of enhancing efficacy of a T cell redirecting therapeutic in a subject having a cancer, comprising administering to the subject an anti-CD38 antibody. The disclosure also provides a method of treating a multiple myeloma in a subject, comprising administering a therapeutically effective amount of a BCMAxCDS bispecific antibody and an anti-CD38 antibody to the subject to treat the multiple myeloma. The disclosure also provides a pharmaceutical combination comprising a GPRC5DxCD3 bispecific antibody. The disclosure also provides a kit comprising a pharmaceutical composition comprising a BCMAxCD3 bispecific antibody and an anti-CD38 antibody.

    MEANS AND METHODS FOR TREATING DIASTOLIC DYSFUNCTION IN A SUBJECT
    88.
    发明专利
    MEANS AND METHODS FOR TREATING DIASTOLIC DYSFUNCTION IN A SUBJECT 未知

    公开(公告)号：CA3060388A1

    公开(公告)日：2017-10-26

    申请号：CA3060388

    申请日：2017-04-21

    Applicant: STICHTING VUMC

    Inventor： PAULUS WALTER JOSEPH

    IPC: A61K38/17 ,  A61K31/121 ,  A61P9/00

    Abstract: The invention relates to the treatment of diastolic dysfunction in a subject, and relates in particular to compositions for use and methods in treating diastolic dysfunction. In one aspect the invention provides a composition for use comprising a therapeutically effective amount of a substance which increases the level and/or activity of a crystalline protein in cardiomyocytes of the subject. In particular the composition for use according to the invention comprises a therapeutically effective amount of the alpha B crystalline protein. It was found that the composition for use is capable of treating diastolic dysfunction and diastolic heart disease in subjects with failing hearts that have a higher cardiomyocyte stiffness than controls. Particularly, addition of alpha B crystalline reduced the higher stiffness of failing cardiomyocytes to the level observed in control cardiomyocytes.

    Differential Diagnosis
    89.
    发明专利
    Differential Diagnosis 未知

    公开(公告)号：GB201621698D0

    公开(公告)日：2017-02-01

    申请号：GB201621698

    申请日：2016-12-20

    Applicant: GE HEALTHCARE LTD (IP) AND STICHTING VUMC AND ACAD MEDICAL CENTER

    Abstract: The present application provides a means for differential diagnosis of Parkinson's disease and the clinically similar Parkinsonian disorders multiple system atrophy with predominantly Parkinsonian features (MSA-P) and progressive supranuclear palsy (PSP).

    A method of analysing a blood sample of a subject for the presence of a disease marker
    90.
    发明专利
    A method of analysing a blood sample of a subject for the presence of a disease marker 未知

    公开(公告)号：AU2011277178B2

    公开(公告)日：2016-10-20

    申请号：AU2011277178

    申请日：2011-07-15

    Applicant: STICHTING VUMC

    Inventor： WURDINGER THOMAS ,  NILSSON ROLF JONAS

    IPC: G01N33/48

    Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

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