公开(公告)号：EP1490359A1

公开(公告)日：2004-12-29

申请号：EP03716591.7

申请日：2003-03-14

Applicant: Sensors for Medicine and Science, Inc.

Inventor： DANILOFF, George, Y. ,  KALIVRETENOS, Aristotle, G. ,  NIKOLAITCHIK, Alexandre, V.

IPC: C07D417/00 ,  C07G3/00 ,  C07H15/00 ,  C12N9/04 ,  C12Q1/54

CPC classification number: G01N33/533 ,  C07F5/025 ,  G01N33/542 ,  G01N33/582 ,  G01N33/66 ,  Y10T436/144444

Abstract: Compositions and methods for determining the presence or concentration of glucose in a sample which may also contain an alpha-hydroxy acid or a beta-diketone. The method uses a compound having at least two recognition elements for glucose, oriented such that the interaction between the compound and glucose is more stable than the interaction between the compound and the alpha-hydroxy acid or beta-diketone, such that the presence of the alpha-hydroxy acid or the beta-diketone does not substantially interfere with said determination.

公开(公告)号：EP1454129A1

公开(公告)日：2004-09-08

申请号：EP02794226.7

申请日：2002-12-11

Applicant: Sensors for Medicine and Science, Inc.

Inventor： COLVIN, Arthur, E., Jr. ,  WALTERS, Steven, J.

IPC: G01N21/64

CPC classification number: G01N21/645 ,  G01N21/6428 ,  G01N21/7703 ,  G01N2201/0642

Abstract: An optical sensor device for determining the presence or concentration of an analyte, contains a waveguide (103) disposed over a light source (101) of a substrate (100) and separated by an internal baffle (104), wherein the waveguide has a thickness corresponding to a far field emission point of the light source as determined by a light shielding baffle between the light source and light detector.

公开(公告)号：EP1388014A2

公开(公告)日：2004-02-11

申请号：EP02713356.0

申请日：2002-01-04

Applicant: Sensors for Medicine and Science, Inc.

Inventor： DANILOFF, George, Y. ,  KALIVRENTENOS, Aristotle, G. ,  NIKOLAITCHIK, Alexandre, V.

IPC: G01N33/66

CPC classification number: G01N33/533 ,  C07F5/025 ,  G01N33/542 ,  G01N33/582 ,  G01N33/66 ,  Y10T436/144444

Abstract: Compositions and methods for determining the presence or concentration of glucose in a sample which may also contain an alpha-hydroxy acid or a beta-diketone. The method uses a compound having at least two recognition elements for glucose, oriented such that the interaction between the compound and glucose is more stable than the interaction between the compound and the alpha-hydroxy acid or beta-diketone, such that the presence of the alpha-hydroxy acid or the beta-diketone does not substantially interfere with said determination.

公开(公告)号：EP2103250B1

公开(公告)日：2015-08-05

申请号：EP09160589.9

申请日：2001-06-27

Applicant: Sensors for Medicine and Science, Inc.

Inventor： Lesho, Jeffery, C.

IPC: A61B5/00

CPC classification number: A61B5/0031 ,  A61B2560/0219 ,  G01N21/645

公开(公告)号：EP2325622B1

公开(公告)日：2014-03-12

申请号：EP10180990.3

申请日：1999-08-26

Applicant: Sensors for Medicine and Science, Inc.

Inventor： Colvin, Arthur E ,  Dale, Gregory A. ,  Zerwekh, Paul Samuel ,  LESHO, Jeffrey C ,  LYNN, Robert W

IPC: G01N21/55 ,  G01N21/64 ,  G01N21/77 ,  G01N33/543 ,  A61B5/00 ,  A61B5/07 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1459

CPC classification number: A61B5/076 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14552 ,  A61B5/1459 ,  A61B5/6861 ,  A61B2560/0219 ,  A61B2562/12 ,  G01N21/552 ,  G01N21/6428 ,  G01N21/648 ,  G01N21/77 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2021/7786 ,  Y10S128/903

Abstract: An optical-based sensor (10) for detecting the presence or amount of an analyte using both indicator and reference channels, The sensor has a sensor body (12) with a source of radiation embedded therein (18). Radiation emitted by the source interacts with indicator membrane (3) indicator molecules (16) proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For exalnple, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte. Preferred embodiments are totally self-contained and are sized and shaped for use in vivo in a human being. Such embodiments preferably include a power source, e.g. an inductor, which powers the source of radiation using external means, as well as a transmitter, e.g. an inductor, to transmit to external pickup means the signal representing the level of analyte.

公开(公告)号：EP2259670A3

公开(公告)日：2011-04-06

申请号：EP10182071.0

申请日：2005-04-07

Applicant: Sensors for Medicine and Science, Inc.

Inventor： Colvin, JR., Arthur E. ,  Lorenz, Carrie R. ,  O'Connor, Casey J. ,  Walters, Steven J.

IPC: H05K5/06 ,  A61B5/00

CPC classification number: A61B5/0031 ,  H05K5/065

Abstract: The present invention provides a biocompatible circuit assembly that includes a circuit encased within a housing. In some embodiments, the housing is a PMMA housing and before the circuit is enclosed within the housing the circuit is encased within a brick of epoxy.

Abstract translation: 本发明提供了生物相容的电路组件确实包括外壳内包封的电路。 在一些实施例中，壳体是PMMA壳体和电路被包围于外壳内之前该电路被环氧树脂的砖内包住。

公开(公告)号：EP1788932B1

公开(公告)日：2010-12-22

申请号：EP05816127.4

申请日：2005-08-22

Applicant: Sensors for Medicine and Science, Inc.

Inventor： COLVIN, JR, Arthur, E. ,  MCLEOD, Benjamin, N. ,  O'CONNOR, Casey J. ,  HUTCHINS, Burleigh, M. ,  SHANNON, Colleen

IPC: A61B5/00

CPC classification number: A61B5/076 ,  A61B5/681 ,  A61B2560/0219 ,  H01Q1/273 ,  H01Q1/44

Abstract: The present invention provides, among other things, a sensor system, having (1) a sensor implanted in a body part of the subject, wherein the sensor has a first antenna, and (2) a sensor reader worn on the subject's body part, wherein the sensor reader has a band housing a second antenna, which is inductively coupled with the first antenna, for enabling the sensor reader to communicate with the sensor.

公开(公告)号：EP1350102A2

公开(公告)日：2003-10-08

申请号：EP02714690.1

申请日：2002-01-04

Applicant: Sensors for Medicine and Science, Inc.

Inventor： DANILOFF, George, Y. ,  KALIVRENTENOS, Aristotle, G. ,  NIKOLAITCHIK, Alexandre V. ,  ULLMAN, Edwin, F.

IPC: G01N33/52 ,  G01N33/66

CPC classification number: G01N33/66

Abstract: Disclosed are methods for detecting analytes, such as sugars, indicator systems which may undergo a molecular configurational change upon exposure to the analyte. The configurational change affects a detectable quality, such as fluorescence associated with the indicator system, thereby allowing detection of the presence or concentration of the analyte.

公开(公告)号：EP1307464A1

公开(公告)日：2003-05-07

申请号：EP01956112.5

申请日：2001-08-03

Applicant: Sensors for Medicine and Science, Inc.

Inventor： COLVIN, Arthur, E., Jr.

IPC: C07F5/02 ,  C07F5/04 ,  G01N33/66

CPC classification number: G01N21/6428 ,  A61B5/14532 ,  A61B5/1459 ,  C07D257/02 ,  G01N31/22 ,  G01N33/542 ,  G01N33/66 ,  G01N33/84 ,  G01N2021/6432 ,  G01N2021/7786 ,  Y10T436/143333 ,  Y10T436/144444

Abstract: The invention relates to indicator molecules for detecting the presence or concentration of an analyte in a medium, such as a liquid, and to methods for achieving such detection. More particularly, the invention relates to copolymer macromolecules containing relatively hydrophobic indicator component monomers, and hydrophilic monomers, such that the macromolecule is capable of use in an aqueous environment.

公开(公告)号：EP2298160A1

公开(公告)日：2011-03-23

申请号：EP10181785.6

申请日：2005-08-22

Applicant: Sensors for Medicine and Science, Inc.

Inventor： Colvin, JR., Arthur E. ,  Mcleod, Benjamin N. ,  O'Connor, Casey J. ,  Hutchins, Burleigh M. ,  Shannon, Colleen

IPC: A61B5/00

CPC classification number: A61B5/076 ,  A61B5/681 ,  A61B2560/0219 ,  H01Q1/273 ,  H01Q1/44

Abstract: The present invention provides, among other things, a sensor system, having (1) a sensor implanted in a body part of the subject, wherein the sensor has a first antenna, and (2) a sensor reader worn on the subject's body part, wherein the sensor reader has a band housing a second antenna, which is inductively coupled with the first antenna, for enabling the sensor reader to communicate with the sensor.

Abstract translation: 本发明尤其提供了一种传感器系统，其具有（1）植入物体的身体部分的传感器，其中传感器具有第一天线，和（2）佩戴在被检体的身体部位上的传感器读取器， 其中所述传感器读取器具有容纳与所述第一天线感应耦合的第二天线的带，以使所述传感器读取器能够与所述传感器通信。