公开(公告)号：EP2325622B1

公开(公告)日：2014-03-12

申请号：EP10180990.3

申请日：1999-08-26

Applicant: Sensors for Medicine and Science, Inc.

Inventor： Colvin, Arthur E ,  Dale, Gregory A. ,  Zerwekh, Paul Samuel ,  LESHO, Jeffrey C ,  LYNN, Robert W

IPC: G01N21/55 ,  G01N21/64 ,  G01N21/77 ,  G01N33/543 ,  A61B5/00 ,  A61B5/07 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1459

CPC classification number: A61B5/076 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14552 ,  A61B5/1459 ,  A61B5/6861 ,  A61B2560/0219 ,  A61B2562/12 ,  G01N21/552 ,  G01N21/6428 ,  G01N21/648 ,  G01N21/77 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2021/7786 ,  Y10S128/903

Abstract: An optical-based sensor (10) for detecting the presence or amount of an analyte using both indicator and reference channels, The sensor has a sensor body (12) with a source of radiation embedded therein (18). Radiation emitted by the source interacts with indicator membrane (3) indicator molecules (16) proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For exalnple, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte. Preferred embodiments are totally self-contained and are sized and shaped for use in vivo in a human being. Such embodiments preferably include a power source, e.g. an inductor, which powers the source of radiation using external means, as well as a transmitter, e.g. an inductor, to transmit to external pickup means the signal representing the level of analyte.

公开(公告)号：EP1956365B1

公开(公告)日：2013-01-23

申请号：EP08155730.8

申请日：1999-08-26

Applicant: Sensors for Medicine and Science, Inc.

Inventor： Colvin, Arthur E ,  Dale, Gregory A ,  Zerwekh, Paul Samuel ,  Lesho, Jeffrey C ,  Lynn, Robert W

IPC: G01N21/64 ,  G01N21/55 ,  G01N21/77 ,  A61B5/00 ,  A61B5/07 ,  A61B5/145 ,  A61B5/1459 ,  G01N33/543 ,  G01N21/00 ,  G01N33/53

CPC classification number: A61B5/076 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14552 ,  A61B5/1459 ,  A61B5/6861 ,  A61B2560/0219 ,  A61B2562/12 ,  G01N21/552 ,  G01N21/6428 ,  G01N21/648 ,  G01N21/77 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2021/7786 ,  Y10S128/903

Abstract: An optical-based sensor (10) for detecting the presence or amount of an analyte using both indicator and reference channels, The sensor has a sensor body (12) with a source of radiation embedded therein (18). Radiation emitted by the source interacts with indicator membrane (3) indicator molecules (16) proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For exalnple, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte. Preferred embodiments are totally self-contained and are sized and shaped for use in vivo in a human being. Such embodiments preferably include a power source, e.g. an inductor, which powers the source of radiation using external means, as well as a transmitter, e.g. an inductor, to transmit to external pickup means the signal representing the level of analyte.

公开(公告)号：EP2325622A1

公开(公告)日：2011-05-25

申请号：EP10180990.3

申请日：1999-08-26

Applicant: Sensors for Medicine and Science, Inc.

Inventor： Colvin, Arthur E ,  Dale, Gregory A ,  Zerwekh, Paul Samuel ,  LESHO, Jeffrey C ,  LYNN, Robert W

IPC: G01N21/64 ,  G01N21/55 ,  G01N21/77 ,  A61B5/00

CPC classification number: A61B5/076 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14552 ,  A61B5/1459 ,  A61B5/6861 ,  A61B2560/0219 ,  A61B2562/12 ,  G01N21/552 ,  G01N21/6428 ,  G01N21/648 ,  G01N21/77 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2021/7786 ,  Y10S128/903

Abstract: An optical-based sensor (10) for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body (12) with a source of radiation embedded therein (18). A matrix layer is disposed on the surface of the sensor body which layer is permeable to an analyte and comprises fluroescent indicator molecules responsive to the concentration of the analyte. Radiation emitted by the source interacts with indicator membrane (3) indicator molecules (16) proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e,g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte.

Abstract translation: 一种用于使用指示器和参考通道来检测分析物的存在或量的基于光学的传感器（10）。 该传感器具有传感器本体（12），其中嵌有辐射源（18）。 矩阵层设置在传感器主体的表面上，该层对分析物是可渗透的，并且包括响应于分析物浓度的荧光指示剂分子。 源发射的辐射与靠近身体表面的指示膜（3）指示剂分子（16）相互作用。 这些指示剂分子的至少一种光学特性随分析物浓度而变化。 例如，荧光指示剂分子的荧光水平或光吸收指示剂分子吸收的光量可以作为分析物浓度的函数而变化。 此外，源发射的辐射也与靠近身体表面的参考膜指示剂分子相互作用。 由这些指示剂分子发射或反射的辐射（例如，光）在传感器体内进入和反射。 传感器体内的感光元件产生指示通道和参考通道信号，以提供分析物浓度的准确指示。

公开(公告)号：EP1956365A3

公开(公告)日：2008-10-29

申请号：EP08155730.8

申请日：1999-08-26

Applicant: Sensors for Medicine and Science, Inc.

Inventor： Colvin, Arthur E ,  Dale, Gregory A ,  Zerwekh, Paul Samuel ,  Lesho, Jeffrey C ,  Lynn, Robert W

IPC: G01N21/64 ,  G01N21/55 ,  G01N21/77 ,  A61B5/00

CPC classification number: A61B5/076 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14552 ,  A61B5/1459 ,  A61B5/6861 ,  A61B2560/0219 ,  A61B2562/12 ,  G01N21/552 ,  G01N21/6428 ,  G01N21/648 ,  G01N21/77 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2021/7786 ,  Y10S128/903

Abstract: An optical-based sensor (10) for detecting the presence or amount of an analyte using both indicator and reference channels, The sensor has a sensor body (12) with a source of radiation embedded therein (18). Radiation emitted by the source interacts with indicator membrane (3) indicator molecules (16) proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For exalnple, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte. Preferred embodiments are totally self-contained and are sized and shaped for use in vivo in a human being. Such embodiments preferably include a power source, e.g. an inductor, which powers the source of radiation using external means, as well as a transmitter, e.g. an inductor, to transmit to external pickup means the signal representing the level of analyte.

公开(公告)号：EP1956365A2

公开(公告)日：2008-08-13

申请号：EP08155730.8

申请日：1999-08-26

Applicant: Sensors for Medicine and Science, Inc.

Inventor： Colvin, Arthur E ,  Dale, Gregory A ,  Zerwekh, Paul Samuel ,  Lesho, Jeffrey C ,  Lynn, Robert W

IPC: G01N21/64 ,  G01N21/55 ,  G01N21/77 ,  A61B5/00

CPC classification number: A61B5/076 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14552 ,  A61B5/1459 ,  A61B5/6861 ,  A61B2560/0219 ,  A61B2562/12 ,  G01N21/552 ,  G01N21/6428 ,  G01N21/648 ,  G01N21/77 ,  G01N21/7703 ,  G01N33/54373 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2021/7786 ,  Y10S128/903

Abstract: An optical-based sensor (10) for detecting the presence or amount of an analyte using both indicator and reference channels, The sensor has a sensor body (12) with a source of radiation embedded therein (18). Radiation emitted by the source interacts with indicator membrane (3) indicator molecules (16) proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For exalnple, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte. Preferred embodiments are totally self-contained and are sized and shaped for use in vivo in a human being. Such embodiments preferably include a power source, e.g. an inductor, which powers the source of radiation using external means, as well as a transmitter, e.g. an inductor, to transmit to external pickup means the signal representing the level of analyte.

Abstract translation: 一种用于使用指示器和参考通道来检测分析物的存在或量的光学传感器（10）。该传感器具有传感器体（12），其具有嵌入其中的辐射源（18）。 源发射的辐射与靠近身体表面的指示膜（3）指示剂分子（16）相互作用。 这些指示剂分子的至少一种光学特性随分析物浓度而变化。 对于以前，荧光指示剂分子的荧光水平或光吸收指示剂分子吸收的光量可以随着分析物浓度的变化而变化。 此外，源发射的辐射也与靠近身体表面的参考膜指示剂分子相互作用。 由这些指示剂分子发射或反射的辐射（例如光）进入并在内部反射在传感器体内。 传感器体内的感光元件产生指示通道和参考通道信号，以提供分析物浓度的准确指示。 优选的实施方案是完全独立的并且其尺寸和形状适于在人体内使用。 这样的实施例优选地包括电源，例如电源。 电感器，其使用外部装置为辐射源供电，以及发射器，例如， 电感器，用于向外部拾取装置传输表示分析物水平的信号。