公开(公告)号：AU2003285932A1

公开(公告)日：2004-05-13

申请号：AU2003285932

申请日：2003-10-22

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA ,  THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY OF THE NAVY

Inventor： EPSTEIN JUDITH E ,  COHEN JOSEPH D ,  HOFFMAN STEPHEN L ,  WANG RUOBING

IPC: A01N43/04 ,  A61K20060101 ,  A61K39/005 ,  A61K39/015 ,  A61K39/02 ,  C07K14/445 ,  G01N33/53

Abstract: The invention pertains to methods for protecting against malaria infection by vaccination. The method of the invention involves priming an anti-malaria immune response with a DNA-based vaccine, and boosting that response with a protein-based vaccine. The method of the invention also relates to broadening the resulting immune response by boosting with a protein-based vaccine.

公开(公告)号：AU2003234210A1

公开(公告)日：2003-11-10

申请号：AU2003234210

申请日：2003-04-25

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY

Inventor： EMMERT-BUCK MICHAEL R ,  AHRAM MAMOUN

IPC: C12Q1/68 ,  G01N33/50 ,  G01N33/53 ,  G01N33/567 ,  G01N33/68 ,  H04B10/08 ,  H04B10/17 ,  A61K39/395

Abstract: Disclosed herein are Direct Cell Target Analysis ("DCTA") molecules and Direct Cell Target ("DCT") methods for directly targeting and acting upon biomolecules. These methods and molecules can be used with specific cells within complex, heterogeneous tissue such that target biomolecules can be procured for subsequent analysis or directly analyzed without the need for physical separation of the biomolecules from other cells or cell components in the population. In general, the methods involve use of a fusion molecule having a first moiety to identify and localize target cells within a tissue sample, and a second moiety to generate detectable products within the target cells that may be detected and subsequently analyzed, and optionally isolated.

公开(公告)号：AU2002337885B1

公开(公告)日：2003-04-28

申请号：AU2002337885

申请日：2002-10-16

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY ,  SCRIPPS RESEARCH INST

Inventor： XIAO XIADONG ,  BURTON DENNIS ,  PHOGAT SANJAY K ,  DIMITROV DIMITER S ,  SHU YUUEI ,  MOULARD MAXIME ,  ZHANG MEI-YUN

IPC: C07K14/73 ,  C07K16/10 ,  C12P21/04 ,  C12P21/08

Abstract: The present invention features antibodies and antibody fragments that specifically bind a CD4-inducible HIV gp120 epitope that is enhanced by binding a co-receptor for HIV, such as CCR5 or CXCR4, and pharmaceutical compositions comprising the antibodies or antibody fragments. The invention also features nucleic acids encoding the antibodies or antibody fragments, pharmaceutical compositions comprising the nucleic acids encoding the antibodies or antibody fragments, vectors comprising the nucleic acids, and cells comprising the vectors. The invention further features methods of identifying antibodies or antibody fragments with broadly neutralizing activity against HIV. The invention also features methods of inhibiting HIV entry into cells and methods of inhibiting replication of HIV in mammals, using the antibodies and nucleic acids of the invention.

公开(公告)号：AU2002254524A1

公开(公告)日：2002-10-21

申请号：AU2002254524

申请日：2002-04-03

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY

Inventor： KRUTZSCH HENRY C ,  ROBERTS DAVID D

IPC: C12Q1/68 ,  C12Q1/6886 ,  G01N33/574 ,  C12Q1/00 ,  G01N33/53 ,  A61K39/395

Abstract: Method of diagnosing cancer in a mammal comprising assaying a test sample from the mammal for an increased level of semenogelin, wherein the increased level of semenogelin in the test sample is diagnostic for the cancer; methods of prognosticating and assessing the effectiveness of treatment of a cancer in a mammal based on the level of semenogelin in a test sample; a composition comprising (a) an immune-response inducing effective amount of (i) semenogelin or polypeptide fragment thereof or (ii) antibody thereto or (b) a recombinant vector encoding and expressing an immune-response inducing effective amount of (i) or (ii); a method of inducing an immune response to a cancer in a mammal comprising administering to the mammal the foregoing composition.

公开(公告)号：AU2296092A

公开(公告)日：1993-02-11

申请号：AU2296092

申请日：1992-06-30

Applicant: THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEP

Inventor： KENNETH A. JACOBSON ,  BARTON J BRADBURY ,  YISHAI KARTON

IPC: C07D471/04 ,  C07D495/04

Abstract: Muscarinic antagonists formed by substitution of the distal N-methyl group of pirenzepine or telenzepine. The group used for substitution can be, for example, a propargyl group, a benzyl group, a substituted benzyl group, a hydroxyethyl group, a chloroethyl group, an aminoethyl group, an omega -amino alkyl group, or an N-substituted omega -amino alkyl group.

公开(公告)号：AU2179192A

公开(公告)日：1993-01-08

申请号：AU2179192

申请日：1992-06-05

Applicant: THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEP

Inventor： DAVID R SIBLEY ,  LAWRENCE C MAHAN ,  ELIZABETH M SMYK-RANDALL ,  FREDERICK J. MONSMA JR.

IPC: C07K14/705

公开(公告)号：AU1785392A

公开(公告)日：1992-10-06

申请号：AU1785392

申请日：1992-02-28

Applicant: THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, UNI

Inventor： RICHARD YANAGIHARA ,  RALPH M GARRUTO ,  ANDREW AJDUKEWICZ ,  D. CARLETON GAJDUSEK

IPC: A61K39/21 ,  C12N7/00 ,  C12Q1/70 ,  G01N33/569

公开(公告)号：DE2851138C2

公开(公告)日：1990-07-05

申请号：DE2851138

申请日：1978-11-25

Applicant: THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, U.S. DEPARTMENT OF COMMERCE, WASHINGTON, D.C., US

Inventor： PETERSON, JOHN IVAN, FALLS CHURCH, VA., US ,  GOLDSTEIN, SETH R., BETHESDA, MD., US

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1459 ,  G01N21/64 ,  G01N21/77 ,  G01N21/80 ,  G01N31/22 ,  G01N33/84

Abstract: A fiber optic pH probe suitable to be implanted in tissue for physiological studies is disclosed. The probe includes an ion permeable membrane envelope which encloses the ends of a pair of optical fibers. A pH sensitive dye indicator composition is present within the envelope. The probe operates on the concept of optically detecting the change in color of a pH sensitive dye.

公开(公告)号：DE2850992C2

公开(公告)日：1987-11-19

申请号：DE2850992

申请日：1978-11-24

Applicant: THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, U.S. DEPARTMENT OF COMMERCE, SPRINGFIELD, VA., US

Inventor： KOLOBOW, THEODOR, ROCKVILLE, MD., US ,  ITO, YOICHIRO, BETHESDA, MD., US

IPC: B04B5/04

公开(公告)号：AT3064T

公开(公告)日：1983-04-15

申请号：AT80301259

申请日：1980-04-18

Applicant: THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY U.S. DEPARTMENT OF COMMERCE

Inventor： JOHNSON SR., CHRISTIAN EDGAR

IPC: C23C18/36 ,  C23F1/28 ,  C23C3/02 ,  C23F5/02

Abstract: The invention provides a method of producing an ultra-black surface coating, having an extremely high light absorption capacity, on a substrate, such as a metal, ceramic, glass, or plastic, the blackness being associated with a unique surface morphology consisting of a dense array of microscopic pores etched into the surface, as well as the resulting coated substrate. The method involves preparing the substrate for plating with a nickel-phosphorus alloy, as by cleaning and/or activating it, immersing the thus-prepared substrate in an electroless plating bath containing nickel and hypophosphite ions in solution until an electroless nickel-phosphorus alloy coating has been deposited on the substrate, and then removing the substrate, coated with the electroless nickel-phosphorus alloy, from the plating bath and washing and drying it. The dried substrate, coated with the electroless nickel-phosphorus alloy, is then immersed in an etchant bath consisting of an aqueous solution of nitric acid, wherein the nitric acid concentration ranges from a 1:5 ratio with distilled or de-ionized water to concentrated, until the coated surface of the substrate develops ultra-blackness, the blackness being associated with the surface morphology as described above. The resulting substrate, covered with the ultra-black coating is thereafter washed and dried. The ultra-black surface, which has a spectral reflectance on the order of about from 0.5 to 1.0% at wavelengths of light of about from 320 to 2140 nanometers, finds use as a solar collector in the field of solar energy.