公开(公告)号：EP0863903A1

公开(公告)日：1998-09-16

申请号：EP96938445.0

申请日：1996-11-24

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： SCHERZ, Avigdor ,  SALOMON, Yoram ,  SCHEER, Hugo ,  HARTWICH, Gerhard ,  BRANDIS, Alexander

IPC: A61K31 ,  A61K41 ,  A61P7 ,  A61P17 ,  A61P31 ,  A61P35 ,  C07D487 ,  C07D491 ,  C07F1 ,  C07F3 ,  C07F11 ,  C07F13 ,  C07F15

CPC classification number: C07D487/22 ,  A61K41/0071 ,  C07D491/22

Abstract: Metalated bacteriochlorophylls of the formula [M]-BChl, wherein M is a metal atom selected from divalent Pd, Co, Ni, Cu, Zn and Mn, trivalent Fe, Mn and Cr, and tetravalent Sn and Pt, and Bchl represents the residue of a demetalated natural or synthetic bacteriochlorophyll derivative, are prepared by transmetalation of the corresponding [Cd]-BChl derivatives carrying at position 173 a group COOR¿1?, wherein R1 is a C1 - C25 hydrocarbyl residue, and further optional transesterification of the 17?3-COOR¿1 of the obtained [M]-BChl. The compounds are for use in photodynamic therapy and diagnosis and for killing cells and infectious agents, e.g. bacteria and viruses, both in biological products and in living tissue. Preferred compounds are those of formula (I') wherein R'1 is a residue selected from (i) optionally substituted hydrocarbyl; (ii) hydroxy-containing amino acid or peptide or a derivative thereof; and (iii) hydroxy-containing peptide or a cell-specific ligand, e.g. peptide or protein, linked to the COO-group via a spacer as defined in (i).

公开(公告)号：EP0426785B1

公开(公告)日：1998-09-02

申请号：EP90905295.3

申请日：1990-03-16

Applicant: NEW YORK UNIVERSITY ,  YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： MERUELO, Daniel ,  LAVIE, Gad ,  MAZUR, Yehuda

IPC: A61K31/12

CPC classification number: C07C39/12 ,  A61K31/12 ,  A61K31/122 ,  A61K31/70 ,  A61K2300/00

Abstract: Disclosed herein are antiviral agents, pharmaceutical formulations comprising effective amounts of these agents and methods for treating mammals suffering from infections caused by viruses. The agents are analogs, isomers, homologs, derivatives and salts of aromatic polycyclic diones.

公开(公告)号：EP0682268A3

公开(公告)日：1998-03-18

申请号：EP95107085.3

申请日：1995-05-10

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： Breskin, Amos ,  Chechik, Rachel ,  Dangendorf, Volker

IPC: G01T3/00 ,  G01N23/05

CPC classification number: G01T3/00 ,  G01N23/05

Abstract: A radiation convertor for use in neutron imaging detectors includes apparatus for conversion of energetic primary charged particles resulting from neutron capture into low energy (eV) secondary electrons. The radiation convertor includes efficient secondary electron emitters, which are preferably alkali halide secondary electron emitters which are preferably CsI secondary electron emitters. The radiation convertor preferably combines at least one layer of Gd and an efficient secondary electron emitter preferably of alkali halide, preferably CsI. The layer of Gd may be at least one metallic layer selected from natural Gd and 157 Gd and this is used in combination with a layer of CsI. The neutron convertor may be alternatively 6Li, LiH or 177 Hf used in combination with an efficient secondary electron emitter, preferably alkali halide emitter, preferably CsI. A neutron imaging detector of the invention may combine a secondary emission composite neutron convertor including efficient secondary electron emitters and an electron multiplier which is sensitive to low energy secondary electrons emitted from the composite neutron convertor. In such a neutron imaging detector combination, the electron multiplier may be a vacuum micro channel plate (MCP) multiplier, a vacuum microsphere plate (MSP), or any other vacuum electron multiplier and imaging device, or a gaseous electron imaging multiplier, preferably a gaseous electron multiplier in which the secondary electron multiplication starts at their emission location from the convertor, preferably a low-pressure multistage electron multiplier.

公开(公告)号：EP0807229A1

公开(公告)日：1997-11-19

申请号：EP96905352.0

申请日：1996-02-06

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： KRIBUS, Avi ,  DORON, Pinchas ,  KARNI, Jacob

IPC: F24J2

CPC classification number: F24S20/20 ,  Y02E10/41

Abstract: A central solar receiver comprising a tubular housing (1) with a central axis, a radiation admitting aperture (5) and an absorber chamber having an outer wall, two oppositely located ends (2, 3), an inner-wall-forming substantially tubular transparent window (6) co-axial with the tubular housing. The solar receiver further comprises injection means (26) near a first of the oppositely located ends and at least one egress opening means (30) near a second of the oppositely located ends. The injection means are capable of injecting into the absorber chamber a multicomponent fluid mixture comprising at least one radiation absorbing component and are so designed that the fluid mixture is injected into the absorber chamber adjacent and essentially tangentially to the outer wall, whereby contact between the mixture and the window is reduced. The egress opening enables the egress of the fluid mixture from the absorber chamber.

公开(公告)号：EP0682327A2

公开(公告)日：1995-11-15

申请号：EP95106967.3

申请日：1995-05-09

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： Shamir, Adi

IPC: G07F7/10 ,  H04L9/32

CPC classification number: G07F7/1008 ,  G06Q20/341 ,  G06Q20/40975 ,  H04L9/0869 ,  H04L9/302 ,  H04L9/3218 ,  H04L9/3234

Abstract: Memory efficient variants of public key encryption and identification schemes for smart card applications with severely limited RAM without using dedicated coprocessors. The variants replace the memory-intensive modular multiplication operation z = x*y (mod n) by a new randomized multiplication operation z' = x*y + r*n , where r is a randomly chosen integer in a suitable range [0,b], and a double convolution process to compute z'is used. Method and apparatus are described.

Abstract translation: Memoryefficientbackup用非常有限的RAM智能卡应用的公共密钥加密和识别方案的变种，而无需使用专用协处理器。 所述变体由新的随机乘法运算Z“= X * Y + R * n，其中r是在一个合适的范围为[0随机选择的整数替换存储器密集型的模乘运算Z = X * Y（MOD N） b]，和双卷积处理来计算Z 1是使用。 方法和装置进行了描述。

公开(公告)号：EP0674709A1

公开(公告)日：1995-10-04

申请号：EP94904448.0

申请日：1993-12-15

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： CITRI, Yoav

IPC: C12N15 ,  C07K14 ,  C12N1 ,  C12P21 ,  C12R1

CPC classification number: C07K14/47

Abstract: A novel Candidate Plasticity-Related cDNA designated CPG-1 and a polypeptide encoded thereby which is believed to be a novel neuropeptide or a neurotrophic factor or a precursor of one of them.

公开(公告)号：EP0646016A1

公开(公告)日：1995-04-05

申请号：EP93916644.0

申请日：1993-06-18

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： SELA, Michael ,  MOZES, Edna

IPC: C07K ,  A61K38 ,  A61P37 ,  A61P43 ,  C07K7 ,  C07K14 ,  A61K39

CPC classification number: C07K14/70571 ,  A61K39/00

Abstract: Peptides having at least nine amino acid residues each including an amino acid sequence which corresponds to position p200-208 or p262-266 of the human acetylcholine receptor α-subunit, but differing therefrom by one or more amino acid substitutions, are disclosed. These peptides inhibit the proliferative response of human peripheral blood lymphocytes to the myasthogenic peptides p195-212 and p259-271 and are suitable for treatment of subjects afflicted with myasthenia gravis.

Abstract translation: 公开了具有至少9个氨基酸残基的肽，每个氨基酸序列包含对应于人乙酰胆碱受体α亚基的位置p200-208或p262-266但与其有一个或多个氨基酸取代不同的氨基酸序列。 这些肽抑制人外周血淋巴细胞对产生肌肉的肽p195-212和p259-271的增殖反应，并且适用于治疗患有重症肌无力的受试者。

公开(公告)号：EP0589181A3

公开(公告)日：1995-02-22

申请号：EP93112173.5

申请日：1993-07-29

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： Shaltiel, Shmuel

IPC: C07K7/08 ,  C07K7/10 ,  A61K37/02

CPC classification number: C07K14/78 ,  A61K38/00

Abstract: The invention relates to synthetic peptides derived from the K³⁴⁸-A³⁸⁰ sequence of the vitronectin molecule. The peptides modulate the biological activities of plasminogen activator inhibitor-1 (PAI-1) and are useful as active ingredients of pharmaceutical compositions for the treatment of disorders such as bleeding disorders, acute myocardial infarction, deep vein thrombosis, pulmonary embolism, disseminated intravascular coagulation, tumor cell invasion and metastasis, inflammation, liver diseases, bacterial blood infections, pregnancy toxicosis, and pathological conditions associated with the control of angiogenesis, or with nerve regeneration, or with excessive tPA-mediated proteolysis..

公开(公告)号：EP0412486B1

公开(公告)日：1994-11-30

申请号：EP90115105.0

申请日：1990-08-06

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： Wallach, David ,  Engelmann, Harmut ,  Aderka, Dan

IPC: C12P21/08 ,  A61K39/395 ,  G01N33/577 ,  G01N33/68 ,  C07K3/18

CPC classification number: C07K16/2866 ,  A61K38/00 ,  C07K14/7151

公开(公告)号：EP0620008A1

公开(公告)日：1994-10-19

申请号：EP94103479.5

申请日：1994-03-08

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD. ,  RAMOT UNIVERSITY AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD.

Inventor： Gozes, Illana ,  Fridkin, Matityahu

IPC: A61K37/02

CPC classification number: C07K14/57563 ,  A61K38/00

Abstract: Use of a peptide selected from the group consisting of:

(i) vasoactive intestinal peptide (VIP);
(ii) analogues of vasoactive intestinal peptide (VIP) in which one or more amino acids has been replaced, added or deleted without substantially altering the biological properties of the parent peptide
(iii) a conjugate being a peptide according to either of (i) and (ii) coupled to a lipophilic moiety;
(iv) a physiologically active fragment of (i), (ii) and (iii); and
(v) a functional derivative of any of (i), (ii), (iii) and (iv) for the preparation of a medicament for the treatment of neurodegenerative disease.

Abstract translation: 选自中选择的肽的用途：（ⅰ）血管活性肠肽（VIP）; 血管活性肠肽（VIP）（II）的类似物，其中一个或多个氨基酸已被取代，添加或删除，而基本上不改变母肽的生物学性质（ⅲ）共轭是根据任一的肽（I） 和（ii）耦合到一个亲脂性部分; （IV）（ⅰ）的生理活性片段，（ii）和（ⅲ）; 和（v）任何（i）的功能性衍生物，（ⅱ），（iii）和（iv）用于制备治疗的神经退化性疾病的治疗。