公开(公告)号：EP0646016A1

公开(公告)日：1995-04-05

申请号：EP93916644.0

申请日：1993-06-18

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： SELA, Michael ,  MOZES, Edna

IPC: C07K ,  A61K38 ,  A61P37 ,  A61P43 ,  C07K7 ,  C07K14 ,  A61K39

CPC classification number: C07K14/70571 ,  A61K39/00

Abstract: Peptides having at least nine amino acid residues each including an amino acid sequence which corresponds to position p200-208 or p262-266 of the human acetylcholine receptor α-subunit, but differing therefrom by one or more amino acid substitutions, are disclosed. These peptides inhibit the proliferative response of human peripheral blood lymphocytes to the myasthogenic peptides p195-212 and p259-271 and are suitable for treatment of subjects afflicted with myasthenia gravis.

Abstract translation: 公开了具有至少9个氨基酸残基的肽，每个氨基酸序列包含对应于人乙酰胆碱受体α亚基的位置p200-208或p262-266但与其有一个或多个氨基酸取代不同的氨基酸序列。 这些肽抑制人外周血淋巴细胞对产生肌肉的肽p195-212和p259-271的增殖反应，并且适用于治疗患有重症肌无力的受试者。

公开(公告)号：EP0646016B1

公开(公告)日：1999-08-25

申请号：EP93916644.3

申请日：1993-06-18

Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY, LTD.

Inventor： SELA, Michael ,  MOZES, Edna

IPC: A61K39/00 ,  A61K38/04 ,  C07K14/705

CPC classification number: C07K14/70571 ,  A61K39/00

Abstract: Peptides having at least nine amino acid residues each including an amino acid sequence which corresponds to position p200-208 or p262-266 of the human acetylcholine receptor α-subunit, but differing therefrom by one or more amino acid substitutions, are disclosed. These peptides inhibit the proliferative response of human peripheral blood lymphocytes to the myasthogenic peptides p195-212 and p259-271 and are suitable for treatment of subjects afflicted with myasthenia gravis.