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公开(公告)号：KR100955075B1
公开(公告)日：2010-04-30
申请号：KR1020070101980
申请日：2007-10-10
Applicant: 대한민국(농촌진흥청장) , 동성제약주식회사
Abstract: 본 발명은 실크 펩타이드를 함유하는 조성물에 관한 것으로, 특히 본 발명에 따른 조성물은 파골세포의 분화 억제에 유효하여, 골다공증의 예방 및 치료에 효과를 가지는 골다공증 예방 및 치료용 조성물을 제공한다.
실크 피브로인, 파골세포, 골다공증, 조골세포-
公开(公告)号：KR100889371B1
公开(公告)日：2009-03-19
申请号：KR1020070096210
申请日：2007-09-21
Applicant: 대한민국(농촌진흥청장) , 주식회사 청진바이오텍
IPC: A61M5/158
Abstract: A papilla needle is provided, which enables to inject the ointment containing bee venom into the papilla of the milk cow without the wound. A papilla needle comprises: grip units(3) formed in the left and the right; and an injection needle unit(5) formed in the center. The external diameter of the injection needle unit is 6mm and the inner diameter is 4.2mm. The papilla needle has the structure that a syringe can be inserted. Three ring segments(9) are protruded at an interval of 2mm in the inner diameter of the hole(11) of the handle unit into which the syringe is inserted. The end unit(7) of the injection needle unit prevents scratch of the papilla.
Abstract translation: 提供乳头针，其能够将含有蜂毒的软膏注射到没有伤口的乳牛的乳头中。 乳头针包括：左右形成的把手单元（3）; 以及形成在中心的注射针单元（5）。 注射针头单元的外径为6mm，内径为4.2mm。 乳头针具有插入注射器的结构。 三个环段（9）在插入注射器的手柄单元的孔（11）的内径中以2mm的间隔突出。 注射针单元的末端单元（7）防止乳头刮伤。
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公开(公告)号：KR100613989B1
公开(公告)日：2006-11-23
申请号：KR1020050007716
申请日：2005-01-27
Applicant: 대한민국(농촌진흥청장) , 동성제약주식회사
Abstract: An oral care composition comprising a nano silk carrier is provided to improve stability and permeation of medicinal components, so that gingivitis is alleviated and periodontal disease is prevented through the mucous membrane. The oral care composition comprises a silk peptide as the nano silk carrier for promoting absorption of medicinal components into human body, wherein the silk peptide has the average diameter of 1-5 mm and average molecular weight of 100-1000 dalton, and contains sericin; the silk peptide is prepared by hydrolysis of cocoon with acids; and the amount of silk peptide is 0.1-20.0 wt.% based on the total weight of composition.
Abstract translation: 提供包含纳米丝载体的口腔护理组合物以改善药用成分的稳定性和渗透性，从而减轻牙龈炎并且通过粘膜防止牙周病。 该口腔护理组合物包含丝肽，作为促进药用成分吸收入人体的纳米丝载体，其中丝肽的平均直径为1-5mm，平均分子量为100-1000道尔顿，并含有丝胶; 丝肽通过用酸水解茧来制备; 并且基于组合物的总重量，丝肽的量为0.1-20.0重量％。
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公开(公告)号：KR1020040073152A
公开(公告)日：2004-08-19
申请号：KR1020030009137
申请日：2003-02-13
Applicant: 주식회사 바이오그랜드 , 대한민국(농촌진흥청장)
IPC: C07K1/12
CPC classification number: C07K1/12 , A23L33/18 , A61K38/1767 , C07K14/43586
Abstract: PURPOSE: A method for preparing silk peptide with nerve cell protecting activity is provided, thereby improving the preparation efficiency of silk peptide, and preparing small molecular weight of silk peptide which can be easily absorbed into the human body. CONSTITUTION: The method for preparing silk peptide with nerve cell protecting activity, having the average molecular weight of 400 to 2,000 dalton comprises the steps of: (a) dissolving silk protein such as silk fibroin in a solution containing calcium salt at 60 to 95 deg. C; (b) removing the calcium salt such as calcium chloride from the silk fibroin solution; and (c) adding protein decomposing enzyme selected from thermoase, flavourzyme, sumizyme, protamex, protin and a combination thereof into the silk fibroin solution at 45 to 60 deg. C.
Abstract translation: 目的：提供丝状肽具有神经细胞保护活性的方法，提高丝肽的制备效率，制备小分子量的丝肽，可以容易地吸收到人体内。 构成：具有平均分子量为400〜2000道尔顿的具有神经细胞保护活性的丝肽的方法包括以下步骤：（a）将丝蛋白如丝素蛋白溶解在含有钙盐的溶液中，其浓度为60至95度 。 C; （b）从丝素蛋白溶液中除去氯化钙等钙盐; 和（c）在45至60℃下将选自热酶，香精酶，辛酸，protamex，protin及其组合的蛋白质分解酶加入到丝素蛋白溶液中。 C。
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公开(公告)号：KR100319473B1
公开(公告)日：2002-01-05
申请号：KR1019990035140
申请日：1999-08-24
Applicant: 대한민국(농촌진흥청장) , 홍영식품 주식회사
IPC: A23G9/04
Abstract: 본발명은실크아미노산수용액을주재로한 아이스크림류의제조방법에관한것이다. 좀더 구체적으로는, 1) 세리신을제거하여견피브로인단백질을얻는공정; 2) 견피브로인단백질에약 0.5N의염산을부가하여견피브로인단백질의농도가약 10%가되도록한 후, 약 121℃에서 4시간동안가수분해한후, 9M의수산화나트륨을부가하여 pH 7의실크아미노산수용액을얻는공정; 3) 실크아미노산수용액을탈색, 탈취시키는공정; 및 4) 실크아미노산수용액을전기투석장치또는겔 여과장치를통과시키는공정으로평균분자량이약 1,500이고, 유리아미노산의함량이 64.4%인실크아미노산수용액을제조한후, 이를탈지분유, 생크림, 설탕, 물엿, 야자경화유, 유화안정제등과혼합하여아이스크림류를제조하는방법에관한것이다. 본발명의실크아미노산수용액을주재로한 아이스크림의조성물로제품화한아이스크림류는맛, 색, 조직감등에있어서고기호성을선호하는현대인들에게적합할뿐만아니라실크아미노산에함유되어있는유리아미노산에의해기능성이강화되었으므로, 아이스크림소비층을좀 더폭넓게함은물론주 소비대상인여성과어린이의건강에도기여할수 있다.
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Patent Agency Ranking
公开(公告)号：KR100306256B1
公开(公告)日：2001-09-13
申请号：KR1019990035142
申请日：1999-08-24
Applicant: 대한민국(농촌진흥청장) , 홍영식품 주식회사
IPC: A23L1/238
Abstract: 본발명은실크아미노산수용액을이용한간장류의제조방법에관한것이다. 좀더 구체적으로는, 혼합간장, 국시간장, 조림간장또는갈비용간장과같은간장류의제조에있어서 1) 세리신을제거하여견피브로인단백질을얻는공정; 2) 견피브로인단백질에약 25%의염산을부가하여견피브로인단백질의농도가약 50%가되도록한 후, 약 98℃에서 48시간동안가수분해한후, 9M의수산화나트륨을부가하여 pH 5.0~5.5의실크아미노산수용액을얻는공정; 3) 실크아미노산수용액을탈색, 탈취시키는공정; 및 4) 실크아미노산수용액을전기투석장치또는겔 여과장치를통과시키는공정으로제조된실크아미노산수용액을첨가하는것에관한것이다.
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公开(公告)号：KR1020000051938A
公开(公告)日：2000-08-16
申请号：KR1019990002672
申请日：1999-01-28
Applicant: 대한민국(농촌진흥청장)
Abstract: PURPOSE: A wound skin-covering film consisting of fibroin protein and preparation method thereof are provided. CONSTITUTION: Fibroin is obtained from silkworms by using protease of Aspergillus oryzae. The fibroin film should have a alpha-helix structure to be attached closely on the wound. A fibrin solution for producing the fibrin film is prepared by the steps of: dissolving fibroin obtained from silkworms in hydrogen chloride, hydrogen sulfate, lithium chloride, lithium bromide, sodium iodine, zinc chloride, and calcium chloride; and removing salts by filtration with filter such as cellophane membrane. The fibroin film is prepared by freeze-drying the fibroin solution and the resulting film should have a 0.1 to 10 mm of thickness.
Abstract translation: 目的：提供一种由丝心蛋白组成的伤口皮肤覆盖膜及其制备方法。 构成：通过使用米曲霉的蛋白酶从蚕获得纤维蛋白。 丝心蛋白膜应具有紧密附着在伤口上的α-螺旋结构。 通过以下步骤制备用于制备纤维蛋白膜的纤维蛋白溶液：将从蚕获得的丝心蛋白溶解在氯化氢，硫酸氢盐，氯化锂，溴化锂，碘化钠，氯化锌和氯化钙中; 并用过滤器如玻璃纸膜过滤除去盐。 丝心蛋白膜通过冷冻干燥丝心蛋白溶液制备，所得膜应具有0.1至10mm的厚度。
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公开(公告)号：KR101694833B1
公开(公告)日：2017-01-12
申请号：KR1020140157995
申请日：2014-11-13
Applicant: 대한민국(농촌진흥청장)
Abstract: 본발명은누에유래가수분해물을포함하는화장료조성물및 식품조성물에관한것이다. 본발명의화장료조성물또는식품조성물의제조방법은, 누에를준비하는제1단계, 상기준비된누에를분쇄하여누에분쇄물을제조하는제2단계, 상기누에분쇄물에산을첨가한후 가수분해하여용해물을제조하는제3단계, 상기용해물을여과한후 걸러져나온용액에알칼리를넣고중화하여중화액을제조하는제4단계, 상기중화액을탈염하여가수분해물을수득하는제5단계및, 상기가수분해물을유효성분으로포함된화장료조성물또는식품조성물을제조하는제6단계를포함하는것이특징이다. 본발명에의해, 누에유래가수분해물을포함하여인체에무해하면서미백효과를갖는화장료조성물및 관절질환에대해개선효과를갖는식품조성물이제공된다.
Abstract translation: 本发明涉及一种化妆品组合物和含有来自蚕的水解产物的食品组合物。 本发明的化妆品组合物和食品组合物的制备方法包括：制备蚕的第一步骤; 用于粉碎所制备的蚕以产生粉碎的蚕的第二步骤; 将第三步骤，将酸添加到粉碎的蚕，然后水解以产生蚕裂解液; 用于过滤裂解物以产生滤液的第四步骤，并加入碱以中和滤液，从而产生中和的溶液; 用于脱盐中和溶液以获得水解产物的第五步骤; 以及用于配制含有水解产物作为活性成分的化妆品组合物或食品组合物的第六步骤。 通过使用来自蚕的水解产物，本发明提供了对人体无害并具有皮肤美白效果的化妆品组合物和具有治疗关节疾病作用的食品组合物。
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公开(公告)号：KR101667544B1
公开(公告)日：2016-10-20
申请号：KR1020140158540
申请日：2014-11-14
Applicant: 대한민국(농촌진흥청장)
Abstract: 본발명은 i) 정제봉독 1g을멸균증류수 50 내지 150 ml에희석시키는단계;ii) 상기희석된정제봉독액을항온수조에서 65 내지 85 ℃의 온도로 1시간내지 8시간동안중탕하는단계; iii) 상기중탕된정제봉독액을 0.45 μm 멤브레인필터로여과하여하청액을얻는단계; 및 iv) 상기하청액을동결건조하는단계;를포함하는포스포리파아제 A2 및히알루로니다아제가불활성화된것을특징으로하는정제봉독의분리방법에관한것이다.
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公开(公告)号：KR1020160057532A
公开(公告)日：2016-05-24
申请号：KR1020140157995
申请日：2014-11-13
Applicant: 대한민국(농촌진흥청장)
Abstract: 본발명은누에유래가수분해물을포함하는화장료조성물및 식품조성물에관한것이다. 본발명의화장료조성물또는식품조성물의제조방법은, 누에를준비하는제1단계, 상기준비된누에를분쇄하여누에분쇄물을제조하는제2단계, 상기누에분쇄물에산을첨가한후 가수분해하여용해물을제조하는제3단계, 상기용해물을여과한후 걸러져나온용액에알칼리를넣고중화하여중화액을제조하는제4단계, 상기중화액을탈염하여가수분해물을수득하는제5단계및, 상기가수분해물을유효성분으로포함된화장료조성물또는식품조성물을제조하는제6단계를포함하는것이특징이다. 본발명에의해, 누에유래가수분해물을포함하여인체에무해하면서미백효과를갖는화장료조성물및 관절질환에대해개선효과를갖는식품조성물이제공된다.
Abstract translation: 本发明涉及一种含有来自蚕的水解产物的化妆品组合物和食品组合物。 本发明的化妆品组合物和食品组合物的制备方法包括：制备蚕的第一步骤; 用于粉碎所制备的蚕以产生粉碎的蚕的第二步骤; 将第三步骤，将酸添加到粉碎的蚕，然后水解以产生蚕裂解液; 用于过滤裂解物以产生滤液的第四步骤，并加入碱以中和滤液，从而产生中和的溶液; 用于脱盐中和溶液以获得水解产物的第五步骤; 以及用于配制含有水解产物作为活性成分的化妆品组合物或食品组合物的第六步骤。 通过使用来自蚕的水解产物，本发明提供了对人体无害并具有皮肤美白效果的化妆品组合物和具有治疗关节疾病作用的食品组合物。
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