公开(公告)号：AU1271201A

公开(公告)日：2001-04-30

申请号：AU1271201

申请日：2000-09-15

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS ,  GRANDEL ROLAND ,  MULLER REINHOLD ,  SCHULT SABINE

IPC: A61K31/55 ,  A61P3/10 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/10 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  C07D487/06 ,  C07D223/00 ,  C07D209/00

Abstract: The invention relates to compounds of formula (I) as well as to the tautomeric forms thereof, possible enantiomeric and diastereomeric forms and the prodrugs thereof, the production and use thereof, whereby the values have the meaning as given in the description.

公开(公告)号：DE19946289A1

公开(公告)日：2001-03-29

申请号：DE19946289

申请日：1999-09-28

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOEGER THOMAS ,  GRANDEL ROLAND ,  MUELLER REINHOLD ,  SCHULT SABINE

IPC: A61K31/5517 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P11/00 ,  A61P13/12 ,  A61P17/02 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/10 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/04 ,  A61P37/02 ,  A61P43/00 ,  C07D487/06 ,  C07D519/00 ,  C07D487/04 ,  A61K31/55 ,  C07D243/18

Abstract: The invention relates to compounds of formula (I) as well as to the tautomeric forms thereof, possible enantiomeric and diastereomeric forms and the prodrugs thereof, the production and use thereof, whereby the values have the meaning as given in the description.

公开(公告)号：AU4558400A

公开(公告)日：2000-11-21

申请号：AU4558400

申请日：2000-04-27

Applicant: BASF AG

Inventor： LUBISCH WILFRIED ,  KOCK MICHAEL ,  HOGER THOMAS ,  GRANDEL ROLAND ,  HOLZENKAMP UTA ,  SCHULT SABINE ,  MULLER REINHOLD

IPC: C07D235/20 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61P3/10 ,  A61P9/00 ,  A61P13/12 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/10 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07D235/18 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04

Abstract: The present invention relates to novel benzimidazoles, their preparation and their use as inhibitors of the enzyme poly(ADP-ribose) polymerase or PARP (EC 2.4.2.30) for producing drugs.

公开(公告)号：CA2371174A1

公开(公告)日：2000-11-02

申请号：CA2371174

申请日：2000-04-11

Applicant: BASF AG

Inventor： MULLER REINHOLD ,  KOCK MICHAEL ,  GRANDEL ROLAND ,  LUBISCH WILFRIED ,  SCHULT SABINE ,  HOGER THOMAS

IPC: C07D235/08 ,  A61K31/4184 ,  A61K31/4427 ,  A61K31/4523 ,  A61K31/496 ,  A61K31/551 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P19/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D235/10 ,  C07D235/12 ,  C07D235/14 ,  C07D235/16 ,  C07D401/08 ,  C07D403/08 ,  C07D235/06

Abstract: The invention relates to a compound of formula (I) or (II), wherein A represents a saturated or mono-unsaturated carbocycle containing 3 to 8 carb on atoms which can also have a condensed benzol ring, whereby the rings can als o be substituted with one or two different or identical radicals; R1 represent s hydrogen, chlorine, fluorine, bromine, iodine, branched and unbranched C1-C6 - alkyl, OH, nitro, CF3, CN, NR11R12, NH-CO-R13, O-C1-C4 alkyl; and R2 represents hydrogen, branched and unbranched C1-C6 alkyl, C1-C4 alkyl-phenyl . The invention also relates to the tautomeric forms, possible enantiomeric an d diastereomeric forms, possible cis-trans isomers on the rings in A and their prodrugs. The substituted benzimidazoles of general formulas (I) and (II) ar e inhibitors of poly(ADP-ribose) polymerase (PARP), or poly(ADP-ribose) syntha se (PARS), as it is also known and can be used for the treatment or prophylaxis of diseases which are associated with the increased enzyme activity of this enzyme.