公开(公告)号：DE4206170A1

公开(公告)日：1993-09-02

申请号：DE4206170

申请日：1992-02-28

Applicant: BASF AG

Inventor： KOENIG HARTMANN DR ,  GOETZ NORBERT DR ,  HARREUS ALBRECHT DR ,  KIRSTGEN REINHARD DR ,  OBERDORF KLAUS DR ,  WINGERT HORST DR ,  KOEHLER ULRICH DR

IPC: C07D207/323 ,  C07D231/06 ,  C07D231/12 ,  C07D231/56 ,  C07D249/04 ,  C07D249/08 ,  C07D261/08 ,  C07D263/32 ,  C07D271/04 ,  C07D271/06 ,  C07D271/10 ,  C07D277/24 ,  C07D285/06 ,  C07D285/08 ,  C07D285/10 ,  C07D285/12 ,  C07D307/46 ,  C07D309/32 ,  C07D333/22 ,  C07D521/00

公开(公告)号：CZ228692A3

公开(公告)日：1993-04-14

申请号：CS228692

申请日：1992-07-22

Applicant: BASF AG

Inventor： SAUTER HUBERT DR ,  BAYER HERBERT DR ,  OBERDORF KLAUS DR ,  WINGERT HORST DR ,  VON DEIN WOLFGANG DR ,  GRAMMENOS WASSILIOS DR ,  KOENIG HARTMANN DR ,  RANG HARALD DR ,  ROEHL FRANZ DR ,  LORENZ GISELA DR ,  AMMERMANN EBERHARD DR

IPC: C07C69/618 ,  A01N37/36 ,  A01N37/38 ,  A01N37/44 ,  A01N37/48 ,  A01N43/08 ,  A01N43/10 ,  A01N43/36 ,  A01N43/56 ,  A01N43/74 ,  A01N43/78 ,  A01N43/80 ,  A01N43/82 ,  A61K31/21 ,  A61K31/40 ,  A61K31/505 ,  C07C67/343 ,  C07C69/65 ,  C07C69/734 ,  C07C69/736 ,  C07C69/738 ,  C07C69/75 ,  C07C69/76 ,  C07C69/84 ,  C07C69/86 ,  C07C69/92 ,  C07C69/94 ,  C07C205/34 ,  C07C205/38 ,  C07C205/56 ,  C07C229/40 ,  C07C229/44 ,  C07C233/11 ,  C07C235/32 ,  C07C235/34 ,  C07C251/38 ,  C07C251/48 ,  C07C251/52 ,  C07C251/60 ,  C07C251/66 ,  C07C255/57 ,  C07C255/64 ,  C07C275/64 ,  C07C309/66 ,  C07C309/73 ,  C07C311/09 ,  C07C311/21 ,  C07C311/29 ,  C07C313/04 ,  C07C313/06 ,  C07C317/44 ,  C07C317/46 ,  C07C323/56 ,  C07C323/62 ,  C07C327/22 ,  C07C327/48 ,  C07D207/32 ,  C07D207/335 ,  C07D207/337 ,  C07D213/53 ,  C07D213/64 ,  C07D213/643 ,  C07D213/66 ,  C07D213/68 ,  C07D213/70 ,  C07D215/22 ,  C07D215/227 ,  C07D215/233 ,  C07D215/36 ,  C07D231/12 ,  C07D233/84 ,  C07D235/28 ,  C07D239/52 ,  C07D249/12 ,  C07D257/04 ,  C07D261/08 ,  C07D263/32 ,  C07D263/34 ,  C07D263/58 ,  C07D271/06 ,  C07D271/10 ,  C07D271/113 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/68 ,  C07D277/74 ,  C07D285/12 ,  C07D285/125 ,  C07D307/46 ,  C07D307/52 ,  C07D307/54 ,  C07D309/06 ,  C07D333/24 ,  C07D409/04 ,  C07D413/04 ,  C07D513/04 ,  C07D521/00 ,  C07F7/08

Abstract: Derivatives of beta -substituted cinnamic acid of the general formula 1 in which R denotes optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl, and in which R can also denote chlorine or bromine, -X- represents the groups -O-, -S-, m denotes 0 or 1, -Y represents the groups -OR , -O-N=CR R , -NR R , -N(OR )R or -Sr , where the abovementioned substituents R to R denote optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl, and for the radicals R , R and R to R can also denote hydrogen, Z denotes halogen, nitro, cyano, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aralkyl, optionally substituted aryloxyalkyl, optionally substituted arylthioalkyl, optionally substituted heteroarylalkyl, optionally substituted heteroaryloxyalkyl, optionally substituted heteroarylthioalkyl, optionally substituted alkenyl, optionally substituted aralkenyl, optionally substituted aryloxyalkenyl, optionally substituted arylthioalkenyl, optionally substituted heteroarylalkenyl, optionally substituted heteroaryloxyalkenyl, optionally substituted heteroarylthioalkenyl, optionally substituted alkynyl, optionally substituted arylalkynyl, optionally substituted heteroarylalkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylazo, optionally substituted acylamino, -OR , -SR ,-SOR , -SO2R , -COOR , -CONR R , -COR , -CR =NR , -N=CR R , -CR =N-OR , -CR R -O-N=CR R , -CH2-OCOR or -NR R , where the groups R to R , and R and R denote hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aralkyl, optionally substituted heteroarylalkyl, optionally substituted aryloxyalkyl, optionally substituted arylthioalkyl, optionally substituted heteroaryloxyalkyl or optionally substituted heteroarylthioalkyl and R denotes hydrogen or C1-C4-alkyl and in which U, V, W denote hydrogen or have one of the meanings mentioned for Z or in which two of the groups Z, U, V or W in adjacent positions of the phenyl ring optionally together form an optionally substituted five- or six-membered, aromatic or aliphatic ring fused to the phenyl ring, which can optionally contain one to three heteroatoms (N, S, O).

公开(公告)号：AT86246T

公开(公告)日：1993-03-15

申请号：AT89123418

申请日：1989-12-19

Applicant: BASF AG

Inventor： WINGERT HORST DR ,  BRAND SIEGBERT DR ,  WENDEROTH BERND DR ,  SCHUETZ FRANZ DR ,  SAUTER HUBERT DR ,  ROEHL FRANZ DR ,  LORENZ GISELA DR ,  AMMERMANN EBERHARD DR

IPC: C07D215/12 ,  A01N37/14 ,  A01N37/50 ,  A01N41/10 ,  A01N43/42 ,  C07C317/44 ,  C07C317/48 ,  C07C323/57 ,  C07D215/36

公开(公告)号：DE4124989A1

公开(公告)日：1993-02-04

申请号：DE4124989

申请日：1991-07-27

Applicant: BASF AG

Inventor： SAUTER HUBERT DR ,  BAYER HERBERT DR ,  OBERDORF KLAUS DR ,  WINGERT HORST DR ,  DEYN WOLFGANG VON DR ,  GRAMMENOS WASSILIOS DR ,  KOENIG HARTMANN DR ,  RANG HARALD DR ,  ROEHL FRANZ DR ,  LORENZ GISELA DR ,  AMMERMANN EBERHARD DR

IPC: A01N37/36 ,  A01N37/38 ,  A01N37/44 ,  A01N37/48 ,  A01N43/08 ,  A01N43/10 ,  A01N43/36 ,  A01N43/56 ,  A01N43/74 ,  A01N43/78 ,  A01N43/80 ,  A01N43/82 ,  C07C69/618 ,  A61K31/21 ,  A61K31/40 ,  A61K31/505 ,  C07C67/343 ,  C07C69/65 ,  C07C69/734 ,  C07C69/736 ,  C07C69/738 ,  C07C69/75 ,  C07C69/76 ,  C07C69/84 ,  C07C69/86 ,  C07C69/92 ,  C07C69/94 ,  C07C205/34 ,  C07C205/38 ,  C07C205/56 ,  C07C229/40 ,  C07C229/44 ,  C07C233/11 ,  C07C235/32 ,  C07C235/34 ,  C07C251/38 ,  C07C251/48 ,  C07C251/52 ,  C07C251/60 ,  C07C251/66 ,  C07C255/57 ,  C07C255/64 ,  C07C275/64 ,  C07C309/66 ,  C07C309/73 ,  C07C311/09 ,  C07C311/21 ,  C07C311/29 ,  C07C313/04 ,  C07C313/06 ,  C07C317/44 ,  C07C317/46 ,  C07C323/56 ,  C07C323/62 ,  C07C327/22 ,  C07C327/48 ,  C07D207/32 ,  C07D207/335 ,  C07D207/337 ,  C07D213/53 ,  C07D213/64 ,  C07D213/643 ,  C07D213/66 ,  C07D213/68 ,  C07D213/70 ,  C07D215/22 ,  C07D215/227 ,  C07D215/233 ,  C07D215/36 ,  C07D231/12 ,  C07D233/84 ,  C07D235/28 ,  C07D239/52 ,  C07D249/12 ,  C07D257/04 ,  C07D261/08 ,  C07D263/32 ,  C07D263/34 ,  C07D263/58 ,  C07D271/06 ,  C07D271/10 ,  C07D271/113 ,  C07D277/28 ,  C07D277/30 ,  C07D277/36 ,  C07D277/68 ,  C07D277/74 ,  C07D285/12 ,  C07D285/125 ,  C07D307/46 ,  C07D307/52 ,  C07D307/54 ,  C07D309/06 ,  C07D333/24 ,  C07D409/04 ,  C07D413/04 ,  C07D513/04 ,  C07D521/00 ,  C07F7/08

Abstract: Derivatives of beta -substituted cinnamic acid of the general formula 1 in which R denotes optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl, and in which R can also denote chlorine or bromine, -X- represents the groups -O-, -S-, m denotes 0 or 1, -Y represents the groups -OR , -O-N=CR R , -NR R , -N(OR )R or -Sr , where the abovementioned substituents R to R denote optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl, and for the radicals R , R and R to R can also denote hydrogen, Z denotes halogen, nitro, cyano, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aralkyl, optionally substituted aryloxyalkyl, optionally substituted arylthioalkyl, optionally substituted heteroarylalkyl, optionally substituted heteroaryloxyalkyl, optionally substituted heteroarylthioalkyl, optionally substituted alkenyl, optionally substituted aralkenyl, optionally substituted aryloxyalkenyl, optionally substituted arylthioalkenyl, optionally substituted heteroarylalkenyl, optionally substituted heteroaryloxyalkenyl, optionally substituted heteroarylthioalkenyl, optionally substituted alkynyl, optionally substituted arylalkynyl, optionally substituted heteroarylalkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted arylazo, optionally substituted acylamino, -OR , -SR ,-SOR , -SO2R , -COOR , -CONR R , -COR , -CR =NR , -N=CR R , -CR =N-OR , -CR R -O-N=CR R , -CH2-OCOR or -NR R , where the groups R to R , and R and R denote hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aralkyl, optionally substituted heteroarylalkyl, optionally substituted aryloxyalkyl, optionally substituted arylthioalkyl, optionally substituted heteroaryloxyalkyl or optionally substituted heteroarylthioalkyl and R denotes hydrogen or C1-C4-alkyl and in which U, V, W denote hydrogen or have one of the meanings mentioned for Z or in which two of the groups Z, U, V or W in adjacent positions of the phenyl ring optionally together form an optionally substituted five- or six-membered, aromatic or aliphatic ring fused to the phenyl ring, which can optionally contain one to three heteroatoms (N, S, O).

公开(公告)号：DE4042283A1

公开(公告)日：1992-07-02

申请号：DE4042283

申请日：1990-12-31

Applicant: BASF AG

Inventor： WOLF BERND DR ,  BENOIT REMY DR ,  SAUTER HUBERT DR ,  WINGERT HORST DR ,  HEPP MICHAEL DR ,  KUEKENHOEHNER THOMAS DR ,  GRAMMENOS WASSILIOS DR

IPC: C07C51/367 ,  C07C65/24 ,  C07C69/738 ,  C07C235/34 ,  C07C249/08 ,  C07C251/48 ,  C07C253/14 ,  C07C255/17 ,  C07C317/24

Abstract: Prepn. of E-oxime-ethers of phenylglyoxylic acid esters of formula (I) comprises (a) reacting a phenol Xm-Ph-PH in a base in the presence of a solvent to give a phenolate; (b) mixing with a lactone of formula (III); (c) distilling off solvent and reacting the mixt. at 50-250 deg.C in the melt; (d) washing with water and acid to give a 2-phenoxymethylbenzoic acid of formula (IV); Q = OH); (e) treating with phosgene or SOCl2 to give the 2-phenoxymethylbenzoyl chloride (IV; Q = Cl); (f) reacting with alkali(ne earth)metal cyanide opt. in the presence of prussic acid; (g) treating the 2-phenoxymethylbenzoyl cyanide (IV; Q = CN) with MeOH in the presence of acid to give (VIIb); (h) opt. splitting under acidic conditions to give (IV; Q = C(O)NHR) or (i) treating (IV; Q=R) with dimethyl sulphoxide in the presence of a base to give a beta ketosulphoxide (IV; Q = CH2SOCH3) and treating with a halogenating agent, and MeOH in acid to give (IV; Q = C(O)OMe); (k) reacting (IV; Q = C(O)OMe) and/or (VIIb) with O-methylhydroxylamine or its acid addn. salt to give (I). Q = R1CH2SOMe, OH, Cl, CN or C(O)NNR; X, Y = halo, 1-4C alkyl, 1-4C alkoxy or CF3; m = 0-4; n = 0-3; R = 1-4C alkyl.

公开(公告)号：DE4042273A1

公开(公告)日：1992-07-02

申请号：DE4042273

申请日：1990-12-31

Applicant: BASF AG

Inventor： WINGERT HORST DR ,  WOLF BERND DR ,  BENOIT REMY DR ,  SAUTER HUBERT DR ,  HEPP MICHAEL DR ,  GRAMMENOS WASSILIOS DR ,  KUEKENHOEHNER THOMAS DR

IPC: C07C51/367 ,  C07C65/24 ,  C07C69/738 ,  C07C235/34 ,  C07C249/08 ,  C07C251/48 ,  C07C253/14 ,  C07C255/17 ,  C07C317/24

Abstract: Prepn. of E-oxime-ethers of phenylglyoxylic acid esters of formula (I) comprises (a) reacting a phenol Xm-Ph-PH in a base in the presence of a solvent to give a phenolate; (b) mixing with a lactone of formula (III); (c) distilling off solvent and reacting the mixt. at 50-250 deg.C in the melt; (d) washing with water and acid to give a 2-phenoxymethylbenzoic acid of formula (IV); Q = OH); (e) treating with phosgene or SOCl2 to give the 2-phenoxymethylbenzoyl chloride (IV; Q = Cl); (f) reacting with alkali(ne earth)metal cyanide opt. in the presence of prussic acid; (g) treating the 2-phenoxymethylbenzoyl cyanide (IV; Q = CN) with MeOH in the presence of acid to give (VIIb); (h) opt. splitting under acidic conditions to give (IV; Q = C(O)NHR) or (i) treating (IV; Q=R) with dimethyl sulphoxide in the presence of a base to give a beta ketosulphoxide (IV; Q = CH2SOCH3) and treating with a halogenating agent, and MeOH in acid to give (IV; Q = C(O)OMe); (k) reacting (IV; Q = C(O)OMe) and/or (VIIb) with O-methylhydroxylamine or its acid addn. salt to give (I). Q = R1CH2SOMe, OH, Cl, CN or C(O)NNR; X, Y = halo, 1-4C alkyl, 1-4C alkoxy or CF3; m = 0-4; n = 0-3; R = 1-4C alkyl.

公开(公告)号：DE4029092A1

公开(公告)日：1992-03-19

申请号：DE4029092

申请日：1990-09-13

Applicant: BASF AG

Inventor： WINGERT HORST DR ,  AMMERMANN EBERHARD DR ,  LORENZ GISELA DR ,  SAUTER HUBERT DR

IPC: A01N37/50 ,  A01N43/40 ,  A01N43/836 ,  C07C327/22 ,  C07C327/36 ,  C07D213/70

Abstract: Thiolcarboxylic acid ester derivs. of formula (I) are new; X = O, S, oxymethylene, methyleneoxy, thiomethylene, methylenethio, ethylene, ethenylene or ethynylene; Y and Z = S or O, provided that they are not both O; R = 1-6C alkyl, mono- di- or tri-nuclear aryl or heteroaryl, these aryl and heteroaryl gps. opt. substd. by R1; R1 = halogen, CN, NO2, 1-6C alkyl, 3-6C cycloalkyl, 1-6C alkoxy, trifluoromethyl, mono or dinuclear aryloxy or mono, di or trinuclear aryl, these aryloxy and aryl gps. being themselves opt. susbtd. by R1.

公开(公告)号：DE4020397A1

公开(公告)日：1992-01-02

申请号：DE4020397

申请日：1990-06-27

Applicant: BASF AG

Inventor： WINGERT HORST DR ,  SAUTER HUBERT DR ,  ROEHL FRANZ DR ,  DOETZER REINHARD DR ,  LORENZ GISELA DR ,  AMMERMANN EBERHARD DR

IPC: A01N37/06 ,  A01N37/42 ,  A01N37/50 ,  C07C59/90 ,  C07C67/343 ,  C07C69/738 ,  C07C205/56 ,  C07C251/48 ,  C07C255/57 ,  C07C255/62 ,  C07C255/64

Abstract: Benzyl ketones of the formula where X is CH or N, Y is O or NR4, R1, R2 are H or alkyl, R3 is halogen, cyano, nitro, alkyl, cycloalkyl, alkoxy, haloalkyl, arylalkyl, arylalkoxy, aryloxy or aryl, and the aryl groups in turn may be substituted, R4 is OH, alkoxy or arylalkoxy and R5 is H, methyl, halogen or methoxy, and fungicides containing these compounds.

公开(公告)号：DE3916719A1

公开(公告)日：1990-12-06

申请号：DE3916719

申请日：1989-05-23

Applicant: BASF AG

Inventor： SEELE RAINER DR ,  SCHUETZ FRANZ DR ,  WINGERT HORST DR ,  SAUTER HUBERT DR ,  AMMERMANN EBERHARD DR ,  LORENZ GISELA DR

IPC: A01N43/20 ,  C07C251/48 ,  C07D303/40

Abstract: 2-Oxiranylphenyl-acrylic acid derivs. of formula (I) are new, wh where A = H, 1-6C alkyl, 3-6C cycloalkyl, naphlhyl, biphenyl, heteroaryl or phenyl, all opt. Substd. by 1-3 halo, NO2,phenoxy, NH2 or 1-4C alkyl, alkoxy or haloalkyl; X = N or CH. Also new are the intermediates (II) and (IVa).

公开(公告)号：DE19738864A1

公开(公告)日：1999-03-11

申请号：DE19738864

申请日：1997-09-05

Applicant: BASF AG

Inventor： KLINTZ RALF DR ,  GOETZ NORBERT DR ,  KEIL MICHAEL DR ,  HEILIG MANFRED DR ,  WINGERT HORST DR ,  VOGELBACHER UWE JOSEF DR ,  WAHL JOSEF ,  WITTERICH FRANK DR

IPC: C07C259/04 ,  C07D231/20 ,  C07C239/10

Abstract: N-acylated (hetero)aromatic hydroxylamine derivatives are prepared by hydrogenation of the corresponding nitro compound in the presence of an inert, aprotic solvent and an aliphatic amine. N-acylated(hetero)aromatic hydroxylamine derivatives of formula (1) are prepared by hydrogenation of a (hetero)aromatic nitro compound of formula (2) in the presence of a hydrogenation catalyst. The hydrogenation is carried out in a mixture at an inert, aprotic solvent and an aliphatic amine followed by removal of the amine by distillation or extraction to yield a crude hydroxylamine without intermediate isolation that is N-acylated to form the compound of formula (3) and optionally by o-alkylation of form the compound of formula (4), R = 1-4 C alkoxycarbonyl, alkylcarbonyl, alkylaminocarbonyl, di(1-4 C alkyl)aminocarbonyl; R = H or 1-6 C alkyl; R = H, halogen, cyano, 1-4 C alkyl, 1-4 C haloalkyl, 1-4 C alkoxy, 1-4 C alkyl-CRd=N-O-1-4 C alkyl, 1-4 C alkoxycarbonyl, -CH2O-N=C(Ra)-C(Rb)=N-O-Rc or A or B; A = -O-, -CH2-, -O-CH2, CH2O-, -CH2OCO-, -CH=CH-, -CH=N-O-, -CH2-O-N=C (Ra) or a single bond; B = phenyl, napthyl, pyridinyl, pyrazinyl, pyrinidinyl, pyridazinyl, pyrazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, 1,2,4-triazolyl; 1,2,3 triazolyl, furanyl, thienyl, pyrrolyl or 3-7 C cycloalkyl, optionally substituted with 1-3 Ri groups. Ri = H, halogen, cyano, 1-4 C alkyl, 1-4 C haloalkyl, 1-4 C alkoxy, 1-4 C alkyl-CR =N-O-1-4 C alkyl, 1-4 C alkoxycarbonyl, 1-4 C alkylaminocarbonyl, 1-4 C dialkylaminocarbonyl, 1-4 C alkylcarbonylamino, 1-4 C alkylcarbonyl-1; 4-alkylamino or phenyl, optionally substituted by halogen or 1-4 C alkyl Rd = H, 1-4 C alkyl, 2-4 C alkoxy or 2-4 C alkenyl; Ra, Rc = H, halogen, cyano, 1-4 C alkyl, 1-4 C alkoxy, 1-4 C alkylthio, cyclopropyl or trifluoromethyl; Rb = 1-4 C alkyl, 2-4 C alkenyl, 3-6 C cycloalkyl, phenyl, hetaryl or heterocyclyl R = halogen, 1-4 C alkyl, 1-4 C haloalkyl or 1-4 C alkoxycarbonyl X = N or CH; n = 0, 1, 2 or 3.