公开(公告)号：WO1990006143A1

公开(公告)日：1990-06-14

申请号：PCT/US1989004531

申请日：1989-10-10

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  DUCAY, James ,  SCHMIDT, Josef ,  FORMAN, Hugh

IPC: A61M05/14

CPC classification number: A61J1/10 ,  B65D41/32

Abstract: A port and closure assembly is provided. The port and closure assembly comprises a port (12 or 112) including a tubular portion (16 or 116) that extends from a base, the tubular portion terminating at an end including an opening (22 or 122). A closure (10, 110 or 210) is provided for sealing at least a portion of the end of the port, the port and closure being constructed from materials that create a tack seal when the closure is positioned on the port and the port and closure are sterilized, the tack seal functioning to secure the closure to the port.

公开(公告)号：WO1990004019A1

公开(公告)日：1990-04-19

申请号：PCT/US1989004527

申请日：1989-10-10

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  HARDWICK, R., Alan ,  LAKE, William, C. ,  PRISCO, Michael, R.

IPC: C12N05/00

CPC classification number: A61M1/362 ,  A61M1/0209 ,  A61M1/3618 ,  A61M1/3693 ,  B03C1/01 ,  B03C1/0332 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  C12M47/04 ,  G01N33/5005 ,  G01N33/54326 ,  G01N33/56966 ,  G01N35/0098

Abstract: A system for the selective separation of a specific cell population from a heterogeneous cell mixture is disclosed herein. Means are provided for obtaining a selective cell concentrate from the heterogeneous cell mixture by separating the selective cell concentrate based upon the physical or biological properties of the concentrate. This may be done by centrifugation, if desired. A container is provided having particle means, the particle means being attached to a substance that is active for binding to a specific desired cell. One brings the cell concentrate into contact with the particle means within the container, for example, by providing sterile connection between the site where the cell concentrate is formed and the container. This permits incubation of the cell concentrate with the particle means, to thereby selectively bind a specific cell population from the cell concentrate to the particle means, creating a particle/cell conjugate. Magnetic means are then provided for separating the particle/cell conjugate from the remainder of the cell concentrate. A two-magnetic system may be used to form the separation.

Abstract translation: 本文公开了用于从异质细胞混合物选择性分离特定细胞群体的系统。 提供了用于通过基于浓缩物的物理或生物学特性分离选择性细胞浓缩物从异质细胞混合物获得选择性细胞浓缩物的方法。 如果需要，这可以通过离心来完成。 提供了一种具有颗粒装置的容器，该颗粒装置连接到活性物质以结合特定的所需细胞。 将细胞浓缩物与容器内的颗粒装置接触，例如通过在形成细胞浓缩物的部位与容器之间提供无菌连接。 这允许细胞浓缩物与颗粒装置孵育，从而选择性地将特定的细胞群从细胞浓缩物结合到颗粒装置，产生颗粒/细胞缀合物。 然后提供磁性装置用于将颗粒/细胞缀合物与细胞浓缩物的其余部分分离。 可以使用双磁系统来形成分离。

公开(公告)号：WO1989007002A1

公开(公告)日：1989-08-10

申请号：PCT/US1989000412

申请日：1989-02-02

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  PRINCE, Paul, R.

IPC: B01D13/00

CPC classification number: A61M1/34 ,  A61M1/262 ,  A61M1/3403 ,  A61M1/341 ,  A61M2205/3331 ,  A61M2205/50 ,  B01D61/22 ,  B01D63/16

Abstract: The efficiency of a blood plasmapheresis filter (12) is purposefully reduced at low input blood flow rates so as to prevent possibly excessive hematocrit which may make it difficult or impossible to handle the resulting blood cell concentrate (e.g., for infusion purposes) and/or which may cause accompanying red cell damage. Where filter (40) efficiency is a function of rpm of a spinning element such controlled reduction may be achieved by simply controlling spinner rpm as a function (e.g., linear over at least some range) of the input blood flow rate.

公开(公告)号：WO1989006969A1

公开(公告)日：1989-08-10

申请号：PCT/US1989000373

申请日：1989-01-30

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  ESTEP, Timothy, N.

IPC: A61K37/14

CPC classification number: A61L2/0023 ,  C07K14/805

Abstract: Hemoglobin solutions are purified by heating in the presence of a reducing agent or other deoxygenating conditions such that non-hemoglobin proteins are selectively precipitated and/or virus is inactivated while minimizing hemoglobin loss. The hemoglobin is maintained in its deoxyhemoglobin form during heating.

Abstract translation: 通过在还原剂或其它脱氧条件的存在下加热来纯化血红蛋白溶液，使得非血红蛋白蛋白质被选择性沉淀和/或病毒灭活同时使血红蛋白损失最小化。 在加热期间血红蛋白维持在其脱氧血红蛋白形式。

公开(公告)号：WO1989004826A1

公开(公告)日：1989-06-01

申请号：PCT/US1988003890

申请日：1988-11-01

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  HALE, Ron, L. ,  SOLAS, Dennis, W.

IPC: C07D213/36

CPC classification number: C07D213/79 ,  C07D213/81 ,  C07D401/14 ,  Y10S436/80

Abstract: A class of fluorescent rare earth chelates and the ligands upon which they are based whose molecular structure incorporates a plurality of substituted arylpyridine diacid units attached to a central template structure is disclosed. These ligands function as efficient energy transfer groups in fluorescent tagging reagents and tracers.

公开(公告)号：WO1989004190A1

公开(公告)日：1989-05-18

申请号：PCT/US1988004365

申请日：1988-10-24

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  ZDEB, Brian, D. ,  JEPSON, Steven, C.

IPC: A61M37/00

CPC classification number: A61M5/1409

Abstract: A cartridge (444) having a drug or other beneficial agent (608) therein and including an adapter (477) is positioned on a receptacle (442) within a parenteral fluid administration set (420). Also disclosed is an adapter (477) for connecting the receptacle (442) to a chamber (606) having a beneficial agent therein. The cartridge and adapter permit a single opening through the injection site at the receptacle and at the chamber at opposite ends of the flow path means while still permetting simultaneous flow both into and out of the chamber and the receptacle.

公开(公告)号：WO1989003703A1

公开(公告)日：1989-05-05

申请号：PCT/US1988004364

申请日：1988-10-24

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  DUDAR, Thomas, E. ,  ZDEB, Brian, D.

IPC: A61M37/00

CPC classification number: A61M5/1409

Abstract: A cartridge (444) is adapted for mounting upon a receptacle in a parenteral fluid administration set for delivering a drug or other beneficial agent to a patient. The cartridge (444) includes a beneficial agent-containing chamber (606) slidable from a first, pre-use position to a second, post-use position. The cartridge includes a hollow tube (496) in which the chamber (606) is at least partially mounted. At least one cannula (500) is mounted to the hollow tube and extends opposite the chamber. A protective cover or cap (530) maintains a chamber protective position that prevents inadvertent movement of the chamber that would accidentally engage the cartridge chamber with flow path means, such as the cannula. The cover is removed in order to engage the chamber.

公开(公告)号：WO1989003229A1

公开(公告)日：1989-04-20

申请号：PCT/US1988003403

申请日：1988-10-03

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  SCHOENDORFER, Donald, W.

IPC: A61M01/00

CPC classification number: A61M1/3672

Abstract: A method of wetting a plasmapheresis filter (26) with anticoagulant in a plasmapheresis system having a venepuncture needle (10), a plasma separation device (26) connected in series by a fluid conduit (12), including operating the system such that an initial limited volume charge of anticoagulant is introduced into the conduit (12) for wetting the filter (26) of the separation device in advance of whole blood flowing from the donor towards the separation device (26) and pushing the anticoagulant charge ahead of the whole blood into the separation device (26).

公开(公告)号：WO1989000947A1

公开(公告)日：1989-02-09

申请号：PCT/US1988002564

申请日：1988-07-28

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  MILLER, Robert, A. ,  STONE, Albert, L.

IPC: B65B07/00

CPC classification number: A61J1/05 ,  A61J1/10 ,  A61M2207/00 ,  B65B55/022

Abstract: A flexible collapsible container (10) is filled with fluid by connecting a fluid conduit (18) to a tubular port (20) which communicates through one of the walls (12) of the container to the container interior, and rupturing a sealing diaphragm (24) that closes the bore (34) of the tubular port. One then passes fluid through the conduit to fill the container. Thereafter, one seals either or both the tubular port and plastic wall which carries it to the other, opposed plastic wall (14) of the container with seal line means to close off flow communication between the bore of the tubular port and a major portion of the container interior which contains the fluid. The effect of this is to block flow communication between the bore and the fluid so that the contents of the container remain sealed on disengagement of the fluid conduit from the tubular port.

公开(公告)号：WO1998042398A1

公开(公告)日：1998-10-01

申请号：PCT/US1997022370

申请日：1997-12-08

Applicant: BAXTER INTERNATIONAL INC.

Inventor： BAXTER INTERNATIONAL INC. ,  MIRAKI, Manoucher ,  PECOR, Robert ,  BOBO, Donald, E., Jr. ,  CIESLAK, Ryszard, S. ,  WORKMAN, Dennis

IPC: A61M25/01

CPC classification number: A61M25/09041 ,  A61M25/0041

Abstract: A guide wire dispenser which is used to introduce a guide wire into the body using one hand. The dispenser utilizes a trigger grip configuration which is arranged in combination with a thumb access platform to provide accurate single-handed control of guide wire delivery to the body. A dual trigger configuration is also disclosed which provides the capability to dispense a guide wire from two different nozzles in a single device.

Abstract translation: 导线分配器，其用于使用一只手将导丝引入身体。 分配器利用触发夹持构造，其与拇指接近平台组合设置，以提供精确的单手控制导丝输送到身体。 还公开了双触发器配置，其提供了在单个设备中从两个不同喷嘴分配引导线的能力。