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    85.
    发明专利
    未知

    公开(公告)号：ES2131241T3

    公开(公告)日：1999-07-16

    申请号：ES95113847

    申请日：1995-09-04

    Applicant: HOECHST AG

    Inventor： KLEEMANN HEINZ-WERNER DR ,  LANG HANS-JOCHEN DR ,  SCHWARK JAN-ROBERT DR ,  WEICHERT ANDREAS DR ,  SCHOLZ WOLFGANG DR ,  ALBUS UDO DR

    IPC: A61K31/165 ,  A61K31/155 ,  A61K31/18 ,  A61K31/27 ,  A61K31/275 ,  A61P3/08 ,  A61P3/10 ,  A61P3/12 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/28 ,  A61P35/00 ,  A61P41/00 ,  A61P43/00 ,  C07C229/00 ,  C07C277/08 ,  C07C279/22 ,  C07C317/46 ,  C07C323/44 ,  C07C323/60 ,  C07C323/63

    Abstract: Benzoyl guanine derivs. of formula(I) and their salts are new. One of the substits. R1-R3 = Y-Ph-Ä(CH2)k-CHR7-CO-R8Ü; and the others = 1-8C alkyl, 2-8C alkenyl, (CH2)mR14, SO2NHC(=Y')NR18R19, H, halo, CN, Z(CH2)p-CqF2q+1, SOuR22, CONR23R24, COR25, SO2NR26R27, OR35 or NR35R36; Ph = phenylene (opt. mono- or di-substd. by Fl, Cl, CF3, Me, OH, OMe or NR37R38); R37, R38 = H or Me; Y = a bond, O, S or NR9; R9 = H or 1-4C alkyl; R7 = OR10 or NR10R11; R10 = H 1-8C alkyl, 1-8C alkanoyl, 1-8C alkoxycarbonyl, benzyl, or benzyloxycarbonyl; R11 = as R10 or trityl; R8 = OR12 or NR12R13; R12, R13 = H, 1-8C alkyl or benzyl; R14 = 3-8C cycloalkyl or phenyl (both opt. substd. by 1-3 F, Cl, CF3, Me, OMe, or NR15R16); R15, R16 = H or Me; Y' = O, S or NR20; R18, R19 = H, 1-8C alkyl, 3-6C alkenyl or (CH2)tR21; or R18+R19 = A; R21 = 5-7C cycloalkyl or phenyl, (both opt. mono- to tri-substd. by F, Cl, OMe or 1-4C alkyl); R20 = as R18 or amidine; Z = a bond, O, S or NR28; R22 = 1-8C alkyl, 3-6C alkenyl, (CH2)nR29 or CF3; R23, R25, R26 = as R22 or H; R24, R27 = H or 1-4C alkyl; or R23+R24, R26+R27 = A; A = (CH2)4 or (CH2)5 (both opt. having a CH2 replaced by O, S, NH, NMe or N-benzyl; R28 = H or 1-3C alkyl; R29 = 3-7C cycloalkyl or phenyl (both opt. substd. by 1-3 F, Cl, CF3, Me, OMe or NR30R31; R30, R31 = H or 1-4C alkyl; R35, R36 = H or 1-6C alkyl; or R35+R36 = (CH2)y (opt. having a CH2 gp. replaced by O, S, NH, NMe or N-benzyl); R4, R5 = H, 1-4C alkyl, F, Cl, OR32, NR33R34 or CrF2r+1; R32-R34 = H or 1-3C alkyl; k, n, t = 0-4; m, u, p = 0-2; q = 1-6; r = 1-4; and y = 4-7.

    New 1-benzyl-imidazole and known tetrazole derivatives
    86.
    发明专利
    New 1-benzyl-imidazole and known tetrazole derivatives 未知

    公开(公告)号：DE19741636A1

    公开(公告)日：1999-03-25

    申请号：DE19741636

    申请日：1997-09-22

    Applicant: HOECHST AG

    Inventor： KLEEMANN HEINZ-WERNER DR ,  LANG HANS-JOCHEN DR ,  SCHWARK JAN-ROBERT DR ,  WEICHERT ANDREAS DR ,  FABER SABINE DR ,  JANSEN HANS-WILLI DR

    IPC: C07D233/54 ,  C07D233/68 ,  C07D233/70 ,  C07D233/84 ,  C07D233/90 ,  A61K31/41 ,  A61K31/415

    Abstract: 1-Benzylimidazole derivatives of formula (I) and their salts are new. R1 = H, 1-8C alkyl, -CaH2a-Ar or -CaH2a-(3-7C)cycloalkyl; a = 0-2; Ar = phenyl or 1-9C heteroaryl (both optionally substituted by 1-3 F, Cl, Br, I, CF3, Me, OMe, OH or NR8R9); R8, R9 = H or 1-4C alkyl; R2, R3 = H, F, Cl, Br, I, CF3, CN, NO2, CH2OR17, COR6 or OR7, 1-8C alkyl, 3-7C cycloalkyl, -CaH2a-Ar or -SOa-R22; R17= H or 1-8C alkyl; R6 = H, 1-8C alkyl, OR30 or phenyl (optionally substituted as in Ar); R7 = H, 1-8C alkyl or Ar; R22 = 1-8C alkyl, 3-7C cycloalkyl or -CaH2a-Ph; R4, R5 = H, 1-8C alkyl, F, Cl, Br, I, CF3, CN, NO2, SOa-R16, COR23 or OR24; R16 = 1-8C alkyl or phenyl (optionally substituted as in Ar); R23 = H, 1-8C alkyl or OR25; R24 = H, 1-8C alkyl or phenyl (optionally substituted as in Ar); and R25 = H or 1-8C alkyl. Also claimed is the treatment or prophylaxis of ischaemia-mediated conditions or the treatment of respiratory disorders using a tetrazole derivative.

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