公开(公告)号：IS3444A7

公开(公告)日：1989-09-05

申请号：IS3444

申请日：1989-03-03

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  NEIDHART WERNER ,  RAMUZ HENRI ,  STADLER HEINZ ,  WOSTL WOLFANG

IPC: A61K20060101 ,  C07C20060101 ,  C07D20060101 ,  C07D233/64 ,  C07K20060101 ,  C07K ,  A61K

公开(公告)号：DK96889A

公开(公告)日：1989-09-05

申请号：DK96889

申请日：1989-02-28

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  NEIDHART WERNER ,  RAMUZ HENRI ,  STADLER HEINZ ,  WOSTL WOLFGANG

IPC: A61K31/16 ,  A61K31/41 ,  A61K31/425 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K38/00 ,  A61P9/04 ,  A61P9/12 ,  C07C215/26 ,  C07C231/02 ,  C07C237/00 ,  C07C237/22 ,  C07C317/44 ,  C07C323/60 ,  C07D231/12 ,  C07D233/54 ,  C07D233/64 ,  C07D263/04 ,  C07D263/06 ,  C07D263/24 ,  C07D277/20 ,  C07D277/30 ,  C07D307/52 ,  C07D333/24 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  C07F9/6506 ,  C07K5/06 ,  C07K14/81 ,  C07C103/50 ,  C07D277/28 ,  C07D295/14 ,  C07D317/28

Abstract: The compounds of the formula I wherein A, R1, R2, R3, R4, R5 and R6 are as set forth above, are described. The compounds of formula I have an inhibitory activity on the natural enzyme renin and can accordingly be used in the form of pharmaceutical preparations for the control or prevention of high blood pressure and cardiac insufficiency.

公开(公告)号：ZA887322B

公开(公告)日：1989-06-28

申请号：ZA887322

申请日：1988-09-29

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  QUIRICO BRANCA ,  EDENHOFER ALBRECHT ,  ALBRECHT EDENHOFER ,  GUTKNECHT EVA-MARIA ,  EVA-MARIA GUTKNECHT ,  NIEDHART WERNER ,  WERNER NIEDHART ,  RAMUZ HENRI ,  HENRI RAMUZ ,  WOSTL WOLFGANG ,  WOLFGANG WOSTL

IPC: C07D209/42 ,  A61K31/16 ,  A61K31/27 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/405 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/535 ,  A61K38/00 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C237/08 ,  C07C261/04 ,  C07C271/18 ,  C07C271/22 ,  C07C327/58 ,  C07D213/50 ,  C07D231/12 ,  C07D233/54 ,  C07D233/64 ,  C07D307/52 ,  C07D401/12 ,  C07D403/12 ,  C07D513/04 ,  C07K5/02 ,  C07K5/097 ,  C07K5/117 ,  C07C ,  C07D ,  A61K

Abstract: Compounds of the formula in which R , R , R , R and A have the meaning given in Claim 1, and pharmaceutically utilisable salts thereof have renin-inhibiting properties and can therefore be used in the form of pharmaceutical preparations as medicaments. They can be prepared by methods which are known per se.

公开(公告)号：ZA8807322B

公开(公告)日：1989-06-28

申请号：ZA8807322

申请日：1988-09-29

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  QUIRICO BRANCA ,  EDENHOFER ALBRECHT ,  ALBRECHT EDENHOFER ,  GUTKNECHT EVA-MARIA ,  EVA-MARIA GUTKNECHT ,  NIEDHART WERNER ,  WERNER NIEDHART ,  RAMUZ HENRI ,  HENRI RAMUZ ,  WOSTL WOLFGANG ,  WOLFGANG WOSTL

IPC: C07D209/42 ,  A61K31/16 ,  A61K31/27 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/405 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/535 ,  A61K38/00 ,  A61P9/00 ,  A61P9/12 ,  A61P43/00 ,  C07C237/08 ,  C07C261/04 ,  C07C271/18 ,  C07C271/22 ,  C07C327/58 ,  C07D213/50 ,  C07D231/12 ,  C07D233/54 ,  C07D233/64 ,  C07D307/52 ,  C07D401/12 ,  C07D403/12 ,  C07D513/04 ,  C07K5/02 ,  C07K5/097 ,  C07K5/117 ,  C07C ,  A61K ,  C07D

CPC classification number: C07D233/64 ,  C07K5/0227 ,  C07K5/0823 ,  C07K5/1024

公开(公告)号：FI76572B

公开(公告)日：1988-07-29

申请号：FI820106

申请日：1982-01-13

Applicant: HOFFMANN LA ROCHE

Inventor： ASCHWANDEN WERNER ,  BRANCA QUIRICO ,  KYBURZ EMILIO ,  PFISTER RUDOLF

IPC: C07D295/02 ,  A61K31/00 ,  A61P37/08 ,  C07C1/00 ,  C07C13/547 ,  C07C17/00 ,  C07C17/16 ,  C07C17/26 ,  C07C22/04 ,  C07C27/00 ,  C07C33/34 ,  C07C35/37 ,  C07C67/00 ,  C07C301/00 ,  C07C303/22 ,  C07C303/32 ,  C07C309/63 ,  C07D207/04 ,  C07D295/03

Abstract: 1-[2-(4,5,10,11-Tetrahydro-1H-dibenzo[a,d]cyclohepten-5-yl)ethyl]pyrro lidine of the formula I and its pharmaceutically acceptable acid addition salts, prepared through various intermediates, are described. The compounds have valuable histamine-H1 antagonistic properties and are suitable for the control or prevention of allergic reactions,such as, urticaria, hay fever, anaphylaxis and over-sensitivity to medicaments.

公开(公告)号：NO874757A

公开(公告)日：1988-05-16

申请号：NO874757

申请日：1987-11-13

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  JAUNIN ROLAND ,  MARKI HANS PETER ,  MARTI FRANZI ,  RAMUZ HENRI

IPC: A61K31/415 ,  A61K31/4184 ,  A61K31/425 ,  A61K31/428 ,  A61K31/44 ,  A61K31/55 ,  A61K31/551 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D233/54 ,  C07D233/64 ,  C07D235/14 ,  C07D235/26 ,  C07D243/14 ,  C07D277/62 ,  C07D277/64 ,  C07D401/06 ,  C07D471/04 ,  C07D487/04 ,  C07D521/00 ,  C07D235/00 ,  C07D277/00 ,  C07D401/00

CPC classification number: C07D233/64 ,  C07D231/12 ,  C07D233/56 ,  C07D235/14 ,  C07D235/26 ,  C07D243/14 ,  C07D249/08 ,  C07D277/64 ,  C07D401/06 ,  C07D471/04 ,  C07D487/04

公开(公告)号：NO874757D0

公开(公告)日：1987-11-13

申请号：NO874757

申请日：1987-11-13

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  JAUNIN ROLAND ,  MAAERKI HANS PETER ,  MARTI FRAAENZI ,  RAMUZ HENRI

IPC: A61K31/415 ,  A61K31/4184 ,  A61K31/425 ,  A61K31/428 ,  A61K31/44 ,  A61K31/55 ,  A61K31/551 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D233/54 ,  C07D233/64 ,  C07D235/14 ,  C07D235/26 ,  C07D243/14 ,  C07D277/62 ,  C07D277/64 ,  C07D401/06 ,  C07D471/04 ,  C07D487/04 ,  C07D521/00 ,  C07D235/00 ,  C07D277/00 ,  C07D401/00

Abstract: Compounds of the formula I wherein R is lower-alkyl, R1 is halogen, R2 is C1-C12-alkyl, R3 is hydroxy, lower-alkoxy, lower-alkyl-carbonyloxy, lower-alkoxy-lower-alkylcarbonoyloxy, lower-alkylaminocarbonyloxy, arylaminocarbonyloxy or aryl-lower alkylaminocarbonyloxy, X is C1-C18-alkylene which optionally can be interrupted by 1,4-phenylene or interrupted or lengthened by 1,4-cyclohexylene, A is di- or tri-substituted 2-imidazolyl attached via an ethylene group or a substituted or unsubstituted heterocycle selected from the group consisting of benzimidazolyl, benzimidazolonyl, imidazo[4,5-c]pyridinyl, imidazo[4,5-c]pyridinonyl, benzthiazolyl, benzodiazepine-2,5-dion-1-yl and pyrrolo[2,1-c]-[1,4]benzodiazepine-5,11-dion-10-yl and n is the number 0 or 1, in the form of racemates and optical antipodes, as well as N-oxides and pharmaceutically usable acid addition salts thereof. The compounds of formual I have a pronounced calcium-antagonistic and anti-arrhythmic activity and can accordingly be used as medicaments, especially for the control or prevention of angina pectoris, ischaemia, arrhythmias, high blood pressure and cardiac insufficiency.

公开(公告)号：CA1160219A

公开(公告)日：1984-01-10

申请号：CA393178

申请日：1981-12-23

Applicant: HOFFMANN LA ROCHE

Inventor： ASCHWANDEN WERNER ,  BRANCA QUIRICO ,  KYBURZ EMILIO ,  PFISTER RUDOLF

IPC: C07D295/02 ,  A61K31/00 ,  A61P37/08 ,  C07C1/00 ,  C07C13/547 ,  C07C67/00 ,  C07C209/00 ,  C07C209/04 ,  C07C209/08 ,  C07C209/22 ,  C07C211/32 ,  C07D295/03 ,  C07C87/459

Abstract: RAN 4016/17 The novel cycloheptene derivatives of the general formula I wherein R1 signifies lower alkyl, the dotted line signifies an optional bond and n signifies the number 1, 2 or 3, and either R2 signifies hydrogen or lower alkyl and R3 signifies lower alkyl or R2 and R3 together with the nitrogen atom signify a 5- or 6-membered heterocycle, and their pharmaceutically acceptable acid addition salts have valuable histamine-H1 antagonistic properties and are suitable for the control or prevention of allergic reactions such as urticaria, hay fever, anaphylaxis and over-sensitivity to medicaments. These compounds can be manufactured according to various processes starting from partly novel starting materials and can be brought into galenical administration forms.

公开(公告)号：CA1157853A

公开(公告)日：1983-11-29

申请号：CA393170

申请日：1981-12-23

Applicant: HOFFMANN LA ROCHE

Inventor： ASCHWANDEN WERNER ,  BRANCA QUIRICO ,  KYBURZ EMILIO ,  PFISTER RUDOLF

IPC: C07D295/02 ,  A61K31/00 ,  A61P37/08 ,  C07C1/00 ,  C07C13/547 ,  C07C17/00 ,  C07C17/16 ,  C07C17/26 ,  C07C22/04 ,  C07C27/00 ,  C07C33/34 ,  C07C35/37 ,  C07C67/00 ,  C07C301/00 ,  C07C303/22 ,  C07C303/32 ,  C07C309/63 ,  C07D207/04 ,  C07D295/03

Abstract: RAN 4016/16 The novel 1-¢2-(4,5,10,11-tetrahydro-1H-dibenzo- ¢a,d!cyclohepten-5-yl)ethyl!pyrrolidine of the formula I and its pharmaceutically acceptable acid addition salts have valuable histamine-H1 antagonistic properties and are suitable for the control or prevention of allergic reactions such as urticaria, hay fever, anaphylaxis and over-sensitivity to medicaments. These compounds can be manufactured according to various processes starting from partly novel starting materials and can be used in galenical administration forms.

公开(公告)号：ZA8105115B

公开(公告)日：1982-08-25

申请号：ZA8105115

申请日：1981-07-24

Applicant: HOFFMANN LA ROCHE

Inventor： BRANCA QUIRICO ,  FISCHLI ALBERT EDUARD ,  SZENTE ANDRE

IPC: A61K31/55 ,  A61K31/551 ,  A61P5/38 ,  C07D243/16 ,  C07D243/18 ,  C07D243/24 ,  C07D243/26 ,  C07D243/28 ,  C07D ,  A61K

CPC classification number: C07D243/24