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    Use of phenyl pyridinyl methylaminomethyl piperidinyl methanone derivatives in the treatment of opioid dependence
    85.
    发明专利
    Use of phenyl pyridinyl methylaminomethyl piperidinyl methanone derivatives in the treatment of opioid dependence 未知

    公开(公告)号：FR2827172A1

    公开(公告)日：2003-01-17

    申请号：FR0109350

    申请日：2001-07-13

    Applicant: PF MEDICAMENT

    Inventor： COLPAERT FRANCIS ,  BRUINS SLOT LIESBETH ,  KOEK WOUTER ,  TARAYRE JEAN PIERRE ,  VACHER BERNARD

    IPC: C07D401/12 ,  A61K31/4545 ,  A61P25/36

    Abstract: The use of a phenyl pyridinyl methylaminomethyl piperidinyl methanone derivative (I) in medicines for the treatment of opioid dependence. The use of a phenyl pyridinyl methylaminomethyl piperidinyl methanone derivative (I) in medicines for the treatment of opioid dependence. u = H or methyl; v = H, Cl, or methyl; w = H, F, or methyl; x = H or F; y = Cl or methyl; z' = H, F, Cl, or methyl; A = H, F, Cl, 1-5C alkyl, mono- di- and trifluoro alkyl, cyclopropyl, cyclobutyl or cyclopentyl, 5-membered heterocycle (with 1-4 heteroatoms (O, N, S) but having no more than 1 O or S atom in the ring), R1-O-, R 1-S-, -NR2R3, a cyclic trimethylene or tetramethylene imine, or alkoxycarbonyl; R1 = 1-5C alkyl, fluoromethyl, trifluoromethyl, cyclopropyl, cyclobutyl, or cyclopentyl; and R2 and R3 = H, 1-5C alkyl, cyclopropyl or trifluoromethyl. Provided that: (1) u is methyl, when v and are H; (2) v is methyl when u and w are H; and (3) w is methyl when u and v are H.

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