公开(公告)号：WO1996029102A1

公开(公告)日：1996-09-26

申请号：PCT/US1996003474

申请日：1996-03-15

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  KOHLER, Anja, S. ,  MOORADIAN, Daniel, L. ,  FURCHT, Leo, T.

IPC: A61L33/00

CPC classification number: A61L33/0082 ,  Y10S514/822

Abstract: A biocompatible material comprising a substrate and a phospholipid moiety covalently attached thereto in an amount and orientation effective to provide an improved nonthrombogenic surface relative to the substrate without the phospholipid moiety covalently attached thereto is provided. In particularly preferred embodiments, the bicompatible material has structure (1) wherein R is a (C1-C30)alkyl group; R is a (C1-C30)alkylene group; m is 1-4; n is 1-4; and L is a divalent linking group covalently bonded to the substrate and to the phospholipid moiety.

Abstract translation: 提供了一种生物相容性材料，其包含以有效提供相对于底物的改进的非凝血基因表面的量和取向共价连接于其上的磷脂部分，而磷脂部分共价连接到其上。 在特别优选的实施方案中，双相容性材料具有结构（1），其中R 1是（C 1 -C 30）烷基; R 2是（C 1 -C 30）亚烷基; m为1-4; n为1-4; 并且L是共价键合到底物和磷脂部分的二价连接基团。

公开(公告)号：WO1996018646A3

公开(公告)日：1996-06-20

申请号：PCT/US1995016284

申请日：1995-12-15

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  McGILL UNIVERSITY

Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  McGILL UNIVERSITY ,  BIRNBAUM, Gary ,  KOTILINEK, Linda, A. ,  BRAUN, Peter, Erich

IPC: C07K14/35

公开(公告)号：WO1996005865A1

公开(公告)日：1996-02-29

申请号：PCT/US1995010940

申请日：1995-08-22

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  UCKUN, Fatih, M.

IPC: A61K47/48

CPC classification number: A61K47/6851 ,  A61K47/6825 ,  A61K47/6849

Abstract: A method is provided which utilizes highly potent and cell-type specific immunotoxins (IT) to systemically treat therapy refractory high risk ALL patients. The method of the present invention decreases the post BMT relapse rate by eliminating the radiation resistant and/or drug resistant residual leukemia burden. With slight modifications the method of the present invention should be generally applicable to preparation of other PAP-MoAb conjugates for treatment of other types of cancer or AIDS.

Abstract translation: 提供了一种利用高效和细胞型特异性免疫毒素（IT）系统治疗难治性高危ALL患者的方法。 本发明的方法通过消除耐辐射和/或耐药性的残留白血病负担来降低BMT后复发率。 通过轻微的修改，本发明的方法通常可用于制备用于治疗其它类型的癌症或AIDS的其它PAP-MoAb缀合物。

公开(公告)号：WO1995031209A1

公开(公告)日：1995-11-23

申请号：PCT/US1995006028

申请日：1995-05-12

Applicant: BAXTER INTERNATIONAL INC. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： BAXTER INTERNATIONAL INC. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA ,  LEVENTHAL, Joseph, R. ,  MÜLLER-DERLICH, Jutta ,  BÖHM, Wolfgang ,  BIEBER, Franz, A. ,  SALIT, Marc ,  SPAETHE, Reiner ,  BOLMAN, R., Morton, III ,  MATAS, Arthur, J.

IPC: A61K35/16

CPC classification number: A61M1/3472 ,  A61K35/16 ,  A61M1/3489 ,  A61M2202/0417

Abstract: The invention provides a method to prevent or ameliorate a hyperacute rejection reaction which would normally occur after transplant of a pig organ to a primate recipient, including a human recipient. Normally, anti-pig antibodies in the blood of the recipient will bind to pig antigens on the endothelial cells of the grafted pig organ, and activate the complement cascade causing necrosis of the pig organ within minutes to hours. The invention method involves passing at least 2-3 plasma volumes of the primate recipient's plasma over a sterile and pyrogen-free column coupled to protein which binds to and thereby removes immunoglobulin from the recipient's plasma, and then transplanting a pig organ to the primate recipient. The column treatment is preferably repeated on several days before and after transplant, and thereby prevents or ameliorates the hyperacute rejection reaction by removing anti-pig antibodies from the recipient's plasma. The method can remove greater than 99 % of the primate recipient's total IgG and greater than 99 % of the recipient's total IgM. The method also effects a 50-500 fold reduction in anti-pig immunoglobulin, and a 15-60 % reduction in potential complement activity. This invention also provides immunoglobulin-depleted human plasma suitable for infusion to a human recipient of a pig organ transplant.

Abstract translation: 本发明提供了一种预防或改善通常在将猪器官移植到包括人接受者的灵长类动物接受者之后通常发生的超急性排斥反应的方法。 通常，受体血液中的抗猪抗体将与接种的猪器官的内皮细胞上的猪抗原结合，并在数分钟至数小时内激活补体级联，引起猪器官的坏死。 本发明方法涉及将至少2-3个等离子体体积的灵长类动物受体的血浆通过无菌无致热原的柱与偶联蛋白质结合，从而从接受者血浆中移除免疫球蛋白，然后将猪器官移植到灵长类动物受体 。 优选在移植前后几天重复柱处理，从而通过从受体血浆中除去抗猪抗体来防止或改善超急性排斥反应。 该方法可以除去大于99％的灵长类动物接受者的总IgG和大于接受者总IgM的99％。 该方法还使抗猪免疫球蛋白降低50-500倍，潜在补体活性降低15-60％。 本发明还提供了适用于向猪器官移植物的人接受者输注的免疫球蛋白缺乏的人血浆。

公开(公告)号：WO1995030385A1

公开(公告)日：1995-11-16

申请号：PCT/US1995005811

申请日：1995-05-04

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  DAS, Gladwin, S.

IPC: A61F02/06

CPC classification number: A61F2/82 ,  A61F2/88 ,  A61F2/95 ,  A61F2/966 ,  A61F2210/0019 ,  A61F2240/001 ,  B21F45/008

Abstract: A stent (1) comprising a self-expandable cylindrical body constructed of a single integral piece of material (8), including a plurality of wavy closed windings (10), and strips (16) interconnecting the windings such that the stent is prevented from stretching longitudinally, is provided. A method of manufacture of the stent by winding a continuous wire (10) upon spikes (44) on an elongated mandrel (40) to form a self-expanding shape memory coil is disclosed. A method of implanting the stent by releasably securing the stent in a sheath for insertion into a body cavity to maintain patency, is also disclosed.

Abstract translation: 一种支架（1），包括由包括多个波状封闭绕组（10）的单个整体材料（8）构成的自扩张圆柱形主体和互连所述绕组的条带（16），使得所述支架不被 提供纵向拉伸。 公开了一种通过在细长心轴（40）上的钉（44）上缠绕连续线（10）以形成自膨胀形状的存储器线圈来制造支架的方法。 还公开了通过将支架可释放地固定在用于插入体腔中以保持开放性的护套中的支架来植入支架的方法。

公开(公告)号：WO1995020934A1

公开(公告)日：1995-08-10

申请号：PCT/US1995001293

申请日：1995-02-02

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  DALRYMPLE, Jon ,  MARTENS, Leslie, V. ,  MAGNUSSON, Jan, H.

Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA

IPC: A61G17/02

CPC classification number: A61L2/24 ,  A61C1/0076 ,  A61C1/052 ,  A61C17/0217 ,  A61C17/20

Abstract: Dental hand tools (140) including disposable water and air treatment cartridges (50). In various construction, cartridges (50) containing selected arrangements of disinfectant media mount to a detachable, hand tool adaptor manifold (2) or to an integral hand tool manifold (142). The cartridges (50) purify water and air discharged from the hand tool (140) and direct liquid and airflow over external surfaces of the cartridge (50) to an interior cavity (156) containing a halogen disinfectant media (e.g. a multivalent iodine resin) and/or halogen scavenger media and porous spacers. A retainer may interlock the cartridge to the manifold (142) and means may be included to prevent leaching of the disinfectant by the scavenger media. Various constructions of handpieces, syringes and scalers compatible with alternative detachable, adaptor manifold or having integral cartridge manifolds are disclosed. Spray tips with integral manifolds and detachable cartridge manifolds which align to water and air discharge ports are also disclosed.

Abstract translation: 牙科手动工具（140），包括一次性水和空气处理盒（50）。 在各种结构中，将包含消毒介质的选择布置的盒（50）安装到可拆卸的手工工具适配器歧管（2）或整体手动工具歧管（142）上。 墨盒（50）净化从手工具（140）排出的水和空气，并将液体和气流引导到墨盒（50）的外表面上，到达含有卤素消毒剂介质（例如多价碘树脂）的内部空腔（156） 和/或卤素清除剂介质和多孔间隔物。 保持器可以将药筒联接到歧管（142），并且可以包括装置以防止消毒剂被清除剂介质浸出。 公开了与可替换的可拆卸的适配器歧管或具有整体的盒式歧管相兼容的手持件，注射器和缩放器的各种结构。 还公开了具有集成歧管的喷嘴和与空气排出口对准的可分离的墨盒歧管。

公开(公告)号：WO1995001437A2

公开(公告)日：1995-01-12

申请号：PCT/US1994007336

申请日：1994-06-29

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  ORR, Harry, T. ,  CHUNG, Ming-yi ,  ZOGHBI, Huda, Y.

IPC: C12N15/12

CPC classification number: G01N33/6896 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172 ,  G01N2800/2835

Abstract: The present invention provides an isolated DNA molecule of the autosomal dominant spinocerebellar ataxia type 1 gene, which is located within the short arm of chromosome 6. This isolated DNA molecule is preferably located within a 3.36 kb EcoRI fragment, i.e., an EcoRI fragment containing about 3360 base pairs, of the SCA1 gene. The isolated sequences contain a CAG repeat region. The number of CAG trinucleotide repeats (n) is 36, preferably n >/= 43.

Abstract translation: 本发明提供了位于染色体6的短臂内的常染色体显性脊髓小脑性共济失调1型基因的分离的DNA分子。该分离的DNA分子优选位于3.36kb的EcoRI片段内，即含有约 SCA1基因的3360个碱基对。 分离的序列包含CAG重复区。 对于正常个体，CAG三核苷酸重复序列（n）的数目为 36，优选n≥43。

公开(公告)号：WO1994027443A1

公开(公告)日：1994-12-08

申请号：PCT/US1994005456

申请日：1994-05-13

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  SCHOTTEL, Janet, L. ,  ANDERSON, Neil, A. ,  LIU, Daqun ,  KINKEL, Linda, L.

Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA

IPC: A01N63/00

CPC classification number: C12R1/465 ,  A01N63/00 ,  C07K16/1292 ,  C12P1/06 ,  Y10S435/886

Abstract: The present invention is directed to methods and compositions for biological control of plant diseases using suppressive avirulent strains of Streptomyces spp. to control disease on a vegetable or other susceptible crop. The method includes applying one or more naturally occurring, suppressive avirulent strains of Streptomyces spp. to the crop to inhibit the growth of Streptomyces scabies or other plant pathogenic organisms that cause scab, wilt, or seedling blight disease. Preferably, at least two suppressive avirulent strains of Streptomyces spp. are applied to reduce the change of resistance from occurring. The suppressive avirulent strains are compatible and will grow in the presence of one another and, when combined with the pathogenic organism, at least one of the suppressive avirulent strains preferably substantially outgrows the pathogen.

Abstract translation: 本发明涉及使用Streptomyces spp的抑制性无毒力菌株生物防治植物病害的方法和组合物。 控制蔬菜或其他易感作物的疾病。 该方法包括施用一种或多种天然存在的，抑制性无毒力的链霉菌属菌株。 作物以抑制引起痂病，枯萎病或幼苗病的Streptomyces sc疮或其他植物致病生物的生长。 优选地，链霉菌属的至少两种抑制性无毒力菌株 适用于减少阻力发生的变化。 抑制性无毒力菌株是相容的并且将在彼此存在下生长，并且当与致病生物体组合时，至少一种抑制性无毒力菌株优选基本上超过病原体。

公开(公告)号：WO1994022895A1

公开(公告)日：1994-10-13

申请号：PCT/US1994003524

申请日：1994-03-30

Applicant: NATIONAL JEWISH CENTER FOR IMMUNOLOGY AND RESPIRATORY MEDICINE ,  NEW ENGLAND MEDICAL CENTER HOSPITAL, INC. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： NATIONAL JEWISH CENTER FOR IMMUNOLOGY AND RESPIRATORY MEDICINE ,  NEW ENGLAND MEDICAL CENTER HOSPITAL, INC. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA ,  LEUNG, Donald ,  SCHLIEVERT, Patrick ,  MEISSNER, Cody ,  FULTON, David

IPC: C07H21/04

CPC classification number: C07K14/31 ,  Y10T436/143333

Abstract: The invention relates to isolated nucleic acid molecules coding for toxins associated with Kawasaki Syndrome. Also described are various applications of the nucleic acid molecules. The figure depicts a Southern blot of isolates from patients with Kawasaki Syndrome.

Abstract translation: 本发明涉及编码与川崎综合征相关的毒素的分离的核酸分子。 还描述了核酸分子的各种应用。 该图描述了川崎综合征患者的分离株的Southern印迹。

公开(公告)号：WO1994016096A2

公开(公告)日：1994-07-21

申请号：PCT/US1994000567

申请日：1994-01-14

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  BLOOMQUIST, Cynthia, G. ,  DOUGLAS, William ,  DUNNY, Gary ,  LILJEMARK, William ,  REILLY, Bernard

Inventor： REGENTS OF THE UNIVERSITY OF MINNESOTA

IPC: C12Q01/00

CPC classification number: C12N15/62 ,  C12N1/38 ,  C12Q1/02

Abstract: The present invention described provides a start microbial replication factor, as well as methods for assaying and using the start microbial replication factor. A start microbial replication factor can be used to stimulate the growth of bacteria in suspension or bound to a surface. Agents that inhibit or enhance a start microbial replication factor can also be identified. The present invention also describes processes to treat or control the growth of bacteria which are bound to surfaces. Both proliferation and metabolism of bacteria which are adhered to surfaces are independent of both time and nutrient supply. Growth of adherent bacteria is density dependent. The present invention also provides a process to predict when bacterial growth will exhibit rapid growth on a surface. The invention also provides novel strains of transformed bacteria and methods of using the bacteria strains to measure microbial growth in the presence or absence of a start microbial replication factor. The transformed bacteria have a bacterial reporter gene under the control of a promoter whose expression is coordinately regulated with cell growth.

Abstract translation: 所述的本发明提供了起始微生物复制因子，以及用于测定和使用起始微生物复制因子的方法。 起始的微生物复制因子可用于刺激悬浮或结合表面的细菌的生长。 还可以鉴定抑制或增强起始微生物复制因子的药剂。 本发明还描述了治疗或控制与表面结合的细菌生长的方法。 粘附在表面上的细菌的增殖和代谢都与时间和营养供应无关。 粘附细菌的生长密度依赖性。 本发明还提供了一种预测何时细菌生长将在表面上表现出快速生长的过程。 本发明还提供了转化细菌的新菌株和在存在或不存在起始微生物复制因子的情况下使用细菌菌株来测量微生物生长的方法。 转化的细菌具有在其表达与细胞生长协调调节的启动子控制下的细菌报道基因。